Undersea and Hyperbaric Medicine最新文献

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Myocardial Ischemia-Associated Arterial Embolism Management from Pulmonary Cryotherapy. 肺冷冻治疗引起心肌缺血相关动脉栓塞的处理。
IF 0.7 4区 医学
Undersea and Hyperbaric Medicine Pub Date : 2025-03-01
Wiaam Y Elkhatib, Miguel T Teixeira, Brian T Welch, William M LeTourneau, Daniel A Diedrich, Gary Toups
{"title":"Myocardial Ischemia-Associated Arterial Embolism Management from Pulmonary Cryotherapy.","authors":"Wiaam Y Elkhatib, Miguel T Teixeira, Brian T Welch, William M LeTourneau, Daniel A Diedrich, Gary Toups","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A 52-year-old male undergoing pulmonary lesion cryoablation developed transient intraprocedural and postprocedural hypotension, transient ST elevations on telemetry with associated bradyarrhythmia, and computed tomography imaging revealing arterial gas embolism within the left ventricle and aorta. Coordinated multidisciplinary efforts involving interventional radiology, anesthesiology, cardiology, critical care, and hyperbaric medicine were employed to ensure a successful recovery, alongside important management considerations aimed at minimizing adverse outcomes.</p>","PeriodicalId":49396,"journal":{"name":"Undersea and Hyperbaric Medicine","volume":"52 3","pages":"349-356"},"PeriodicalIF":0.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145507985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Risk factors and Outcome Analysis of Delayed Neurological Sequelae in elderly patients with carbon monoxide poisoning. 老年一氧化碳中毒迟发性神经系统后遗症的危险因素及预后分析。
IF 0.7 4区 医学
Undersea and Hyperbaric Medicine Pub Date : 2025-03-01
Yuehong Ma, Wenying Lv, Huijun Hu, Yuehong Ma, Yuehong Ma
{"title":"Risk factors and Outcome Analysis of Delayed Neurological Sequelae in elderly patients with carbon monoxide poisoning.","authors":"Yuehong Ma, Wenying Lv, Huijun Hu, Yuehong Ma, Yuehong Ma","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Carbon monoxide (CO) poisoning is one of the common causes of poisoning and can result in significant neurological sequelae. However, few studies have focused on the elderly population. We retrospectively reviewed elderly (age≥65 years) with CO poisoning from non-fire accidents and non-suicide at the 6th Medical Center PLA General Hospital in China from 2013 to 2023. A total of 167 patients were enrolled. The annual case number decreased from 2013 to 2023, particularly during the cold months (November to February). The most common source of exposure was coal heating (90%). The most common presenting symptoms were changes in consciousness (90%). Eighty-eight patients (52%) developed delayed neurological sequelae (DNS), of which sixty-nine (78%) converted to long-term neurological sequelae (LNS). The most common imaging manifestations were hypoxic-ischemic damage in the basal ganglia (54%) and demyelination in white matter (46%). After multivariate analysis, initial GCS score and coma time (GCS scores<8) were the independent risk factors for patients with DNS (p<0.001). Interestingly, myocardial injury was more common in non-DNS elderly patients than in DNS patients (p<0.001); only coma time was an independent risk factor for patients with LNS (p<0.001). There was no significant difference between HBO₂ (p=0.19) and NBO (p=0.38) in the occurrence of DNS and LNS in elderly patients with CO poisoning. Therefore, initial GCS score and coma time (GCS scores<8) may be the risk factors of DNS, and coma time may be a high-risk factor for poor prognosis in elderly patients with CO poisoning. Moreover, HBO₂ treatment did not show benefit or harm to those patients. Special attention should be given, and follow-up should be performed on elderly patients, particularly those who have longer coma time and CO exposure time and lower initial GCS scores in acute CO poisoning.</p>","PeriodicalId":49396,"journal":{"name":"Undersea and Hyperbaric Medicine","volume":"52 3","pages":"283-292"},"PeriodicalIF":0.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145508001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hyperbaric oxygen therapy for high performance athletes: a narrative review. 高水平运动员的高压氧治疗:叙述性回顾。
IF 0.7 4区 医学
Undersea and Hyperbaric Medicine Pub Date : 2025-03-01
Kelly Johnson-Arbor
{"title":"Hyperbaric oxygen therapy for high performance athletes: a narrative review.","authors":"Kelly Johnson-Arbor","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Elite athletes who sustain severe injuries may experience physiological, psychological, and financial repercussions. Many therapies, including hyperbaric oxygenation (HBO₂), have been investigated as potential methods of preventing and treating injuries in elite athlete populations. This narrative review explores several applications of HBO₂ therapy relevant to athletes, based on the available human and animal literature. In animal studies, the administration of HBO₂ is associated with improved muscle healing after soft tissue injury. Although human studies are inconclusive, some data suggest that short courses of HBO₂ may result in reduced pain and faster return to play after soft tissue musculoskeletal injury. For individuals with sequelae of traumatic brain injury, limited data suggest that HBO₂ may improve neurobehavioral symptoms. However, studies involving the use of hyperbaric oxygen therapy to treat concussions in athletes are limited. Mild HBO₂ has been used to facilitate post-exercise recovery and reduce fatigue and performance decrements. The treatment vessels used to deliver mild HBO₂ are typically intended for treating altitude sickness only. They are associated with safety and regulatory concerns when used for other purposes, including athletic recovery. Overall, there is limited evidence to support the use of HBO₂ to enhance recovery in athletes with musculoskeletal and mild traumatic brain injury. Further investigations should explore the optimal use of this therapy in the elite athlete population.</p>","PeriodicalId":49396,"journal":{"name":"Undersea and Hyperbaric Medicine","volume":"52 3","pages":"337-347"},"PeriodicalIF":0.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145507962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hyperbaric Oxygen Treatment after Surgery and Radiation for Oral Cancers Does not Increase the Likelihood of a Second Primary Development, nor Reduce Disease Specific or Overall Survival. 口腔癌手术和放疗后高压氧治疗不会增加第二次原发性发展的可能性,也不会降低疾病特异性或总生存期。
IF 0.7 4区 医学
Undersea and Hyperbaric Medicine Pub Date : 2025-03-01
Chiao-Hsuan Hsieh, Yu-Wen Wen, Chun-Ta Liao, Shu-Ru Lee
{"title":"Hyperbaric Oxygen Treatment after Surgery and Radiation for Oral Cancers Does not Increase the Likelihood of a Second Primary Development, nor Reduce Disease Specific or Overall Survival.","authors":"Chiao-Hsuan Hsieh, Yu-Wen Wen, Chun-Ta Liao, Shu-Ru Lee","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to analyze whether receiving Hyperbaric oxygen (HBO₂) therapy affects oral cancer prognosis using real-world data from the National Health Insurance Research Database (NHIRD) in Taiwan.</p><p><strong>Method: </strong>This study is a retrospective cohort study. Cancer registration files, the NHIRD, and death statistics files from 2011 to 2019 were used for data extraction. We identified 6,297 oral cancer patients, all of whom underwent tumor resection surgery and radiation therapy. Among them, 254 patients received HBO₂ therapy for osteoradionecrosis. We then divided them into two groups for comparison based on whether they received HBO₂ therapy or not. First, propensity score matching was used to eliminate basic characteristic differences between the groups, and then Kaplan-Meier survival analysis was conducted. To eliminate immortal time bias and obtain hazard ratios, a time-dependent Cox proportional hazards model was used for estimation.</p><p><strong>Result: </strong>After undergoing curative tumor resection combined with adjunctive radiation therapy, oral cancer patients were divided into two groups based on whether they received hyperbaric oxygen therapy. The estimation using a time-dependent Cox proportional hazards model showed no statistically significant differences in the three follow-up endpoints of this study: incidence of second primary cancer, disease-specific mortality, and all-cause mortality, in terms of hazard ratios.</p><p><strong>Conclusion: </strong>In Taiwan, whether oral cancer patients receive hyperbaric oxygen therapy after curative tumor resection surgery combined with radiation therapy does not affect the incidence of second primary cancer, disease-specific mortality rate, and all-cause mortality rate.</p>","PeriodicalId":49396,"journal":{"name":"Undersea and Hyperbaric Medicine","volume":"52 3","pages":"271-278"},"PeriodicalIF":0.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145508070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Does Covid-19 Cause Avascular Necrosis? Covid-19会导致缺血性坏死吗?
IF 0.7 4区 医学
Undersea and Hyperbaric Medicine Pub Date : 2025-03-01
Kübra Canarslan-Demir, Kübra Ozgok-Kangal, Esat Artan, Burak Turgut
{"title":"Does Covid-19 Cause Avascular Necrosis?","authors":"Kübra Canarslan-Demir, Kübra Ozgok-Kangal, Esat Artan, Burak Turgut","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>COVID-19 has been associated with an increased risk of avascular necrosis (AVN), which affects various joints, including the hip, vertebrae, knee, and jaw. Understanding AVN's pathogenesis and risk factors as a consequence of COVID-19 is essential for improving treatment and identifying preventive measures. This retrospective cohort study aims to assess the impact of COVID-19 on the etiology of AVN and raise awareness among clinicians. The study analyzed patients diagnosed with AVN and treated with Hyperbaric Oxygen Therapy at Gülhane Training and Research Hospital from January 2018 to January 2023. Patients were categorized into two groups: those admitted before the pandemic (the control group) and those admitted after (the study group). The results showed a significant increase in AVN cases during the post-pandemic period, with a higher incidence of femoral head involvement and more advanced stages of AVN in patients with a history of COVID-19. The findings suggest that COVID-19 and high-dose steroid use may increase AVN risk, highlighting the need for careful steroid management and monitoring for joint pain in these patients. Further research is recommended to explore the link between COVID-19 and AVN, the duration of symptoms, and the prognostic implications.</p>","PeriodicalId":49396,"journal":{"name":"Undersea and Hyperbaric Medicine","volume":"52 3","pages":"361-368"},"PeriodicalIF":0.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145507925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acute Traumatic Ischemias: Roles of Hyperbaric Oxygen. 急性创伤性缺血:高压氧的作用。
IF 0.7 4区 医学
Undersea and Hyperbaric Medicine Pub Date : 2025-03-01
Michael B Strauss
{"title":"Acute Traumatic Ischemias: Roles of Hyperbaric Oxygen.","authors":"Michael B Strauss","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Acute traumatic ischemias are a constellation of disorders that range from crush injuries to compartment syndromes, from burns to frostbite, and from threatened flaps to compromised re-implantations. They represent a significant economic burden to the health care system. In 2016, the National Trauma Organization reported that $672 billion was spent on trauma care without consideration for loss of employment income and psychological trauma associated with the problems. In the most severe orthopedically related traumatic ischemias, for example, Gustilo Grade III-B & C open fractures [1]. Fifty percent complication rates occur even with state of the art orthopaedic and other optimal ancillary care. Hyperbaric oxygen (HBO₂) has mechanisms that mitigate the pathophysiology of the traumatic ischemias with the potential for improving those that have predicably less than optimal outcomes. This selection discusses the surgical types of traumatic ischemias, focusing primarily on crush injuries. It is noteworthy that all the traumatic ischemias have similar pathophysiology. Other sections of this Hyperbaric Medicine Indications Manual are specifically devoted to burn injuries and threatened flaps and grafts.</p>","PeriodicalId":49396,"journal":{"name":"Undersea and Hyperbaric Medicine","volume":"52 3","pages":"397-412"},"PeriodicalIF":0.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145507888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of hyperbaric oxygen therapy on tolerability, clinical signs, lactatemia and glycemia in patients with pyometra. 高压氧治疗对脓脓患者耐受性、临床体征、乳酸血症和血糖的影响。
IF 0.7 4区 医学
Undersea and Hyperbaric Medicine Pub Date : 2025-03-01
Emanuelle B Degregori, Pamela Caye, Ana Barbara U Soares, Otávio H M Schiefler, Bernardo N Antunes, Rainer S Reinstein, Jenifer Freitas, Valentina K Polanczyk, Nathalia P Mangini, Guilherme H S Amancio, Maurício V Brun, Daniel C M Müller
{"title":"Impact of hyperbaric oxygen therapy on tolerability, clinical signs, lactatemia and glycemia in patients with pyometra.","authors":"Emanuelle B Degregori, Pamela Caye, Ana Barbara U Soares, Otávio H M Schiefler, Bernardo N Antunes, Rainer S Reinstein, Jenifer Freitas, Valentina K Polanczyk, Nathalia P Mangini, Guilherme H S Amancio, Maurício V Brun, Daniel C M Müller","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This study evaluated the physical parameters, lactatemia, glycemia, and tolerability in canines with pyometra and sepsis who underwent hyperbaric oxygen therapy (HBO₂). Eighteen female dogs were randomly assigned to two groups: the hyperbaric group (HG) (three sequential sessions of HBO₂ [O₂ with 2 ATA for 45 min] after ovariohysterectomy) and the control group (CG) (ovariohysterectomy). Glycemia and lactatemia were measured at admission (T0), 1 hour after the end of the surgical procedure (T1), 24 hours (T2), 48 hours (T3), and 72 hours (T4) after surgery. Physical assessments were conducted at the same times, except for HG, which was assessed before and after each HBO session. There was no difference between the groups in relation to the physical parameters evaluated; however, rectal temperature was reduced in the group subjected to HBO₂. We observed an increase in lactate at T0 and T2, and a reduction at T3 and T4 in both groups. We did not identify changes in blood glucose levels. HBO₂ is acceptable and safe, but may reduce rectal temperature, although hypothermia can be expected in dogs with pyometra following the surgical procedure. Lactate may take up to 48 hours to begin, but it does not appear to be linked to prognosis or length of stay.</p>","PeriodicalId":49396,"journal":{"name":"Undersea and Hyperbaric Medicine","volume":"52 3","pages":"293-304"},"PeriodicalIF":0.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145508061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Systematic Review of Hyperbaric Oxygen for Late Radiation Tissue Injury (Bowel, Bladder). 高压氧治疗晚期放射性组织损伤(肠、膀胱)的系统评价。
IF 0.7 4区 医学
Undersea and Hyperbaric Medicine Pub Date : 2025-03-01
Kristen Allison Eckert, Caroline E Fife, Marissa Janine Carter
{"title":"Systematic Review of Hyperbaric Oxygen for Late Radiation Tissue Injury (Bowel, Bladder).","authors":"Kristen Allison Eckert, Caroline E Fife, Marissa Janine Carter","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>This systematic review evaluated comparative studies to determine if hyperbaric oxygen therapy (HBO₂) is beneficial to late radiation tissue injury (LRTI) of the bowel/bladder.</p><p><strong>Methods: </strong>We included adequately powered, comparative studies evaluating the effect of HBO₂ on patients with LRTI (≥3 months duration and/or ≥6 months after radiation therapy) to the bowel/bladder compared to no HBO₂ or placebo/sham; complete outcomes data must have corresponded to the tools used to measure change in LRTI symptoms. Medline was searched through May 4, 2023, Embase through May 29, 2023, and Google Scholar through May 5, 2023. The Cochrane risk-of-bias tool and GRADE approach were used with a certainty of outcomes assessment.</p><p><strong>Results: </strong>Three RCTs were included with 273 subjects. Two double-blinded studies evaluated rectal symptoms; one open study evaluated cystitis. One study had a low risk of bias; two had some concerns. All had moderate certainty of outcomes. There is moderate certainty with a weak recommendation for using HBO₂ for rectal complications or cystitis, which (in context of GRADE terminology) means the decision to treat depends on a case-by-case basis.</p><p><strong>Discussion: </strong>The highly heterogeneous design of the trials made meta-analysis impossible, but moderate certainty of the beneficial effect of HBO₂ on LRTI to the rectum and bladder was confirmed. With the weak recommendation, a discussion should take place between the patient and their physician as to whether or not the patient is likely to benefit from HBO₂.</p>","PeriodicalId":49396,"journal":{"name":"Undersea and Hyperbaric Medicine","volume":"52 3","pages":"313-325"},"PeriodicalIF":0.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145508058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characteristic of volume-controlled ventilation with small tide volume in hyperbaric oxygen chamber. 高压氧舱小潮气量气量控制通风特性研究。
IF 0.7 4区 医学
Undersea and Hyperbaric Medicine Pub Date : 2025-03-01
Cong Wang, Lei Zhang, Qiuhong Yu, Yaling Liu, Ziqi Ren, Lianbi Xue
{"title":"Characteristic of volume-controlled ventilation with small tide volume in hyperbaric oxygen chamber.","authors":"Cong Wang, Lei Zhang, Qiuhong Yu, Yaling Liu, Ziqi Ren, Lianbi Xue","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the characteristics of tidal volume (VT) delivered by a Shangrila590 ventilator with preset tide volume (VTset) 50-300 mL in volume-controlled ventilation (VCV) during hyperbaric oxygen (HBO₂) therapy.</p><p><strong>Methods: </strong>Experiments were conducted in a multi-place HBO₂ chamber at 1.0, 2.0, and 2.8 atmospheres absolute (ATA abs) and were divided into three groups accordingly. The ventilator was connected to the test lung in the chamber. The VTset of the ventilator was adjusted before the experiments. At five VTset levels (50, 100, 150, 200, 300 mL), the VT and inspiratory peak pressure (Ppeak) detected by the ventilator and the test lung were recorded for 30 cycles (n=30). The measurements of the test lung were considered to be the true value, and the ventilator and test lung data were compared to evaluate the accuracy of the ventilator. Test lung compliance (CTL) was detected by the ventilator, and breathing circuit compliance (CBC) was calculated by measuring the pressure and volume of the breathing circuit. Ventilation data were compared among three groups to clarify the change during HBO₂.</p><p><strong>Results: </strong>At every VTset, the VT detected by the test lung was different from the ventilator at 1.0~2.8 atm abs (p<0.05), and the VT changed differently among the three groups (p<0.05). CTL and the CBC decreased with increasing ambient pressure (p<0.05). The Ppeak of VCV increased (p<0.05) with increasing ambient pressure.</p><p><strong>Conclusions: </strong>The Shangrila590 ventilator has limitations in small VTset (50- 300 mL) VCV during HBO₂ therapy. CBC and CTL levels change due to high gas density. High Ppeak may occur in VCV with stable VT, also caused by high gas density.</p>","PeriodicalId":49396,"journal":{"name":"Undersea and Hyperbaric Medicine","volume":"52 3","pages":"305-312"},"PeriodicalIF":0.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145507930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Oxy-inflammation after repetitive "open circuit" dives in the Baltic Sea. 在波罗的海反复“开放回路”潜水后的氧性炎症。
IF 0.7 4区 医学
Undersea and Hyperbaric Medicine Pub Date : 2025-03-01
Andrea Brizzolari, Simona Mrakic-Sposta, Alessandra Vezzoli, Costantino Balestra, Barbara Bonini, Alessandra Barassi, Enrico Camporesi, Gerardo Bosco
{"title":"Oxy-inflammation after repetitive \"open circuit\" dives in the Baltic Sea.","authors":"Andrea Brizzolari, Simona Mrakic-Sposta, Alessandra Vezzoli, Costantino Balestra, Barbara Bonini, Alessandra Barassi, Enrico Camporesi, Gerardo Bosco","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>SCUBA diving involves exposure to a hyperbaric environment that can induce oxidative stress and inflammation. This study investigates the evolution of oxy-inflammation status in divers who performed repetitive dives in cold water.</p><p><strong>Methods: </strong>In the Baltic Sea, nine expert divers were recruited to perform five dives (T1-T5). Urine and saliva were collected before (A) and after (B) each dive. Reactive Oxygen Species (ROS), total antioxidant capacity (TAC), lipid peroxidation (8-iso-PGF2α), DNA damage (8-OH-dG), inflammatory status (IL-6), nitric oxide metabolites, neopterin, and electrolyte balance changes were investigated.</p><p><strong>Results: </strong>Pre-dive values showed significant increases at the fourth to fifth days in ROS (+45 and +89%) and consequently in lipid peroxidation (+65%) at the fourth day and in DNA damage (+49 and +61%) at the fourth to fifth days, respectively, compared to the first day value. Post-dive significant increases were recorded at the fourth to fifth days in ROS (+83 % and +146%), and at the fifth day in lipid peroxidation (+59%) and DNA damage (+41%) with respect to the post-dive value of the first day. TAC showed a decrease from the fourth to fifth days post-dive (-15% and -24%) compared to the value on the first day post-dive. Finally, IL-6 increased at the basal level of the fifth day (+183%) and post dive (+154%) with respect to the corresponding values of the first day.</p><p><strong>Conclusion: </strong>Repetitive dives in cold water induced a progressive increase in pre-dive ROS, 8-iso-PGF2α, 8-OH-dG, and IL-6. Oxidative stress was only partially contained by activation of endogenous antioxidant defenses, while IL-6 variation resulted from diving-related physical effort or oxy-inflammation. We did not find notable changes in the electrolyte balance, probably because all subjects examined were well- trained and experienced divers.</p>","PeriodicalId":49396,"journal":{"name":"Undersea and Hyperbaric Medicine","volume":"52 3","pages":"211-225"},"PeriodicalIF":0.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145508073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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