Accumulation of Nitric Oxide Stabilized Forms in Rat Organs as a Result of Dinitrosyl Iron Complexes with N-Acetyl-L-Cysteine Ligand Administration

IF 4.033 Q4 Biochemistry, Genetics and Molecular Biology

Biophysics Pub Date : 2026-04-01 DOI:10.1134/S0006350925701118

A. A. Timoshin, V. L. Lakomkin, A. A. Abramov, M. V. Ivanova, K. B. Shumaev

引用次数: 0

Abstract

The EPR method revealed that as a result of sublingual administration of dinitrosyl iron complexes with the ligand N-acetyl-L-cysteine in rats the transfer and accumulation of stable forms of nitric oxide (NO) occurs in brain tissue. The magnitude of this effect was found to be similar to that observed in the heart, lungs, and liver of the animals.

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二硝基铁配合物与n -乙酰- l-半胱氨酸配体在大鼠器官中积累一氧化氮稳定形式

EPR方法显示，大鼠舌下给药二硝基铁配合物与n -乙酰- l-半胱氨酸配体，导致脑组织中稳定形式的一氧化氮（NO）的转移和积累。这种影响的程度与在动物的心脏、肺和肝脏中观察到的相似。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biophysics Biochemistry, Genetics and Molecular Biology-Biophysics

CiteScore

1.20

自引率

0.00%

发文量

期刊介绍： Biophysics is a multidisciplinary international peer reviewed journal that covers a wide scope of problems related to the main physical mechanisms of processes taking place at different organization levels in biosystems. It includes structure and dynamics of macromolecules, cells and tissues; the influence of environment; energy transformation and transfer; thermodynamics; biological motility; population dynamics and cell differentiation modeling; biomechanics and tissue rheology; nonlinear phenomena, mathematical and cybernetics modeling of complex systems; and computational biology. The journal publishes short communications devoted and review articles.