Sleep Medicine Reviews最新文献

筛选
英文 中文
Sleep bruxism (SB) may be not associated with obstructive sleep apnea (OSA): A comprehensive assessment employing a systematic review and meta-analysis 睡眠磨牙症(SB)可能与阻塞性睡眠呼吸暂停(OSA)无关:通过系统回顾和荟萃分析进行全面评估
IF 11.2 1区 医学
Sleep Medicine Reviews Pub Date : 2024-08-22 DOI: 10.1016/j.smrv.2024.101994
Bartłomiej Błaszczyk , Marta Waliszewska-Prosół , Mieszko Więckiewicz , Rafał Poręba , Piotr Niemiec , Jakub Przegrałek , Helena Martynowicz
{"title":"Sleep bruxism (SB) may be not associated with obstructive sleep apnea (OSA): A comprehensive assessment employing a systematic review and meta-analysis","authors":"Bartłomiej Błaszczyk ,&nbsp;Marta Waliszewska-Prosół ,&nbsp;Mieszko Więckiewicz ,&nbsp;Rafał Poręba ,&nbsp;Piotr Niemiec ,&nbsp;Jakub Przegrałek ,&nbsp;Helena Martynowicz","doi":"10.1016/j.smrv.2024.101994","DOIUrl":"10.1016/j.smrv.2024.101994","url":null,"abstract":"<div><p>Associations between obstructive sleep apnea (OSA) and sleep bruxism (SB) are the subject of discussion but have not been confirmed definitively. Therefore, the objective of this meta-analysis was to examine the relationship between OSA and SB. This systematic review was conducted in accordance with PRISMA 2020 guidelines. PubMed, Embase and Web of Science were screened up to February 2024. The risk of bias was assessed with the Joanna Briggs Institute tool. 2260 records were identified, but only 14 studies were included. The odds of SB presence in OSA did not differ from the control group (OR: 1.23, 95 % CI: 0.47–3.20). The chance of SB compared to controls also did not differ in mild OSA (OR: 1.56, 95 % CI: 0.76–3.18), in moderate OSA (OR: 1.51, 95 % CI: 0.77–2.94) and in severe OSA (OR: 1.50, 95 % CI: 0.68–3.29). Additionally, the odds of SB were not increased in moderate OSA in comparison to mild OSA (OR: 1.14, 95 % CI: 0.63–2.94), in severe OSA compared to moderate OSA (OR: 1.31, 95 % CI: 0.61–2.79) or in severe OSA compared to mild OSA (OR = 1.42, 95 % CI: 0.69–2.93). The presence of SB in OSA did not differ between genders (OR: 2.14, 95 % CI: 0.65–7.05). The quality of the major studies included is low; therefore, the noted lack of correlation between OSA and SB may require further research. The relationship between OSA and SB seems to be multi-faceted. Presented results should not exempt clinicians from exact diagnosis of concomitant sleep conditions in OSA subjects.</p></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"78 ","pages":"Article 101994"},"PeriodicalIF":11.2,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1087079224000984/pdfft?md5=e219d7a506ed1a81ea067c1376d03a41&pid=1-s2.0-S1087079224000984-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142047832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent insights into the pathophysiology of narcolepsy type 1 对 1 型嗜睡症病理生理学的最新见解。
IF 11.2 1区 医学
Sleep Medicine Reviews Pub Date : 2024-08-15 DOI: 10.1016/j.smrv.2024.101993
Marieke Vringer , Jingru Zhou , Jari K. Gool , Denise Bijlenga , Gert Jan Lammers , Rolf Fronczek , Mink S. Schinkelshoek
{"title":"Recent insights into the pathophysiology of narcolepsy type 1","authors":"Marieke Vringer ,&nbsp;Jingru Zhou ,&nbsp;Jari K. Gool ,&nbsp;Denise Bijlenga ,&nbsp;Gert Jan Lammers ,&nbsp;Rolf Fronczek ,&nbsp;Mink S. Schinkelshoek","doi":"10.1016/j.smrv.2024.101993","DOIUrl":"10.1016/j.smrv.2024.101993","url":null,"abstract":"<div><p>Narcolepsy type 1 (NT1) is a sleep-wake disorder in which people typically experience excessive daytime sleepiness, cataplexy and other sleep-wake disturbances impairing daily life activities. NT1 symptoms are due to hypocretin deficiency. The cause for the observed hypocretin deficiency remains unclear, even though the most likely hypothesis is that this is due to an auto-immune process. The search for autoantibodies and autoreactive T-cells has not yet produced conclusive evidence for or against the auto-immune hypothesis. Other mechanisms, such as reduced corticotrophin-releasing hormone production in the paraventricular nucleus have recently been suggested. There is no reversive treatment, and the therapeutic approach is symptomatic. Early diagnosis and appropriate NT1 treatment is essential, especially in children to prevent impaired cognitive, emotional and social development. Hypocretin receptor agonists have been designed to replace the attenuated hypocretin signalling. Pre-clinical and clinical trials have shown encouraging initial results. A better understanding of NT1 pathophysiology may contribute to faster diagnosis or treatments, which may cure or prevent it.</p></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"78 ","pages":"Article 101993"},"PeriodicalIF":11.2,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1087079224000972/pdfft?md5=3cbe55fdaf8bc495d07cbc9dc8be12cd&pid=1-s2.0-S1087079224000972-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142146685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Eating disorders and sleep disorders: A bidirectional interaction? 进食障碍和睡眠障碍:双向互动?
IF 11.2 1区 医学
Sleep Medicine Reviews Pub Date : 2024-08-13 DOI: 10.1016/j.smrv.2024.101992
Andrea Romigi
{"title":"Eating disorders and sleep disorders: A bidirectional interaction?","authors":"Andrea Romigi","doi":"10.1016/j.smrv.2024.101992","DOIUrl":"10.1016/j.smrv.2024.101992","url":null,"abstract":"","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"77 ","pages":"Article 101992"},"PeriodicalIF":11.2,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142089000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnostic accuracy of portable sleep monitors in pediatric sleep apnea: A systematic review 便携式睡眠监测仪对小儿睡眠呼吸暂停的诊断准确性:系统综述。
IF 11.2 1区 医学
Sleep Medicine Reviews Pub Date : 2024-08-08 DOI: 10.1016/j.smrv.2024.101991
Vivianne Landry , Koorosh Semsar-Kazerooni , Tanya Chen , Joshua Gurberg , Lily H.P. Nguyen , Evelyn Constantin
{"title":"Diagnostic accuracy of portable sleep monitors in pediatric sleep apnea: A systematic review","authors":"Vivianne Landry ,&nbsp;Koorosh Semsar-Kazerooni ,&nbsp;Tanya Chen ,&nbsp;Joshua Gurberg ,&nbsp;Lily H.P. Nguyen ,&nbsp;Evelyn Constantin","doi":"10.1016/j.smrv.2024.101991","DOIUrl":"10.1016/j.smrv.2024.101991","url":null,"abstract":"<div><p>In recent years, a plethora of new type III and IV portable sleep monitors (PSM) have been developed, although evidence regarding their diagnostic accuracy for use in children remains heterogeneous. This study systematically reviews the literature addressing the diagnostic accuracies of type III and IV PSM for pediatric sleep apnea. Publications indexed in Medline, Embase, or Web of Science were reviewed using the PRISMA framework. Of 1054 studies, 62 fulfilled the inclusion criteria. Of the studies evaluating oximetry-based type IV PSM, one (6.25 %) demonstrated a balanced set of high (≥80 %) sensitivities and specificities for the diagnosis of any pediatric sleep apnea, while five studies (27.8 %) showed similar accuracies for moderate-to-severe sleep apnea. For non-oximetry-based type IV PSM, two studies (40 %) reported a balanced set of high diagnostic accuracies for moderate-to-severe sleep apnea. Type III PSM repeatedly demonstrated higher diagnostic accuracies, with six studies (66.7 %) reporting a balanced set of high diagnostic accuracies for moderate-to-severe sleep apnea. This review highlights the potential of type III PSM to detect moderate-to-severe pediatric sleep apnea, although current evidence is limited to support the stand-alone use of type IV PSM for the diagnosis of sleep apnea in most children.</p></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"78 ","pages":"Article 101991"},"PeriodicalIF":11.2,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1087079224000959/pdfft?md5=cb4b0c810422d9e65502ecd742836be1&pid=1-s2.0-S1087079224000959-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142037494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
To nap or not? Evidence from a meta-analysis of cohort studies of habitual daytime napping and health outcomes 打盹还是不打盹?关于习惯性日间小睡与健康结果的队列研究荟萃分析提供的证据
IF 11.2 1区 医学
Sleep Medicine Reviews Pub Date : 2024-08-08 DOI: 10.1016/j.smrv.2024.101989
Ying-Bo Yang , Yong-Bo Zheng , Jie Sun , Lu-Lu Yang , Jiao Li , Yi-Miao Gong , Ming-Zhe Li , Xin Wen , Hao-Yun Zhao , Pei-Pei Shi , Gui-Hua Yu , Zhou-Long Yu , Yu Chen , Kai Yuan , Jia-Hui Deng , Su-Xia Li , Yong-Feng Yang , Zhao-Hui Zhang , Michael V. Vitiello , Jie Shi , Yan-Ping Bao
{"title":"To nap or not? Evidence from a meta-analysis of cohort studies of habitual daytime napping and health outcomes","authors":"Ying-Bo Yang ,&nbsp;Yong-Bo Zheng ,&nbsp;Jie Sun ,&nbsp;Lu-Lu Yang ,&nbsp;Jiao Li ,&nbsp;Yi-Miao Gong ,&nbsp;Ming-Zhe Li ,&nbsp;Xin Wen ,&nbsp;Hao-Yun Zhao ,&nbsp;Pei-Pei Shi ,&nbsp;Gui-Hua Yu ,&nbsp;Zhou-Long Yu ,&nbsp;Yu Chen ,&nbsp;Kai Yuan ,&nbsp;Jia-Hui Deng ,&nbsp;Su-Xia Li ,&nbsp;Yong-Feng Yang ,&nbsp;Zhao-Hui Zhang ,&nbsp;Michael V. Vitiello ,&nbsp;Jie Shi ,&nbsp;Yan-Ping Bao","doi":"10.1016/j.smrv.2024.101989","DOIUrl":"10.1016/j.smrv.2024.101989","url":null,"abstract":"<div><p>Habitual daytime napping is a common behavioral and lifestyle practice in particular countries and is often considered part of a normal daily routine. However, recent evidence suggests that the health effects of habitual daytime napping are controversial. We systematically searched PubMed, Web of Science, Embase, and Cochrane Library databases from inception to March 9, 2024, to synthesize cohort studies of napping and health outcome risk. A total of 44 cohort studies with 1,864,274 subjects aged 20-86 years (mean age 56.4 years) were included. Overall, habitual napping increased the risk of several adverse health outcomes, including all-cause mortality, cardiovascular disease, metabolic disease, and cancer, and decreased the risk of cognitive impairment and sarcopenia. Individuals with a napping duration of 30 min or longer exhibited a higher risk of all-cause mortality, cardiovascular disease, and metabolic disease, whereas those with napping durations less than 30 min had no significant risks. No significant differences in napping and health risks were observed for napping frequency, percentage of nappers, sample size, sex, age, body mass index, follow-up years, or comorbidity status. These findings indicate that individuals with a long napping duration should consider shortening their daily nap duration to 30 min or less.</p></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"78 ","pages":"Article 101989"},"PeriodicalIF":11.2,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141993480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
REM sleep in narcolepsy 嗜睡症的快速动眼期睡眠
IF 11.2 1区 医学
Sleep Medicine Reviews Pub Date : 2024-08-03 DOI: 10.1016/j.smrv.2024.101976
Michael J. Thorpy , Jerome M. Siegel , Yves Dauvilliers
{"title":"REM sleep in narcolepsy","authors":"Michael J. Thorpy ,&nbsp;Jerome M. Siegel ,&nbsp;Yves Dauvilliers","doi":"10.1016/j.smrv.2024.101976","DOIUrl":"10.1016/j.smrv.2024.101976","url":null,"abstract":"<div><p>Narcolepsy is mainly associated with excessive daytime sleepiness, but the characteristic feature is abnormal rapid eye movement (REM) sleep phenomena. REM sleep disturbances can manifest as cataplexy (in narcolepsy type 1), sleep paralysis, sleep-related hallucinations, REM sleep behavior disorder, abnormal dreams, polysomnographic evidence of REM sleep disruption with sleep-onset REM periods, and fragmented REM sleep. Characterization of REM sleep and related symptoms facilitates the differentiation of narcolepsy from other central hypersomnolence disorders and aids in distinguishing between narcolepsy types 1 and 2. A circuit comprising regions within the brainstem, forebrain, and hypothalamus is involved in generating and regulating REM sleep, which is influenced by changes in monoamines, acetylcholine, and neuropeptides. REM sleep is associated with brainstem functions, including autonomic control, and REM sleep disturbances may be associated with increased cardiovascular risk. Medications used to treat narcolepsy (and REM-related symptoms of narcolepsy) include stimulants/wake-promoting agents, pitolisant, oxybates, and antidepressants; hypocretin agonists are a potential new class of therapeutics. The role of REM sleep disturbances in narcolepsy remains an area of active research in pathophysiology, symptom management, and treatment. This review summarizes the current understanding of the role of REM sleep and its dysfunction in narcolepsy.</p></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"77 ","pages":"Article 101976"},"PeriodicalIF":11.2,"publicationDate":"2024-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1087079224000807/pdfft?md5=9da4663693f4e7206d66d61e0ee1aa1f&pid=1-s2.0-S1087079224000807-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142058062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Physiology during sleep in preterm infants: Implications for increased risk for the sudden infant death syndrome 早产儿睡眠时的生理状况:婴儿猝死综合征风险增加的影响。
IF 11.2 1区 医学
Sleep Medicine Reviews Pub Date : 2024-07-31 DOI: 10.1016/j.smrv.2024.101990
Rosemary SC. Horne , Inge Harrewijn , Carl E. Hunt
{"title":"Physiology during sleep in preterm infants: Implications for increased risk for the sudden infant death syndrome","authors":"Rosemary SC. Horne ,&nbsp;Inge Harrewijn ,&nbsp;Carl E. Hunt","doi":"10.1016/j.smrv.2024.101990","DOIUrl":"10.1016/j.smrv.2024.101990","url":null,"abstract":"<div><p>Approximately 15 million babies are born preterm (&lt;37 weeks of completed gestation) worldwide annually. Although neonatal and perinatal medicine have contributed to the increased survival rate of preterm newborn infants, premature infants are at increased risk of mortality in the first years of life.</p><p>Infants born preterm are at four times the risk of Sudden Infant Death Syndrome (SIDS) compared to infants born at term. SIDS is believed to be multifactorial in origin. The Triple Risk hypothesis has been proposed to explain this. The model suggests that when a vulnerable infant, such as one born preterm, is at a critical but unstable developmental period in homeostatic control, death may occur if exposed to an exogenous stressor, such as being placed prone for sleep. The highest risk period is at ages 2–4 months, with 90 % of deaths occurring before 6 months. The final pathway to SIDS is widely believed to involve some combination of immature cardiorespiratory control and a failure of arousal from sleep. This review will focus on the physiological factors which increase the risk for SIDS in preterm infants and how these factors may be identified and potentially lead to effective preventative strategies.</p></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"78 ","pages":"Article 101990"},"PeriodicalIF":11.2,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1087079224000947/pdfft?md5=9b716a4bab8afc545d320a5d455b2822&pid=1-s2.0-S1087079224000947-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141908168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of school start time and its interaction with the solar clock on adolescents’ chronotype and sleep: A systematic review and meta-analysis 开学时间及其与太阳钟的相互作用对青少年时间型和睡眠的影响:系统综述和元分析
IF 11.2 1区 医学
Sleep Medicine Reviews Pub Date : 2024-07-26 DOI: 10.1016/j.smrv.2024.101988
Guadalupe Rodríguez Ferrante , Florencia Lee , María Juliana Leone
{"title":"Effects of school start time and its interaction with the solar clock on adolescents’ chronotype and sleep: A systematic review and meta-analysis","authors":"Guadalupe Rodríguez Ferrante ,&nbsp;Florencia Lee ,&nbsp;María Juliana Leone","doi":"10.1016/j.smrv.2024.101988","DOIUrl":"10.1016/j.smrv.2024.101988","url":null,"abstract":"<div><p>Adolescents' late chronotypes colliding with early school start times (SSTs) are associated with students' unhealthy sleep habits. Most studies comparing different SSTs associate later SSTs with longer sleep duration and lower social jetlag. However, the magnitude of the effect varies between studies and the effect of different SSTs on chronotype is not well established. Importantly, although human circadian rhythms are entrained by sunlight, when studying the effect of different SSTs on adolescents' sleep habits usually only the social clock, and not the solar clock, is considered. This meta-analysis investigates whether later SSTs affect adolescents’ sleep habits and chronotype and it assesses factors that can modulate this effect, including the relative importance of social and solar clocks. Here, through a database search we identify 37 studies comparing the effect of different SSTs on adolescents' sleep habits and/or chronotype. Random effect meta-analyses showed that later SSTs are associated with later sleep timings and longer sleep duration on weekdays, lower levels of social jetlag, and later chronotypes. Several meta-regressions reveal that the distance between compared SSTs and the interplay between SSTs and the solar clock modulate the effect of different SSTs on sleep timings and duration on weekdays.</p></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"78 ","pages":"Article 101988"},"PeriodicalIF":11.2,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141840925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rethinking clinical trials in restless legs syndrome: A roadmap 重新思考不宁腿综合征的临床试验:路线图
IF 11.2 1区 医学
Sleep Medicine Reviews Pub Date : 2024-07-18 DOI: 10.1016/j.smrv.2024.101978
Diego Garcia-Borreguero , Jed Black , Christopher J. Earley , Stephany Fulda , Birgit Högl , Mauro Manconi , William Ondo , Thomas Roth , Claudia Trenkwalder , John W. Winkelman , on behalf of the International Restless Legs Syndrome Study Group (IRLSSG)
{"title":"Rethinking clinical trials in restless legs syndrome: A roadmap","authors":"Diego Garcia-Borreguero ,&nbsp;Jed Black ,&nbsp;Christopher J. Earley ,&nbsp;Stephany Fulda ,&nbsp;Birgit Högl ,&nbsp;Mauro Manconi ,&nbsp;William Ondo ,&nbsp;Thomas Roth ,&nbsp;Claudia Trenkwalder ,&nbsp;John W. Winkelman ,&nbsp;on behalf of the International Restless Legs Syndrome Study Group (IRLSSG)","doi":"10.1016/j.smrv.2024.101978","DOIUrl":"10.1016/j.smrv.2024.101978","url":null,"abstract":"<div><p>The number of large clinical trials of restless legs syndrome (RLS) have decreased in recent years, this coincides with reduced interest in developing and testing novel pharmaceuticals. Therefore, the International Restless Legs Syndrome Study Group (IRLSSG) formed a task force of global experts to examine the causes of these trends and make recommendations to facilitate new clinical trials. In our article, we delve into potential complications linked to the diagnostic definition of RLS, identify subpopulations necessitating more attention, and highlight issues pertaining to endpoints and study frameworks. In particular, we recommend developing alternative scoring methods for more accurate RLS diagnosis, thereby improving clinical trial specificity. Furthermore, enhancing the precision of endpoints will increase study effect sizes and mitigate study costs. Suggestions to achieve this include developing online, real-time sleep diaries with high-frequency sampling of nightly sleep latency and the use of PLMs as surrogate markers. Furthermore, to reduce the placebo response, strategies should be adopted that include placebo run-in periods. As RLS is frequently a chronic condition, priority should be given to long-term studies, using a randomized, placebo-controlled, withdrawal design. Lastly, new populations should be investigated to develop targeted treatments such as mild RLS, pregnancy, hemodialysis, or iron-deficient anemia.</p></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"77 ","pages":"Article 101978"},"PeriodicalIF":11.2,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141849748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Primary snoring: Bridging gaps in management and research 原发性鼾症:缩小管理和研究方面的差距
IF 11.2 1区 医学
Sleep Medicine Reviews Pub Date : 2024-07-15 DOI: 10.1016/j.smrv.2024.101979
Ahmed S. BaHammam
{"title":"Primary snoring: Bridging gaps in management and research","authors":"Ahmed S. BaHammam","doi":"10.1016/j.smrv.2024.101979","DOIUrl":"10.1016/j.smrv.2024.101979","url":null,"abstract":"","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"77 ","pages":"Article 101979"},"PeriodicalIF":11.2,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141708951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信