Sleep Medicine Reviews最新文献

{"title":"Asthma and obstructive sleep apnea: A complex but treatable relationship","authors":"Ignasi Español ,&nbsp;Ebymar Arismendi ,&nbsp;Pilar Martínez-Olondris ,&nbsp;Concepción Ruiz ,&nbsp;Cristina Embid ,&nbsp;Jennifer Garcia ,&nbsp;Alvar Agustí ,&nbsp;Mireia Dalmases","doi":"10.1016/j.smrv.2025.102146","DOIUrl":"10.1016/j.smrv.2025.102146","url":null,"abstract":"<div><div>Asthma and obstructive sleep apnea are complex diseases that significantly impact the health-related quality of life and overall health status of patients. Recent evidence points towards an increased prevalence of obstructive sleep apnea in asthmatic patients, especially in those with severe and uncontrolled asthma, potentially leading to worse asthma control with increased symptoms, diminished health status and more frequent exacerbations. The mechanisms underlying this association are not fully elucidated. However, because obstructive sleep apnea is treatable, screening for sleep disorders should be considered in patients with severe asthma and uncontrolled disease. The efficacy and implications of treatment with continuous positive airway pressure to improve asthma control remain unclear, although there are some promising results showing improved asthma outcomes. Further research is needed to enlighten the relationship between asthma and obstructive sleep apnea, and to better define the role of continuous positive airway pressure therapy in improving asthma control and outcomes in comorbid patients with asthma and obstructive sleep apnea. Here we review the state-of-the-art in this field.</div></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"83 ","pages":"Article 102146"},"PeriodicalIF":9.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144888802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond explainable AI: Enhancing trust and robustness in machine learning for sleep apnea diagnosis","authors":"Yoshiyasu Takefuji","doi":"10.1016/j.smrv.2025.102152","DOIUrl":"10.1016/j.smrv.2025.102152","url":null,"abstract":"<div><div>Kilic et al. reviewed machine learning (ML) and deep learning (DL) for sleep apnea detection, emphasizing explainable AI (XAI) while noting challenges like Apnea-Hypopnea Index (AHI) discrepancies. This paper extends their critique, arguing that XAI tools like SHAP inherit model biases, and high prediction accuracy does not guarantee reliable feature importances, which inherently lack ground truth validation. To overcome these limitations and build clinical trust, we advocate for a comprehensive approach combining unsupervised ML (e.g., feature agglomeration, highly variable gene selection) with nonlinear nonparametric statistical methods (e.g., Spearman's correlation). This strategy robustly evaluates variable relationships and p-values, particularly for monotonic associations, mitigating misapplications stemming from assumption violations and inadequate interpretation of model ground truth, thus fostering real-world applicability.</div></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"83 ","pages":"Article 102152"},"PeriodicalIF":9.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144852758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep abnormalities in bipolar disorders across mood phases: A systematic review and meta-analysis","authors":"Mattia Marchetti ,&nbsp;Ahmad Mayeli ,&nbsp;Claudio Sanguineti ,&nbsp;Francesco L. Donati ,&nbsp;Omeed Chaichian ,&nbsp;Allison Kim ,&nbsp;Katerina Piskun ,&nbsp;Armando D'Agostino ,&nbsp;Nicholas Meyer ,&nbsp;James D. Wilson ,&nbsp;Paolo Fusar-Poli ,&nbsp;Mary L. Phillips ,&nbsp;Fabio Ferrarelli","doi":"10.1016/j.smrv.2025.102137","DOIUrl":"10.1016/j.smrv.2025.102137","url":null,"abstract":"<div><div>Sleep abnormalities are core features of bipolar disorders (BD), but they have not been thoroughly examined across mood phases. This meta-analysis investigated sleep disturbance prevalence and sleep characteristics differences in BD across mood phases. A systematic search through September 2024 identified 44 studies (7614 BD cases, 3164 controls), including 11 prevalence and 34 case-control studies. Poor sleep quality prevalence was 52% during euthymia, and insomnia prevalence was 63% during the depressive phase. Individuals with euthymic BD reported worse sleep quality and objectively measured longer total sleep time and sleep onset latency than controls. Depressive phase BD showed higher rapid eye movement percentages, while manic/mixed phase exhibited shorter total sleep time, lower sleep efficiency, and longer sleep onset latency. During euthymia, BD demonstrated greater variability in sleep duration and continuity, and more prominent sleep differences when assessed with sleep diary versus objective sleep measures, highlighting the importance of integrating objective assessments and patient-reported outcomes. Overall, these findings indicate that poor sleep quality and insomnia are highly prevalent in BD, and that some sleep parameter differences are present during euthymia, while others occur during depressive and manic phases, emphasizing the need for sleep assessments and tailored management throughout the course of BD.</div></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"83 ","pages":"Article 102137"},"PeriodicalIF":11.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144685987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing subjective and objective nighttime- and daytime variables between patients with insomnia disorder and controls – a systematic umbrella review of meta-analyses","authors":"Elisabeth Hertenstein ,&nbsp;Marie Angelillo ,&nbsp;Pauline Henckaerts ,&nbsp;Carlotta L. Schneider ,&nbsp;Kristoffer D. Fehér ,&nbsp;Dieter Riemann ,&nbsp;Bernd Feige ,&nbsp;Kai Spiegelhalder ,&nbsp;Anna Johann ,&nbsp;Cagdas Türkmen ,&nbsp;Christoph Nissen","doi":"10.1016/j.smrv.2025.102153","DOIUrl":"10.1016/j.smrv.2025.102153","url":null,"abstract":"<div><div>Insomnia disorder is a prevalent health problem with adverse consequences for mental health and quality of life. Although insomnia disorder is defined in diagnostic systems as a subjective complaint about sleep, this understanding is not consistently applied in clinical settings. There remains a lack of clarity regarding the mechanisms underlying subjective sleep complaints and associated daytime impairments.</div><div>This systematic umbrella review of meta-analyses aimed to compare subjective and objective health-related variables between patients with insomnia disorder and controls, characterizing insomnia comprehensively. After a systematic literature search, we included six meta-analyses comparing patients with insomnia disorder and controls in terms of subjective sleep (sleep diaries), objective sleep (polysomnography), peripheral brain-derived neurotrophic factor, cortisol, objective cognitive performance, blood pressure and EEG spectral power.</div><div>The pattern of results suggests that differences between patients with insomnia disorder and healthy controls are largest and most consistent for subjective sleep. Objective between-group effect sizes were largest for unspecific stress markers such as brain-derived neurotrophic factor and cortisol. Variables expected to be abnormal in those with objective sleep deprivation, such as objective attention and alertness, showed minimal group differences. Also in terms of sleep, effect sizes for subjective variables were consistently larger than those for objective variables. Critical appraisal of the quality of the included meta-analyses using the AMSTAR 2 tool suggested moderate overall confidence in the results, whereby shortcomings in several critical domains such as pre-registration of the study protocol and justification for the inclusion of individual studies have been identified.</div><div>Our findings highlight that insomnia disorder is characterized by large reductions in subjective sleep quality, in the absence of large objective alterations. This body of evidence supports a biopsychosocial conceptualization of chronic insomnia disorder with a strong psychological component.</div></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"83 ","pages":"Article 102153"},"PeriodicalIF":9.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144888658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep program efficacy across gender and racial/ethnic groups: A content review and meta-analysis","authors":"Allison E. Nickel ,&nbsp;Candice Lage ,&nbsp;Abbye Porro ,&nbsp;Chenlu Gao ,&nbsp;Dayna A. Johnson ,&nbsp;Lauren Hale ,&nbsp;Michael K. Scullin","doi":"10.1016/j.smrv.2025.102135","DOIUrl":"10.1016/j.smrv.2025.102135","url":null,"abstract":"<div><div>Female and under-represented minority students (URMs) in higher education disproportionately experience sleep disturbances. Incorporating sleep education and other psychological interventions (e.g., cognitive behavioral therapy for insomnia; CBT-I) into college settings might provide a scalable solution, but it is unknown whether such psychoeducational interventions produce equivalent outcomes across groups. We addressed this question with two approaches. First, we identified 36 US-based studies that had student participants and a psychoeducational sleep intervention. Fifteen authors shared data on sleep knowledge, quality, and/or duration separated by gender and URM groups (N = 599). Hedges' g was computed for each group within each study. Second, we systematically reviewed the content of 21 available programs. We found that, relative to national collegiate data (59.4 % female, 41.5 % URM), females were over-represented (63.4 %) and URM groups were under-represented (23.7 %) in these studies. Interventions improved sleep knowledge (g = 0.69, p&lt;.001) and sleep quality (g = 0.25, p&lt;.001), but not sleep duration (g = 0.13, p = .18). Effect sizes were similar in males, females, URM students, and non-URM students. There were no studies that incorporated financial, social, or neighborhood-level barriers to sleep in students. Future interventions in student groups might be improved by combining individualized, CBT-I-based education while concomitantly addressing environmental/institutional barriers to sleep.</div></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"83 ","pages":"Article 102135"},"PeriodicalIF":9.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144769155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oximetry at the crossroads of innovation and equity in sleep apnea diagnosis","authors":"Miguel Meira e Cruz ,&nbsp;Meir Kryger","doi":"10.1016/j.smrv.2025.102144","DOIUrl":"10.1016/j.smrv.2025.102144","url":null,"abstract":"","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"83 ","pages":"Article 102144"},"PeriodicalIF":9.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144771015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"REM sleep in schizophrenia: a systematic review and meta-analysis","authors":"Dario Morra,&nbsp;Giuseppe Barbato","doi":"10.1016/j.smrv.2025.102134","DOIUrl":"10.1016/j.smrv.2025.102134","url":null,"abstract":"<div><div>A systematic review and meta-analysis of REM studies in schizophrenia were conducted using published articles researched in major databases within the period from January 1, 1955, to March 15, 2025. REM sleep parameters such as REM time, REM percentage, REM latency and REM density of drug-naive, drug-free and treated schizophrenic patients were analyzed and, where available, compared with case-control data of healthy controls and depressed patients. One hundred ninety studies were identified in the systematic review. Ninety-two case-control studies with 1845 schizophrenic patients, 1269 healthy controls and 262 depressed patients were included in the meta-analyses. The primary outcome was the standard mean difference. Data were fitted with a random-effects model. Publication bias assessment was checked by Egger's Regression and funnel plot asymmetry. Compared to healthy controls, REM time and REM latency were found respectively reduced and shortened in both drug-naive and drug-free schizophrenics, while REM density was found increased in drug-free and treated schizophrenics. No significant difference, compared to healthy control, emerged for REM percentages either in drug-naive, drug-free and treated schizophrenics. Reduced REM latency in drug-free and drug-naive schizophrenics was like that of depressed patients. Antipsychotic treatment appeared to have a normalizing effect on REM time and REM latency but not on REM density: increased density in both drug-free and treated schizophrenics suggest that this variable might be controlled by different mechanisms and/or neurotransmitters than those controlling REM occurrence.</div></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"83 ","pages":"Article 102134"},"PeriodicalIF":11.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144694548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Slow wave activity during non-rapid eye movement (NREM) sleep in patients with major depressive disorder: a meta-analysis","authors":"Pauline Henckaerts ,&nbsp;Kristoffer D. Fehér ,&nbsp;Elisabeth Hertenstein ,&nbsp;Carlotta L. Schneider ,&nbsp;Marie Angelillo ,&nbsp;Christian Mikutta ,&nbsp;Bernd Feige ,&nbsp;Dieter Riemann ,&nbsp;Christoph Nissen","doi":"10.1016/j.smrv.2025.102141","DOIUrl":"10.1016/j.smrv.2025.102141","url":null,"abstract":"<div><div>Slow-wave activity (SWA) during non-rapid eye movement (NREM) sleep is the primary marker of sleep homeostasis and proposed to reflect synaptic strength. SWA might be reduced in patients with major depressive disorder (MDD), potentially reflecting reduced synaptic strength (synaptic plasticity hypothesis of MDD). In view of inconsistent findings in the previous literature, the aim of this meta-analysis was to test the hypothesis of reduced SWA in patients with MDD compared to healthy controls. PubMed, CINAHL and PsychInfo were searched for original publications comparing SWA during NREM sleep in adult patients with MDD to healthy controls. A random-effects model for meta-analyses was calculated using Hedges' <em>g</em>. The study was pre-registered in the international prospective register of systematic reviews (PROSPERO CRD42024537138). Five studies comprising 229 participants were included. The meta-analysis demonstrated a significant reduction of SWA during NREM sleep in patients with MDD compared to healthy controls (<em>p</em> = 0.0003, <em>g</em> = −0.5, medium effect-size, confidence interval −0.8 to −0.2) with low heterogeneity (Q-test; <em>p</em> = 0.518, I² = 0 %). This meta-analysis demonstrates a significant reduction of SWA during NREM sleep in patients with MDD compared to healthy controls, consistent with the concept of reduced synaptic strength in patients with MDD.</div></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"83 ","pages":"Article 102141"},"PeriodicalIF":9.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144896682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A paediatric group neglected in research: A systematic review on the sleep patterns, chronotype, latitude and ethnicity.","authors":"Sandra Figueiredo, Genta Kulari, Ana Gomes","doi":"10.1016/j.smrv.2025.102143","DOIUrl":"10.1016/j.smrv.2025.102143","url":null,"abstract":"<p><p>This study presents a systematic review design aiming to explore how chronotype features are assessed in school-aged children (ages 4-11) and how chronotype is related to sleep habits, household dynamics, ethnicity, and geographical latitude. The review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Thirty-one studies were identified as eligible and reviewed by three independent researchers. The main findings indicate that chronotype is often under-assessed in school-aged children, with both professionals and parents reporting limited knowledge of children's sleep patterns. Additionally, there is a lack of information in the literature regarding how chronotype, sleep patterns, and vigilance are influenced by latitude and sociocultural factors. Most research on the relationship among the aforementioned variables is focused on adults rather than children. Furthermore, the methods for measuring sleep quality and chronotype were found to be inconsistent, with chronotype and sleep quality often used interchangeably. Based on these findings, further research is needed to explore how chronotype, sleep habits, and cultural or latitudinal factors might predict mental health and cognitive development in children. In terms of practical implications, there is an urgent need for re-education of parents on establishing healthy sleep and wake routines for their children.</p>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"83 ","pages":"102143"},"PeriodicalIF":9.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144812552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary on \"The impact of maternal sleep during pregnancy on childhood health: A systematic review\"","authors":"Lili Yi","doi":"10.1016/j.smrv.2025.102151","DOIUrl":"10.1016/j.smrv.2025.102151","url":null,"abstract":"","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"83 ","pages":"Article 102151"},"PeriodicalIF":9.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144830695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}