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Antitumor Activity of Drugs of Various Mechanisms of Action in Experimental Models of Advanced Tumors 不同作用机制药物在晚期肿瘤实验模型中的抗肿瘤活性
IF 4.033
Biophysics Pub Date : 2026-06-30 DOI: 10.1134/S0006350926700156
L. A. Ostrovskaya, D. B. Korman, A. F. Vanin, N. V. Bluhterova, V. A. Rykova, K. A. Abzaeva
{"title":"Antitumor Activity of Drugs of Various Mechanisms of Action in Experimental Models of Advanced Tumors","authors":"L. A. Ostrovskaya,&nbsp;D. B. Korman,&nbsp;A. F. Vanin,&nbsp;N. V. Bluhterova,&nbsp;V. A. Rykova,&nbsp;K. A. Abzaeva","doi":"10.1134/S0006350926700156","DOIUrl":"10.1134/S0006350926700156","url":null,"abstract":"<p>The effectiveness of drugs with various mechanisms of antitumor action, representing the following classes of compounds: precious metal polyacrylates (aurumacryl and argacryl), binuclear dinitrosyl iron complexes (B-DNIC-cysteine), and nitrosoalkyl ureas (metinur, dimethinur, chlonisol, and nimustine) has been studied on the advanced solid tumors. The range of tumor models included xenografts of human melanoma BRO, the first generation of spontaneous breast cancer in mice, Lewis lung carcinoma, adenocarcinoma Ca-755, melanoma B-16, and leukemia P-388 (solid form). The mass of tumors when exposed to the drugs varied from 120 to 420 mg, and the time to start using the drugs ranged from 5 to 12 days of tumor growth. It was shown that it is possible in principle to achieve a very high antitumor effect with late initiation of treatment and the effect of drugs on advanced tumors.</p>","PeriodicalId":493,"journal":{"name":"Biophysics","volume":"71 1","pages":"140 - 149"},"PeriodicalIF":4.033,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148342950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Biophysical Multiplier Effect: How the Cost of Transformation of an Organism Changes During Ontogenesis 生物物理乘数效应：生物体在个体发生过程中转化的成本如何变化
IF 4.033
Biophysics Pub Date : 2026-06-30 DOI: 10.1134/S000635092670017X
G. R. Ivanitskii
{"title":"The Biophysical Multiplier Effect: How the Cost of Transformation of an Organism Changes During Ontogenesis","authors":"G. R. Ivanitskii","doi":"10.1134/S000635092670017X","DOIUrl":"10.1134/S000635092670017X","url":null,"abstract":"<p>All complex living organisms consist of two interconnected domains: information and energy (the brain and the systems of internal and external mobility of the body). Adaptation to the external environment is based on the perception and processing of information. The external actions of the organism are the result of the influence of the information system on the energy system. The cost of exchange transactions between the body’s domains can be defined as the biophysical multiplier effect in which there is an oscillatory exchange of energy quanta for quanta of the body’s characteristic action time. This cost varies during ontogenesis from childhood to old age. This explains age-related changes in the scales of perception of time and space intervals.</p>","PeriodicalId":493,"journal":{"name":"Biophysics","volume":"71 1","pages":"167 - 182"},"PeriodicalIF":4.033,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148342885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dynamics of Connection of Electroencephalograms Patterns in a Computer Game 电脑游戏中脑电图模式的动态连接
IF 4.033
Biophysics Pub Date : 2026-06-30 DOI: 10.1134/S0006350926700107
O. V. Zhukova, O. E. Dick
{"title":"Dynamics of Connection of Electroencephalograms Patterns in a Computer Game","authors":"O. V. Zhukova,&nbsp;O. E. Dick","doi":"10.1134/S0006350926700107","DOIUrl":"10.1134/S0006350926700107","url":null,"abstract":"<p>The work is performed in the hyperscanning paradigm and is devoted to the analysis of the interaction of simultaneously registered electroencephalographic patterns for each pair of healthy subjects under conditions of cognitive load in the form of a computer game with nonverbal interaction between the leading and the led players. Using the method of studying the wavelet coherence of electroencephalograms of two players, patterns of electroencephalograms with different types of synchronization were found. Phase synchronization patterns were revealed in symmetrical occipital and parietal leads, as well as in asymmetric occipital-parietal leads. Lag synchronization patterns (with a time delay in synchronization of one of the players) were found in the occipital and temporal leads, in the occipital-parietal and in the temporoparietal leads. These types of synchronization turned out to be statistically significantly determined for the alpha, beta, and gamma ranges of the analyzed electroencephalograms of paired players.</p>","PeriodicalId":493,"journal":{"name":"Biophysics","volume":"71 1","pages":"97 - 109"},"PeriodicalIF":4.033,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148342933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prioritization of Neoantigens Based on an Integrated Assessment of Their Immunogenic Properties 基于免疫原性综合评估的新抗原优先排序
IF 4.033
Biophysics Pub Date : 2026-06-30 DOI: 10.1134/S0006350926700119
I. V. Bezdvornykh, V. A. Stanin, A. A. Samsonova, A. A. Kanapin
{"title":"Prioritization of Neoantigens Based on an Integrated Assessment of Their Immunogenic Properties","authors":"I. V. Bezdvornykh,&nbsp;V. A. Stanin,&nbsp;A. A. Samsonova,&nbsp;A. A. Kanapin","doi":"10.1134/S0006350926700119","DOIUrl":"10.1134/S0006350926700119","url":null,"abstract":"<p>A new computational approach has been developed for predicting and prioritizing neoantigens, peptides that arise during tumor transformation and are promising candidates for creating anticancer vaccines. The IIS indicator is an integral indicator of immunogenicity that combines two key parameters: the affinity of the peptide to MHC I and its ability to elicit an immune response. The developed modular system, implemented in Python, uses an efficient computing strategy that includes a preliminary calculation of immunogenicity to reduce computational load. The platform supports analysis for both individual HLA alleles and population data, which allows it to be used to develop both personalized and universal vaccines. The results of the work include a ranked list of candidates with verification against the IEAtlas and IEDb databases. The system is available in an open repository on GitHub and represents a significant step forward in identifying targets for cancer immunotherapy.</p>","PeriodicalId":493,"journal":{"name":"Biophysics","volume":"71 1","pages":"110 - 113"},"PeriodicalIF":4.033,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148342949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erratum to: Heterogeneity of Responses to Potassium Loading of Glutamatergic Neurons in the Ventral and Dorsal Parts of the Hippocampal CA1 Zone 海马CA1区腹侧和背侧谷氨酸能神经元对钾负荷反应的异质性
IF 4.033
Biophysics Pub Date : 2026-04-07 DOI: 10.1134/S000635092601001X
A. S. Galashin, M. V. Konakov, V. V. Dynnik
{"title":"Erratum to: Heterogeneity of Responses to Potassium Loading of Glutamatergic Neurons in the Ventral and Dorsal Parts of the Hippocampal CA1 Zone","authors":"A. S. Galashin,&nbsp;M. V. Konakov,&nbsp;V. V. Dynnik","doi":"10.1134/S000635092601001X","DOIUrl":"10.1134/S000635092601001X","url":null,"abstract":"","PeriodicalId":493,"journal":{"name":"Biophysics","volume":"71 1","pages":"183 - 183"},"PeriodicalIF":4.033,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148342886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Method for Obtaining Covalent Conjugates of QD Particles with Enzymes Involved in Thrombosis and Thrombolysis 一种获得与血栓和溶栓酶相关的量子点粒子共价偶联物的方法
IF 4.033
Biophysics Pub Date : 2026-04-01 DOI: 10.1134/S0006350925700940
L. P. Savochkina, T. N. Belyanko, Z. I. Tsokolaeva, R. Sh. Bibilashvili
{"title":"A Method for Obtaining Covalent Conjugates of QD Particles with Enzymes Involved in Thrombosis and Thrombolysis","authors":"L. P. Savochkina,&nbsp;T. N. Belyanko,&nbsp;Z. I. Tsokolaeva,&nbsp;R. Sh. Bibilashvili","doi":"10.1134/S0006350925700940","DOIUrl":"10.1134/S0006350925700940","url":null,"abstract":"<div><p>Covalent complexes of prourokinase, miniplasmin, and thrombin with QD nanoparticles containing aldehyde, amino, and carboxyl groups on the surface were obtained. It was shown that under the selected immobilization conditions, the listed enzymes immobilized on QD nanoparticles fully retained their enzymatic activity and the formed complexes were stable colloids. The coating density of nanoparticles with enzymes reached 50–100 molecules per particle. The immobilization of enzymes on carboxylic nanoparticles was performed using cabodiimide. Unlike the technology with carboxyl groups, the immobilization of enzymes on aldehyde nanoparticles does not require the use of carbodiimide to form a covalent complex and does not require a procedure for washing reagents before adding enzymes to nanoparticles, which improves the reproducibility of the immobilization procedure. It has been shown that particles with immobilized thrombin, when incubated with fibrinogen or blood plasma, form microemboli, which in vitro are completely destroyed by plasmin in the physiological concentration of the latter.</p></div>","PeriodicalId":493,"journal":{"name":"Biophysics","volume":"70 5","pages":"871 - 885"},"PeriodicalIF":4.033,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147606383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Accumulation of Nitric Oxide Stabilized Forms in Rat Organs as a Result of Dinitrosyl Iron Complexes with N-Acetyl-L-Cysteine Ligand Administration 二硝基铁配合物与n -乙酰- l-半胱氨酸配体在大鼠器官中积累一氧化氮稳定形式
IF 4.033
Biophysics Pub Date : 2026-04-01 DOI: 10.1134/S0006350925701118
A. A. Timoshin, V. L. Lakomkin, A. A. Abramov, M. V. Ivanova, K. B. Shumaev
{"title":"Accumulation of Nitric Oxide Stabilized Forms in Rat Organs as a Result of Dinitrosyl Iron Complexes with N-Acetyl-L-Cysteine Ligand Administration","authors":"A. A. Timoshin,&nbsp;V. L. Lakomkin,&nbsp;A. A. Abramov,&nbsp;M. V. Ivanova,&nbsp;K. B. Shumaev","doi":"10.1134/S0006350925701118","DOIUrl":"10.1134/S0006350925701118","url":null,"abstract":"<p>The EPR method revealed that as a result of sublingual administration of dinitrosyl iron complexes with the ligand <i>N</i>-acetyl-L-cysteine in rats the transfer and accumulation of stable forms of nitric oxide (NO) occurs in brain tissue. The magnitude of this effect was found to be similar to that observed in the heart, lungs, and liver of the animals.</p>","PeriodicalId":493,"journal":{"name":"Biophysics","volume":"70 6","pages":"1027 - 1032"},"PeriodicalIF":4.033,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147606765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Peroxiredoxins as Key Markers of Radioresistance and Potential Targets in Cancer Radiotherapy 过氧化物还毒素是肿瘤放疗中放射耐药的关键标志物和潜在靶点
IF 4.033
Biophysics Pub Date : 2026-04-01 DOI: 10.1134/S0006350925701155
E. E. Karmanova, S. B. Parfenyuk, O. V. Glushkova, D. E. Burmistrov, V. I. Novoselov, M. G. Sharapov
{"title":"Peroxiredoxins as Key Markers of Radioresistance and Potential Targets in Cancer Radiotherapy","authors":"E. E. Karmanova,&nbsp;S. B. Parfenyuk,&nbsp;O. V. Glushkova,&nbsp;D. E. Burmistrov,&nbsp;V. I. Novoselov,&nbsp;M. G. Sharapov","doi":"10.1134/S0006350925701155","DOIUrl":"10.1134/S0006350925701155","url":null,"abstract":"<p>Radiation therapy is the cornerstone of the treatment of malignant tumors; however, its effectiveness is often limited by radioresistance and treatment-related toxicity. Peroxiredoxins, multifunctional proteins with antioxidant and chaperone activity, play a key role in maintaining redox homeostasis, regulating signaling pathways, and forming radioresistance. Due to these properties, they are considered as prognostic biomarkers and potential therapeutic targets for improving the effectiveness of antitumor radiation therapy. This review presents experimental strategies for overcoming radioresistance through peroxiredoxin modulation, including direct targeting, the use of exogenous proteins, engineered mutants, synthetic peptides, nanoplatforms, and combined effects on the peroxiredoxin–thioredoxin system.</p>","PeriodicalId":493,"journal":{"name":"Biophysics","volume":"70 6","pages":"1056 - 1072"},"PeriodicalIF":4.033,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147606767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interaction of Ascorbic Acid with Spin-Labeled Derivatives of Stearic Acid Embedded in Liposome Membranes 抗坏血酸与脂质体膜中自旋标记硬脂酸衍生物的相互作用
IF 4.033
Biophysics Pub Date : 2026-04-01 DOI: 10.1134/S0006350925701040
V. A. Medvedeva, M. V. Ivanova, E. K. Ruuge, K. B. Shumaev
{"title":"Interaction of Ascorbic Acid with Spin-Labeled Derivatives of Stearic Acid Embedded in Liposome Membranes","authors":"V. A. Medvedeva,&nbsp;M. V. Ivanova,&nbsp;E. K. Ruuge,&nbsp;K. B. Shumaev","doi":"10.1134/S0006350925701040","DOIUrl":"10.1134/S0006350925701040","url":null,"abstract":"<div><p>The interaction of ascorbic acid with nitroxyl radicals from spin labels of 5-doxyl stearic and 16-doxyl stearic acids embedded in phosphatidylcholine liposomal membranes was studied using electron paramagnetic resonance (EPR) spectroscopy. Ascorbic acid was shown to effectively restore the 5-doxyl stearic acid tag in liposomes. After 90 min of incubation with 10 mM ascorbic acid the EPR signal from this label decreased by 70%. After 20 min, the signal decreased by only 50%. At the same time, there was a decrease in the EPR amplitude of 16-doxyl stearic acid by no more than 35% after incubation of the liposomes for 120 min at a concentration of 100 mM ascorbic acid. It is also significant that the signal of 16-doxyl stearic acid remained stable for more than 3 hours. During the reduction of 5-doxyl stearic acid an ascorbate radical was formed but this was not observed for 16-doxyl stearic acid. This is likely due to the limited diffusion of ascorbic acid into the bilayer. In the absence of active transport, ascorbic acid is able to penetrate the membrane and interact with radicals near the polar region, reaching the level of 5-doxyl stearic acid tags. These findings are important for our understanding of the antioxidant role of vitamin C in lipid membranes.</p></div>","PeriodicalId":493,"journal":{"name":"Biophysics","volume":"70 6","pages":"970 - 976"},"PeriodicalIF":4.033,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147606838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Production of Polyclonal Antibodies Specific to Obscurin of the Long-Tailed Ground Squirrel Urocitellus undulatus: Problems and Prospects 长尾地鼠波尾鼠盲蛋白多克隆抗体的制备：问题与展望
IF 4.033
Biophysics Pub Date : 2026-04-01 DOI: 10.1134/S0006350925701015
T. A. Uryupina, S. S. Popova, G. Z. Mikhailova, L. G. Bobyleva, A. D. Ulanova, A. G. Bobylev, S. N. Udaltsov, N. M. Zakharova, I. M. Vikhlyantsev
{"title":"Production of Polyclonal Antibodies Specific to Obscurin of the Long-Tailed Ground Squirrel Urocitellus undulatus: Problems and Prospects","authors":"T. A. Uryupina,&nbsp;S. S. Popova,&nbsp;G. Z. Mikhailova,&nbsp;L. G. Bobyleva,&nbsp;A. D. Ulanova,&nbsp;A. G. Bobylev,&nbsp;S. N. Udaltsov,&nbsp;N. M. Zakharova,&nbsp;I. M. Vikhlyantsev","doi":"10.1134/S0006350925701015","DOIUrl":"10.1134/S0006350925701015","url":null,"abstract":"<p>Polyclonal antibodies specific to the N-sequence (76–289 aa) of obscurin of the long-tailed ground squirrel (<i>Urocitellus undulatus</i>) were used to study the isoform composition of this protein in two striated muscles: the myocardium of the left ventricle and M. gastrocnemius medialis. One low-molecular-weight isoform of obscurin with a molecular weight of 115 kDa has been identified. No other isoforms of obscurin, including giant A- and B-isoforms, have been detected. Seasonal changes in the levels of the low-molecular-weight obscurin isoform visualized in the cardiac and skeletal muscles of long-tailed ground squirrels were not observed. Further research could focus on sequencing the <i>obscn</i> gene of long-tailed ground squirrels and analyzing obscurin transcripts to obtain antibodies specific to the giant isoforms of this protein.</p>","PeriodicalId":493,"journal":{"name":"Biophysics","volume":"70 6","pages":"944 - 949"},"PeriodicalIF":4.033,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147606839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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