Simon Cheung-Chi Lam, Michael Shu-Yue Sze, Chun-Ka Wong, Kwong-Yue Eric Chan, Ka-Chun Un, On-Yat Wong, Ming Lau, Ho-On Alston Conrad Chiu, Daniel Tai-Leung Chan
{"title":"Unilateral folding of anterior mitral valve leaflet (UNIFOLD) for transcatheter mitral valve replacement: first-in-human experience.","authors":"Simon Cheung-Chi Lam, Michael Shu-Yue Sze, Chun-Ka Wong, Kwong-Yue Eric Chan, Ka-Chun Un, On-Yat Wong, Ming Lau, Ho-On Alston Conrad Chiu, Daniel Tai-Leung Chan","doi":"10.25270/jic/25.00022","DOIUrl":"10.25270/jic/25.00022","url":null,"abstract":"","PeriodicalId":49261,"journal":{"name":"Journal of Invasive Cardiology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143574355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sahib Singh, Aakash Garg, Ukaya S Tantry, Kevin Bliden, Paul A Gurbel, Ajay Kochar, Michael G Nanna, Abdulla A Damluji
{"title":"Combined atherectomy and intravascular lithotripsy in calcified coronary lesions: a meta-analysis.","authors":"Sahib Singh, Aakash Garg, Ukaya S Tantry, Kevin Bliden, Paul A Gurbel, Ajay Kochar, Michael G Nanna, Abdulla A Damluji","doi":"10.25270/jic/24.00312","DOIUrl":"10.25270/jic/24.00312","url":null,"abstract":"<p><strong>Objectives: </strong>Studies exploring the feasibility and safety of combined atherectomy and intravascular lithotripsy (IVL) for treatment of severely calcified coronary lesions are limited. The authors aimed to study the pooled evidence for the safety and efficacy of this combined approach in severely calcified coronary lesions and evaluate its clinical and procedural outcomes.</p><p><strong>Methods: </strong>Online databases were searched for studies using combined atherectomy (rotational, orbital, or excimer laser) and IVL during PCI for calcified coronary lesions. The outcomes of interest were acute procedural success, periprocedural complications, and cardiovascular (CV) events. Pooled proportions with 95% CI were calculated using a random-effects model.</p><p><strong>Results: </strong>A total of 12 observational studies with 720 patients were included. The mean age was 73 years, 76% were men, and 48% of the patients had an acute coronary syndrome. The pooled procedural success rate of combined atherectomy and IVL was 93% (95% CI, 89.56-96.25). Coronary perforation occurred in 2.9% (95% CI, 1.76-4.36) of the cases. Over a mean follow-up of 111 days, the incidence of CV outcomes was myocardial infarction 2.0% (95% CI, 0.67-3.93), stroke 1.4% (95% CI, 0.36-3.14), target vessel revascularization 2.2% (95% CI, 1.01-3.79), stent thrombosis 1.1% (95% CI, 0.21-2.84), major bleeding 5.8% (95% CI, 0.00-21.40), CV death 3.6% (95% CI, 1.53-6.42), and all-cause death 4.8% (95% CI, 2.75-7.33).</p><p><strong>Conclusions: </strong>Combined atherectomy and IVL for calcified coronary lesions is feasible with a high procedural success rate. However, there is a low but meaningful risk of procedural complications including coronary perforations, and a low risk of adverse CV events.</p>","PeriodicalId":49261,"journal":{"name":"Journal of Invasive Cardiology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12328123/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143494055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Atul D Bali, Sadrine Lebrun, Abduljabar Adi, Varinder Singh, Michael C Kim, Arber Kodra
{"title":"Intravascular brachytherapy for the management of drug-eluting in-stent restenosis.","authors":"Atul D Bali, Sadrine Lebrun, Abduljabar Adi, Varinder Singh, Michael C Kim, Arber Kodra","doi":"10.25270/jic/24.00341","DOIUrl":"10.25270/jic/24.00341","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to evaluate the utilization and clinical outcomes of coronary intravascular brachytherapy (IVBT) as a treatment modality for multilayer in-stent restenosis (ISR).</p><p><strong>Methods: </strong>This multicenter study retrospectively analyzed 101 patients who presented for percutaneous intervention of recurrent drug-eluting stent ISR using IVBT from 2019 to 2023. The primary outcome assessed was target lesion revascularization (TLR) at 1 year. Secondary endpoints were aimed to establish procedural safety. All lesions had evaluation by either angiography, intravascular ultrasound, or both.</p><p><strong>Results: </strong>The majority of ISR was related to neointimal hyperplasia (61.4%), with stent underexpansion (11.9%) being the second most common cause. The average layer of stents in the sample was 1.90 layers. Prior to delivery of IVBT, lesions were prepared with balloon angioplasty, laser atherectomy, intravascular lithotripsy, or a combination of pretreatment strategies. The average time of the IVBT dwell period was 11 minutes, with an average dose of 21.76 Gy. Of the 101 patients evaluated, TLR occurred in 10.9% of patients at 1 year. Readmission at 30 days was 4.9% and vascular complications occurred in 3.9% of the patients. Major adverse cardiac events were limited to 0.9% of the patients, and no peri-procedural myocardial infarctions, urgent need for revascularization within 24 hours, need for mechanical support, nor cardiac arrest were observed.</p><p><strong>Conclusions: </strong>In this study, IVBT proved to be a safe and effective treatment modality for multilayer ISR. The study generates the hypothesis for the routine use of IVBT in this commonly encountered clinical scenario. Larger and prospective randomized studies are needed.</p>","PeriodicalId":49261,"journal":{"name":"Journal of Invasive Cardiology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143574351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Neil Zhang, Kyla Sherwood, Brian Claggett, Sanket Dhruva, Ashishdeep Sandhu, Susan Cheng, Joseph Ebinger
{"title":"Sex differences and the role of anemia in contrast-associated acute kidney injury after percutaneous coronary intervention.","authors":"Neil Zhang, Kyla Sherwood, Brian Claggett, Sanket Dhruva, Ashishdeep Sandhu, Susan Cheng, Joseph Ebinger","doi":"10.25270/jic/24.00353","DOIUrl":"10.25270/jic/24.00353","url":null,"abstract":"<p><p>Many, though not all, studies suggest that contrast-associated acute kidney injury (CA-AKI) after percutaneous coronary intervention (PCI) rates are higher in women. The authors sought to clarify the presence of and factors contributing to possible sex differences. Among 2971 consecutive patients undergoing PCI, women experienced higher crude rates of CA-AKI. However, this association was significantly attenuated after adjusting for demographic and comorbid conditions, particularly pre-procedural anemia, which accounted for a substantial proportion of the excess risk. The study offers clarification regarding the higher post-PCI risks among women and underscores the role of anemia as a prevalent contributor to CA-AKI.</p>","PeriodicalId":49261,"journal":{"name":"Journal of Invasive Cardiology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12328099/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143574353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Leo Kar Lok Lai, Hussayn Alrayes, Georgi Fram, James C Lee, Bryan Zweig, Brian P O'Neill, Tiberio M Frisoli, Pedro Engel Gonzalez, William W O'Neill, Pedro A Villablanca
{"title":"Iatrogenic atrial septal defect closure with PASCAL guide system post-mitral valve transcatheter edge-to-edge repair.","authors":"Leo Kar Lok Lai, Hussayn Alrayes, Georgi Fram, James C Lee, Bryan Zweig, Brian P O'Neill, Tiberio M Frisoli, Pedro Engel Gonzalez, William W O'Neill, Pedro A Villablanca","doi":"10.25270/jic/25.00031","DOIUrl":"10.25270/jic/25.00031","url":null,"abstract":"","PeriodicalId":49261,"journal":{"name":"Journal of Invasive Cardiology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143494068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tullio Palmerini, Francesco Saia, Antonio Giulio Bruno, Won-Keun Kim, Alessandro Iadanza, Gabriele Ghetti, Ole De Backer, Francesco Burzotta, Nicholas M Van Mieghem, Elena Nardi, Mateusz Orzalkiewicz, Thomas Pilgrim, Tiziana Claudia Aranzulla, Max M Meertens, Nevio Taglieri, Michael Joner, Giulia Nardi, Stefan Toggweiler, Enrico Gallitto, Mauro Gargiulo, Luca Testa, Sergio Berti, Matteo Montorfano, Alessandro Leone, Davide Pacini, Daniel Braun, Fausto Castriota, Marco De Carlo, Marco Barbanti, Pier Pasquale Leone, Georg Nickenig, Tommaso Piva, Azeem Latib, Matteo Vercellino, Pablo Codner, Antonio L Bartorelli, Chiara Fraccaro, Mohamed Abdel-Wahab, Gregg W Stone
{"title":"Cerebrovascular events with self-expanding versus balloon-expandable valves in patients with or without peripheral arterial disease.","authors":"Tullio Palmerini, Francesco Saia, Antonio Giulio Bruno, Won-Keun Kim, Alessandro Iadanza, Gabriele Ghetti, Ole De Backer, Francesco Burzotta, Nicholas M Van Mieghem, Elena Nardi, Mateusz Orzalkiewicz, Thomas Pilgrim, Tiziana Claudia Aranzulla, Max M Meertens, Nevio Taglieri, Michael Joner, Giulia Nardi, Stefan Toggweiler, Enrico Gallitto, Mauro Gargiulo, Luca Testa, Sergio Berti, Matteo Montorfano, Alessandro Leone, Davide Pacini, Daniel Braun, Fausto Castriota, Marco De Carlo, Marco Barbanti, Pier Pasquale Leone, Georg Nickenig, Tommaso Piva, Azeem Latib, Matteo Vercellino, Pablo Codner, Antonio L Bartorelli, Chiara Fraccaro, Mohamed Abdel-Wahab, Gregg W Stone","doi":"10.25270/jic/25.00020","DOIUrl":"10.25270/jic/25.00020","url":null,"abstract":"<p><strong>Objectives: </strong>The authors compared the risk of cerebrovascular events (CVE) with self-expanding vales (SEV) vs balloon-expandable valves (BEV) in patients with or without peripheral artery disease (PAD), stratified by the access route and the complexity of PAD (Hostile score).</p><p><strong>Methods: </strong>The PAD-related risk of CVE between SEV vs BEV was investigated using data from the HOSTILE Registry, an observational study including 1707 patients with severe PAD undergoing transcatheter aortic valve replacement (TAVR) via different access routes. The relative risk of CVE with SEV vs BEV in patients without PAD was investigated in a meta-analysis of randomized controlled transfemoral access (TFA)-TAVR trials of patients with normal femoral arteries. The primary endpoint was the risk of 30-day CVE.</p><p><strong>Results: </strong>Among the 1021 patients undergoing TAVR through TFA or transaxillary access (TAxA), 674 (66.0%) received SEVs and 329 (32.2%) received BEVs. The 30-day propensity-adjusted risk of CVE was higher for SEV compared with BEV (adjusted hazard ratio [HR], 2.70; 95% CI, 1.16-6.23), with no significant interaction between the transcatheter heart valve and either the access route or the Hostile score. Similar results were apparent at 1 year (adjusted HR, 2.98; 95% CI, 1.30-6.83). In contrast, in a meta-analysis of 4 RCTs and 2131 patients with femoral arteries suitable for TAVR, there were no significant differences in the 30-day rates of CVE between SEV and BEV (odds ratio, 0.58; 95% CI, 0.24-1.40).</p><p><strong>Conclusions: </strong>Compared with BEVs, SEVs were associated with higher 30-day and 1-year rates of CVE in patients with PAD, a finding not apparent in patients with suitable femoral arteries enrolled in RCTs.</p>","PeriodicalId":49261,"journal":{"name":"Journal of Invasive Cardiology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143494054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Stents to the rescue: battling a ruptured abdominal aneurysm.","authors":"Jie Wang, Ping Hu, Ming Qi, Xiao-Jing Ma","doi":"10.25270/jic/25.00034","DOIUrl":"10.25270/jic/25.00034","url":null,"abstract":"","PeriodicalId":49261,"journal":{"name":"Journal of Invasive Cardiology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143494311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Richard Casazza, Bilal Malik, Arsalan Hashmi, Joshua Fogel, Enrico Montagna, Darren Gibson, Andres Palacio, Habiba Beginyazova, Robert Frankel, Jacob Shani
{"title":"Operator radiation dose comparing left radial artery and right radial artery approaches among patients with subclavian tortuosity.","authors":"Richard Casazza, Bilal Malik, Arsalan Hashmi, Joshua Fogel, Enrico Montagna, Darren Gibson, Andres Palacio, Habiba Beginyazova, Robert Frankel, Jacob Shani","doi":"10.25270/jic/25.00143","DOIUrl":"https://doi.org/10.25270/jic/25.00143","url":null,"abstract":"<p><strong>Background: </strong>Operator radiation exposure (ORE) is one of the most adverse occupational hazards faced by interventional cardiologists. The presence of subclavian tortuosity can influence ORE.</p><p><strong>Methods: </strong>This single-center retrospective study compared the cumulative radiation (CR) exposure in μSv and normalized radiation exposure (CR/DAP) of the primary operator during cardiac catheterization of all patients with subclavian tortuosity from left (LRA) and right radial artery approaches (RRA). ORE was measured at 4 anatomical locations: thorax, abdomen, left eye, and right eye.</p><p><strong>Results: </strong>CR dose was significantly higher in the RRA group than in the LRA group at the left eye (P = .004), right eye (P = .01), thorax (P = .01) and abdomen (P = .01). CR/DAP dose was significantly higher in the RRA group than in the LRA group at the left eye (P = .04) and right eye (P = .03).</p><p><strong>Conclusions: </strong>In cases with subclavian tortuosity, the LRA was associated with less CR to the operator than the RRA. The LRA was also associated with less CR/DAP that persisted at the anatomical location of the left eye. The authors recommend operators have time thresholds to exchange for appropriate catheters in patients with subclavian tortuosity. Furthermore, operators should consider time thresholds to change access sites to avoid potential procedural complications and excessive fluoroscopic times.</p>","PeriodicalId":49261,"journal":{"name":"Journal of Invasive Cardiology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144800729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kristian Rivera, Humberto Coimbra, Diego Fernández-Rodríguez, Eva Pueo, Mireia Martínez, Juan Casanova-Sandoval
{"title":"Stentless revascularization of spontaneous coronary dissection using a cutting balloon.","authors":"Kristian Rivera, Humberto Coimbra, Diego Fernández-Rodríguez, Eva Pueo, Mireia Martínez, Juan Casanova-Sandoval","doi":"10.25270/jic/25.00212","DOIUrl":"https://doi.org/10.25270/jic/25.00212","url":null,"abstract":"","PeriodicalId":49261,"journal":{"name":"Journal of Invasive Cardiology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144800733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}