Undersea and Hyperbaric Medicine最新文献_第7页

Safety Of Hyperbaric Oxygen Therapy In Patients Aged 75 And Older: A Multicenter Retrospective Study. 75岁及以上患者高压氧治疗的安全性：一项多中心回顾性研究。

IF 0.7 4区医学

Undersea and Hyperbaric Medicine Pub Date : 2025-04-01

Andrea Neville Cracchiolo, Daniela Maria Palma, Erik Flavio Giuseppe Saporito, Carmelo Palazzolo, Salvatore Massimo Mannino, Fabio Genco, Filippo Vitale, Luigi Profera, Santi Maurizio Raineri, Giuseppe Accurso

{"title":"Safety Of Hyperbaric Oxygen Therapy In Patients Aged 75 And Older: A Multicenter Retrospective Study.","authors":"Andrea Neville Cracchiolo, Daniela Maria Palma, Erik Flavio Giuseppe Saporito, Carmelo Palazzolo, Salvatore Massimo Mannino, Fabio Genco, Filippo Vitale, Luigi Profera, Santi Maurizio Raineri, Giuseppe Accurso","doi":"","DOIUrl":"","url":null,"abstract":"Background: The increasing life expectancy presents new challenges in managing elderly patients requiring hyperbaric oxygen (HBO₂) therapy. This retrospective study evaluates the safety and adherence to HBO₂ guidelines in patients aged 75 years and older, focusing on side effects and adverse events.Methods: Data from 69 elderly patients treated between 2019 and 2023 at two Sicilian hyperbaric centres were analyzed. Demographics, indications for HBO₂, comorbidities, treatment protocols, and side effects were collected. Pre-treatment evaluations included ENT checkups, ECG, chest X-rays, and laboratory tests. Patients underwent HBO₂ sessions at 2.4-2.8 ATA, with clinical monitoring pre-and post-treatment.Results: 1,799 HBO₂ sessions were performed in 69 patients (mean age 78 years; 59.4% male). The most common indications were progressive necrotizing infections (33.3%), sudden sensorineural hearing loss (17.3%), and chronic radiation-induced tissue injuries (14.5%). Side effects occurred in 14 patients (20.3%), primarily middle ear barotrauma (8.7%), sinus barotrauma (4.3%), confinement anxiety (4.3%), hypoglycemia (1.4%), and chest pain (1.4%). Most side effects were resolved with prompt care, and no life-threatening events were recorded. Adherence to guidelines and meticulous pre-treatment evaluations minimized risks.Conclusions: HBO₂ is a safe therapeutic option for elderly patients when strict pre-treatment evaluations and monitoring protocols are implemented. Despite this population's increased vulnerability, the incidence of side effects was comparable to that in younger cohorts. Future research is warranted to optimize treatment protocols and explore outcomes in larger elderly populations.","PeriodicalId":49396,"journal":{"name":"Undersea and Hyperbaric Medicine","volume":"52 4","pages":"495-506"},"PeriodicalIF":0.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145812109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the efficacy of modified low-dose HBO₂ therapy. 改良低剂量HBO 2治疗的疗效评价。

IF 0.7 4区医学

Undersea and Hyperbaric Medicine Pub Date : 2025-04-01

Subhranshu Kumar, Vishal Kansal, Harsh Bir Singh Chaudhry, Sourabh Bhutani, Chandra Sekhar Mohanty

{"title":"Evaluation of the efficacy of modified low-dose HBO₂ therapy.","authors":"Subhranshu Kumar, Vishal Kansal, Harsh Bir Singh Chaudhry, Sourabh Bhutani, Chandra Sekhar Mohanty","doi":"","DOIUrl":"","url":null,"abstract":"Background: The COVID-19 pandemic, being an airborne disease, posed a challenge in providing Hyperbaric Oxygen (HBO2) Therapy in multiplace chambers by increasing the risk of cross-infectivity while on air break inside the chamber. The standard regimen consisting of two air breaks was modified, and a new low-dose HBO₂ therapy regimen with no air breaks was introduced to mitigate the risk of cross- infection. This study aimed to evaluate the efficacy of the modified HBO₂ therapy regimen compared to the standard HBO2 therapy regimen for patients with soft tissue radiation injury.Methods: A retrospective observational study compared the modified low-dose HBO₂ therapy regimen of 2.4 Atmosphere Absolute (ATA) for 60 minutes without air-break vis-a-vis the standard regimen of 2.4 ATA for 100 minutes with two air breaks of five minutes each. Patients with soft tissue radiation injury in the form of radiation cystitis and radiation proctitis were selected for comparison in the study. Data was retrieved from patients who underwent the standard and modified regimen during the COVID-19 pandemic. Late Effects Normal Tissue (LENT)/ Subjective Objective Management Analytic (SOMA) questionnaire-based scoring was compared for 30 sessions of HBO₂ therapy. Standard biostatistical methodology was used to compare the outcomes of both regimens.Results: The mean LENT SOMA score decreased from the baseline to the end of 30 sessions in the HBO₂ therapy protocols. Overall, mean values decreased more for the patients who were offered the standard regimen of HBO₂ therapy.Conclusion: A modified low-dose HBO₂ therapy treatment regimen achieved statistically significant therapeutic benefits. However, the results were statistically more promising for the patients who underwent the standard HBO₂ therapy regimen.","PeriodicalId":49396,"journal":{"name":"Undersea and Hyperbaric Medicine","volume":"52 4","pages":"507-513"},"PeriodicalIF":0.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145812042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Case Report: Complete Coverage Of Chronic Sickle Cell Leg Ulcer Using Hyperbaric Oxygen Therapy Combined With Skin Grafting. 病例报告：高压氧联合植皮完全覆盖慢性镰状细胞性腿部溃疡。

IF 0.7 4区医学

Undersea and Hyperbaric Medicine Pub Date : 2025-04-01

Koga Luhulla, Queen Martin, Agape Bhoke, Samira Mahfudh, Aslam Nkya, Albert Magohe, Mbonea Yonazi, Jay C Buckey

引用次数: 0

Increased ventilatory response to carbon dioxide after dive training. 潜水训练后对二氧化碳的通气反应增加。

IF 0.7 4区医学

Undersea and Hyperbaric Medicine Pub Date : 2025-04-01

Lars Ekman, Clara Sjöblom, Magnus Ekström, Oskar Frånberg

{"title":"Increased ventilatory response to carbon dioxide after dive training.","authors":"Lars Ekman, Clara Sjöblom, Magnus Ekström, Oskar Frånberg","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: Divers are reported to have a lower ventilatory response to elevated levels of carbon dioxide (CO₂) than non-divers. Hypoventilation with CO₂ retention during diving is potentially dangerous. It is unknown if CO₂ retention is largely inherited or develops during diving training. We aimed to investigate if a military dive training course would influence the ventilatory response to CO₂.Methods: Novice rebreather Divers with Amphibious Rangers as controls were tested at baseline, after 12 weeks of water exercise training, and after 15 weeks of diving: participants rebreathed in a Douglas bag filled with an initial 100% oxygen, resulting in increasing levels of inspiratory CO₂ (iCO₂). The test was performed until symptom-limitation or an expiratory CO₂ of 8.0 kPa. To decrease conscious control of breathing, participants were distracted with a memory game during the test. Differences between groups and over time were analyzed using independent and paired t-tests.Results: Ten Divers and six Amphibious Rangers completed baseline testing and eight Divers completed all tests. Divers had a statistically significant higher Minute Ventilation (V'E) after dive training, compared to after water exercise training and baseline, at all levels of iCO₂. However, the change in Hypercapnic ventilatory response (HCVR) before and after dive training across pCO₂ values 5.0-7.9, did not reach statistical significance. At baseline, Amphibious Rangers had a non-significant higher V'E compared to Divers at higher levels of iCO₂.Conclusion: A military rebreather diving program might be associated with increased ventilatory response to CO₂.","PeriodicalId":49396,"journal":{"name":"Undersea and Hyperbaric Medicine","volume":"52 4","pages":"587-597"},"PeriodicalIF":0.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145812091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synergistic Neuroprotection by Caffeine and Astaxanthin Against CNS-OT. 咖啡因和虾青素对CNS-OT的协同神经保护作用。

IF 0.7 4区医学

Undersea and Hyperbaric Medicine Pub Date : 2025-04-01

Mia Rosenberg, Rafael Ezra, Ran Arieli, Uri Barash

引用次数: 0

Dermatologic medical ozone therapy complications treated with hyperbaric oxygen. 高压氧治疗皮肤医学臭氧治疗并发症。

IF 0.7 4区医学

Undersea and Hyperbaric Medicine Pub Date : 2025-04-01

Patricia McCray, Kelly Johnson-Arbor

{"title":"Dermatologic medical ozone therapy complications treated with hyperbaric oxygen.","authors":"Patricia McCray, Kelly Johnson-Arbor","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: Medical ozone therapy, which involves topical or systemic administration of ozone gas, is promoted as a treatment for various infections and inflammatory conditions, although evidence supporting its clinical effectiveness in humans is limited. Medical ozone administration is also associated with serious adverse effects, including gas embolus and fatality. We present the case of a patient who experienced dermatologic complications after receiving medical ozone therapy. The complications were managed with surgical intervention and hyperbaric oxygen therapy.Case report: A 43-year-old female was administered medical ozone therapy injections to the temples and central forehead by a dermatologist to enhance hair growth and collagen formation. After the procedure, the patient experienced worsening alopecia and scarring in the treated areas. She eventually underwent surgical excision and closure that was performed by a plastic and reconstructive surgeon. Intraoperatively, she was noted to have significantly fibrotic, scarred, and poorly vascularized tissue, which raised concern for poor wound healing. Her plastic surgeon referred her for adjunctive hyperbaric medicine evaluation to treat presumed skin flap vascular compromise. She completed a course of forty hyperbaric oxygen treatments before returning to the plastic surgeon for scar tissue excision and local tissue rearrangement that ultimately resulted in acceptable cosmesis.Conclusion: While medical ozone therapy may result in favorable effects on a cellular level, the treatment is associated with significant clinical risks that may outweigh its potential therapeutic benefits. Systemic hyperbaric oxygenation may enhance vascularity and improve the quality of devitalized tissue in areas previously treated with medical ozone therapy.","PeriodicalId":49396,"journal":{"name":"Undersea and Hyperbaric Medicine","volume":"52 4","pages":"515-519"},"PeriodicalIF":0.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145812028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transcutaneous Oximetry Optimizes Clinical Management and Cost-Effectiveness of Diabetic Foot Ulcers Treated with Hyperbaric Oxygen: A Review of Point-of-Care Vascular Screening Options. 经皮血氧测定优化临床管理和成本效益的糖尿病足溃疡治疗高压氧：回顾点护理血管筛查的选择。

IF 0.7 4区医学

Undersea and Hyperbaric Medicine Pub Date : 2025-04-01

Richard E Clarke

{"title":"Transcutaneous Oximetry Optimizes Clinical Management and Cost-Effectiveness of Diabetic Foot Ulcers Treated with Hyperbaric Oxygen: A Review of Point-of-Care Vascular Screening Options.","authors":"Richard E Clarke","doi":"","DOIUrl":"","url":null,"abstract":"Hyperbaric oxygen therapy has been employed to treat diabetic foot ulcers for more than four decades. While supported by some high-quality evidence, there is sufficient conflicting data to render its use open to criticism. Even systematic and other reviews favorably disposed to this treatment adjunct invariably plead for better patient selection. Common among several causes of non-healing ulcers is persistent hypoxia. Transcutaneous oximetry uniquely measures tissue oxygen tension. Combination air and oxygen testing provides an evidence-based approach to hyperbaric patient selection through demonstration of locally reversible hypoxia. Transcutaneous oximetry differentiates hyperbaric responders from non- responders early in their treatment course by detecting neoangiogenesis, thereby providing a basis for continuing hyperbaric dosing only in those who benefit. Finally, such testing guides therapeutic endpoint determination, namely, normalized peri-ulcer oxygen tensions. This contrasts with continuing medically unnecessary and costly hyperbaric treatments until wound closure. Measurements of blood pressure and blood flow are imperfect surrogates for oxygen delivery. Recently introduced near-infrared spectroscopy and long-wave infrared thermography provide insights into tissue oxygen saturation and changes in micro-vascular density, respectively. Neither, however, guides clinically efficacious and cost-effective hyperbaric oxygenation in the manner afforded by transcutaneous oximetry. This paper describes evidence-based guidance on hyperbaric oxygen dosing for diabetic foot ulcers, reviews point-of-care screening options, and argues for the continued superiority of transcutaneous oximetry in the current era.","PeriodicalId":49396,"journal":{"name":"Undersea and Hyperbaric Medicine","volume":"52 4","pages":"521-535"},"PeriodicalIF":0.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145812181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hyperbaric Oxygen Therapy Enhances Autologous Bone Graft Integration: A Meta-Analysis 高压氧疗法辅助治疗胸骨-锁骨感染性关节炎并发复杂伤口。

IF 0.7 4区医学

Undersea and Hyperbaric Medicine Pub Date : 2025-04-01

Ansab Zulfiqar, Kever Spindari

{"title":"Hyperbaric Oxygen Therapy Enhances Autologous Bone Graft Integration: A Meta-Analysis","authors":"Ansab Zulfiqar, Kever Spindari","doi":"","DOIUrl":"","url":null,"abstract":"Background: Autologous bone grafting is crucial in reconstructive surgeries, yet high-risk patients often face challenges in achieving robust graft integration. Hyperbaric Oxygen Therapy (HBO₂) has been proposed to improve graft outcomes by enhancing osteogenesis and vascularization. This systematic review and meta-analysis evaluated HBO₂'s efficacy in promoting autologous bone graft integration and identified contexts in which HBO₂ may be most beneficial.Methods: A systematic search identified 11 studies that met the inclusion criteria, of which seven provided quantitative data for meta-analysis. Random-effects models generated pooled Standardized Mean Differences (SMD) and assessed heterogeneity (I²). Subgroup analysis focused on orthopedic applications.Results: Compared to control groups, HBO₂ demonstrated a moderate to strong effect on bone graft integration in the primary analysis (SMD: 1.476, 95% CI: 0.814-2.138). However, heterogeneity was substantial (I² ≈ 77%), reflecting diverse protocols and patient populations. A subgroup of orthopedic studies showed a stronger, consistent effect (SMD: 1.995, 95% CI: 1.117-2.873) with low heterogeneity (I² = 3.361%). Although observational data suggest potential benefits in maxillofacial grafts, many studies in this domain are small or lack controls. One cranial study reported a negative result, indicating possible variability in craniofacial contexts.Conclusions: HBO₂ appears to substantially enhance autologous bone graft integration, particularly in orthopedic and high-risk patients, by stimulating osteogenesis and vascularization. Nonetheless, reliance on animal models, limited human data in maxillofacial settings, and considerable heterogeneity underscore the need for further research, standardized protocols, and well-powered clinical trials to confirm HBO₂'s effectiveness across diverse grafting scenarios.","PeriodicalId":49396,"journal":{"name":"Undersea and Hyperbaric Medicine","volume":"52 4","pages":"549-564"},"PeriodicalIF":0.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145812073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hyperbaric Oxygenation Therapy as Adjunctive Treatment of Complex Wound Associated with Sterno-clavicular Septic Arthritis. 高压氧疗法辅助治疗胸骨-锁骨感染性关节炎并发复杂伤口。

IF 0.7 4区医学

Undersea and Hyperbaric Medicine Pub Date : 2025-03-01

Nandini Nukala, Rohini Rao, Denise Nemeth, Manjulatha Badam

{"title":"Hyperbaric Oxygenation Therapy as Adjunctive Treatment of Complex Wound Associated with Sterno-clavicular Septic Arthritis.","authors":"Nandini Nukala, Rohini Rao, Denise Nemeth, Manjulatha Badam","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: Sternoclavicular septic arthritis with pyomyositis is a relatively rare condition. While most cases of septic arthritis are caused by gram-positive organisms, such as Staphylococci and Streptococci spp., a small number of patients present with gram-negative organisms as the cause of their condition. Signs and symptoms can be non-specific, and although CT imaging aids in diagnosis, a timely identification relies primarily on a high index of clinical suspicion.Case description: We present a case of a 44-year-old female patient with a history of poorly controlled diabetes mellitus who presented with a chronic, non-healing wound that developed on a background of non-traumatic sternoclavicular septic arthritis, chronic osteomyelitis of the clavicle and manubrium, and concomitant pectoralis pyomyositis caused by a gram-negative pathogen. The use of HBO₂ as an addition to this patient's treatment regimen hastened the healing process.Conclusion: Given the rarity of this condition, we consider that adding to the body of literature with regards to the diagnosis and treatment of this condition can help clinicians develop a keen eye for it, decreasing the morbidity and mortality associated with it.","PeriodicalId":49396,"journal":{"name":"Undersea and Hyperbaric Medicine","volume":"52 3","pages":"279-282"},"PeriodicalIF":0.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145508022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rapid Progression of Cutaneous Large B-Cell Lymphoma During Hyperbaric Oxygen Therapy: A Case Report. 皮肤大b细胞淋巴瘤在高压氧治疗期间快速进展1例报告。

IF 0.7 4区医学

Undersea and Hyperbaric Medicine Pub Date : 2025-03-01

Matthew Kelly, Emily T Jones, Dag Shapshak

引用次数: 0