{"title":"Deep learning Radiomics Based on Two-Dimensional Ultrasound for Predicting the Efficacy of Neoadjuvant Chemotherapy in Breast Cancer","authors":"Zhan Wang, Xiaoqin Li, Heng Zhang, Tongtong Duan, Chao Zhang, Tong Zhao","doi":"10.1177/01617346241276168","DOIUrl":"https://doi.org/10.1177/01617346241276168","url":null,"abstract":"We investigate the predictive value of a comprehensive model based on preoperative ultrasound radiomics, deep learning, and clinical features for pathological complete response (pCR) after neoadjuvant chemotherapy (NAC) for the breast cancer. We enrolled 155 patients with pathologically confirmed breast cancer who underwent NAC. The patients were randomly divided into the training set and the validation set in the ratio of 7:3. The deep learning and radiomics features of pre-treatment ultrasound images were extracted, and the random forest recursive elimination algorithm and the least absolute shrinkage and selection operator were used for feature screening and DL-Score and Rad-Score construction. According to multifactorial logistic regression, independent clinical predictors, DL-Score, and Rad-Score were selected to construct the comprehensive prediction model DLRC. The performance of the model was evaluated in terms of its predictive effect, and clinical practicability. Compared to the clinical, radiomics (Rad-Score), and deep learning (DL-Score) models, the DLRC accurately predicted the pCR status, with an area under the curve (AUC) of 0.937 (95%CI: 0.895–0.970) in the training set and 0.914 (95%CI: 0.838–0.973) in the validation set. Moreover, decision curve analysis confirmed that the DLRC had the highest clinical value among all models. The comprehensive model DLRC based on ultrasound radiomics, deep learning, and clinical features can effectively and accurately predict the pCR status of breast cancer after NAC, which is conducive to assisting clinical personalized diagnosis and treatment plan.","PeriodicalId":49401,"journal":{"name":"Ultrasonic Imaging","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142184610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"SPGAN Optimized by Piranha Foraging Optimization for Thyroid Nodule Classification in Ultrasound Images","authors":"Siddalingesh Bandi, Ravikumar K.P, Manjunatha Reddy H.S","doi":"10.1177/01617346241271240","DOIUrl":"https://doi.org/10.1177/01617346241271240","url":null,"abstract":"In this research work, Semantic-Preserved Generative Adversarial Network optimized by Piranha Foraging Optimization for Thyroid Nodule Classification in Ultrasound Images (SPGAN-PFO-TNC-UI) is proposed. Initially, ultrasound images are gathered from the DDTI dataset. Then the input image is sent to the pre-processing step. During pre-processing stage, the Multi-Window Savitzky-Golay Filter (MWSGF) is employed to reduce the noise and improve the quality of the ultrasound (US) images. The pre-processed output is supplied to the Generalized Intuitionistic Fuzzy C-Means Clustering (GIFCMC). Here, the ultrasound image’s Region of Interest (ROI) is segmented. The segmentation output is supplied to the Fully Numerical Laplace Transform (FNLT) to extract the features, such as geometric features like solidity, orientation, roundness, main axis length, minor axis length, bounding box, convex area, and morphological features, like area, perimeter, aspect ratio, and AP ratio. The Semantic-Preserved Generative Adversarial Network (SPGAN) separates the image as benign or malignant nodules. Generally, SPGAN does not express any optimization adaptation methodologies for determining the best parameters to ensure the accurate classification of thyroid nodules. Therefore, the Piranha Foraging Optimization (PFO) algorithm is proposed to improve the SPGAN classifier and accurately identify the thyroid nodules. The metrics, like F-score, accuracy, error rate, precision, sensitivity, specificity, ROC, computing time is examined. The proposed SPGAN-PFO-TNC-UI method attains 30.54%, 21.30%, 27.40%, and 18.92% higher precision and 26.97%, 20.41%, 15.09%, and 18.27% lower error rate compared with existing techniques, like Thyroid detection and classification using DNN with Hybrid Meta-Heuristic and LSTM (TD-DL-HMH-LSTM), Quantum-Inspired convolutional neural networks for optimized thyroid nodule categorization (QCNN-OTNC), Thyroid nodules classification under Follow the Regularized Leader Optimization based Deep Neural Networks (CTN-FRL-DNN), Automatic classification of ultrasound thyroids images using vision transformers and generative adversarial networks (ACUTI-VT-GAN) respectively.","PeriodicalId":49401,"journal":{"name":"Ultrasonic Imaging","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142184612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ultrasonic ImagingPub Date : 2024-09-01Epub Date: 2024-05-28DOI: 10.1177/01617346241255879
Thomas J Wilkinson, Luke A Baker, Emma L Watson, Katerina Nikopoulou, Christina Karatzaferi, Matthew Pm Graham-Brown, Alice C Smith, Giorgos K Sakkas
{"title":"Skeletal Muscle Texture Assessment Using Ultrasonography: Comparison with Magnetic Resonance Imaging in Chronic Kidney Disease.","authors":"Thomas J Wilkinson, Luke A Baker, Emma L Watson, Katerina Nikopoulou, Christina Karatzaferi, Matthew Pm Graham-Brown, Alice C Smith, Giorgos K Sakkas","doi":"10.1177/01617346241255879","DOIUrl":"10.1177/01617346241255879","url":null,"abstract":"<p><p>Skeletal muscle dysfunction is common in chronic kidney disease (CKD). Of interest is the concept of \"muscle quality,\" of which measures include ultrasound-derived echo intensity (EI). Alternative parameters of muscle texture, for example, gray level of co-occurrence matrix (GCLM), are available and may circumvent limitations in EI. The validity of EI is limited in humans, particularly in chronic diseases. This study aimed to investigate the associations between ultrasound-derived parameters of muscle texture with MRI. Images of the thigh were acquired using a 3 Tesla MRI scanner. Quantification of muscle (contractile), fat (non-contractile), and miscellaneous (connective tissue, fascia) components were estimated. Anatomical rectus femoris cross-sectional area was measured using B-mode 2D ultrasonography. To assess muscle texture, first (i.e., EI)- and second (i.e., GLCM)-order statistical analyses were performed. Fourteen participants with CKD were included (age: 58.0 ± 11.9 years, 50% male, eGFR: 27.0 ± 7.4 ml/min/1.73m<sup>2</sup>, 55% Stage 4). Higher EI was associated with lower muscle % (quadriceps: β = -.568, <i>p</i> = .034; hamstrings: β = -.644, <i>p</i> = .010). Higher EI was associated with a higher fat % in the hamstrings (β = -.626, <i>p</i> = .017). A higher angular second moment from GLCM analysis was associated with greater muscle % (β = .570, <i>p</i> = .033) and lower fat % (β = -.534, <i>p</i> = .049). A higher inverse difference moment was associated with greater muscle % (β = .610, <i>p</i> = .021 and lower fat % (β = -.599, <i>p</i> = .024). This is the first study to investigate the associations between ultrasound-derived parameters of muscle texture with MRI. Our preliminary findings suggest ultrasound-derived texture analysis provides a novel indicator of reduced skeletal muscle % and thus increased intramuscular fat.</p>","PeriodicalId":49401,"journal":{"name":"Ultrasonic Imaging","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11325600/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141162295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ultrasonic ImagingPub Date : 2024-09-01Epub Date: 2024-06-21DOI: 10.1177/01617346241259049
Kai Fan, Yunye Cai, Enxiang Shen, Yuxin Wang, Jie Yuan, Chao Tao, Xiaojun Liu
{"title":"Elevation Resolution Enhancement Oriented 3D Ultrasound Imaging.","authors":"Kai Fan, Yunye Cai, Enxiang Shen, Yuxin Wang, Jie Yuan, Chao Tao, Xiaojun Liu","doi":"10.1177/01617346241259049","DOIUrl":"10.1177/01617346241259049","url":null,"abstract":"<p><p>Three-dimensional (3D) ultrasound imaging can be accomplished by reconstructing a sequence of two-dimensional (2D) ultrasound images. However, 2D ultrasound images usually suffer from low resolution in the elevation direction, thereby impacting the accuracy of 3D reconstructed results. The lateral resolution of 2D ultrasound is known to significantly exceed the elevation resolution. By combining scanning sequences acquired from orthogonal directions, the effects of poor elevation resolution can be mitigated through a composite reconstructing process. Moreover, capturing ultrasound images from multiple perspectives necessitates a precise probe positioning method with a wide angle of coverage. Optical tracking is popularly used for probe positioning for its high accuracy and environment-robustness. In this paper, a novel large-angle accurate optical positioning method is used for enhancing resolution in 3D ultrasound imaging through orthogonal-view scanning and composite reconstruction. Experiments on two phantoms proved that our method could significantly improve reconstruction accuracy in the elevation direction of the probe compared with single-angle parallel scanning. The results indicate that our method holds the potential to improve current 3D ultrasound imaging techniques.</p>","PeriodicalId":49401,"journal":{"name":"Ultrasonic Imaging","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141433223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ultrasonic ImagingPub Date : 2024-09-01Epub Date: 2024-06-14DOI: 10.1177/01617346241256120
Pauline Muleki-Seya, William D O'Brien
{"title":"Evaluation of Scatterer Parameters From Ultrasound Scattering Models Taking Into Account Scattering From Nuclei and Cells of Cell-Pellet Biophantoms and Ex Vivo Tumors.","authors":"Pauline Muleki-Seya, William D O'Brien","doi":"10.1177/01617346241256120","DOIUrl":"10.1177/01617346241256120","url":null,"abstract":"<p><p>The Quantitative Ultrasound backscatter coefficient provides the capability to evaluate tissue microstructure parameters. Tissue-based scatterer parameters are extracted using ultrasound scattering models. It is challenging to correlate ultrasound scatterer parameters of tissue structures from optical-measured histology, possibly because of inappropriate scattering models or the presence of multiple scatterers. The objective of this study is to pursue the quantification of pertinent scatterer parameters with scattering models that consider ultrasound scattering from nuclei and cells. The concentric sphere model (CSM) and the structure factor model adapted for two types of scatterers (SFM2) are evaluated for cell-pellet biophantoms and ex vivo tumors of four cell lines: 4T1, JC, LMTK, and MAT. The structure factor model (SFM) was used for comparison. CSM and SFM2 provided scatterer parameters closer to histology (lower relative errors) for nucleus and cell radii and volume fractions than SFM but were not always accompanied by lower dispersion of the scatterer distribution (lower coefficient of variation). CSM and SFM2 quantified cell and nucleus radius and volume fraction parameters with lower relative error compared to SFM. For tumors, CSM provided better results than SFM2.</p>","PeriodicalId":49401,"journal":{"name":"Ultrasonic Imaging","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141318747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Automatic Quantitative Assessment of Muscle Strength Based on Deep Learning and Ultrasound.","authors":"Xiao Yang, Beilei Zhang, Ying Liu, Qian Lv, Jianzhong Guo","doi":"10.1177/01617346241255590","DOIUrl":"10.1177/01617346241255590","url":null,"abstract":"<p><p>Skeletal muscle is a vital organ that promotes human movement and maintains posture. Accurate assessment of muscle strength is helpful to provide valuable insights for athletes' rehabilitation and strength training. However, traditional techniques rely heavily on the operator's expertise, which may affect the accuracy of the results. In this study, we propose an automated method to evaluate muscle strength using ultrasound and deep learning techniques. B-mode ultrasound data of biceps brachii of multiple athletes at different strength levels were collected and then used to train our deep learning model. To evaluate the effectiveness of this method, this study tested the contraction of the biceps brachii under different force levels. The classification accuracy of this method for grade 4 and grade 6 muscle strength reached 98% and 96%, respectively, and the overall average accuracy was 93% and 87%, respectively. The experimental results confirm that the innovative methods in this paper can accurately and effectively evaluate and classify muscle strength.</p>","PeriodicalId":49401,"journal":{"name":"Ultrasonic Imaging","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141332352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ultrasonic ImagingPub Date : 2024-09-01Epub Date: 2024-05-21DOI: 10.1177/01617346241253798
Bryan J Ranger, Kevin M Moerman, Micha Feigin, Hugh M Herr, Brian W Anthony
{"title":"3D Ultrasound Shear Wave Elastography for Musculoskeletal Tissue Assessment Under Compressive Load: A Feasibility Study.","authors":"Bryan J Ranger, Kevin M Moerman, Micha Feigin, Hugh M Herr, Brian W Anthony","doi":"10.1177/01617346241253798","DOIUrl":"10.1177/01617346241253798","url":null,"abstract":"<p><p>Given its real-time capability to quantify mechanical tissue properties, ultrasound shear wave elastography holds significant promise in clinical musculoskeletal imaging. However, existing shear wave elastography methods fall short in enabling full-limb analysis of 3D anatomical structures under diverse loading conditions, and may introduce measurement bias due to sonographer-applied force on the transducer. These limitations pose numerous challenges, particularly for 3D computational biomechanical tissue modeling in areas like prosthetic socket design. In this feasibility study, a clinical linear ultrasound transducer system with integrated shear wave elastography capabilities was utilized to scan both a calibrated phantom and human limbs in a water tank imaging setup. By conducting 2D and 3D scans under varying compressive loads, this study demonstrates the feasibility of volumetric ultrasound shear wave elastography of human limbs. Our preliminary results showcase a potential method for evaluating 3D spatially varying tissue properties, offering future extensions to computational biomechanical modeling of tissue for various clinical scenarios.</p>","PeriodicalId":49401,"journal":{"name":"Ultrasonic Imaging","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141071776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Abstracts for the 2024 Ultrasonic Imaging and Tissue Characterization Symposium (UITC)","authors":"","doi":"10.1177/01617346241257304","DOIUrl":"https://doi.org/10.1177/01617346241257304","url":null,"abstract":"","PeriodicalId":49401,"journal":{"name":"Ultrasonic Imaging","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141550365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ultrasonic ImagingPub Date : 2024-05-01Epub Date: 2024-03-18DOI: 10.1177/01617346241236160
Matthew T Huber, Katelyn M Flint, Patricia J McNally, Sarah C Ellestad, Gregg E Trahey
{"title":"Human Observer Sensitivity to Temporal Noise During B-Mode Ultrasound Scanning: Characterization and Imaging Implications.","authors":"Matthew T Huber, Katelyn M Flint, Patricia J McNally, Sarah C Ellestad, Gregg E Trahey","doi":"10.1177/01617346241236160","DOIUrl":"10.1177/01617346241236160","url":null,"abstract":"<p><p>This work measures temporal signal-to-noise ratio (SNR) thresholds that indicate when random noise during ultrasound scanning becomes imperceptible to expert human observers. Visible noise compromises image quality and can potentially lead to non-diagnostic scans. Noise can arise from both stable acoustic sources (clutter) or randomly varying electronic sources (temporal noise). Extensive engineering effort has focused on decreasing noise in both of these categories. In this work, an observer study with five practicing sonographers was performed to assess sonographer sensitivity to temporal noise in ultrasound cine clips. Understanding the conditions where temporal noise is no longer visible during ultrasound imaging can inform engineering efforts seeking to minimize the impact this noise has on image quality. The sonographers were presented with paired temporal noise-free and noise-added simulated speckle cine clips and asked to select the noise-added clips. The degree of motion in the imaging target was found to have a significant effect on the SNR levels where noise was perceived, while changing imaging frequency had little impact. At realistic in vivo motion levels, temporal noise was not perceived in cine clips at and above 28 dB SNR. In a case study presented here, the potential of adaptive intensity adjustment based on this noise perception threshold is validated in a fetal imaging scenario. This study demonstrates how noise perception thresholds can be applied to help design or tune ultrasound systems for different imaging tasks and noise conditions.</p>","PeriodicalId":49401,"journal":{"name":"Ultrasonic Imaging","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140144470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ultrasonic ImagingPub Date : 2024-05-01Epub Date: 2024-02-09DOI: 10.1177/01617346241227900
Jacob R McCall, Arthur Chavignon, Olivier Couture, Paul A Dayton, Gianmarco F Pinton
{"title":"Element Position Calibration for Matrix Array Transducers with Multiple Disjoint Piezoelectric Panels.","authors":"Jacob R McCall, Arthur Chavignon, Olivier Couture, Paul A Dayton, Gianmarco F Pinton","doi":"10.1177/01617346241227900","DOIUrl":"10.1177/01617346241227900","url":null,"abstract":"<p><p>Two-dimensional ultrasound transducers enable the acquisition of fully volumetric data that have been demonstrated to provide greater diagnostic information in the clinical setting and are a critical tool for emerging ultrasound methods, such as super-resolution and functional imaging. This technology, however, is not without its limitations. Due to increased fabrication complexity, some matrix probes with disjoint piezoelectric panels may require initial calibration. In this manuscript, two methods for calibrating the element positions of the Vermon 1024-channel 8 MHz matrix transducer are detailed. This calibration is a necessary step for acquiring high resolution B-mode images while minimizing transducer-based image degradation. This calibration is also necessary for eliminating vessel-doubling artifacts in super-resolution images and increasing the overall signal-to-noise ratio (SNR) of the image. Here, we show that the shape of the point spread function (PSF) can be significantly improved and PSF-doubling artifacts can be reduced by up to 10 dB via this simple calibration procedure.</p>","PeriodicalId":49401,"journal":{"name":"Ultrasonic Imaging","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139708353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}