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REM sleep in schizophrenia: a systematic review and meta-analysis 精神分裂症的快速眼动睡眠:系统回顾和荟萃分析
IF 11.2 1区 医学
Sleep Medicine Reviews Pub Date : 2025-10-01 Epub Date: 2025-07-15 DOI: 10.1016/j.smrv.2025.102134
Dario Morra, Giuseppe Barbato
{"title":"REM sleep in schizophrenia: a systematic review and meta-analysis","authors":"Dario Morra,&nbsp;Giuseppe Barbato","doi":"10.1016/j.smrv.2025.102134","DOIUrl":"10.1016/j.smrv.2025.102134","url":null,"abstract":"<div><div>A systematic review and meta-analysis of REM studies in schizophrenia were conducted using published articles researched in major databases within the period from January 1, 1955, to March 15, 2025. REM sleep parameters such as REM time, REM percentage, REM latency and REM density of drug-naive, drug-free and treated schizophrenic patients were analyzed and, where available, compared with case-control data of healthy controls and depressed patients. One hundred ninety studies were identified in the systematic review. Ninety-two case-control studies with 1845 schizophrenic patients, 1269 healthy controls and 262 depressed patients were included in the meta-analyses. The primary outcome was the standard mean difference. Data were fitted with a random-effects model. Publication bias assessment was checked by Egger's Regression and funnel plot asymmetry. Compared to healthy controls, REM time and REM latency were found respectively reduced and shortened in both drug-naive and drug-free schizophrenics, while REM density was found increased in drug-free and treated schizophrenics. No significant difference, compared to healthy control, emerged for REM percentages either in drug-naive, drug-free and treated schizophrenics. Reduced REM latency in drug-free and drug-naive schizophrenics was like that of depressed patients. Antipsychotic treatment appeared to have a normalizing effect on REM time and REM latency but not on REM density: increased density in both drug-free and treated schizophrenics suggest that this variable might be controlled by different mechanisms and/or neurotransmitters than those controlling REM occurrence.</div></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"83 ","pages":"Article 102134"},"PeriodicalIF":11.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144694548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Slow wave activity during non-rapid eye movement (NREM) sleep in patients with major depressive disorder: a meta-analysis 重度抑郁症患者非快速眼动(NREM)睡眠中的慢波活动:一项荟萃分析
IF 9.7 1区 医学
Sleep Medicine Reviews Pub Date : 2025-10-01 Epub Date: 2025-08-05 DOI: 10.1016/j.smrv.2025.102141
Pauline Henckaerts , Kristoffer D. Fehér , Elisabeth Hertenstein , Carlotta L. Schneider , Marie Angelillo , Christian Mikutta , Bernd Feige , Dieter Riemann , Christoph Nissen
{"title":"Slow wave activity during non-rapid eye movement (NREM) sleep in patients with major depressive disorder: a meta-analysis","authors":"Pauline Henckaerts ,&nbsp;Kristoffer D. Fehér ,&nbsp;Elisabeth Hertenstein ,&nbsp;Carlotta L. Schneider ,&nbsp;Marie Angelillo ,&nbsp;Christian Mikutta ,&nbsp;Bernd Feige ,&nbsp;Dieter Riemann ,&nbsp;Christoph Nissen","doi":"10.1016/j.smrv.2025.102141","DOIUrl":"10.1016/j.smrv.2025.102141","url":null,"abstract":"<div><div>Slow-wave activity (SWA) during non-rapid eye movement (NREM) sleep is the primary marker of sleep homeostasis and proposed to reflect synaptic strength. SWA might be reduced in patients with major depressive disorder (MDD), potentially reflecting reduced synaptic strength (synaptic plasticity hypothesis of MDD). In view of inconsistent findings in the previous literature, the aim of this meta-analysis was to test the hypothesis of reduced SWA in patients with MDD compared to healthy controls. PubMed, CINAHL and PsychInfo were searched for original publications comparing SWA during NREM sleep in adult patients with MDD to healthy controls. A random-effects model for meta-analyses was calculated using Hedges' <em>g</em>. The study was pre-registered in the international prospective register of systematic reviews (PROSPERO CRD42024537138). Five studies comprising 229 participants were included. The meta-analysis demonstrated a significant reduction of SWA during NREM sleep in patients with MDD compared to healthy controls (<em>p</em> = 0.0003, <em>g</em> = −0.5, medium effect-size, confidence interval −0.8 to −0.2) with low heterogeneity (Q-test; <em>p</em> = 0.518, I<sup>2</sup> = 0 %). This meta-analysis demonstrates a significant reduction of SWA during NREM sleep in patients with MDD compared to healthy controls, consistent with the concept of reduced synaptic strength in patients with MDD.</div></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"83 ","pages":"Article 102141"},"PeriodicalIF":9.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144896682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A paediatric group neglected in research: A systematic review on the sleep patterns, chronotype, latitude and ethnicity. 在研究中被忽视的儿科群体:一项关于睡眠模式、生物钟、纬度和种族的系统综述。
IF 9.7 1区 医学
Sleep Medicine Reviews Pub Date : 2025-10-01 Epub Date: 2025-08-06 DOI: 10.1016/j.smrv.2025.102143
Sandra Figueiredo, Genta Kulari, Ana Gomes
{"title":"A paediatric group neglected in research: A systematic review on the sleep patterns, chronotype, latitude and ethnicity.","authors":"Sandra Figueiredo, Genta Kulari, Ana Gomes","doi":"10.1016/j.smrv.2025.102143","DOIUrl":"10.1016/j.smrv.2025.102143","url":null,"abstract":"<p><p>This study presents a systematic review design aiming to explore how chronotype features are assessed in school-aged children (ages 4-11) and how chronotype is related to sleep habits, household dynamics, ethnicity, and geographical latitude. The review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Thirty-one studies were identified as eligible and reviewed by three independent researchers. The main findings indicate that chronotype is often under-assessed in school-aged children, with both professionals and parents reporting limited knowledge of children's sleep patterns. Additionally, there is a lack of information in the literature regarding how chronotype, sleep patterns, and vigilance are influenced by latitude and sociocultural factors. Most research on the relationship among the aforementioned variables is focused on adults rather than children. Furthermore, the methods for measuring sleep quality and chronotype were found to be inconsistent, with chronotype and sleep quality often used interchangeably. Based on these findings, further research is needed to explore how chronotype, sleep habits, and cultural or latitudinal factors might predict mental health and cognitive development in children. In terms of practical implications, there is an urgent need for re-education of parents on establishing healthy sleep and wake routines for their children.</p>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"83 ","pages":"102143"},"PeriodicalIF":9.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144812552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Commentary on "The impact of maternal sleep during pregnancy on childhood health: A systematic review" 《孕妇孕期睡眠对儿童健康的影响:系统综述》评论
IF 9.7 1区 医学
Sleep Medicine Reviews Pub Date : 2025-10-01 Epub Date: 2025-08-12 DOI: 10.1016/j.smrv.2025.102151
Lili Yi
{"title":"Commentary on \"The impact of maternal sleep during pregnancy on childhood health: A systematic review\"","authors":"Lili Yi","doi":"10.1016/j.smrv.2025.102151","DOIUrl":"10.1016/j.smrv.2025.102151","url":null,"abstract":"","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"83 ","pages":"Article 102151"},"PeriodicalIF":9.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144830695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Variants of time in bed manipulation therapy for patients with insomnia: A scoping review 失眠患者床上手法治疗时间的变化:一项范围综述
IF 9.7 1区 医学
Sleep Medicine Reviews Pub Date : 2025-10-01 Epub Date: 2025-08-09 DOI: 10.1016/j.smrv.2025.102150
Ann Rosén , Maria Cassel , Johanna Stjernberg , Joel Stenfalk , Kerstin Blom , Sandra Tamm , Torbjörn Åkerstedt , Rickard Carlsson , Susanna Jernelöv
{"title":"Variants of time in bed manipulation therapy for patients with insomnia: A scoping review","authors":"Ann Rosén ,&nbsp;Maria Cassel ,&nbsp;Johanna Stjernberg ,&nbsp;Joel Stenfalk ,&nbsp;Kerstin Blom ,&nbsp;Sandra Tamm ,&nbsp;Torbjörn Åkerstedt ,&nbsp;Rickard Carlsson ,&nbsp;Susanna Jernelöv","doi":"10.1016/j.smrv.2025.102150","DOIUrl":"10.1016/j.smrv.2025.102150","url":null,"abstract":"<div><div>Cognitive behavioural therapy for insomnia includes methods to adjust bedtimes and risetimes. The most well-known is sleep restriction therapy, but alternatives like sleep compression therapy and bedtime regularization also exist. Instructions and terminology vary. This scoping review uses \"time-in-bed manipulation therapy\" to encompass all such interventions, aiming to synthesize information on their implementation in adult populations, focusing on different instructions found in the literature.</div><div>We searched five electronic databases. Two independent reviewers screened full-text papers, followed by data extraction. Both quantitative (e.g., instruction frequencies) and qualitative (e.g., analysis of content) syntheses were conducted.</div><div>Of 7474 citations and 500 full-text papers, 52 studies met inclusion criteria, covering 60 therapies. Most interventions were termed sleep restriction therapy, but other names, such as sleep compression and bedtime restriction, were also used. Nine different methods for calculating the initial sleep window were identified, with further variation in other instructions. About half of the studies were randomized controlled trials.</div><div>This review provides a comprehensive overview of time-in-bed manipulation therapies, aiding researchers and clinicians in selecting appropriate approaches. It highlights the need for clearer reporting, increased direct comparisons, and suggests a new model, The Restriction and Flexibility Model, describing key dimensions of these interventions.</div></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"83 ","pages":"Article 102150"},"PeriodicalIF":9.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144865998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Winding down for sleep: How behavioral, cognitive, motivational, and emotional factors interact to influence sleep regulation and health 放松睡眠:行为、认知、动机和情感因素如何相互作用,影响睡眠调节和健康
IF 9.7 1区 医学
Sleep Medicine Reviews Pub Date : 2025-10-01 Epub Date: 2025-08-13 DOI: 10.1016/j.smrv.2025.102154
Debora Meneo , Chiara Baglioni
{"title":"Winding down for sleep: How behavioral, cognitive, motivational, and emotional factors interact to influence sleep regulation and health","authors":"Debora Meneo ,&nbsp;Chiara Baglioni","doi":"10.1016/j.smrv.2025.102154","DOIUrl":"10.1016/j.smrv.2025.102154","url":null,"abstract":"<div><div>Animals do not simply fall asleep when they need rest. Without conscious effort, most animals engage in a series of sleep-preparatory behaviors, such as nesting. These are stereotypical actions performed in a temporally structured pre-sleep phase. Researchers have examined these behaviors from an evolutionary perspective, as they must provide some advantage. One hypothesis is that they have an indirect fitness benefit by facilitating de-arousal, making it easier to transition from wakefulness to sleep. In humans, regular positive bedtime routines are considered a main pediatric dimension of sleep health. In adults, difficulty in de-arousal at bedtime is a major issue for people with insomnia. Cognitive models of insomnia stress the strict association between arousal and cognitive-emotional factors driving behaviors. However, there is a lack of a unified framework to address the interplay between pre-sleep behaviors, psychological processes, and arousal levels in promoting or inhibiting evening winding down and wake-to-sleep transition. This narrative review aims to explore the role of behavioral components of sleep regulation, by focusing on the dynamical association between pre-sleep behaviors, cognitions, motivations, emotions, and arousal in relation to sleep health. We propose a framework to understand and investigate winding down behaviors as part of sleep regulation in humans.</div></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"83 ","pages":"Article 102154"},"PeriodicalIF":9.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144880267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmacological impact on sleep architecture and polysomnographic measures in Restless Legs Syndrome: A systematic review. 药物对不宁腿综合征患者睡眠结构和多导睡眠图测量的影响:一项系统综述。
IF 9.7 1区 医学
Sleep Medicine Reviews Pub Date : 2025-10-01 Epub Date: 2025-08-05 DOI: 10.1016/j.smrv.2025.102147
Maria P Mogavero, Elias G Karroum, Giuseppe Lanza, Elena Antelmi, Oliviero Bruni, Rosalia Silvestri, Sara Marelli, Alessandra Castelnuovo, Luigi Ferini-Strambi, Raffaele Ferri
{"title":"Pharmacological impact on sleep architecture and polysomnographic measures in Restless Legs Syndrome: A systematic review.","authors":"Maria P Mogavero, Elias G Karroum, Giuseppe Lanza, Elena Antelmi, Oliviero Bruni, Rosalia Silvestri, Sara Marelli, Alessandra Castelnuovo, Luigi Ferini-Strambi, Raffaele Ferri","doi":"10.1016/j.smrv.2025.102147","DOIUrl":"10.1016/j.smrv.2025.102147","url":null,"abstract":"<p><p>Restless Legs Syndrome (RLS) is a sensorimotor disorder with diverse clinical manifestations that significantly impact sleep and quality of life, particularly among women. Polysomnography (PSG) plays a key role in evaluating motor features of RLS, such as periodic leg movements during sleep (PLMS). This review examines the effects of pharmacological treatments on PSG parameters and sleep architecture in RLS. Dopamine agonists are the most studied, consistently reducing PLMS but offering limited improvements in sleep structure and carrying risks of augmentation with long-term use. In contrast, alpha-2-delta ligands (e.g., pregabalin, gabapentin) improve sleep efficiency and reduce wakefulness, particularly benefiting patients with sensory symptoms or insomnia. Research on opioids and intravenous iron remains limited, though both show potential: opioids may reduce PLMS and improve sleep but raise respiratory safety concerns, while intravenous iron has shown efficacy, especially in pregnant women and children. We also conducted a meta-analysis assessing treatment effects of dopamine agonists on total sleep time, wakefulness after sleep onset, and sleep stage percentages (N1, N2, N3, REM). Given the heterogeneity of RLS and variable treatment responses across age and sex, future research should prioritize individualized therapeutic strategies and further investigate underexplored options to support precision medicine in RLS.</p>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"83 ","pages":"102147"},"PeriodicalIF":9.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144805094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The human chronotype: A multidimensional construct at the crossroad of physiology and behavior, with important health implications 人类时型:生理和行为交叉路口的多维结构,具有重要的健康意义
IF 9.7 1区 医学
Sleep Medicine Reviews Pub Date : 2025-10-01 Epub Date: 2025-07-26 DOI: 10.1016/j.smrv.2025.102142
Gabriela Yuri , Rodrigo Chamorro , Nicolás Tobar , Mariana Cifuentes
{"title":"The human chronotype: A multidimensional construct at the crossroad of physiology and behavior, with important health implications","authors":"Gabriela Yuri ,&nbsp;Rodrigo Chamorro ,&nbsp;Nicolás Tobar ,&nbsp;Mariana Cifuentes","doi":"10.1016/j.smrv.2025.102142","DOIUrl":"10.1016/j.smrv.2025.102142","url":null,"abstract":"<div><div>Chronotype has been defined according to an individual's preference regarding the timing for daily activities and behaviors such as waking up, eating, exercising and going to bed. These behavioral preferences have been related to genetic, endocrine, behavioral, and other biological, psychological, environmental, and social traits. Research in chronobiology has linked the \"morning\" vs. \"evening\" preference to different risk for several health problems. The assessment of our current knowledge of chronotype and its influence on the development and persistence of the current pandemic of obesity and metabolism-related chronic diseases is timely and relevant. The present narrative review aims to examine the available evidence regarding chronotype and metabolic health. We also discuss the potential use of chronotype-based therapeutic approaches in clinical practice and describe literature gaps to propose future research directions in this field. Understanding molecular, physiological, psychological, and social mechanisms underlying differences between \"<em>larks</em>\" and \"<em>owls</em>\" will provide the opportunity to translate this knowledge into clinical practice and may be vital to implementing and/or improving individualized treatment outcomes.</div></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"83 ","pages":"Article 102142"},"PeriodicalIF":9.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144750717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Oximetry-based devices in diagnosis of obstructive sleep apnea: A systematic review and meta-analysis 基于血氧测量的设备诊断阻塞性睡眠呼吸暂停:系统回顾和荟萃分析
IF 9.7 1区 医学
Sleep Medicine Reviews Pub Date : 2025-10-01 Epub Date: 2025-07-22 DOI: 10.1016/j.smrv.2025.102139
Eder Leandro da Silva Dantas , Fernando Gustavo Stelzer , Wanderley Marques Bernardo , Alan Luiz Eckeli
{"title":"Oximetry-based devices in diagnosis of obstructive sleep apnea: A systematic review and meta-analysis","authors":"Eder Leandro da Silva Dantas ,&nbsp;Fernando Gustavo Stelzer ,&nbsp;Wanderley Marques Bernardo ,&nbsp;Alan Luiz Eckeli","doi":"10.1016/j.smrv.2025.102139","DOIUrl":"10.1016/j.smrv.2025.102139","url":null,"abstract":"<div><div>Obstructive sleep apnea (OSA) is a common disorder, associated with significant morbidity and mortality. Recently, several oximetry-based devices have been developed to assist with diagnosing OSA. Therefore, this study aims to evaluate the diagnostic performance of these tools compared to PSG. We included studies that evaluated oximetry-based devices in comparison to PSG for OSA diagnosis in adults. 18 selected studies were divided into two subgroups: <em>consumer wearable</em> and medical devices. Overall sensitivity was 97 % (95 % Confidence Interval [CI]: 96–97 %) and specificity, 63 % (95 % CI: 61–65. In the <em>consumer wearable devices subgroup, sensitivity was 93 % (95 % CI: 90 – 96) and specificity, 63 % (95 % CI: 53 – 71). In the</em> medical devices subgroup, sensitivity was also high as 97 % (95 % CI: 96–97) with a specificity of 63 % (95 % CI: 61–65). Accuracy measured by area under the curve and post-test probability were both 90 %. Oximetry-based devices demonstrate high sensitivity for ruling out OSA in high-risk adults. However, their low specificity raises concerns regarding potential unnecessary healthcare costs. Therefore, these devices may be considered for screening in high-risk individuals, provided that all positive results are confirmed by a gold-standard diagnostic method.</div></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"83 ","pages":"Article 102139"},"PeriodicalIF":9.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144750716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genetic association between sleep quality, insomnia, and psychological distress: a systematic review and meta-analysis 睡眠质量、失眠和心理困扰之间的遗传关联:一项系统综述和荟萃分析
IF 9.7 1区 医学
Sleep Medicine Reviews Pub Date : 2025-10-01 Epub Date: 2025-08-07 DOI: 10.1016/j.smrv.2025.102149
Federico J. Blanco-García , José A. López-López , Juan R. Ordoñana , Juan J. Madrid-Valero
{"title":"Genetic association between sleep quality, insomnia, and psychological distress: a systematic review and meta-analysis","authors":"Federico J. Blanco-García ,&nbsp;José A. López-López ,&nbsp;Juan R. Ordoñana ,&nbsp;Juan J. Madrid-Valero","doi":"10.1016/j.smrv.2025.102149","DOIUrl":"10.1016/j.smrv.2025.102149","url":null,"abstract":"<div><div>There is a well-established link between sleep disorders and psychological problems such as anxiety and depression. Twin studies and genome-wide association studies (GWAS) have consistently found significant genetic overlap between these traits. However, there is considerable variation among studies. The aims of this meta-analysis were therefore: 1) to estimate the mean genetic correlation between sleep problems and psychological distress; 2) to assess heterogeneity among the included studies; and 3) to search for potential moderators that could contribute to this heterogeneity. To this end, we performed several multivariate meta-analyses. The mean genetic correlations were estimated to be 0.55 (CI: 0.47–0.63) for sleep quality and depression, 0.72 (CI: 0.59–0.85) for insomnia symptoms and depression, 0.42 (CI: 0.30–0.54) for sleep quality and anxiety, and 0.75 (CI: 0.59–0.91) for insomnia symptoms and anxiety. Similar results were obtained when depression and anxiety were collapsed (0.54 [CI: 0.44–0.64] for sleep quality and 0.77 [CI: 0.63–0.91] for insomnia symptoms). Sex did not significantly moderate these associations. Study type (twin studies vs GWAS) and age, however, were significant moderators (p &lt; 0.001). These findings highlight the substantial genetic overlap between psychological distress and sleep problems, which appears to be stronger for insomnia symptoms than for sleep quality.</div></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"83 ","pages":"Article 102149"},"PeriodicalIF":9.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144885594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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