Undersea and Hyperbaric Medicine最新文献

{"title":"Hyperbaric Oxygen Treatment in the Management of Post-surgical Pyoderma Gangrenosum Following Reduction Mammoplasty: A Case Report.","authors":"Gamze Aydin, Taylan Zaman","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Postoperative pyoderma gangrenosum (PSPG) is a rare but potentially destructive complication following surgery, often misdiagnosed as infection or necrosis. Mismanagement with antibiotics or debridement can exacerbate lesions due to the pathergy phenomenon. Hyperbaric oxygen treatment (HBO₂) has been proposed as an adjunctive treatment through its effects on tissue oxygenation, angiogenesis, and immunomodulation.</p><p><strong>Case report: </strong>A 52-year-old woman developed a painful ulcer at the surgical site following bilateral reduction mammoplasty. Initially treated as a wound infection with antibiotics and repeated debridements, the lesion rapidly progressed. Histopathology and clinical features supported the diagnosis of PSPG. Despite systemic corticosteroids, cyclosporine, and infliximab, wound healing stagnated after three months. The patient was then referred for HBO₂(2.4 ATA, 120 minutes, once daily). After 17 sessions of HBO₂ combined with atraumatic wound care, marked improvement was observed with progressive contraction and granulation. Complete epithelialization was achieved by postoperative week 38, and no recurrence occurred during six months of follow-up.</p><p><strong>Discussion: </strong>This case highlights the diagnostic challenges of PSPG and the hazards of inappropriate interventions. HBO₂, when combined with immunosuppressive treatment, may provide an effective and safe adjunctive option, accelerating wound healing by improving oxygenation and modulating the inflammatory response. Controlled studies are needed to confirm its role and to establish treatment protocols in PSPG.</p>","PeriodicalId":49396,"journal":{"name":"Undersea and Hyperbaric Medicine","volume":"53 3","pages":"505-510"},"PeriodicalIF":0.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149117355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Lung Injury Based on the Decompression Scheme of Lung Toxicity Dose Unit and K Value.","authors":"Li Yifan, Liu Wenwu, Zheng Haoze, Li Chenglong, He Jia, Wang Shifeng","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to assess hyperoxic lung injury (HLI) during a heliox dive based on the unit pulmonary toxic dose (UPTD), K index, and equivalent surface oxygen time (ESOT).</p><p><strong>Methods: </strong>The UPTD, K index, and ESOT values of each schedule in the Helium-Oxygen Decompression Table of China were calculated. Based on the recommended thresholds, the risk of lung injury was analyzed, and suggestions were proposed to modify certain schedules.</p><p><strong>Results: </strong>The K index and ESOT were more conservative than UPTD in predicting HLI. After a deeper dive, the UPTD, K index, and ESOT values were generally higher than the recommended thresholds. For schedules in which the UPTD, K index, and ESOT values do not exceed the thresholds, we recommend prolonging time on oxygen with or without reducing time on air, or recommending oxygen inhalation after surfacing, which may improve safety without increasing the risk of lung injury. For most schedules, the lung injury may resolve within 12 hours after surfacing, according to the K index.</p><p><strong>Discussion: </strong>Decompression schedules can be adjusted in real time according to K or ESOT values, which may improve safety while effectively controlling the risk of HLI.</p>","PeriodicalId":49396,"journal":{"name":"Undersea and Hyperbaric Medicine","volume":"53 3","pages":"433-442"},"PeriodicalIF":0.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149117296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"REPRINTED FROM THE 2023 HYPERBARIC INDICATIONS MANUAL 15TH EDITION:Randomized Controlled Trials in Hyperbaric Medicine.","authors":"Michael H Bennett","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The criticism has been made of hyperbaric medicine that treatment is based on little or no good clinical evidence. Recently, improved awareness among medical practitioners of the importance of evidence has highlighted this perception, as has the proliferation of both funder-generated reviews and technology assessments [1-3]. In fact, many clinical randomized controlled trials (RCTs) investigating the application of hyperbaric oxygen (HBO₂) therapy have been reported, albeit of variable quality. It is the purpose of this review to describe the place of RCTs within the practice of evidence-based medicine (EBM), summarize the methods by which such trials can be located, discuss the appraisal and performance of RCTs with specific reference to hyperbaric medicine, and to provide a list of RCTs and meta-analyses in hyperbaric medicine to date.</p><p><p>Particular reference is made to the work of the Cochrane Collaboration within the field. An appendix provides a comprehensive list of published RCTs and meta-analyses arranged by indication (Appendix 1). To date, this list includes 416 citations of 390 trials.</p>","PeriodicalId":49396,"journal":{"name":"Undersea and Hyperbaric Medicine","volume":"53 3","pages":"543-568"},"PeriodicalIF":0.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149117356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ostwald Ripening for Gas Bubbles and Decompression in Diving.","authors":"Oswaldo Monteiro Del Cima, Alvaro Vianna Novaes de Carvalho Teixeira, César Melo Rocha, Bruce Ray Wienke","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>The Ostwald ripening phenomenon for gas bubbles in a liquid consists mainly in gas transfer from smaller to larger bubbles. While the phenomenon itself is well known, the consequence of the temporal evolution of bubbles in the bloodstream in human physiology lacks deeper investigation.</p><p><strong>Methods: </strong>In this work, a series of direct experiments was carried out in which the Ostwald ripening for air bubbles in a viscous fluid was reproduced. There, the time evolution of the bubbles' mean radius, number of bubbles, and radius size distribution was measured, where the initial bubble distribution behaves like a Tsallis (q-Weibull) distribution.</p><p><strong>Results: </strong>The results show the usual behavior of wet foam, where smaller bubbles disappear, whereas the larger bubbles, potentially dangerous for the diver, grow, and the number of bubbles decreases in time. On the other hand, a long-time power-law regime was found with an exponent smaller than that of the LSW (Lifshitz-Slyozov-Wagner) model, and the radius size distribution showed positive asymmetry throughout the experiment.</p><p><strong>Discussion: </strong>From the results obtained, it is presumed that such a bubble broadening effect could contribute, even minimally, to decompression illness: decompression sickness and arterial gas embolism. This conjecture is reinforced by the preliminary results of Ostwald broadening to RGBM (Reduced Gradient Bubble Model) decompression schedules for a closed-circuit rebreather (CCR) dive to 420 feet of seawater (fsw) (128 meters of seawater (msw)) with a 21/79 Heliox gas mixture, where the first decompression stops lengthening time thanks to Ostwald ripening is at the Pyle-type deep stop, a stop at the half bottom depth, 210 fsw (64 msw).</p>","PeriodicalId":49396,"journal":{"name":"Undersea and Hyperbaric Medicine","volume":"53 3","pages":"443-454"},"PeriodicalIF":0.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149117358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myopic Shift in Patients During Hyperbaric Oxygen Treatment: A Systematic Review.","authors":"Knut Evanger, Guro Vaagbø, Olav Henrik Haugen, Bernd Müller","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>CReversible myopic shift (MS) is a common side effect of hyperbaric oxygen treatment (HBO₂) resulting from refractive changes in the lens. Single studies indicate that the myopic shift increases with longer duration of HBO₂ and may differ between hyperbaric chamber types and oxygen breathing systems. This review aims to improve knowledge on the frequency and magnitude of myopic shift after standard-length HBO₂.</p><p><strong>Methods: </strong>A systematic search for original studies of myopic shift after HBO₂ was conducted in medical databases. Included were published full-text articles in English with specified details on oxygen administration, pressure, number of treatments, and use of conventional techniques to measure refraction. Studies with exposure other than HBO₂, patients with artificial lenses, and single-case reports were excluded.</p><p><strong>Results: </strong>Of 153 reports identified, eight studies with 263 patients were included. Treatment durations covered 18-21, 30, and 40 treatments in either monoplace or multiplace chambers using hoods or masks. For the mean values of myopic shift and the incidence of a myopic shift ≥ 0.5 D, a range was seen from the lowest values after 20 treatments in multiplace chambers using a mask (0.4 D and 53%, respectively), to the highest values after 40 treatments using hoods (1.6 D and 100%, respectively). For monoplace treatment, the corresponding numbers were 0.6 D and 70% after 18 treatments, and 0.95 D and 91% after 30 treatments.</p><p><strong>Discussion: </strong>This review indicates that both the magnitude and incidence of myopic shift increase with the number of HBO₂ sessions and in the order multiplace-mask < monoplace < multiplace-hood.</p>","PeriodicalId":49396,"journal":{"name":"Undersea and Hyperbaric Medicine","volume":"53 3","pages":"481-494"},"PeriodicalIF":0.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149117371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time-Dependent Efficacy of Hyperbaric Oxygen Therapy in Central Retinal Artery Occlusion.","authors":"Sadık Görkem Çevik, Merve Ozbek, Metehan Simsek, Gizem Taşkın, Mehmet Sait Orak, Ozgur Artunay","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>To determine the effect of the timing of hyperbaric oxygen (HBO₂) treatment on functional and structural outcomes in central retinal artery occlusion (CRAO).</p><p><strong>Methods: </strong>This single‑center retrospective cohort study analyzed 101 eyes with CRAO treated with HBO₂. Eyes were stratified by symptom‑to‑treatment interval: ≤12 hours (Group 1), 12-24 hours (Group 2), 24-36 hours (Group 3), and >36 hours (Group 4). Best‑corrected visual acuity (BCVA-logMAR), central macular thickness (CMT), and inner retinal hyperreflective band thickness (IRHBT) were recorded at presentation, week 1, and month 6.</p><p><strong>Results: </strong>Presentation BCVA was 2.16 ± 1.04, improving to 1.77 ± 1.02 at month 6 (p = 0.03). The mean BCVA gain was greatest in Group 1: -0.85 ± 0.96, and declined markedly with delayed treatment initiation (Group 2: -0.48 ± 1.38; Group 3: -0.10 ± 1.50; Group 4: -0.08 ± 1.77). In Group 1, the mean BCVA improved significantly from 2.04 ± 0.78 logMAR at presentation to 1.19 ± 0.56 logMAR at the 6-month follow-up (p = 0.02). Early treatment was also associated with more pronounced reductions in CMT and IRHBT, whereas anatomical changes were negligible when therapy was initiated beyond 24 hours. Baseline CMT and IRHBT showed modest but significant correlations with final BCVA (r = 0.37, p = 0.03 , and r=0.34, p=0.04, respectively).</p><p><strong>Discussion: </strong>HBO₂ provides a significant, time-sensitive benefit for CRAO; initiating treatment within 12-24 hours maximizes recovery and retinal remodeling, validating HBO₂ as a critical adjunct and necessitating rapid triage in ophthalmic emergencies.</p>","PeriodicalId":49396,"journal":{"name":"Undersea and Hyperbaric Medicine","volume":"53 3","pages":"471-480"},"PeriodicalIF":0.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149117447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bubbles or microparticles: which are the main initial cause of decompression illness?","authors":"Ran Arieli","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>There are two leading schools of thought on the mechanism that causes decompression illness (DCI). The old school attributes DCI to decompression bubbles, while the new school, mostly led by S. Thom, attributes DCI mainly to microparticles (MP).</p><p><strong>Microparticles: </strong>Microparticles were found to be elevated at high pressures before decompression and, more so, after decompression. Decompression MP activate neutrophils and platelets, enhance inflammation, stimulate proinflammatory cytokines, and proto-coagulant activity. The predominant presence of endothelial MP is obvious. It was suggested that large MP contain a gas phase of nitric oxide (NO) and its derivatives and serve as gas micronuclei for decompression bubbles. Formation of a gas phase from very soluble NO is unlikely.</p><p><strong>Bubbles: </strong>Bubbling is crucial in the decompression from depth, and one cannot simply shoot up from the depth to the surface. The inconsistency between the relations of venous bubbles and DCI can be related to DCI unrelated to shunted/non-shunted venous bubbles, like distal arterial bubbles and local bubble formation. It was suggested that a detached bubble tears off the underlying endothelial cells, and when the bubble becomes lodged in the lung, it diminishes to a gas-containing microparticle enveloped by an endothelial membrane.</p><p><strong>Discussion: </strong>The main initial cause for DCI is the formation of decompression bubbles, and microparticles add to the injury but would not cause DCI without decompression bubbles.</p>","PeriodicalId":49396,"journal":{"name":"Undersea and Hyperbaric Medicine","volume":"53 3","pages":"535-540"},"PeriodicalIF":0.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149117230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hyperbaric Oxygen Therapy in Septic Shock: A First-in-Human Pilot Trial.","authors":"Leon Sun, Nicholas M Mohr, Hafeez Rajwani, Alexandra C Fietsam, Brett Wagner, Melissa L Bates, Mikhail Vasilyev, Kevin C Doerschug, Archit Sharma","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Septic shock, a severe, life-threatening infection resulting in organ failure, has seen no successful, novel therapies emerge in the past two decades. In addition to hypoperfusion and inflammation, organ dysfunction in septic shock is caused by microvascular, mitochondrial, and immune dysfunction. Animal studies support the use of hyperbaric oxygen treatment to improve mitochondrial function and reduce the inflammatory cascade, suggesting a potential role for hyperbaric oxygen in treating septic shock.</p><p><strong>Methods: </strong>A phase I open-label matched clinical trial was conducted to measure the effect of hyperbaric oxygen on microvascular function, mitochondrial function, and inflammatory cytokines. Four experimental subjects who received 60 minutes of hyperbaric oxygen (2.5 ATA, 25-min descent and ascent) plus standard sepsis management, then four age-matched (ages 29-75) and vasopressor dose-matched (norepinephrine equivalents of 0.05-0.35 ug/kg/min at enrollment) controls were enrolled. The primary outcome was microvascular function, measured using the rate of reoxygenation after upper-limb ischemia by real-time near-infrared spectroscopy. Secondary outcomes included mitochondrial function (ex vivo neutrophils and monocytes) and serum inflammatory cytokine levels (IL-6, IL-10, TNF-alpha). The data were analyzed graphically to identify trends in matched subjects.</p><p><strong>Results: </strong>Hyperbaric oxygen treatment led to transient improvements in microvascular function in two subjects and no change in the other two experimental subjects. In contrast, all control subjects had declines in microvascular function. No differences were observed in mitochondrial function or cytokine profiles between the groups. No adverse events occurred in any septic shock subjects in the intervention arm.</p><p><strong>Discussion: </strong>Our study did not find a statistically or clinically significant benefit of hyperbaric oxygen in septic shock. Future adequately powered trials are needed to assess efficacy better and identify subgroups most likely to benefit.</p>","PeriodicalId":49396,"journal":{"name":"Undersea and Hyperbaric Medicine","volume":"53 3","pages":"511-522"},"PeriodicalIF":0.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149117254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Dysbaric Osteonecrosis in Professional Divers and Analysis of Influencing Factors.","authors":"Şefika Körpinar, Enes Esen, Duygu Siddikoğlu, Nilüfer Aylanç","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Dysbaric osteonecrosis (DON) is an occupational hazard that can lead to joint deformity in professional divers who represent the young workforce. This study aimed to determine the prevalence of DON in professional divers and to investigate the factors that would justify requests for magnetic resonance imaging (MRI) as part of periodic fitness-to-dive examinations, particularly in asymptomatic cases.</p><p><strong>Methods: </strong>In this retrospective study, medical records and imaging data of 120 professional divers who underwent routine fitness-to-dive evaluations between June 2018 and March 2024 were reviewed. Both X-rays and MRI scans were assessed for signs of osteonecrosis. Demographic data, diving profiles, clinical history, and biochemical parameters were analyzed to identify potential risk factors associated with DON.</p><p><strong>Results: </strong>Dysbaric osteonecrosis was identified in 10 out of 120 divers (8.3%). The most affected anatomical region was the right humerus. MRI detected 9 of 10 DON cases, while X-rays identified only one. Statistically significant risk factors for DON included a cumulative diving duration exceeding 900 hours, weekly diving time over 15 hours, diving depths beyond 35 meters, and diving experience greater than 9.5 years. A previous history of decompression sickness (DCS) and a prior diagnosis of DON were also strongly associated with current lesions. MRI demonstrated significantly higher sensitivity compared to radiography (p < 0.0001).</p><p><strong>Discussion: </strong>MRI is considerably more sensitive than conventional radiography in detecting DON, particularly in its early stages. Routine MRI screening may be beneficial for divers with prolonged or intense diving exposure or a history of decompression-related complications, enabling early diagnosis and timely intervention to prevent long-term sequelae.</p>","PeriodicalId":49396,"journal":{"name":"Undersea and Hyperbaric Medicine","volume":"53 3","pages":"423-432"},"PeriodicalIF":0.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149117328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hyperbaric Oxygen Therapy for Medication-Related Osteonecrosis of the Jaw: Retrospective Study.","authors":"Ana Rita Reis Aguiar, Rafaela Noversa, Inês Queiroz, Clara Gaio-Lima, Pedro Barata, Óscar Camacho","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Medication-related osteonecrosis of the jaw (MRONJ) is a complication associated with the use of different drugs, including bisphosphonates. Hyperbaric oxygen (HBO₂) treatment might be effective in this condition through multiple mechanisms, although evidence in the literature remains limited.</p><p><strong>Methods: </strong>A single-institutional retrospective study included patients who underwent HBO₂ treatment for MRONJ in our Unit. Data were collected at baseline and after treatment. The primary outcome was clinical response to HBO₂ treatment. Descriptive analysis was followed by paired samples tests comparing variables before and after treatment. Univariate analyses were made to investigate possible predictors of clinical response and relapse rate. Statistical analysis was performed using SPSS® (p < 0.05).</p><p><strong>Results: </strong>Eighteen patients were included, mostly female, with a mean age of 60.6 ± 13.5 years. Clinical response was observed in most patients (61.1%), with a significant decrease in MRONJ stage severity. There was a significant decrease in pain intensity, number of oral lesions, area of bone exposure, and orofacial inflammatory signs. Five patients relapsed after treatment, with a median time until relapse of 2.0 months. No significant predictors of clinical improvement or relapse rate were found in the univariate analysis.</p><p><strong>Discussion: </strong>Clinical improvement was present in most patients, as demonstrated by improvement in disease stage. Our findings support the hypothesis that HBO₂ treatment is beneficial as an adjunct in treating MRONJ related to bisphosphonates. However, larger studies are necessary to confirm these findings.</p>","PeriodicalId":49396,"journal":{"name":"Undersea and Hyperbaric Medicine","volume":"53 3","pages":"495-504"},"PeriodicalIF":0.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149117286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}