Muhammad Etiwy, Adam N Berman, Michael H Picard, Chiara Fraccaro, Nicole Karam, Meagan M Wasfy, Yunong Zhao, Magdi Zordok, John Hsu, Jason H Wasfy
{"title":"Survival with aortic valve replacement in asymptomatic individuals with severe aortic stenosis and a left ventricular ejection fraction of 50% to 54.","authors":"Muhammad Etiwy, Adam N Berman, Michael H Picard, Chiara Fraccaro, Nicole Karam, Meagan M Wasfy, Yunong Zhao, Magdi Zordok, John Hsu, Jason H Wasfy","doi":"10.25270/jic/25.00332","DOIUrl":"10.25270/jic/25.00332","url":null,"abstract":"<p><strong>Objectives: </strong>Severe aortic stenosis (AS) with a left ventricular ejection fraction (LVEF) of 50% to 54% is associated with worse outcomes than an LVEF greater than or equal to 55%. European guidelines consider aortic valve replacement (AVR) a Class IIa indication for asymptomatic patients with an LVEF of less than 55%, whereas American guidelines recommend AVR when the LVEF is less than 50%. The authors assessed outcomes of AVR vs conservative management in this range where guidelines differ.</p><p><strong>Methods: </strong>A registry was created for individuals with severe high-gradient AS (AVA ≤ 1 cm²), an LVEF of 50% to 54%, and a mean gradient greater than or equal to 40 mm Hg from 2000 to 2022 using queries of transthoracic echocardiogram (TTE) reports. Only asymptomatic cases were included; time-zero was defined as the time of the index TTE, and both AVR (considered as a time-dependent covariate) and mortality could occur at any point after. Proportional hazard modeling assessed the AVR-mortality association, with subset analyses for individuals with AVAs of less than 0.9 cm² and less than or equal to 0.75 cm².</p><p><strong>Results: </strong>Among 693 included individuals, 83 were asymptomatic at their index TTE. Of these, 38 (45.8%) underwent AVR within 2 years. After adjusting for immortal time, individuals with AVR had a trend toward decreased mortality (HR, 0.56; 95% CI, 0.31-1.01; P = .054). Among individuals with AVAs of less than 0.9 cm² and less than or equal to 0.75 cm², AVR was associated with improved survival (HR, 0.42; 95% CI, 0.21-0.84; P less tan .01 and HR, 0.33; 95% CI, 0.15-0.75; P less than .008, respectively).</p><p><strong>Conclusions: </strong>AVR within 2 years was associated with improved survival among asymptomatic individuals with high-grade severe AS and an LVEF of 50% to 54%.</p>","PeriodicalId":49261,"journal":{"name":"Journal of Invasive Cardiology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145985616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Anomalous origin of the right coronary artery from the left anterior descending artery: a rare trifurcation lesion.","authors":"Prabhjot Hundal, M Fuad Jan, Suhail Q Allaqaband","doi":"10.25270/jic/25.00326","DOIUrl":"10.25270/jic/25.00326","url":null,"abstract":"","PeriodicalId":49261,"journal":{"name":"Journal of Invasive Cardiology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146126830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kaitlyn Krebushevski, Allison K Cabalka, Nathaniel W Taggart, Pradyumna Agasthi, Alexander C Egbe, William R Miranda, Peter M Pollak, Abigail M Sutter, Frank Cetta, Jason H Anderson
{"title":"Self-expanding aortic endografts for endovascular repair of native and recurrent coarctation of the aorta.","authors":"Kaitlyn Krebushevski, Allison K Cabalka, Nathaniel W Taggart, Pradyumna Agasthi, Alexander C Egbe, William R Miranda, Peter M Pollak, Abigail M Sutter, Frank Cetta, Jason H Anderson","doi":"10.25270/jic/25.00394","DOIUrl":"10.25270/jic/25.00394","url":null,"abstract":"<p><strong>Objectives: </strong>Endovascular repair of coarctation of the aorta (CoA) can be challenging in the presence of arch angulation, post-stenotic dilation, or prior surgical repair, which may limit the performance of balloon-expandable covered stents. To address these anatomic constraints, the authors evaluated the use of a self-expanding thoracic aortic endoprosthesis for CoA repair.</p><p><strong>Methods: </strong>The authors performed a multicenter retrospective review of patients who underwent endovascular repair of native or recurrent CoA using the GORE TAG Thoracic Branch Endoprosthesis Extender or GORE TAG Conformable Thoracic Stent Graft (W.L. Gore & Associates) between January 1, 2023, and December 31, 2025.</p><p><strong>Results: </strong>Thirteen patients (median age 32 years; range, 21-49 years; 77% male) underwent endovascular treatment. All patients exhibited significant baseline peak-to-peak gradients (median = 23 mm Hg; IQR: 10, 27). Hemodynamic resolution was achieved in all cases (median = 0 mm Hg; IQR: 0, 2; P < .001). Median waist diameter increased from 11 mm (IQR: 9, 12) to 20 mm (IQR: 18, 22) (P < .001). Aortic isthmus ratio increased from 0.46 (IQR: 0.39, 0.54) to 0.87 (IQR: 0.77, 0.92) (P < .001). No intraprocedural complications were observed.</p><p><strong>Conclusions: </strong>Self-expanding thoracic endografts demonstrated excellent conformability, effective gradient elimination, and early procedural success in the treatment of CoA. Continued follow-up, including protocolized imaging, will be essential to assess mid- and long-term durability and to define the role of this approach in patients with complex aortic anatomy.</p>","PeriodicalId":49261,"journal":{"name":"Journal of Invasive Cardiology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146068169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tara Seirafi, Jeremy Y Levett, Areesha Moiz, Tetiana Zolotarova, Kristian B Filion, Adelina Dobromir Angheluta, Pauline Reynier, Mark J Eisenberg
{"title":"Extracorporeal versus conventional cardiopulmonary resuscitation for out-of-hospital cardiac arrests.","authors":"Tara Seirafi, Jeremy Y Levett, Areesha Moiz, Tetiana Zolotarova, Kristian B Filion, Adelina Dobromir Angheluta, Pauline Reynier, Mark J Eisenberg","doi":"10.25270/jic/25.00405","DOIUrl":"https://doi.org/10.25270/jic/25.00405","url":null,"abstract":"<p><strong>Objectives: </strong>It remains unclear whether extracorporeal cardiopulmonary resuscitation (ECPR) is more efficacious than conventional cardiopulmonary resuscitation (CPR) at improving survival with favorable neurological outcomes among patients with out-of-hospital cardiac arrests (OHCA). The authors sought to determine the efficacy of ECPR vs conventional CPR among patients with OHCA in the pre-hospital setting.</p><p><strong>Methods: </strong>The authors searched MEDLINE, EMBASE, and the Cochrane Library for randomized controlled trials (RCTs) comparing ECPR with conventional CPR for patients with OHCA. The primary outcome was survival with a favorable neurological outcome at 6-month follow-up. Count data were pooled across trials through random-effects models with inverse variance weighting to estimate risk ratios (RRs) and 95% confidence intervals (CIs).</p><p><strong>Results: </strong>A total of 3 RCTs (n = 420) were included. Most patients (85%) were male, and the mean/median age ranged from 54 to 59 years. At 6 months, 28.4% of the patients randomized to ECPR survived with favorable neurological outcomes compared with 18.6% of the patients randomized to conventional CPR (RR, 1.47; 95% CI, 0.43-5.09). Similar results were obtained for survival at hospital discharge (RR, 1.35; 95% CI, 0.35-5.19). Risk of Bias 2 analysis indicated low risk in 1 trial and some concerns in others.</p><p><strong>Conclusions: </strong>ECPR may be associated with improved survival with favorable neurological outcomes at 6 months compared to conventional CPR for the treatment of OHCA. However, the available evidence remains inconclusive, and additional trials are needed to definitively assess the efficacy of ECPR compared to conventional CPR for OHCA.</p>","PeriodicalId":49261,"journal":{"name":"Journal of Invasive Cardiology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147845052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tarek Abdeldayem, Mustafa Tigen, Omer Gogtekin, Mohaned Egred
{"title":"Controlled antegrade and retrograde tracking (CART) technique via epicardial collaterals: feasible and safe.","authors":"Tarek Abdeldayem, Mustafa Tigen, Omer Gogtekin, Mohaned Egred","doi":"10.25270/jic/26.00039","DOIUrl":"https://doi.org/10.25270/jic/26.00039","url":null,"abstract":"","PeriodicalId":49261,"journal":{"name":"Journal of Invasive Cardiology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147845073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The prevalence of cardiac symptoms in Ehlers-Danlos syndrome and hypermobility spectrum disorder: a pilot study.","authors":"Ermin Tale, Riya Kaushal, Bilal Niazi, Katie Nikishina, Amy Chen, Bernadette Riley, Todd J Cohen","doi":"10.25270/jic/25.00395","DOIUrl":"https://doi.org/10.25270/jic/25.00395","url":null,"abstract":"<p><strong>Objectives: </strong>The authors compared palpitations, presyncope, syncope, and postural orthostatic tachycardia syndrome (POTS) prevalence among patients with hypermobile Ehlers-Danlos syndrome (hEDS) and hypermobility spectrum disorder (HSD).</p><p><strong>Methods: </strong>A retrospective analysis of patients referred for cardiac evaluation at the New York Institute of Technology Ehlers-Danlos Syndrome/Hypermobility Treatment Center between January 2019 and November 2023 was conducted. hEDS and HSD patients underwent cardiac evaluation and were stratified by median age into younger (<35 years) and older (≥35 years) groups. Symptom prevalence was compared between hypermobile patients overall and by age cohort. Data were presented as mean ± SD; P < .05 was considered statistically significant.</p><p><strong>Results: </strong>One hundred-nine patients (75 hEDS, 34 HSD) underwent cardiac evaluation: 75 hEDS (71 females/4 males; age 33.9 + 11.6 years) and 34 HSD (29 females/ 5 males; age 40.0 + 13.8 years). POTS (48% vs 23.5%, P = .016) was significantly more prevalent in the hEDS group; palpitations, presyncope, and syncope were common in both groups. No significant differences were observed in Cohort 1 (age less than 35 years). In Cohort 2 (age ≥35 years), presyncope (100% vs 82.6%, P = .04) differed; palpitations, syncope, and POTS were similar. POTS was prevalent in patients younger than 35 years with hEDS (58.3% vs 29.6%, P = .022) and HSD (45.5% vs 13.0%, P = .042).</p><p><strong>Conclusions: </strong>Patients with h EDS exhibited greater symptoms than HSD patients, and symptoms were particularly more pronounced with age. POTS prevalence decreased with age in both groups. Larger prospective studies are needed to explore underlying mechanisms.</p>","PeriodicalId":49261,"journal":{"name":"Journal of Invasive Cardiology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147845092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nicolás Del Cuerpo Salinas, Eduardo Arroyo Úcar, Ignacio Alfaro Paniagua, Marta Monteagudo Viana, María Araceli Frutos García
{"title":"Optical coherence tomography features in coronary vasculitis: a Takayasu's disease manifestation.","authors":"Nicolás Del Cuerpo Salinas, Eduardo Arroyo Úcar, Ignacio Alfaro Paniagua, Marta Monteagudo Viana, María Araceli Frutos García","doi":"10.25270/jic/26.00091","DOIUrl":"https://doi.org/10.25270/jic/26.00091","url":null,"abstract":"","PeriodicalId":49261,"journal":{"name":"Journal of Invasive Cardiology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147787243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}