Sleep Medicine Reviews最新文献_第4页

Effect of obstructive sleep apnoea treatment on sleep spindles: A systematic review and meta-analysis 阻塞性睡眠呼吸暂停治疗对睡眠纺锤波的影响：系统回顾和荟萃分析

IF 9.7 1区医学

Sleep Medicine Reviews Pub Date : 2026-02-01 Epub Date: 2026-01-14 DOI: 10.1016/j.smrv.2026.102231

Ainhoa Álvarez-Ruiz-Larrinaga , Jorge Ullate , Carla Pía , Angela L. D'Rozario , Carlos Egea-Santaolalla , Maria Comas

{"title":"Effect of obstructive sleep apnoea treatment on sleep spindles: A systematic review and meta-analysis","authors":"Ainhoa Álvarez-Ruiz-Larrinaga , Jorge Ullate , Carla Pía , Angela L. D'Rozario , Carlos Egea-Santaolalla , Maria Comas","doi":"10.1016/j.smrv.2026.102231","DOIUrl":"10.1016/j.smrv.2026.102231","url":null,"abstract":"<div><div>The consequences of untreated obstructive sleep apnea (OSA) on health are well established. OSA alterations to sleep microarchitecture include a reduction in sleep spindles during NREM sleep, a neurophysiological biomarker that reflects sleep stability, cognitive function and brain health. However, the effects of OSA treatment on reversing sleep spindle abnormalities remains unclear. This systematic review evaluated the effect of continuous positive airway pressure (CPAP) treatment on spindles during polysomnography in adults diagnosed with OSA. We identified five papers meeting inclusion criteria with a total of 202 participants. Two studies analyzed spindle density after 6 months of CPAP use and three analyzed spindle activity during CPAP titration. Three studies used automatic spindle detection methods. Meta-analysis showed a significant increase in spindle density after CPAP use (mean difference = 1.16 spindles/min, 95 % CI [0.27, 2.04], p = 0.010). However, heterogeneity was high due to variability in study designs, sample sizes, and methodological factors. In conclusion, CPAP treatment increased spindle density in adult patients with OSA. Future research should aim to standardize spindle detection protocols and incorporate both objective and subjective measures. Establishing whether spindle changes mediate the functional recovery seen with CPAP will be essential to investigate their potential clinical utility.</div></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"85 ","pages":"Article 102231"},"PeriodicalIF":9.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146076975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Response to commentary on “Sleep abnormalities in mouse models of depression: a systematic review” 对“抑郁症小鼠模型中的睡眠异常：一项系统综述”评论的回应

IF 9.7 1区医学

Sleep Medicine Reviews Pub Date : 2026-02-01 Epub Date: 2025-11-22 DOI: 10.1016/j.smrv.2025.102208

Alberto Potenzieri , Andrea Escelsior , Gianluca Serafini , Antonio Uccelli , Antoine Adamantidis , Lino Nobili

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Unravelling the association between sleep traits and reproductive cancers: A systematic review and meta-analysis 揭示睡眠特征与生殖癌症之间的关系：一项系统回顾和荟萃分析。

IF 9.7 1区医学

Sleep Medicine Reviews Pub Date : 2026-02-01 Epub Date: 2026-01-13 DOI: 10.1016/j.smrv.2026.102235

Eirini Pagkalidou , Christos K. Papagiannopoulos , Maria Manou , Panagiotis Filis , Rebecca C. Richmond , Konstantinos K. Tsilidis , Georgios Markozannes , Christos V. Chalitsios

{"title":"Unravelling the association between sleep traits and reproductive cancers: A systematic review and meta-analysis","authors":"Eirini Pagkalidou , Christos K. Papagiannopoulos , Maria Manou , Panagiotis Filis , Rebecca C. Richmond , Konstantinos K. Tsilidis , Georgios Markozannes , Christos V. Chalitsios","doi":"10.1016/j.smrv.2026.102235","DOIUrl":"10.1016/j.smrv.2026.102235","url":null,"abstract":"<div><div>Sleep traits (duration, insomnia, chronotype, snoring) are modifiable lifestyle factors that may influence cancer risk, but their association with reproductive cancers remains unclear. We systematically searched PubMed, Scopus, and Web of Science (until 09/2024) for observational studies investigating associations between sleep traits and reproductive cancers (including breast, prostate, endometrial, epithelial ovarian). We extracted estimates from maximally adjusted models and performed random-effects and dose-response meta-analyses. This study included 62 observational studies (45 cohort, 17 case-control) from 55 publications, but cohorts were primarily considered in interpretation. Compared to a morning chronotype, evening chronotype was associated with higher risk of breast cancer (HR = 1.12; 95 %CI: 1.07–1.17; I<sup>2</sup> = 14 %; 4 cohorts) and epithelial ovarian cancer (HR = 1.15; 95 %CI: 1.02–1.29; I<sup>2</sup> = 0 %; 2 cohorts). Insomnia was associated with elevated breast cancer risk (RR = 1.23; 95 %CI: 1.01–1.50; I<sup>2</sup> = 94 %; 9 cohorts), and the association remained similar for diagnosed insomnia (RR = 1.26; 95 %CI: 1.01–1.58; I<sup>2</sup> = 96 %; 5 studies), but high between-study heterogeneity was observed and the association was lost in properly adjusted studies (RR = 1.04; 95 %CI: 0.95–1.14; I<sup>2</sup> = 41.5 %; 3 cohorts). These findings support a role for circadian disruption in carcinogenesis. Future research should use objective sleep assessments and evaluate whether modifying sleep behaviours or circadian alignment can reduce cancer risk.</div></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"85 ","pages":"Article 102235"},"PeriodicalIF":9.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146012980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Does short- and long-term exposure to air pollution affect the risk of obstructive sleep apnea? A systematic review and meta-analysis 短期和长期暴露在空气污染中会影响阻塞性睡眠呼吸暂停的风险吗？系统回顾和荟萃分析

IF 9.7 1区医学

Sleep Medicine Reviews Pub Date : 2026-02-01 Epub Date: 2025-12-11 DOI: 10.1016/j.smrv.2025.102225

Yansu He , Shuting Wang , Tianhang Zhang , Yuxuan Gu , Zuyao Yang , Linying Wu , Kin Fai Ho

{"title":"Does short- and long-term exposure to air pollution affect the risk of obstructive sleep apnea? A systematic review and meta-analysis","authors":"Yansu He , Shuting Wang , Tianhang Zhang , Yuxuan Gu , Zuyao Yang , Linying Wu , Kin Fai Ho","doi":"10.1016/j.smrv.2025.102225","DOIUrl":"10.1016/j.smrv.2025.102225","url":null,"abstract":"<div><div>The contribution of air pollution to obstructive sleep apnea (OSA) remains unclear. This systematic review and meta-analysis evaluated the impact of air pollution across different exposure windows on OSA and examined effect modifiers. Pubmed, Web of Science, and Embase were searched from inception to September 2024. Meta-analyses synthesized risk estimates using fixed- or random-effects models with I<sup>2</sup> heterogeneity assessment. Certainty of evidence was assessed using the GRADE (Grading of Recommendations Assessment, Development, and Evaluation) approach. Of 5196 potential papers, 20 studies were included, with 13 eligible for meta-analysis. High-certainty evidence indicated that each 10 μg/m<sup>3</sup> increase in short- and long-term PM<sub>2.5</sub> exposure was associated with a 2.25 % (95 % CI: 1.10 to 3.41) and 13.33 % (95 % CI: 9.85 to 16.80) increase in apnea-hypopnea index (AHI), respectively. For NO<sub>2</sub>, each 10 ppb increase in short- and long-term exposure was associated with a 2.92 % (95 % CI: 1.29 to 4.54) and 8.93 % (95 % CI: 2.06 to 15.79) increase in AHI, with high- and moderate-certainty evidence, respectively. Medium-term PM<sub>2.5</sub> and NO<sub>2</sub> exposure were also associated with AHI, although with low certainty. No significant associations were observed for PM<sub>10</sub> and O<sub>3</sub>. Exposure to PM<sub>2.5</sub> and NO<sub>2</sub>, but not PM<sub>10</sub> or O<sub>3</sub>, was associated with OSA severity.</div></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"85 ","pages":"Article 102225"},"PeriodicalIF":9.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145797313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Time to take the Declaration of Helsinki seriously? A systematic review of comparison conditions in clinical trials on internet-delivered cognitive behavioral therapy for insomnia 是时候认真对待《赫尔辛基宣言》了？网络认知行为治疗失眠症临床试验比较条件的系统回顾

IF 9.7 1区医学

Sleep Medicine Reviews Pub Date : 2026-02-01 Epub Date: 2025-12-11 DOI: 10.1016/j.smrv.2025.102224

Lorenz Grolig , Hanna Brückner , Hannah Heimes , Claudia Buntrock , Christin Hempeler , Kai Spiegelhalder , Dirk Lehr

{"title":"Time to take the Declaration of Helsinki seriously? A systematic review of comparison conditions in clinical trials on internet-delivered cognitive behavioral therapy for insomnia","authors":"Lorenz Grolig , Hanna Brückner , Hannah Heimes , Claudia Buntrock , Christin Hempeler , Kai Spiegelhalder , Dirk Lehr","doi":"10.1016/j.smrv.2025.102224","DOIUrl":"10.1016/j.smrv.2025.102224","url":null,"abstract":"<div><div>The Declaration of Helsinki (DoH) provides guidance on the choice of comparators in clinical trials, stating that new treatments must be compared against the best proven treatment. This systematic review examines whether research on a new treatment – internet-delivered cognitive behavioral therapy for insomnia (iCBT-I) – has adhered to these DoH requirements. A systematic literature search for randomized controlled trials (RCTs) testing iCBT-I in clinical samples was conducted following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. To identify the gold standard treatment, national guidelines were analyzed for all countries where published research on iCBT-I had been conducted.</div><div>After screening, 32 RCTs and seven guidelines for 12 countries were included. Almost all guidelines recommend face-to-face CBT-I as the gold standard, but only four (12.5 %) of the RCTs used this gold standard as a comparator. None of the other trials explained why they did not follow the DoH's recommendation.</div><div>The majority of clinical trials did not compare iCBT-I against the gold standard. As the DoH is intended to guide clinical research ethics, this low level of adherence is remarkable, and it raises uncertainty for patients, therapists, and policymakers about the effectiveness of iCBT-I compared to the gold standard treatment.</div></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"85 ","pages":"Article 102224"},"PeriodicalIF":9.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145737280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Letter to the editor: Higher risk evidence underlying claims of therapist-delivered CBT-I superiority 致编辑的信：高风险证据支持治疗师提供的CBT-I优势

IF 9.7 1区医学

Sleep Medicine Reviews Pub Date : 2026-02-01 Epub Date: 2026-01-21 DOI: 10.1016/j.smrv.2026.102234

Christopher B. Miller , Ian Wood , Colin A. Espie

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Post-stroke sleep disordered breathing and the effect of positive airway pressure treatment: An updated systematic review and meta-analysis of randomized control trials 卒中后睡眠呼吸障碍和气道正压治疗的效果：随机对照试验的最新系统综述和荟萃分析

IF 9.7 1区医学

Sleep Medicine Reviews Pub Date : 2026-02-01 Epub Date: 2025-11-22 DOI: 10.1016/j.smrv.2025.102207

Fotios Sampsonas , Vasileios Karamouzos , Michael Doulberis , Kyriakos Karkoulias , Dimosthenis Lykouras , Paschalis Steiropoulos , Argyrios Tzouvelekis

{"title":"Post-stroke sleep disordered breathing and the effect of positive airway pressure treatment: An updated systematic review and meta-analysis of randomized control trials","authors":"Fotios Sampsonas , Vasileios Karamouzos , Michael Doulberis , Kyriakos Karkoulias , Dimosthenis Lykouras , Paschalis Steiropoulos , Argyrios Tzouvelekis","doi":"10.1016/j.smrv.2025.102207","DOIUrl":"10.1016/j.smrv.2025.102207","url":null,"abstract":"<div><div>Obstructive sleep apnea is under-diagnosed, under-reported and therefore under-treated in patients after a stroke. The aim of this meta-analysis of Randomized Control Trials (RCTs) was to investigate the effectiveness of positive airway treatment on recurrent vascular events, neurological deficit, functional independence, depression, sleepiness and cognitive function in patients post-stroke.</div><div>Records identified from Embase Elsevier Database (Embase, Medline/PubMed, Preprints, PubMed-not-Medline) were searched from inception in July 2024, up to September 2024. After screening 72387 records, 21 RCTs were included with 1457 patients with stroke. Out of these 753 patients were in the PAP arm and 704 in the conventional arm.</div><div>Metanalysis showed that PAP treatment reduced recurrent vascular events OR 0.45, (95 % Confidence Interval (CI) 0.28 to 0.78; p < 0.01), improved neurological deficit OR -0.30, (95 % CI -0.47 to −0.14; p < 0.01), reduced daytime sleepiness OR: −0.96, (95 % CI -1.47 to −0.45; p < 0.01), improved depression levels; OR: −0.58, (95 % CI -1.05 to −0.11; p = 0.02), improved cognitive function; OR1.10; (95 % CI 0.35 to 1.86; p = 0.02), but did not improve functional independence OR 0.25, (95 % CI -0.11 to 0.60; p = 0.17)</div><div>Therefore, positive airway pressure treatment is effective in patients with stroke and can reduce recurrent vascular events and improve recovery of these patients.</div></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"85 ","pages":"Article 102207"},"PeriodicalIF":9.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145584159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unpacking sleep and mental health disparities across childhood and adolescence: A meta-analytic and systematic review 儿童期和青春期的睡眠和心理健康差异：一项荟萃分析和系统回顾

IF 9.7 1区医学

Sleep Medicine Reviews Pub Date : 2026-02-01 Epub Date: 2025-11-22 DOI: 10.1016/j.smrv.2025.102206

Morgan J. Thompson , Alexandra D. Ehrhardt , Ekjyot K. Saini , Emily F. Brigham , Zeynep Su Altinoz , Tiffany Yip , Joseph A. Buckhalt , Mona El-Sheikh

{"title":"Unpacking sleep and mental health disparities across childhood and adolescence: A meta-analytic and systematic review","authors":"Morgan J. Thompson , Alexandra D. Ehrhardt , Ekjyot K. Saini , Emily F. Brigham , Zeynep Su Altinoz , Tiffany Yip , Joseph A. Buckhalt , Mona El-Sheikh","doi":"10.1016/j.smrv.2025.102206","DOIUrl":"10.1016/j.smrv.2025.102206","url":null,"abstract":"<div><div>Children and adolescents from racial and ethnic minority and socioeconomically disadvantaged backgrounds are at greater risk for health disparities. This meta-analysis examined the association between sleep and mental health, with attention to variations by: (a) race, ethnicity, and socioeconomic status, and (b) individual sleep parameters and mental health domains. The review included 104 studies (66 independent samples, 326,478 participants). Less optimal sleep was associated with worse mental health (<em>r</em> = −.20, 95% CI [–.23, −.16]). Subjective sleep quality was a stronger correlate of mental health relative to all other sleep parameters (<em>b</em>s ranged from .11 to .19, <em>p</em>s < .001). Sleep schedule was a stronger correlate than objective sleep duration and quality (<em>b</em>s = .08 and .07, respectively, <em>p</em>s < .01). Sleep consistency was also a stronger correlate than objective sleep duration (<em>b</em> = .05, <em>p</em> = .03). Socioeconomic status moderated two associations. Objective sleep quality was more strongly linked to mental health among middle- relative to mixed-SES samples (<em>b</em> = .11, <em>p</em> = .01). Sleep consistency was more strongly associated with mental health among low- compared to mixed-SES samples (<em>b</em> = .05, <em>p</em> = .002). Findings are discussed in the context of methodological challenges in studying health disparities.</div></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"85 ","pages":"Article 102206"},"PeriodicalIF":9.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145625382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Network models of subjective sleep health: a systematic review and statistical evaluation 主观睡眠健康的网络模型：系统回顾和统计评价

IF 9.7 1区医学

Sleep Medicine Reviews Pub Date : 2026-02-01 Epub Date: 2026-01-15 DOI: 10.1016/j.smrv.2026.102233

Meng-Yi Chen , Hua-Qing Xing , Qian-Hua Huang , Yuan Feng , Qinge Zhang , Ping Fan , Han-Xi Chen , Matteo Malgaroli , Todd Jackson , Gang Wang , Yu-Tao Xiang

{"title":"Network models of subjective sleep health: a systematic review and statistical evaluation","authors":"Meng-Yi Chen , Hua-Qing Xing , Qian-Hua Huang , Yuan Feng , Qinge Zhang , Ping Fan , Han-Xi Chen , Matteo Malgaroli , Todd Jackson , Gang Wang , Yu-Tao Xiang","doi":"10.1016/j.smrv.2026.102233","DOIUrl":"10.1016/j.smrv.2026.102233","url":null,"abstract":"<div><h3>Background</h3><div>Given the increased use of network analysis in sleep studies, this systematic review and statistical evaluation aimed to aggregate network studies to identify the most central symptoms in composite network models of sleep-related symptoms.</div></div><div><h3>Methods</h3><div>A systematic search of cross-sectional network studies focused exclusively on sleep within community or clinical samples was conducted across PubMed, Web of Science (WOS), PsycINFO, and EMBASE databases up to March 5, 2025. Studies were categorized by topic and measurement instruments. Statistical evaluations extracted the most central symptoms across network models.</div></div><div><h3>Results</h3><div>The review included 23 studies of 84,510 participants and 29 network models. Explored topics included insomnia/sleep disturbances, sleep quality, sleep attitudes and behaviors, daytime function, and dream content. Regarding main analyses, key central symptoms in network models of insomnia were “Difficulty staying asleep” [median rank:1.5, Interquartile range (IQR): 1–2], “Distress caused by the sleep difficulties” (median rank:2, IQR: 2–3) and “Interference with daytime functioning” (median rank:3.5, IQR: 2.25–4). For sleep quality, “Subjective sleep quality” (median rank:1, IQR: 1-1), “Daytime dysfunction” (median rank:3, IQR: 2–5.25) and “Sleep disturbance” (median rank:3.5, IQR: 2–4.5) were the most central experiences.</div></div><div><h3>Conclusions</h3><div>Identified central symptoms offer plausible targets for intervention across populations and guide future research directions.</div></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"85 ","pages":"Article 102233"},"PeriodicalIF":9.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146076977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Beyond the pulse and the pressure: human intelligence in the age of algorithmic Sleep Medicine 超越脉搏和压力：算法睡眠医学时代的人类智能

IF 9.7 1区医学

Sleep Medicine Reviews Pub Date : 2026-02-01 Epub Date: 2026-01-20 DOI: 10.1016/j.smrv.2026.102238

Monica Levy Andersen PhD (Editor in Chief of Sleep Medicine Reviews)

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