Sleep and male (In)Fertility: A comprehensive overview

IF 11.2 1区医学 Q1 CLINICAL NEUROLOGY

Sleep Medicine Reviews Pub Date : 2025-03-18 DOI:10.1016/j.smrv.2025.102080

Catarina Cavalhas-Almeida , Maria Inês Cristo , Cláudia Cavadas , João Ramalho-Santos , Ana Rita Álvaro , Sandra Amaral

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引用次数: 0

Abstract

Infertility affects millions of couples globally, with male factors contributing up to 50 % of cases. Despite the existing Assisted Reproduction Technologies (ART), decreased sperm quality and male infertility persist.

Evidence suggests that sleep is crucial for normal reproductive function, and the noticeable increase in infertility rates aligns with the growing prevalence of sleep deprivation, suggesting a connection between both conditions.

This literature review explores the possible links between sleep disturbances, with a special emphasis on insomnia, the most prevalent sleep disorder, and male reproductive health. It delves into the latest findings regarding factors such as sperm quality, hormone levels, and overall reproductive function from studies in mammals, both rodents and humans. Through a concise synthesis of these findings, we unveil potential mechanisms and provide crucial insights for clinicians and researchers in the field of reproductive health.

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睡眠和男性生育能力：一个全面的概述

不孕不育影响着全球数百万对夫妇，其中男性因素占50%。尽管现有的辅助生殖技术（ART），精子质量下降和男性不育持续存在。有证据表明，睡眠对正常的生殖功能至关重要，不孕症发生率的显著上升与睡眠剥夺的日益普遍相吻合，这表明两者之间存在联系。这篇文献综述探讨了睡眠障碍与男性生殖健康之间的可能联系，特别强调了最普遍的睡眠障碍——失眠。它深入研究了有关精子质量、激素水平和哺乳动物（包括啮齿动物和人类）整体生殖功能等因素的最新发现。通过对这些发现的简明综合，我们揭示了潜在的机制，并为生殖健康领域的临床医生和研究人员提供了重要的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Sleep Medicine Reviews 医学-临床神经学

CiteScore

20.10

自引率

3.80%

发文量

107

期刊介绍： Sleep Medicine Reviews offers global coverage of sleep disorders, exploring their origins, diagnosis, treatment, and implications for related conditions at both individual and public health levels. Articles comprehensively review clinical information from peer-reviewed journals across various disciplines in sleep medicine, encompassing pulmonology, psychiatry, psychology, physiology, otolaryngology, pediatrics, geriatrics, cardiology, dentistry, nursing, neurology, and general medicine. The journal features narrative reviews, systematic reviews, and editorials addressing areas of controversy, debate, and future research within the field.