Sleep Medicine Reviews最新文献

{"title":"Periodic limb movement disorder in children: A systematic review","authors":"Lourdes M. DelRosso ,&nbsp;Daniel L. Picchietti ,&nbsp;Denise Sharon ,&nbsp;Karen Spruyt ,&nbsp;Judith A. Owens ,&nbsp;Arthur S. Walters ,&nbsp;Marco Zucconi ,&nbsp;Raffaele Ferri ,&nbsp;International Restless Legs Syndrome Study Group (IRLSSG)","doi":"10.1016/j.smrv.2024.101935","DOIUrl":"https://doi.org/10.1016/j.smrv.2024.101935","url":null,"abstract":"<div><p>This systematic review evaluates the scientific literature on pediatric periodic limb movement disorder (PLMD), adhering to PRISMA guidelines and utilizing PICOS criteria. The search across PubMed, EMBASE, and Scopus yielded 331 articles, with 17 meeting inclusion criteria. Diagnostic criteria evolved, with polysomnography and PLMS index ≥5 required since 2003. Also, PLMD diagnosis mandates clinical consequences like insomnia, hypersomnia, and fatigue, excluding comorbidities causing sleep disruption. Prevalence in children is low (0.3%), emphasizing the need for meticulous investigation. Comorbidities, particularly the bidirectional relationship with ADHD, were explored. Challenges in diagnosis and understanding arise from overlapping conditions such as sleep disordered breathing, psychotropic medication, and criteria non-adherence. Despite generally good study quality, weaknesses include sample size justification and biases. The periodic leg movement index shows high sensitivity but low specificity, underscoring strict diagnostic criteria adherence. Diverse metrics for symptoms necessitate standardized approaches. Family history of RLS in children with PLMD suggests unexplored aspects. Treatment, mainly iron supplementation, lacks standardized assessment metrics. The review emphasizes diagnostic and treatment challenges, recommending unbiased studies with precise techniques. Comprehensive research, quantifying PLMS and objectively assessing sleep parameters, is crucial for advancing understanding in pediatric PLMD.</p></div><div><h3>Prospero registration number</h3><p>CRD42021251406.</p></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"76 ","pages":"Article 101935"},"PeriodicalIF":10.5,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140631262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationships between insomnia, nightmares, and dreams: A systematic review","authors":"Julia-Pizzamiglio Delage ,&nbsp;Jeannie Côté ,&nbsp;William-Girard Journault ,&nbsp;Alexandre Lemyre ,&nbsp;Célyne H. Bastien","doi":"10.1016/j.smrv.2024.101931","DOIUrl":"10.1016/j.smrv.2024.101931","url":null,"abstract":"<div><p>Insomnia and nightmares are both prevalent and debilitating sleep difficulties. The present systematic review aims to document the relationships between insomnia and nightmares in individuals without a concomitant psychopathology. The relationships between insomnia and dreams are also addressed. PsycINFO and Medline were searched for papers published in English or French from 1970 to March 2023. Sixty-seven articles were included for review. Most results support positive relationships between insomnia variables and nightmare variables in individuals with insomnia, individuals with nightmares, the general population, students, children and older adults, and military personnel and veterans. These positive relationships were also apparent in the context of the COVID-19 pandemic. Some psychological interventions, such as Imagery Rehearsal Therapy, might be effective in alleviating both nightmares and insomnia symptoms. Regarding the relationships between insomnia and dreams, compared with controls, the dreams of individuals with insomnia are characterized by more negative contents and affects. The results show that insomnia and nightmares are connected and may be mutually aggravating. A model is proposed to explain how insomnia might increase the likelihood of experiencing nightmares, and how nightmares can in turn lead to sleep loss and nonrestorative sleep.</p></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"75 ","pages":"Article 101931"},"PeriodicalIF":10.5,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1087079224000352/pdfft?md5=d1cf9baf4c9ed50297e5efffe927c053&pid=1-s2.0-S1087079224000352-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140757225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep hygiene – What do we mean? A bibliographic review","authors":"Carla De Pasquale ,&nbsp;Mary El Kazzi ,&nbsp;Kate Sutherland ,&nbsp;Alexandra E. Shriane ,&nbsp;Grace E. Vincent ,&nbsp;Peter A. Cistulli ,&nbsp;Yu Sun Bin","doi":"10.1016/j.smrv.2024.101930","DOIUrl":"10.1016/j.smrv.2024.101930","url":null,"abstract":"<div><p>There is no consensus on the definition of sleep hygiene and its components. We examined the definition of sleep hygiene based on its use in published studies. Four databases (Medline, EMBASE, PsycINFO and CINAHL) were searched from inception until December 31, 2021 for the phrase ‘sleep hygiene’ in the title or abstract. We identified 548 relevant studies in adults: 250 observational and 298 intervention studies. A definition of sleep hygiene was provided in only 44% of studies and converged on three themes: behavioural factors, environmental factors, and an aspect of control. Sleep hygiene components were explicitly defined in up to 70% of observational studies, but in only 35% of intervention studies. The most commonly considered components of sleep hygiene were caffeine (in 51% of studies), alcohol (46%), exercise (46%), sleep timing (45%), light (42%), napping (39%), smoking (38%), noise (37%), temperature (34%), wind-down routine (33%), stress (32%), and stimulus control (32%), although the specific details of each component varied. Lack of consistency in definitions of sleep hygiene and its components may hinder communication between researchers, clinicians, and the public, and likely limits the utility of sleep hygiene as an intervention.</p></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"75 ","pages":"Article 101930"},"PeriodicalIF":10.5,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1087079224000340/pdfft?md5=dc6fa8adf0a67212b3e6478c66a5f5a3&pid=1-s2.0-S1087079224000340-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140791767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of physical therapy techniques and common interventions on sleep quality in patients with chronic pain: A systematic review","authors":"Santiago Navarro-Ledesma ,&nbsp;Dina Hamed-Hamed ,&nbsp;Ana Gonzalez-Muñoz ,&nbsp;Leo Pruimboom","doi":"10.1016/j.smrv.2024.101937","DOIUrl":"https://doi.org/10.1016/j.smrv.2024.101937","url":null,"abstract":"<div><p>This systematic review aims to find effectful healthcare strategies, with special focus on drug-free interventions and physical therapy, as part of the treatment for sleep in patients with chronic musculoskeletal pain. Data search was conducted across seven scientific databases. This review is deposited in the Prospero International prospective register of systematic reviews (CRD42023452574). Seventeen RCTs from different healthcare fields complied with our inclusion criteria. Two RCTs investigated manual therapy, five RCTs therapeutic exercise, one RCT Fu's subcutaneous needling, two RCTs physical agents (one on balneotherapy and one on cryo-stimulation), two RCTs cognitive-behavioral therapy, and four RCTs pharmacological therapy and their effect on sleep quality and/or quantity in patients suffering from chronic pain. We included the four RCT's in this systematic review with the purpose to be able to compare natural interventions with allopathic ones. As allopathic interventions are more prone to have secondary negative effects than physical therapy, compare the two types of interventions could be in favor of choosing the most effective treatment with the least secondary negative effects. Additionally, two RCTs on neurofeedback and limbic neuromodulation were also included. The results of the included studies suggest that strategies such as manual therapy, therapeutic exercise, Fu's subcutaneous needling, balneotherapy, cryo-stimulation, neurofeedback, limbic neuromodulation, cognitive-behavioral therapy, and pharmacological therapies have positive effects on patients suffering from chronic pain and sleep disturbances, especially when they suffer musculoskeletal pain. Secondary negative effects were found for the possible overuse of certain medicines such as morphine, a huge problem in the United States. Sleep deficiency is an independent risk factor for many diseases, including chronic pain syndrome and therefore more studies are needed to find non-toxic interventions for people suffering sleep disorders associated with systemic diseases and pain.</p></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"76 ","pages":"Article 101937"},"PeriodicalIF":10.5,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1087079224000418/pdfft?md5=68bad779831a0e32c0aeba81950645ce&pid=1-s2.0-S1087079224000418-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140644385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary patterns and insomnia symptoms: A systematic review and meta-analysis","authors":"Arman Arab ,&nbsp;Elham Karimi ,&nbsp;Marta Garaulet ,&nbsp;Frank A.J.L. Scheer","doi":"10.1016/j.smrv.2024.101936","DOIUrl":"10.1016/j.smrv.2024.101936","url":null,"abstract":"<div><p>We aimed to systematically review and synthesize the available evidence regarding the link between dietary patterns and insomnia symptoms among the general population using observational studies. We reviewed 16,455 references, of which 37 studies met inclusion criteria with a total sample size of 591,223. There was a significant association of the Mediterranean diet (OR: 0.86; 95 % CI, 0.79, 0.93; <em>P</em> &lt; 0.001; I² = 32.68 %), a high-quality diet (OR: 0.66; 95 % CI, 0.48, 0.90; <em>P</em> = 0.010; I² = 84.62 %), and an empirically-derived healthy dietary pattern (OR: 0.91; 95 % CI, 0.85, 0.98; <em>P</em> = 0.010; I² = 57.14 %) with a decreased risk of insomnia symptoms. Moreover, the dietary glycemic index (OR: 1.16; 95 % CI, 1.08, 1.25; <em>P</em> &lt; 0.001; I² = 0.0 %), the dietary glycemic load (OR: 1.10; 95 % CI, 1.01, 1.20; <em>P</em> = 0.032; I² = 74.36 %), and an empirically-derived unhealthy dietary pattern (OR: 1.20; 95 % CI, 1.01, 1.42; <em>P</em> = 0.040; I² = 68.38 %) were linked with a higher risk of insomnia symptoms. Most individual studies were of good quality (NOS) but provided very low certainty of evidence (GRADE). Consistent data reveals that following healthy diets is associated with decreased insomnia symptoms prevalence, while adherence to an unhealthy pattern is associated with an increased prevalence of insomnia symptoms.</p></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"75 ","pages":"Article 101936"},"PeriodicalIF":10.5,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140762009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A bidirectional model of sleep and technology use: A theoretical review of How much, for whom, and which mechanisms","authors":"Serena Bauducco ,&nbsp;Meg Pillion ,&nbsp;Kate Bartel ,&nbsp;Chelsea Reynolds ,&nbsp;Michal Kahn ,&nbsp;Michael Gradisar","doi":"10.1016/j.smrv.2024.101933","DOIUrl":"https://doi.org/10.1016/j.smrv.2024.101933","url":null,"abstract":"<div><p>The link between technology and sleep is more complex than originally thought. In this updated theoretical review, we propose a new model informed by the growing body of evidence in the area over the past 10 years. The main theoretical change is the addition of bi-directional links between the use of technology and sleep problems. We begin by reviewing the evidence to date for the originally proposed mechanisms of bright light, arousal, nighttime sleep disruptions, and sleep displacement. Then, in support of the new direction of effect (sleep problems preceding technology use), we propose two new mechanisms: technology before sleep might be used as a time filler and/or as an emotional regulation strategy to facilitate the sleep-onset process. Finally, we present potential moderators of the association between technology and sleep, in recognition of protective and vulnerability factors that may mitigate or exacerbate the effects of technology on sleep and vice versa. The goal of this theoretical review is to update the field, guide future public health messages, and to prompt new research into <em>how much</em> technology and sleep affect each other, <em>for whom</em> it may be problematic, and <em>which mechanisms</em> may explain their association.</p></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"76 ","pages":"Article 101933"},"PeriodicalIF":10.5,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1087079224000376/pdfft?md5=fdbe49260b64fe7ac1b02a79aa630b6d&pid=1-s2.0-S1087079224000376-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140638616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The PAP-RES algorithm: Defining who, why and how to use positive airway pressure therapy for OSA","authors":"Frédéric Gagnadoux ,&nbsp;Emilie Bequignon ,&nbsp;Arnaud Prigent ,&nbsp;Jean-Arthur Micoulaud-Franchi ,&nbsp;Juliette Chambe ,&nbsp;Joëlle Texereau ,&nbsp;Sarah Alami ,&nbsp;Frédéric Roche","doi":"10.1016/j.smrv.2024.101932","DOIUrl":"https://doi.org/10.1016/j.smrv.2024.101932","url":null,"abstract":"<div><p>Obstructive sleep apnea (OSA) is a common condition that is increasing in prevalence worldwide. Untreated OSA has a negative impact on health-related quality of life and is an independent risk factor for cardiovascular diseases. Despite available data suggesting that cardiovascular risk might differ according to clinical phenotypes and comorbidities, current approaches to OSA treatment usually take a “one size fits all” approach. Identification of cardiovascular vulnerability biomarkers and clinical phenotypes associated with response to positive airway pressure (PAP) therapy could help to redefine the standard treatment paradigm. The new PAP-RES (PAP-RESponsive) algorithm is based on the identification of OSA phenotypes that are likely to impact therapeutic goals and modalities. The paradigm shift is to propose a simplified approach that defines therapeutic goals based on OSA phenotype: from a predominantly “symptomatic phenotype” (individuals with high symptom burden that negatively impacts on daily life and/or accident risk or clinically significant insomnia) to a “vulnerable cardiovascular phenotype” (individuals with comorbidities [serious cardiovascular or respiratory disease or obesity] that have a negative impact on cardiovascular prognosis or a biomarker of hypoxic burden and/or autonomic nervous system dysfunction). Each phenotype requires a different PAP therapy care pathway based on differing health issues and treatment objectives.</p></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"75 ","pages":"Article 101932"},"PeriodicalIF":10.5,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140546120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep apnea and ischemic stroke— a perspective for translational preclinical modelling","authors":"I.J. Biose ,&nbsp;A.B. Bakare ,&nbsp;H. Wang ,&nbsp;T.E. Gressett ,&nbsp;G.J. Bix","doi":"10.1016/j.smrv.2024.101929","DOIUrl":"https://doi.org/10.1016/j.smrv.2024.101929","url":null,"abstract":"<div><p>Obstructive sleep apnea (OSA) is associated with ischemic stroke. There is, however, a lack of knowledge on the exact cause-effect relationship, and preclinical models of OSA for experimental ischemic stroke investigations are not well characterized. In this review, we discuss sleep apnea and its relationship with stroke risk factors. We consider how OSA may lead to ischemic stroke and how OSA-induced metabolic syndrome and hypothalamic-pituitary axis (HPA) dysfunction could serve as therapeutic targets to prevent ischemic stroke. Further, we examine the translational potential of established preclinical models of OSA. We conclude that metabolic syndrome and HPA dysfunction, which are often overlooked in the context of experimental stroke and OSA studies, are crucial for experimental consideration to improve the body of knowledge as well as the translational potential of investigative efforts.</p></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"75 ","pages":"Article 101929"},"PeriodicalIF":10.5,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1087079224000339/pdfft?md5=df203ace84f4972a8fca42aa3b5ed2ca&pid=1-s2.0-S1087079224000339-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140350394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of acute exposure to hypoxia on sleep structure in healthy adults: A systematic review","authors":"Chao Guo,&nbsp;Li Lan,&nbsp;Yan Yan,&nbsp;Mengyuan Kang","doi":"10.1016/j.smrv.2024.101928","DOIUrl":"https://doi.org/10.1016/j.smrv.2024.101928","url":null,"abstract":"<div><p>The sleep quality of lowlanders in hypoxic environments has become increasingly important with an increase in highland and alpine activities. This study aimed to identify the effects of acute exposure to hypoxia on the sleep structure of lowlanders and to analyze the changes in sleep indicators at varying levels of hypoxia. This review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Twenty-three studies were screened and included in the quantitative analysis. The results showed that acute exposure to hypoxia reduced sleep quality in lowlanders. Post-sleep arousal events and the percentage of N1 were significantly increased, whereas total sleep time, sleep efficiency, and the percentage of N3 and rapid eye movement sleep were significantly decreased in hypoxic environments. Acute exposure to hypoxia had the greatest negative impact on wakefulness after sleep onset (WASO). In addition, a larger decrease in sleep efficiency and higher increase in the percentages of N1 and WASO were observed when lowlanders were exposed to higher levels of hypoxia. This study clarifies the quantitative effects of acute hypoxic exposure on sleep in lowlanders based on original studies and explains the sleep disorders faced by lowlanders in hypoxic environments.</p></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"75 ","pages":"Article 101928"},"PeriodicalIF":10.5,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140548506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep, mental health and physical health in new shift workers transitioning to shift work: Systematic review and meta-analysis","authors":"Rachael Harris,&nbsp;Eleni Kavaliotis,&nbsp;Sean P.A. Drummond,&nbsp;Alexander P. Wolkow","doi":"10.1016/j.smrv.2024.101927","DOIUrl":"10.1016/j.smrv.2024.101927","url":null,"abstract":"<div><p>This systematic review and meta-analysis (PROSPERO registration CRD42022309827) aimed to describe how shift work impacts new workers' sleep, mental health, and physical health during the transition to shift work and to consolidate information regarding predictors of shift work tolerance (SWT) during this transition period. Inclusion criteria included: new shift workers; sleep, mental health, or physical health outcomes; prospective study design with the first timepoint assessing workers within three months of starting shift work; and written in English. Searches from six databases returned 12,172 articles as of August 2023. The final sample included 48 papers. Publication quality and risk of bias was assessed using the critical appraisal skills program. Forty-five studies investigated longitudinal changes in sleep, mental health, or physical health outcomes and 29 studies investigated predictors of SWT (i.e., better sleep, mental and physical health). Sleep and mental health outcomes worsened following the onset of shift work, while physical health did not significantly change. Pre-shift work mental health, sleep, and work characteristics predicted SWT later in workers' careers. Shift work adversely impacts new workers’ sleep and mental health early in their career, and interventions before beginning shift work are needed to promote better SWT.</p></div>","PeriodicalId":49513,"journal":{"name":"Sleep Medicine Reviews","volume":"75 ","pages":"Article 101927"},"PeriodicalIF":10.5,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1087079224000315/pdfft?md5=3f3442e5d245798a3c7606e84b2f9ec1&pid=1-s2.0-S1087079224000315-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140406714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}