Eileen Galvani, Oludamilola Akinmolayemi, Srivatsan Swaminathan, Carlo Mannina, Sahil Khera, Lucy M Safi, Gilbert H L Tang, Samin K Sharma, Annapoorna S Kini, Stamatios Lerakis
{"title":"Clinical outcomes after transcatheter aortic valve replacement by sex and subtype of low-flow aortic stenosis.","authors":"Eileen Galvani, Oludamilola Akinmolayemi, Srivatsan Swaminathan, Carlo Mannina, Sahil Khera, Lucy M Safi, Gilbert H L Tang, Samin K Sharma, Annapoorna S Kini, Stamatios Lerakis","doi":"10.25270/jic/26.00096","DOIUrl":"https://doi.org/10.25270/jic/26.00096","url":null,"abstract":"<p><strong>Objectives: </strong>Prior studies suggest sex differences in clinical outcomes following transcatheter aortic valve replacement (TAVR) in patients with severe aortic stenosis (AS). The authors hypothesized that among patients with low-flow aortic stenosis (LFAS), outcomes differ based on sex and subtype of LFAS: classical (cLFLG), paradoxical (pLFLG), and high gradient (LFHG).</p><p><strong>Methods: </strong>This single-center, observational, longitudinal cohort study included adults with LFAS who underwent TAVR. Differences in clinical outcomes (all-cause mortality, heart failure hospitalization [HFH], and myocardial infarction [MI]) by subtype of LFAS within each sex were examined via Kaplan Meier curves. Log rank P-values were reported.</p><p><strong>Results: </strong>A total of 599 patients with LFAS were followed for 12 months after TAVR. Of the male patients (n = 373), 25.2% had LFHG, 32.7% cLFLG, and 42.1% pLFLG AS. Of females (n = 226), 26.1% had LFHG, 13.3% cLFLG, and 60.6% pLFLG AS. Event rates in males were 13.1% all-cause mortality, 6.2% HFH, and 0.8% MI. Event rates in females included 6.6% all-cause mortality, 8.0% HFH, and 0 MI. In males, the LFHG vs cLFLG vs pLFLG subtypes demonstrated significant differences in time to all-cause mortality (P < .001), HFH (P = .014), and MI (P = .045).</p><p><strong>Conclusions: </strong>In this cohort, clinical outcomes in males significantly differed by subtype of LFAS, whereas these differences were not found in females.</p>","PeriodicalId":49261,"journal":{"name":"Journal of Invasive Cardiology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147845118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vikash Jaiswal, Muhammad Hanif, Yusra Mashkoor, Aymen Ahmed, Gregory Mishkel, Jonathan Rosenberg, Mark J Ricciardi, Arman Qamar
{"title":"Real-world analysis of outcomes of patients undergoing coronary intravascular lithotripsy versus atherectomy for calcified coronary artery disease: findings from the TriNetX database.","authors":"Vikash Jaiswal, Muhammad Hanif, Yusra Mashkoor, Aymen Ahmed, Gregory Mishkel, Jonathan Rosenberg, Mark J Ricciardi, Arman Qamar","doi":"10.25270/jic/25.00351","DOIUrl":"https://doi.org/10.25270/jic/25.00351","url":null,"abstract":"<p><strong>Objectives: </strong>Coronary intravascular lithotripsy (IVL) and coronary atherectomy are increasingly used for calcified coronary lesions, yet comparative data on their cardiovascular benefits remain limited. This real-world study compared outcomes of coronary IVL vs atherectomy using the TriNetX Global Collaborative Network.</p><p><strong>Methods: </strong>Adult patients (≥18 years) undergoing PCI with either IVL or atherectomy between 2021 and 2024 were identified using procedural and diagnosis codes. Propensity score matching (1:1) balanced baseline demographics, comorbidities, laboratory values, and concomitant medications. The primary endpoint was all-cause mortality (ACM), while secondary endpoints included major adverse cardiovascular events (MACE), heart failure exacerbation (HFE), and procedural safety outcomes.</p><p><strong>Results: </strong>Among 51 856 patients, 18 686 underwent IVL and 33 170 underwent atherectomy. After matching, 13 617 patients were retained in each group. At 30 days, IVL was associated with significantly lower risks of ACM (risk ratio [RR]: 0.67; 95% CI, 0.60-0.75; P < .001), MACE (RR: 0.42, 95% CI, 0.36-0.48; P < .001), and HFE (RR: 0.64; 95% CI, 0.57-0.72; P < .001) compared with atherectomy. These benefits persisted at 1 year for ACM (RR: 0.78; 95% CI, 0.73-0.84; P < .001), MACE (RR: 0.66; 95% CI, 0.60-0.72; P < .001), and HFE (RR: 0.79; 95% CI, 0.73-0.85; P < .001). Safety outcomes were comparable between groups.</p><p><strong>Conclusions: </strong>In this propensity-matched, real-world cohort, IVL was associated with lower mortality and fewer adverse cardiovascular events than atherectomy, with a comparable safety profile. Given the likelihood of residual selection bias, these observational findings require confirmation in randomized trials.</p>","PeriodicalId":49261,"journal":{"name":"Journal of Invasive Cardiology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147845126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Excessive force-induced eversion endarterectomy on the radial artery spasm: uncontrolled force is not force.","authors":"Murat Akcay, Fuatcan Balaban, Nisanur Danacı Kol","doi":"10.25270/jic/25.00344","DOIUrl":"10.25270/jic/25.00344","url":null,"abstract":"","PeriodicalId":49261,"journal":{"name":"Journal of Invasive Cardiology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145460240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ahmad Mustafa, Denny Wang, Cole Dutton, Arber Kodra, Muhammad Abubakar Shakir, Ythan Goldberg, Mei Chau, Shankar Thampi, Priti Mehla, Chapman Wei, Shangyi Liu, Michael Cinelli, Bruce Rutkin, Elana Koss, Gregory Maniatis, Alexander Iribarne, Apurva Patel, Sean Wilson, Wally Omar, Robert Kalimi, Alan Hartman, Jacob Scheinerman, Chad Kliger
{"title":"Early outcomes of facilitated transfemoral versus alternative access for transcatheter aortic valve replacement in patients with peripheral arterial disease.","authors":"Ahmad Mustafa, Denny Wang, Cole Dutton, Arber Kodra, Muhammad Abubakar Shakir, Ythan Goldberg, Mei Chau, Shankar Thampi, Priti Mehla, Chapman Wei, Shangyi Liu, Michael Cinelli, Bruce Rutkin, Elana Koss, Gregory Maniatis, Alexander Iribarne, Apurva Patel, Sean Wilson, Wally Omar, Robert Kalimi, Alan Hartman, Jacob Scheinerman, Chad Kliger","doi":"10.25270/jic/25.00171","DOIUrl":"10.25270/jic/25.00171","url":null,"abstract":"<p><strong>Objectives: </strong>Transfemoral (TF) access for transcatheter aortic valve replacement (TAVR) may be challenging in patients with peripheral arterial disease (PAD). Alternative access through intra- and extrathoracic approaches can be performed. Recently, a facilitated TF access strategy, which involves the use of intravascular lithotripsy to optimize the iliofemoral arteries prior to TAVR, has been utilized. The aim of this study was to evaluate early outcomes of facilitated TF access compared to alternative access in patients with severe PAD.</p><p><strong>Methods: </strong>Patients with severe PAD who underwent TAVR from 2021 to 2023 were included in the study and were divided into 2 groups: facilitated and alternative access. The primary endpoint was a composite of mortality, stroke, and vascular complications. Mortality was evaluated in-hospital and at 1-month follow-up.</p><p><strong>Results: </strong>Of 150 TAVR patients with severe PAD, 24 underwent facilitated access. Baseline characteristics including age, Society of Thoracic Surgeons score, and mean gradients were similar between the 2 groups. The most common alternative access was transsubclavian, followed by transcarotid. Primary outcomes were numerically higher in the alternative access group (14% vs 8%); however, this did not reach statistical significance (P = .49). General anesthesia use and postoperative length of stay were higher in the alternative access group. Postoperative and 1-month mortalities were similar between the 2 groups.</p><p><strong>Conclusions: </strong>Although the primary endpoint did not reach statistical significance, the numerical trend toward better outcomes in the facilitated TAVR group indicates a potential advantage. Large-scale prospective studies are required to determine the appropriate access strategy for TAVR in patients with severe PAD.</p>","PeriodicalId":49261,"journal":{"name":"Journal of Invasive Cardiology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145985577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jonas Leavitt, Dimitrios Varrias, Christopher Gasparis, Elliot Wolf, Stefanos Zafeiropoulos, Ari Zimmer, Laurence M Epstein, Kristie M Coleman, Stavros E Mountantonakis
{"title":"Clinical predictors of long-term atrial fibrillation recurrence post catheter ablation: an ITHACA-database analysis.","authors":"Jonas Leavitt, Dimitrios Varrias, Christopher Gasparis, Elliot Wolf, Stefanos Zafeiropoulos, Ari Zimmer, Laurence M Epstein, Kristie M Coleman, Stavros E Mountantonakis","doi":"10.25270/jic/25.00273","DOIUrl":"10.25270/jic/25.00273","url":null,"abstract":"<p><strong>Objectives: </strong>Shared decision making regarding how to best manage atrial fibrillation (AF) includes the use and efficacy of catheter ablation (CA) as a treatment option. However, the long-term success rate for the procedure based on patients' baseline demographics and comorbidities remains unclear. The authors aimed to create a user-friendly predictive model to help provide an individualized risk score for long-term AF recurrence.</p><p><strong>Methods: </strong>Ablation outcomes reported in the electronic medical records were documented from 3, 12, and 24 months, and last follow-up visit, which was an average of 42 months. Multivariate logistic regression was used to identify independent variables associated with AF recurrence. Based on respective coefficients, associated variables were used to create the ORACLE-AF (symptOmatic AF, race [White], AF type [persistent], cardioversion, late age > 70, early AF recurrence, asthma/COPD, heart failure) model. A k-1 machine learning model was used for validation, using an 80/20 development test cohort ratio.</p><p><strong>Results: </strong>A total of 3440 patients (69.4 ± 10.2 years, 44% women) who received a de novo CA were included in the analysis. Forty-eight percent of patients had the primary composite outcome of AF recurrence by the end of the 42-month observation period. After analysis, the ORACLE-AF model was created with an area under the curve of 0.80.</p><p><strong>Conclusions: </strong>Using machine learning, the authors created a predictive tool to allow for individualized risk prediction for long-term AF recurrence following CA. These findings highlight the need to consider risk factors not typically associated with long-term AF recurrence during the pre-ablation consultation.</p>","PeriodicalId":49261,"journal":{"name":"Journal of Invasive Cardiology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145985623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gabriele L Gasparini, Laura Novelli, Jacopo A Oreglia, Yoshihisa Kinoshita, Jorge Sanz-Sanchez
{"title":"Catch the branch: the new Miracle Neo 3 guidewire for complex bifurcation rewiring.","authors":"Gabriele L Gasparini, Laura Novelli, Jacopo A Oreglia, Yoshihisa Kinoshita, Jorge Sanz-Sanchez","doi":"10.25270/jic/25.00343","DOIUrl":"10.25270/jic/25.00343","url":null,"abstract":"","PeriodicalId":49261,"journal":{"name":"Journal of Invasive Cardiology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145596973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Konstantinos C Theodoropoulos, Spyridon-Filippos Papadopoulos, George Samprokatsidis, Alexandra Liakopoulou, George Perdikos, Matthaios Didagelos, George Kassimis, Antonios Ziakas
{"title":"Occluded left circumflex artery in a patient with the de Winter sign on electrocardiography.","authors":"Konstantinos C Theodoropoulos, Spyridon-Filippos Papadopoulos, George Samprokatsidis, Alexandra Liakopoulou, George Perdikos, Matthaios Didagelos, George Kassimis, Antonios Ziakas","doi":"10.25270/jic/25.00341","DOIUrl":"10.25270/jic/25.00341","url":null,"abstract":"","PeriodicalId":49261,"journal":{"name":"Journal of Invasive Cardiology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145490701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Leili Pourafkari, Jeong Hwan J Kim, Jonathan Lalezari, Ali Sovari
{"title":"Hybrid left atrial appendage exclusion management: WATCHMAN after AtriClip.","authors":"Leili Pourafkari, Jeong Hwan J Kim, Jonathan Lalezari, Ali Sovari","doi":"10.25270/jic/25.00353","DOIUrl":"10.25270/jic/25.00353","url":null,"abstract":"","PeriodicalId":49261,"journal":{"name":"Journal of Invasive Cardiology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145597272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Percutaneous retrieval of an intracardiac fractured vascular access port catheter using a looped guidewire.","authors":"Kazuhiro Asano, Tatsuya Nakama, Kotaro Obunai","doi":"10.25270/jic/25.00334","DOIUrl":"10.25270/jic/25.00334","url":null,"abstract":"","PeriodicalId":49261,"journal":{"name":"Journal of Invasive Cardiology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145460265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}