Blood Transfusion最新文献

{"title":"A Survey on the implementation of Patient Blood Management programs in Italy.","authors":"Vanessa Agostini, Francesca Masiello, Stefania Vaglio, Eva Veropalumbo, Ursula La Rocca, Simonetta Pupella, Vincenzo De Angelis","doi":"10.2450/BloodTransfus.724","DOIUrl":"10.2450/BloodTransfus.724","url":null,"abstract":"<p><strong>Background: </strong>Since 2012, in line with the World Health Organization (WHO) resolution WHA63.12 of 05/21/2010, the Italian National Blood Center has been promoting patient blood management (PBM). In order to verify the level of PBM implementation nationwide, we submitted a survey to all healthcare providers.</p><p><strong>Material and methods: </strong>In line with what was proposed in the international scientific literature in the field, a series of indicators was used derived from the four main blocks related to PBM strategies: the management of patient anemia; the optimization of hemostasis; blood conservation strategies; patient-centred decision-making. We also added two blocks containing important information on general PBM management and other PBM-related aspects.</p><p><strong>Results: </strong>The survey showed good implementation of anemia screening programs in accordance with the timelines established by national and international guidelines, and the single unit policy is used in line with national guideline recommendations. However, the survey also revealed limited auditing of PBM programs and reduced monitoring and reporting of clinical outcomes and indicators.</p><p><strong>Discussion: </strong>The first national survey on the level of PBM implementation in Italy shows widespread adoption of diagnostic-therapeutic care pathways aimed at the diagnosis and treatment of anemia in the perioperative setting.</p>","PeriodicalId":49260,"journal":{"name":"Blood Transfusion","volume":" ","pages":"223-231"},"PeriodicalIF":2.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12108067/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140337446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficiency assessment of cord blood banking and compatibility with delayed cord clamping.","authors":"Geethika S Manchanayake, Elisenda Farssac Busquets, Ana García Buendia, Patrícia Ferrer, Gisela Palomar, Maria José Pelegay, Irene Ribera, Carmen Azqueta, Dinara Samarkanova, Jesus Fernandez-Sojo, Nerea Castillo Flores, Sergio Querol","doi":"10.2450/BloodTransfus.767","DOIUrl":"10.2450/BloodTransfus.767","url":null,"abstract":"<p><strong>Background: </strong>There is debate whether delayed umbilical cord clamping following delivery, the current gold standard, affects the proportion of cord blood units (CBU) suitable for public cord blood banking. This study was designed to assess the impact of delayed cord clamping on the number of CBU suitable for therapeutic uses.</p><p><strong>Materials and methods: </strong>To minimize variability, data from the four most active collection centers within the Programa Concordia (Spain) were included. Data on CBU collected in utero from mothers following normal vaginal deliveries from July 2018 to December 2021 were analyzed. The weight of the collection bags (as a surrogate of volume) and total nucleated cell (TNC) count were analyzed according to three defined clamping times: 30 s, 60 s and ≥120 s. The CBU were stratified as suitable for stem cell transplantation (≥110 g and ≥1,500x10⁶ TNC/unit) or other clinical applications (≥100 g but TNC count below the threshold).</p><p><strong>Results: </strong>There were 131 (18%), 548 (76%), and 40 (5%) CBU collected at 30 s, 60 s and ≥120 s, respectively. The median weight of the CBU decreased gradually with time, with a significant difference between units collected when the cord was clamped at 30 s or 60 s (p=0.036), so significantly fewer CBU met the minimal weight criterion (100 g) at 60 s than at 30 s (p=0.002). However, this was not reflected by the TNC available, resulting in non-statistical differences in CBU eligible for banking between these times. The major predictor of collection success was the neonate's birth-weight.</p><p><strong>Discussion: </strong>Despite decreases in the volume of cord blood collected when cord clamping at 30 s or 60 s, TNC count is maintained resulting in similar numbers of CBU eligible for banking. The different clamping delays investigated in this study are, therefore, compatible with public cord blood banking needs.</p>","PeriodicalId":49260,"journal":{"name":"Blood Transfusion","volume":" ","pages":"242-249"},"PeriodicalIF":2.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12108076/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141972195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Warm autoimmune hemolytic anemia: transfusion lessons and therapeutic perspectives learn from a particular patient.","authors":"Jun Yu Woon, Li-Te Chin, Yu-Ting Lee","doi":"10.2450/BloodTransfus.851","DOIUrl":"10.2450/BloodTransfus.851","url":null,"abstract":"","PeriodicalId":49260,"journal":{"name":"Blood Transfusion","volume":" ","pages":"266-270"},"PeriodicalIF":2.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12108081/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142774058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of platelet function by Total Thrombus-Formation Analysis System (T-TAS®01) in term and preterm infants and its relationship with patent ductus arteriosus. A prospective observational pilot study.","authors":"Ester Capecchi, Valeria Cortesi, Genny Raffaeli, Irene Picciolli, Nicola Pesenti, Monica Fumagalli, Giacomo Cavallaro, Stefano Ghirardello, Gaia Francescato","doi":"10.2450/BloodTransfus.765","DOIUrl":"10.2450/BloodTransfus.765","url":null,"abstract":"<p><strong>Background: </strong>Newborns exhibit a pro-coagulant hemostatic profile despite platelet hyporeactivity and reduced coagulation factors. Assessing infant hemostasis, particularly in preterm infants, is challenging, with inconsistent findings regarding the relationship between platelet count and function in patients with patent ductus arteriosus (PDA).</p><p><strong>Materials and methods: </strong>This study aims to assess platelet function using the Total Thrombus-Formation Analysis System (T-TAS®01) in term and preterm newborns. T-TAS®01 measures the Occlusion Start Time (OST), Occlusion Time (OT), and the Area Under the Curve (AUC) at the end of thrombus formation. The study includes term and preterm newborns below 30 weeks' gestational age (GA) admitted to the Neonatal Intensive Care Unit. Blood samples were collected from preterm newborns on the 1^st day of life (T0), between 48-72 hours of life (T1), between the 7^th and 10^th day of life (T2), and from term newborns at T0 and T2. Secondary endpoints include the relationship between T-TAS®01 parameters and significant PDA in preterm newborns and the correlation between T-TAS®01 parameters, GA, and complete blood count (CBC).</p><p><strong>Results: </strong>OST is delayed by 65.5 seconds in preterm infants at T0 (p<0.001) and by 46 seconds at T2 (p=0.041) compared to full-term newborns. OT is delayed by 164 seconds in preterm infants at T0 (p=0.002) and by 352 seconds at T2 (p=0.002). AUC at T0 is lower in preterm infants (p=0.028). There is no significant correlation between T-TAS®01 parameters and GA or CBC. Additionally, OST and OT are delayed, and AUC is reduced in preterm infants with PDA and hemodynamically significant PDA (hsPDA).</p><p><strong>Discussion: </strong>T-TAS®01 is a reliable tool for evaluating platelet function in term newborns. However, measurements show higher variability in preterm infants, with significantly lower platelet activity observed in preterm infants with PDA and hsPDA.</p>","PeriodicalId":49260,"journal":{"name":"Blood Transfusion","volume":" ","pages":"255-265"},"PeriodicalIF":2.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12108063/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142773757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of HLA matching between deceased organ donors and cord blood units from a National Bank Network as a basis for potential platforms for chimerism-based immune tolerance after solid organ transplantation.","authors":"Roberto Crocchiolo, Letizia Lombardini, Nicoletta Sacchi, Ilaria Lombardi, John Blake, David Allan, Mohamad Sobh, Francesca Puoti, Silvia Trapani, Anna Maria Gallina, Marco Sacchi, Simonetta Pupella, Paola Bergamaschi, Silvano Rossini, Massimo Cardillo","doi":"10.2450/BloodTransfus.759","DOIUrl":"10.2450/BloodTransfus.759","url":null,"abstract":"","PeriodicalId":49260,"journal":{"name":"Blood Transfusion","volume":" ","pages":"250-254"},"PeriodicalIF":2.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12108091/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141471937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient Blood Management in 2023: a Nationwide Survey of Anesthesiologists in Romania following the 2018 Guidelines.","authors":"Daniela Filipescu, Mihai-Gabriel Ștefan, Șerban Ion Bubenek Turconi, Dan Corneci, Gabriela Droc, Raluca Goicea, Ioana Grigoraș, Ioana M Grințescu, Liliana Mirea, Cornelia Predoi, Anca-Irina Ristescu, Silvius Negoiță, Dorel Săndesc, Ecaterina Scărlătescu, Liana Văleanu, Ștefan Andrei, Dana Tomescu","doi":"10.2450/BloodTransfus.776","DOIUrl":"10.2450/BloodTransfus.776","url":null,"abstract":"<p><strong>Background: </strong>In 2018, Romania established national guidelines for patient blood management (PBM), endorsed by the Romanian Society of Anesthesia and Intensive Care (SRATI) and approved by the Ministry of Health. These guidelines emphasize managing anemia, coagulation issues, and the cautious use of allogeneic transfusions to improve patient outcomes.</p><p><strong>Materials and methods: </strong>A national survey was conducted among Romanian anesthesiologists to assess PBM guideline adoption. It included 38 questions addressing PBM strategies, resources, transfusion practices, and barriers to implementation. The survey was distributed via email to the SRATI database.</p><p><strong>Results: </strong>Out of 512 professionals who opened the survey, 74% had adopted some PBM measures, and 97% recognized PBM's efficacy in improving outcomes. However, only 33% of anesthesiologists worked in hospitals with formal PBM groups, and 39% had attended PBM-related educational events. Preoperative anemia management was inconsistent, with only 33.5% routinely treating anemia. Access to diagnostic and therapeutic tools was limited; transferrin saturation testing was available in 27% of cases, and erythropoietin was used in 24%. Despite these limitations, 72% of respondents treated anemia with intravenous iron.The main challenges to implementation included insufficient time for pre-surgical assessments, lack of standardized procedures, and difficulties in surgeon-anesthetist collaboration.</p><p><strong>Discussion: </strong>The survey highlights the need for systemic improvements in PBM adoption. Recommendations include enhancing organizational structures, standardizing protocols, and improving interdisciplinary collaboration to boost PBM implementation in Romania. While progress has been made, a national program with dedicated funding and auditing could facilitate widespread PBM integration into clinical practice.</p>","PeriodicalId":49260,"journal":{"name":"Blood Transfusion","volume":" ","pages":"232-241"},"PeriodicalIF":2.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12108093/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142511372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of trisomy 9 with mixed-field ABO blood type.","authors":"Sena Fujii, Yuji Shimura, Keiichi Shigehara, Yuji Sasada, Tohru Inaba","doi":"10.2450/BloodTransfus.729","DOIUrl":"10.2450/BloodTransfus.729","url":null,"abstract":"","PeriodicalId":49260,"journal":{"name":"Blood Transfusion","volume":" ","pages":"212-215"},"PeriodicalIF":2.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12108054/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141471936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ELP protocol: an original approach for the mitigation of anti-CD38 interference.","authors":"Erica Maiorana, Maria Bortolati, Steluta Croitoru, Gledis Llanaj, Cinzia Ongaro, Eva Polga, Melissa Salvo, Alessandra Sandini, Krizia Succoli, Tiziana Tortomasi, Giacomina Vicino, Francesco Fiorin","doi":"10.2450/BloodTransfus.779","DOIUrl":"10.2450/BloodTransfus.779","url":null,"abstract":"<p><strong>Background: </strong>Transfusion medicine is facing new challenges from therapies which interfere with pre-transfusional tests, such as monoclonal antibodies targeting blood-cell antigens. Anti-CD38 monoclonal antibodies, widely used to treat multiple myeloma, cause panreactivity of indirect antiglobulin test; this can be resolved by treating cells with dithiothreitol to disrupt the CD38 disulphide bonds expressed on red blood cell surfaces. Interference mitigation strategy with dithiothreitol, however, has some drawbacks: it entails losing the traceability of results and the denaturation of blood group systems sensitive to reducing agents; it takes time to perform and quality controls are lost.</p><p><strong>Materials and methods: </strong>Panels were treated with 0.2 mol/L dithiothreitol and stored for 30 days with a commercial preservative solution. On day 30, we measured the hemolysis indices and ability to eliminate daratumumab and isatuximab interference in the treated cells using indirect antiglobulin test. We also tested the stability of erythrocyte antigenic structure by screening 42 samples with known antibodies; tests were repeated on day 1, 7, 15 and 30. All indirect antiglobulin testing was performed on gel card.</p><p><strong>Results: </strong>After 30 days from treatment, panels preserved in preservative solution showed hemolysis indices comparable to untreated panels: all cases of interference by anti-CD38 in pre-transfusional tests were successfully mitigated. All antibodies were detected after 30 days, except for KEL system antibodies, as expected, although there was a detectability of anti-Kell antibodies in high titer samples (the first detection in dithiothreitol-treated cells since 1983).</p><p><strong>Discussion: </strong>We propose the Extended Lifetime Protocol; a simple card-based method which is cheap and traceable, that combines the strengths of anti-CD38 mitigation strategies. It makes it possible to treat and store, at the same time, a sufficient volume of red blood cells, that can be used for the following 30 days, to avoid any delay in transfusional requests.</p>","PeriodicalId":49260,"journal":{"name":"Blood Transfusion","volume":" ","pages":"203-211"},"PeriodicalIF":2.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12108082/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141471938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe aplastic anemia secondary to immune checkpoint inhibitor: case report and literature review.","authors":"Alessandro Bosi, Maria C Di Chio, Marta Bortolotti, Giorgio A Croci, Francesco Passamonti, Wilma Barcellini, Bruno Fattizzo","doi":"10.2450/BloodTransfus.723","DOIUrl":"10.2450/BloodTransfus.723","url":null,"abstract":"","PeriodicalId":49260,"journal":{"name":"Blood Transfusion","volume":" ","pages":"271-274"},"PeriodicalIF":2.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12108092/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141471940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A \"movement\" worth making: why and how Transfusion Services can play a role in Fecal Microbiota Transplant programs.","authors":"Daniele Prati, Flavio Caprioli, Luisa Stea, Alessandra Berzuini, Denise Pizzotti, Errica Petrillo, Elena Coluccio, Elisa Erba, Giuseppe Lamorte, Francesca Ferrari, Lisa Cariani, Chiara Amoroso, Anna C Preti, Alessandra Bandera, Annapaola Callegaro, Silvana Castaldi, Massimo Cardillo, Maurizio Vecchi, Luca Valenti, Vincenzo De Angelis","doi":"10.2450/BloodTransfus.929","DOIUrl":"10.2450/BloodTransfus.929","url":null,"abstract":"<p><p>Fecal Microbiota Transplantation (FMT) is an innovative therapy with growing applications, particularly for recurrent Clostridioides difficile infections (rCDI). However, the broader use of FMT is challenged by the complexities of donor recruitment, the necessity of stringent screening protocols, and the need for maintaining high-quality stool biobanks. This paper explores the integration of FMT programs within transfusion medicine departments, taking advantage of their expertise in donor management and biological material processing. Despite the complexities of donor screening, including a low eligibility rate, the collaboration between transfusion services and other hospital departments demonstrates a viable model for expanding FMT access. Additionally, the recent EU regulations on substances of human origin (SoHO) offer a framework for standardizing and scaling stool banking, enhancing the safety and efficacy of FMT procedures.</p>","PeriodicalId":49260,"journal":{"name":"Blood Transfusion","volume":" ","pages":"275-282"},"PeriodicalIF":2.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12108094/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}