{"title":"A Scoping Review of the Equivalent Air Depth Concept.","authors":"Jan Risberg, Kåre Segadal, Mikael Gennser","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Surface-oriented diving with nitrogen-oxygen breathing gases (nitrox) other than air will commonly be planned according to the Equivalent Air Depth (EAD) principle. EAD is the depth at which a diver breathing air will inhale the same pN₂ as the nitrox-breathing diver. Using conventional air decompression tables based on the EAD depth will allow longer bottom times or shorter decompression times compared to air breathing at the same water depth. This scoping review aimed to investigate the validity of the EAD principle. A literature review identified 13 eligible studies that reported DCS incidence or vascular bubbles following air and nitrox exposures in humans and experimental animals. Four experimental (N=1,597 mandives) and two epidemiological (N=249,109 mandives) studies on humans did not disclose a higher DCS incidence or bubble scores following nitrox dives compared to air dives of similar EAD. Seven experimental animal studies consistently showed that a high pO₂ (>2 atm) increased DCS susceptibility in goats and rats. This can likely be explained by the reduction of the \"oxygen window\" due to the high tissue and venous pO₂. There is insufficient data from animal studies to conclude whether this can be reproduced within a pO₂ range applicable for human operational diving (<1.6 atm). There is presently no reason to modify the EAD principle for manned diving. Still, we would advise improving the monitoring of operational nitrox dives to confirm that nitrox dives have a DCS incidence similar to that of EAD- and bottom time-matched air dives.</p>","PeriodicalId":49396,"journal":{"name":"Undersea and Hyperbaric Medicine","volume":"52 3","pages":"239-259"},"PeriodicalIF":0.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145507975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Effect of Hyperbaric Oxygen on Compromised Grafts and Flaps.","authors":"Evan J Childers, Richard C Baynosa","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The use of grafts and flaps serves as an integral tool in the armamentarium of the reconstructive surgeon. Proper planning and surgical judgment are critical in the ultimate success of these procedures. However, there are situations when grafts and/or flaps can become compromised and require urgent intervention for salvage. These instances can include irradiated or otherwise hypoxic wound beds, excessively large harvested grafts, random flap ischemia, venous or arterial insufficiency, and ischemia- reperfusion injury. Alternatively, compromised grafts and flaps can be inadvertently created secondary to trauma. It is in these types of cases that HBO₂ therapy can serve as a useful adjunct in the salvage of compromised flaps and grafts. This review outlines the extensive basic science and clinical evidence available in support of the use of HBO₂ therapy for compromised grafts and flaps. The literature demonstrates the benefit of adjunctive HBO₂ therapy for multiple types of grafts and flaps with various etiologies of compromise. HBO₂ therapy can enhance graft and flap survival by several methods including decreasing the hypoxic insult, enhancing fibroblast function and collagen synthesis, stimulating angiogenesis, and inhibiting ischemia-reperfusion injury. The expedient initiation of hyperbaric oxygen therapy as soon as flap or graft compromise is identified maximizes tissue viability and ultimately graft/flap salvage.</p>","PeriodicalId":49396,"journal":{"name":"Undersea and Hyperbaric Medicine","volume":"52 3","pages":"381-396"},"PeriodicalIF":0.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145507100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Experience of Hyperbaric Oxygen Therapy in Earthquake-Related Crush Injuries: Could Be Beneficial Even with Delay in Initiation.","authors":"Ahmet Uğur Avcı, Selcen Yüsra Abaylı","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Two significant earthquakes struck southeastern Turkey on February 6. The study aimed to evaluate the effect of HBO₂ on patients with crush injuries who received therapy at the Akyurt Hyperbaric Oxygen Therapy Center following the earthquakes.</p><p><strong>Methods: </strong>Thirty-three crush injury patients were included in the study. The Gustilo crush injury grading system, the Mangled Extremity Severity Score (MESS), and the five assessment host function scores were used to evaluate patients. Additionally, the duration from the time under the rubble until HBO₂ started, as well as the presence of fasciotomy/amputation before or after HBO₂, was recorded.</p><p><strong>Results: </strong>The mean duration from rescue to the initiation of HBO₂ was 195 hours. Of the patients, 63.6% were severely injured according to the MESS (≥7). The Gustilo crush injury classification distribution was 30.3% IIIC, 42.4% IIIB, and 27.3% IIIA. Before HBO₂, 87.9% of the patients had fasciotomies. Fasciotomy lines were closed (without requiring another fasciotomy or additional complications) during or immediately after HBO₂ in 72.4% of 29 patients. Following HBO₂, 78.8% of the patients did not require amputation, while 21.2% had amputations. All patients who underwent amputation after HBO₂ were in the Gustilo IIIC group and scored MESS ≥ 7. Furthermore, 71.4% of patients who had an amputation scored MESS ≥ 10.</p><p><strong>Conclusions: </strong>Hyperbaric oxygen therapy is beneficial in limb salvage and reduces complications in crush injuries and should be included in treatment plans. In countries with active tectonic activity, appropriate planning should be implemented to ensure patients' access to HBO₂, and the number of HBO₂ centers should be increased.</p>","PeriodicalId":49396,"journal":{"name":"Undersea and Hyperbaric Medicine","volume":"52 3","pages":"261-270"},"PeriodicalIF":0.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145507277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fernanda Valeriano Zamora, Ana Clara Felix de Farias Santos, Andres Villca Zamora, Lorhayne Kerley Capuchinho Scalioni Galvao, Nicole Dos Santos Pimenta, João Pedro Costa Esteves Almuinha Salles, Vitoria Batista Carneiro, Carlos Ernesto Ferreira Starling
{"title":"Hyperbaric Oxygen Treatment for Long-COVID syndrome: A Systematic Review of Current Evidence on Cognitive Decline.","authors":"Fernanda Valeriano Zamora, Ana Clara Felix de Farias Santos, Andres Villca Zamora, Lorhayne Kerley Capuchinho Scalioni Galvao, Nicole Dos Santos Pimenta, João Pedro Costa Esteves Almuinha Salles, Vitoria Batista Carneiro, Carlos Ernesto Ferreira Starling","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>There is no established specific treatment for long-COVID syndrome (LCS), yet hyperbaric oxygen (HBO₂) treatment has been studied as a potential option. Therefore, we conducted a systematic review to evaluate the benefits of HBO₂ treatment in LCS patients.</p><p><strong>Methods: </strong>We systematically searched PubMed, Embase, and Cochrane databases until April 2024. Risk of bias and GRADE quality assessment were evaluated. This study was registered in the International Prospective Register of Systematic Reviews (PROSPERO) with ID CRD42024530421.</p><p><strong>Results: </strong>Seven studies from seven countries, divided into RCTs and observational studies, included 199 participants. HBO₂ treatment protocols included breathing 100% oxygen at 2.0 ATA until 2.5 ATA; the number of sessions varied from ten to 60 depending on the patient's comorbidities and symptoms. Memory, executive function, attention, fatigue, and pain level improved with HBO2 treatment. The intervention had minimal side effects, and none were serious.</p><p><strong>Conclusion: </strong>HBO₂ treatment might be a potential option and safe treatment in LCS patients. However, further research should be focused on evaluating its efficacy in a larger number of patients through randomized studies.</p>","PeriodicalId":49396,"journal":{"name":"Undersea and Hyperbaric Medicine","volume":"52 3","pages":"327-335"},"PeriodicalIF":0.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145508006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Konstantinos Athanasiou, George Sotiropoulos, Vasileios N Kalentzos
{"title":"Arterial Gas Embolism after breath-hold diving. An interesting case report in Greece.","authors":"Konstantinos Athanasiou, George Sotiropoulos, Vasileios N Kalentzos","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Pulmonary overinflation syndrome (POIS) is a group of barotrauma-related conditions caused by the expansion of gas trapped in the lung or over-pressurization of the lung with subsequent overexpansion and rupture of the alveolar air sacs. We report a case in which neurological sequelae (arterial gas embolism-AGE) and pneumothorax occurred after breath-hold diving. Treatment with Hyperbaric Oxygen Therapy (HBO₂) led to resolution.</p><p><strong>Case report: </strong>A 20-year-old male diver was transferred to the Athens Naval Hospital with symptoms after breath-hold diving. He developed neurological deficits presenting as reduced visual acuity and hemiparesis, along with subcutaneous emphysema, pneumomediastinum, and bilateral pneumothoraces. The treatment strategy involved initial management of the pneumothorax, followed by HBO₂ combined with medication to resolve the neurological injury. The patient's clinical improvement was remarkable a week later, and he was discharged.</p>","PeriodicalId":49396,"journal":{"name":"Undersea and Hyperbaric Medicine","volume":"52 3","pages":"233-237"},"PeriodicalIF":0.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145507923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Heather Murphy-Lavoie, Frank Butler, Catherine Hagan
{"title":"Arterial Insufficiencies: Central Retinal Artery Occlusion.","authors":"Heather Murphy-Lavoie, Frank Butler, Catherine Hagan","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Central retinal artery occlusion (CRAO) is a relatively rare emergent condition of the eye resulting in sudden painless vision loss. This vision loss is usually dramatic and permanent, and the prognosis for visual recovery is poor. Patients particularly at risk include those with giant cell arteritis, atherosclerosis, and thromboembolic disease. A wide variety of treatment modalities have been tried over the last one hundred years with little to no success, with the exception of hyperbaric oxygen therapy (HBO₂).</p>","PeriodicalId":49396,"journal":{"name":"Undersea and Hyperbaric Medicine","volume":"52 2","pages":"187-201"},"PeriodicalIF":0.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144862551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Arterial Gas Embolism After CT-Guided Lung Biopsy.","authors":"William Zhu, Siamak Moayedi, Kinjal Sethuraman","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Arterial gas embolism (AGE) is a rare complication of percutaneous lung biopsy. We report a case of a patient undergoing lung biopsy complicated by AGE and transient ventricular tachycardia. The patient was placed in the Trendelenburg position, treated with normobaric oxygen therapy, and ultimately discharged from the emergency department. We review the evidence regarding optimal patient positioning for AGE management.</p>","PeriodicalId":49396,"journal":{"name":"Undersea and Hyperbaric Medicine","volume":"52 2","pages":"117-120"},"PeriodicalIF":0.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144862550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Liu Wenwu, Zhang Tingting, Yin Lijun, Xu Jiajun, Yu Xuhua, Wang Shifeng
{"title":"Effect of hyperbaric air exposure with prolonged oxygen inhalation during decompression on the cardiovascular function in divers.","authors":"Liu Wenwu, Zhang Tingting, Yin Lijun, Xu Jiajun, Yu Xuhua, Wang Shifeng","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate the effect of prolonged oxygen inhalation during decompression on the cardiovascular function in divers with hyperbaric air exposure.</p><p><strong>Methods: </strong>Eight divers were pressurized to 400 kPa and then depressurized 30 minutes later. During the decompression, the time of oxygen breathing was prolonged at different depths. The cardiac, carotid, and brachial arterial functions were evaluated by ultrasonography immediately before and after exposure and then compared.</p><p><strong>Results: </strong>After hyperbaric exposure, diastolic blood pressure increased significantly, heart rate reduced markedly, but systolic blood pressure tended to reduce. The peak systolic velocity and end diastolic velocity of the common carotid artery reduced markedly, but its resistance index slightly increased, and the diameter of the brachial artery tended to increase. In addition, the end-diastolic volume, cardiac output, E wave, and A wave of the heart reduced markedly, but the flow velocity of the pulmonary artery tended to reduce.</p><p><strong>Conclusion: </strong>Hyperbaric air exposure at 400 kPa with prolonged oxygen inhalation during decompression mildly affects divers' cardiovascular function.</p>","PeriodicalId":49396,"journal":{"name":"Undersea and Hyperbaric Medicine","volume":"52 2","pages":"163-168"},"PeriodicalIF":0.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144862599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abigail Winn, Mark Billingsley, Marc Pullis, Daniel Popa, Christopher Logue
{"title":"Predictive modeling of the performance of the Zoll Z Vent® under hyperbaric conditions.","authors":"Abigail Winn, Mark Billingsley, Marc Pullis, Daniel Popa, Christopher Logue","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Prior work demonstrated challenges with ventilators in the hyperbaric environment; few ventilators are fully equipped to address these concerns. We hypothesized the Zoll Z-vent® would deliver set tidal volumes incorrectly in volume control mode, but we could correct it using an algorithm. We used the Zoll Z-vent® in assist control mode in a Class A multiplace chamber and the Michigan test lung system. We identified the set tidal volumes on the ventilator that were necessary to achieve target tidal volumes at various depths. We graphed set tidal volume as a function of depth and performed linear regression modeling. From the regressions, we graphed the slope of each versus the target tidal volume and performed a second set of regressions. We generated an equation from our data to predict set tidal volumes. Set tidal volumes necessary to deliver target tidal volumes were directly proportional to depth in a linear manner. The slope of the regressions as a function of target tidal volume was also linearly proportional. The slope of the second set of regressions generated an equation that is used to predict set tidal volume for a given target tidal volume, PEEP, and gas. The Z-vent® can safely deliver mechanical ventilation under hyperbaric conditions with correction using our model. We use a spreadsheet to calculate set tidal volume for any given depth in clinical practice. We have internally validated this model on over 100 patients with multiple quality control measures in place.</p>","PeriodicalId":49396,"journal":{"name":"Undersea and Hyperbaric Medicine","volume":"52 2","pages":"65-72"},"PeriodicalIF":0.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144862604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zdenka Krajčovičová, Rastislav Zigo, Vladimír Meluš, Eva Králová
{"title":"Efficacy of hyperbaric oxygen salvage therapy for sudden sensorineural hearing loss after ineffective primary treatment in the Slovak Republic.","authors":"Zdenka Krajčovičová, Rastislav Zigo, Vladimír Meluš, Eva Králová","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We evaluated the efficacy of hyperbaric oxygen (HBO₂) therapy used to salvage sudden sensorineural hearing loss (SSNHL) at a short distance from ineffective primary treatment. We examined the data on 70 patients who suffered from SSNHL. The treatment was administered from 1 to 3 months after the onset of the hearing loss, i.e., after ineffective primary corticosteroid therapy. The monitored group was divided into three subgroups according to the degree of hearing impairment. Treatment success was assessed by using pre- and post-treatment audiograms. A statistically significant improvement in auditory threshold in all three frequency bands was observed in patients with severe hearing impairment of more than 60 dB, with mean auditory gains of 14.5 dB in low frequencies, 11.2 dB in middle (spoken speech) frequencies, and 13.2 dB in high frequencies. In this subgroup, 54.17 % of patients with severe hearing impairment experienced an improvement in hearing gain by 5 dB or more, 33.33 % by > 10 dB, and 25.00 % by > 20 dB. In patients with moderate and slight hearing impairments, the tendency to improve the hearing gain was not statistically significant. Based on our findings, we conclude that salvage HBO₂ treatment in patients with SSNHL is apparently most efficacious for individuals with severe hearing impairment. This finding is valuable for effective resource management in healthcare and public health.</p>","PeriodicalId":49396,"journal":{"name":"Undersea and Hyperbaric Medicine","volume":"52 2","pages":"109-115"},"PeriodicalIF":0.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144862600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}