Sultan Alotaibi, Abdelhakim Allai, Hajo Heyer, Nader Mankerious, Martin Landt, Mohamed Abdel-Wahab, Volker Geist, Ralph Tölg, Mohamed Samy, Gert Richardt, Karim Elbasha
{"title":"Rotational atherectomy for calcified coronary lesions in severe aortic stenosis before transcatheter aortic valve implantation.","authors":"Sultan Alotaibi, Abdelhakim Allai, Hajo Heyer, Nader Mankerious, Martin Landt, Mohamed Abdel-Wahab, Volker Geist, Ralph Tölg, Mohamed Samy, Gert Richardt, Karim Elbasha","doi":"10.25270/jic/25.00007","DOIUrl":"https://doi.org/10.25270/jic/25.00007","url":null,"abstract":"<p><strong>Objectives: </strong>Calcified coronary artery disease (CAD) is prevalent in elderly patients with degenerative severe aortic stenosis (AS). Preparation of such calcified CAD using rotational atherectomy (RA) in those patients with severe AS is controversial and may carry a high risk of complications. The authors aimed to compare in-hospital outcomes following RA in patients with severe AS before transcatheter aortic valve implantation (TAVI) vs patients without AS.</p><p><strong>Methods: </strong>The authors retrieved data from the Prospective Segeberg TAVI Registry from January 2016 to October 2021. All AS patients who underwent RA within 6 months prior to TAVI were included for our analysis and compared with patients without AS. In-hospital MACE, defined as cardiac mortality, myocardial infarction, and target lesion revascularization was evaluated in both groups.</p><p><strong>Results: </strong>From a total of 472 patients who underwent RA, 38 (8.1%) patients had severe AS. The group with AS was older than the group without AS (84.4 ± 6.19 vs 75.2 ± 8.31; P less than .001). About one-fourth of the RA procedures in the patients with AS were performed for aorto-ostial lesions (26.3%). Slow flow was reported in 1 (2.6%) patient in AS group, but no perforation or trapped burr was reported. In-hospital major adverse cardiovascular events (MACE) occurred in 41 (8.7%) patients and was comparable in both groups (7.9% in AS group vs 8.8% in non-AS group; P = .857). Furthermore, the presence of severe AS was not associated with occurrence of more in-hospital MACE following RA (OR 1.12: 95% CI, 0.33-3.81; P = .857). The cumulative rate of all-cause and cardiac mortality was higher in the AS group than in the non-AS group ((44.6% vs 22.2%, P = .002; 31.9% vs 17.2%, P = .017, respectively).</p><p><strong>Conclusions: </strong>RA for preparing heavily calcified coronary lesions in patients with severe AS showed comparable in-hospital outcomes to patients without severe AS.</p>","PeriodicalId":49261,"journal":{"name":"Journal of Invasive Cardiology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dimitrios Strepkos, Athanasios Rempakos, Michaella Alexandrou, Deniz Mutlu, Pedro E P Carvalho, Ozgur Selim Ser, Khaldoon Alaswad, Mir B Basir, Dmitrii Khelimskii, Oleg Krestyaninov, Jaikirshan J Khatri, Laura Young, Omer Goktekin, Paul Poommipanit, Farouc Jaffer, Sevket Gorgulu, Ahmed M ElGuindy, Nidal Abi Rafeh, Olga Mastrodemos, Bavana V Rangan, Sandeep Jalli, Konstantinos Voudris, Yader Sandoval, M Nicholas Burke, Emmanouil S Brilakis
{"title":"Can iodixAnol ReducE the incidence of adverse renal or cardiac events in chronic total occlusion interventions (CARE-CTO): a substudy of the PROGRESS-CTO registry.","authors":"Dimitrios Strepkos, Athanasios Rempakos, Michaella Alexandrou, Deniz Mutlu, Pedro E P Carvalho, Ozgur Selim Ser, Khaldoon Alaswad, Mir B Basir, Dmitrii Khelimskii, Oleg Krestyaninov, Jaikirshan J Khatri, Laura Young, Omer Goktekin, Paul Poommipanit, Farouc Jaffer, Sevket Gorgulu, Ahmed M ElGuindy, Nidal Abi Rafeh, Olga Mastrodemos, Bavana V Rangan, Sandeep Jalli, Konstantinos Voudris, Yader Sandoval, M Nicholas Burke, Emmanouil S Brilakis","doi":"10.25270/jic/25.00004","DOIUrl":"https://doi.org/10.25270/jic/25.00004","url":null,"abstract":"<p><strong>Objectives: </strong>The impact of contrast type in chronic total occlusion (CTO) percutaneous coronary intervention (PCI) remains controversial. The authors sought to evaluate the impact of contrast medium selection on patients undergoing CTO PCI.</p><p><strong>Methods: </strong>The authors examined the outcomes of patients who underwent CTO PCI using iso-osmolar (iodixanol) vs pooled low-osmolar contrast media (LOCM) using data from the PROGRESS-CTO registry.</p><p><strong>Results: </strong>Iodixanol was used in 1007 (18.1%) of 5558 CTO PCIs. Compared with pooled LOCM, iodixanol-treated patients were more likely to be women, were older, and more likely to have diabetes, dyslipidemia, hypertension, history of heart failure, myocardial infarction, coronary artery bypass graft surgery, and stroke. Iodixanol cases had higher complexity, with longer lesion length (35.25 ± 25.16 vs 28.91 ± 19.46 mm, P less than .001), higher prevalence of moderate or severe calcification (43% vs 37%, P less than .001) and moderate or severe proximal tortuosity (30% vs 24%, P less than .001), and higher Japanese-CTO (2.52 vs 2.17, P less than .001) and PROGRESS-CTO scores (1.30 vs 1.16, P less than .001). Iodixanol cases required longer procedure times but similar contrast volumes. Technical (85.3% vs 89.2%, P = .001) and procedural success (83.4% vs 87.3%, P = .001) were lower in iodixanol cases. Acute kidney injury (AKI) occurred in 6.4% of cases. After propensity score matching, the patients who received iodixanol had lower incidence of AKI (odds ratio [OR]: 0.67; 95% CI, 0.47, 0.97; P = .032) and a trend for lower incidence of major adverse renal or cardiovascular events (OR: 0.75; 95% CI, 0.56, 1.0; P = .061).</p><p><strong>Conclusions: </strong>AKI occurred in approximately 6% of CTO PCI cases. Iodixanol use was associated with a lower incidence of AKI, despite being used in more complex patients.</p>","PeriodicalId":49261,"journal":{"name":"Journal of Invasive Cardiology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sant Kumar, Ahmed Al-Ogaili, Allison Hall, Lorenzo Azzalini, Khaldoon Alaswad, Stéphane Rinfret, Jimmy Kerrigan, Jason Wollmuth, Anastasios Milkas, Subhash Banerjee, Yader Sandoval, Emmanouil S Brilakis
{"title":"Update on the diagnosis and treatment of coronary complications of percutaneous coronary interventions.","authors":"Sant Kumar, Ahmed Al-Ogaili, Allison Hall, Lorenzo Azzalini, Khaldoon Alaswad, Stéphane Rinfret, Jimmy Kerrigan, Jason Wollmuth, Anastasios Milkas, Subhash Banerjee, Yader Sandoval, Emmanouil S Brilakis","doi":"10.25270/jic/24.00260","DOIUrl":"10.25270/jic/24.00260","url":null,"abstract":"<p><p>Prevention, prompt diagnosis, and rapid treatment are crucial for improving outcomes of complications that occur during percutaneous coronary intervention (PCI). The authors summarize studies on PCI complications published between January 1, 2023, and May 1, 2024, including coronary dissection, no reflow, perforation, and equipment loss/entrapment.</p>","PeriodicalId":49261,"journal":{"name":"Journal of Invasive Cardiology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142683089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Modified transcatheter aortic valve replacement: the pros and cons of removing the guidewire immediately after valve deployment.","authors":"Brig Navreet Singh, Guilerme F Attizzani","doi":"10.25270/jic/24.00224","DOIUrl":"10.25270/jic/24.00224","url":null,"abstract":"<p><p>The authors propose a modified transcatheter aortic valve replacement technique wherein the removal of the guidewire and delivery catheter immediately after the valve implantation helps to not only shorten the procedure but also decrease complications induced by the guidewire and delivery catheter.</p>","PeriodicalId":49261,"journal":{"name":"Journal of Invasive Cardiology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143014942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Federico Ronco, Gianpiero D'Amico, Samuele Meneghin, Domenico G Della Rocca, Patrizio Mazzone, Stefano Bordignon, Gavino Casu, Pierluigi Merella, Francesco Giannini, Sergio Berti, Giuseppe D'Angelo, Maria Rita Romeo, Marco Barbierato, Andrea Natale, Sakis Themistoclakis, Francesco Gallo
{"title":"Left atrial appendage occlusion in patients with non-valvular atrial fibrillation and cerebral amyloid angiopathy: insights from the LOGIC (Left atrial appendage Occlusion in patients with Gastrointestinal or IntraCranial bleeding) international multicenter registry.","authors":"Federico Ronco, Gianpiero D'Amico, Samuele Meneghin, Domenico G Della Rocca, Patrizio Mazzone, Stefano Bordignon, Gavino Casu, Pierluigi Merella, Francesco Giannini, Sergio Berti, Giuseppe D'Angelo, Maria Rita Romeo, Marco Barbierato, Andrea Natale, Sakis Themistoclakis, Francesco Gallo","doi":"10.25270/jic/24.00239","DOIUrl":"10.25270/jic/24.00239","url":null,"abstract":"<p><strong>Objectives: </strong>Oral anticoagulation therapy (OAC) is often contraindicated in patients with atrial fibrillation (AF) and cerebral amyloid angiopathy (CAA) because of the high hemorrhagic risk. Left atrial appendage occlusion (LAAO) can prevent thromboembolic events while avoiding long-term anticoagulation. However, a short period of antithrombotic therapy (AT) is still recommended after LAAO, and, therefore, it is unclear whether patients with CAA can be candidates for LAAO. The aim of the study was to investigate the safety and efficacy of LAAO in patients with CAA and AF.</p><p><strong>Methods: </strong>In this sub-study of the LOGIC (Left atrial appendage Occlusion in patients with Gastrointestinal or IntraCranial bleeding) registry, the authors considered only patients with previous intracranial (IC) bleeding, and patients with CAA were compared with patients who did not have CAA. Outcomes of interest were death from any causes and cardiovascular death, ischemic stroke, transient ischemic attack and systemic embolization, and any bleeding and major bleeding at 12 months.</p><p><strong>Results: </strong>The analysis included 270 patients, 49 (18%) of whom had CAA. Patients with CAA were more frequently discharged without AT after LAAO compared with patients who did not have CAA (36.7% vs 6.8%, P less than .001), and this was confirmed at the 1-year follow-up (30.4% vs 14.1%, P = .001). There were no significant differences in all-cause or cardiovascular mortality, or ischemic or hemorrhagic endpoints at 1 and 12 months.</p><p><strong>Conclusions: </strong>LAAO seems to be safe and effective in reducing both ischemic and hemorrhagic risk in patients with AF and CAA. Although patients with CAA are more likely to be discharged without AT after LAAO, there are no significant differences in ischemic and hemorrhagic outcomes compared with patients with a history of IC bleeding from other causes.</p>","PeriodicalId":49261,"journal":{"name":"Journal of Invasive Cardiology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142683079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ahmet Hakan Ates, Ahmet Kivrak, Ugur Canpolat, Can Menemencioglu, Mert Dogan, Cem Coteli, Mehmet Levent Sahiner, Ergun Barıs Kaya, Necla Ozer, Kudret Aytemir
{"title":"Polidocanol ablation in midventricular obstructive cardiomyopathy: novel approach and early outcomes.","authors":"Ahmet Hakan Ates, Ahmet Kivrak, Ugur Canpolat, Can Menemencioglu, Mert Dogan, Cem Coteli, Mehmet Levent Sahiner, Ergun Barıs Kaya, Necla Ozer, Kudret Aytemir","doi":"10.25270/jic/25.00035","DOIUrl":"https://doi.org/10.25270/jic/25.00035","url":null,"abstract":"<p><strong>Objectives: </strong>Midventricular obstructive hypertrophic cardiomyopathy (MVOHCM) poses significant challenges in diagnosis and treatment because of its unique anatomical and hemodynamic characteristics. Traditional interventions, such as alcohol septal ablation and surgical myectomy, are associated with complications and technical difficulties, prompting the search for alternative options. This study aimed to assess the safety, feasibility, and efficacy of polidocanol ablation in patients with symptomatic MVOHCM.</p><p><strong>Methods: </strong>Polidocanol was utilized as a novel ablation agent to achieve septal reduction in a retrospective cohort of 11 patients. Procedural success was defined as a reduction of at least 50% in the midventricular gradient. Echocardiography, computed tomography, and cardiac magnetic resonance imaging guided the selection of patients and the planning of procedures.</p><p><strong>Results: </strong>The procedure significantly reduced midventricular gradients in all patients, with no reports of polidocanol leakage. The New York Heart Association (NYHA) functional class improved notably (P = .003), and interventricular septum thickness decreased from 22.73 ± 3.9 mm to 20.09 ± 3.7 mm (P = .022). Conduction defects occurred in 54.5% of patients, necessitating the placement of an implantable cardioverter-defibrillator in 27.3% of cases. There was no peri-procedural mortality. During a median follow-up period of 14 months, significant and persistent improvements in midventricular gradient and NYHA functional class were observed.</p><p><strong>Conclusions: </strong>Polidocanol ablation was safe and effective as a minimally invasive option for managing MVOHCM, providing noteworthy procedural advantages. However, additional multicenter trials are needed to validate its use and establish standardized protocols.</p>","PeriodicalId":49261,"journal":{"name":"Journal of Invasive Cardiology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}