Aortic valve calcification alone identifies transcatheter aortic valve replacement benefit in classical low-flow, low-gradient aortic stenosis.

IF 1.4 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Invasive Cardiology Pub Date : 2025-09-25 DOI:10.25270/jic/25.00290

Yash Prakash, Eric J Kim, Ranbir Singh, Lakshay Chopra, Akarsh Sharma, Eileen Galvani, Thomas Hanlon, Ankita Naraparaju, Carlo Mannina, Oludamilola Akinmolayemi, Annapoorna S Kini, Samin K Sharma, Stamatios Lerakis

引用次数: 0

Abstract

Aortic valve calcification (AVC) is a guideline-endorsed diagnostic tool in low-flow, low-gradient (LFLG) aortic stenosis (AS), but its prognostic value across LFLG subtypes remains debated. In this retrospective cohort of 457 patients undergoing transcatheter aortic valve replacement (TAVR), severe AVC was associated with significantly fewer heart failure rehospitalizations in classical LFLG AS (adjusted hazard ratio [HR], 0.41; P = .023) but not in paradoxical LFLG AS (adjusted HR, 0.76; P = .422). AVC also correlated with true-severe AS when dobutamine stress echocardiography (DSE) was performed. These findings suggest that AVC alone can identify classical LFLG AS patients likely to benefit from TAVR, even when DSE results are unavailable or inconclusive.

查看原文本刊更多论文

主动脉瓣钙化单独确定经导管主动脉瓣置换术对经典低流量、低梯度主动脉瓣狭窄的益处。

主动脉瓣钙化（AVC）是低流量、低梯度（LFLG）主动脉瓣狭窄（AS）的一种经指南认可的诊断工具，但其在LFLG亚型中的预后价值仍存在争议。在这项纳入457例经导管主动脉瓣置换术（TAVR）患者的回顾性队列研究中，在经典LFLG AS中，严重AVC与心力衰竭再住院率显著降低相关（校正风险比[HR]， 0.41; P = 0.023），而在矛盾LFLG AS中则无相关（校正风险比，0.76;P = 0.422）。当进行多巴酚丁胺应激超声心动图（DSE）时，AVC也与真重度AS相关。这些发现表明，即使在DSE结果不可用或不确定的情况下，仅AVC可以识别可能从TAVR获益的典型LFLG AS患者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Invasive Cardiology CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

2.90

自引率

6.70%

发文量

214

审稿时长

3-8 weeks

期刊介绍： The Journal of Invasive Cardiology will consider for publication suitable articles on topics pertaining to the invasive treatment of patients with cardiovascular disease.