Blood Transfusion最新文献

{"title":"Perinatal outcome in pregnant women: the impact of blood transfusion.","authors":"Elvira Grandone, Antonella Cromi, Marina Vincinguerra, Giovanni L Tiscia, Alexander Makatsariya, Jamilya Khizroeva, Viktoria Bitsadze, Antonio De Laurenzo, Donatella Colaizzo, Natale Sciannamè, Giuseppe Loverro, Ettore Cicinelli, Maurizio Margaglione, Angelo Ostuni, Luigi Nappi, Mario Mastroianno","doi":"10.2450/BloodTransfus.864","DOIUrl":"https://doi.org/10.2450/BloodTransfus.864","url":null,"abstract":"<p><strong>Background: </strong>Obstetric hemorrhage is a life-threatening complication of pregnancy. Systematic collection of data on transfusion practice during pregnancy and post-partum period are scarce, as well as data on fetal or neonatal outcomes of women transfused during pregnancy. We examined the prevalence of obstetric hemorrhage and outcome of pregnancies in hospitalized transfused women.</p><p><strong>Materials and methods: </strong>This is a retrospective cohort study collecting clinical and laboratory data of women transfused from 2015 to 2017 in three Italian Tertiary level Obstetrical Departments. Inclusion criteria were: 1) age >18 years; 2) antepartum or peripartum hospital admission and 3) transfusion during the hospital stay of at least one unit of packed red blood cell (RBC) units. Women below 18 years and/or with transfusion outside pregnancy were excluded. During the observation period, 18,495 women gave birth across the three Obstetrics Departments: transfusion rate was 1.7%.</p><p><strong>Results: </strong>315 women were included in the final analysis. Most (75.2%) needed transfusion from 35 weeks onwards. A percentage higher that that observed in general population of transfused women showed co-morbidities such as hypertensive disorders or diabetes (13.9 vs 5.5%). We recorded 90% of live births and 7.6% of Intra Uterine Fetal Demise or neonatal death. Perinatal outcomes were impacted by the dose of transfusion: logistic regression, correcting for age and assisted conception, showed that women transfused with 3 or more RBC units have about 3-fold higher risk of perinatal death (OR: 2.9, 95% CI: 1.0-8.4).</p><p><strong>Discussion: </strong>In this series, several known risk factors were associated with adverse feto-neonatal outcome. In addition, the number of RBC units transfused was significantly and independently associated with the perinatal outcome. Present data can be helpful to design prospective studies taking into account timing and dose of transfusion during pregnancy with the objective to improve feto-maternal outcome.</p>","PeriodicalId":49260,"journal":{"name":"Blood Transfusion","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143416056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of oral platelet lysate gel to treat oral mucosal manifestations associated with chronic graft versus host disease.","authors":"Arnau Torrent-Rodríguez, Thais Lizondo-López, Paola Charry, Maria Suárez-Lledó, Maria M Mestre-Ribot, Cristina Cremades-Artacho, Maria Queralt Salas, Carmen Martínez Muñoz, Montserrat Rovira, Francesc Fernández-Avilés, Carmen López-Cabezas, Laura Aranda-Cortés, Joan Cid, Miquel Lozano","doi":"10.2450/BloodTransfus.880","DOIUrl":"10.2450/BloodTransfus.880","url":null,"abstract":"<p><strong>Background: </strong>Chronic graft-vs-host disease (cGvHD) is a severe immune-mediated complication that affects patients following allogeneic hematopoietic stem cell transplantation (allo-HSCT). Oral manifestations of cGvHD, such as ulcers and mucosal inflammation, significantly impair quality of life and often require long-term treatment. Existing therapies provide limited relief, prompting the exploration of new approaches, including the use of autologous platelet lysate (PL) gel for its regenerative properties.</p><p><strong>Materials and methods: </strong>This observational study evaluated the effectiveness and safety of a topical autologous PL gel in treating oral ulcers associated with cGvHD in seven patients who had undergone allo-HSCT for hematological malignancies. The PL gel was prepared by mixing autologous PL with a gel base under aseptic conditions, and patients applied the gel three times daily. Clinical assessments, including the severity of oral damage and pain levels, were conducted using the NIH-CTCAE scale.</p><p><strong>Results: </strong>Of the seven patients treated, five completed the study with a median follow-up of 20 months. Significant reductions in oral damage severity and pain levels were observed, with a p-value of 0.0495 for symptom severity and 0.0196 for pain reduction. The average adherence rate was 81.4%, and no adverse effects were reported.</p><p><strong>Discussion: </strong>The study demonstrated that autologous PL gel is a promising and well-tolerated treatment for oral manifestations of cGvHD, offering significant symptom relief. Despite the small sample size, these findings align with previous studies and support further research into PL gel as a therapeutic option in cGvHD management.</p>","PeriodicalId":49260,"journal":{"name":"Blood Transfusion","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142980339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety of intraoperative blood salvage in cancer surgery: what is new?","authors":"Suma Choorapoikayil, Kai Zacharowski, Patrick Meybohm","doi":"10.2450/BloodTransfus.921","DOIUrl":"10.2450/BloodTransfus.921","url":null,"abstract":"","PeriodicalId":49260,"journal":{"name":"Blood Transfusion","volume":" ","pages":"90-92"},"PeriodicalIF":2.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11841942/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142774003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Direct oral anticoagulants measurement: when is it necessary?","authors":"Armando Tripodi, Marina Marchetti, Erica Scalambrino","doi":"10.2450/BloodTransfus.942","DOIUrl":"10.2450/BloodTransfus.942","url":null,"abstract":"","PeriodicalId":49260,"journal":{"name":"Blood Transfusion","volume":" ","pages":"55-58"},"PeriodicalIF":2.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11841951/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142980336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is there no such thing as a free lunch? With Patient Blood Management, maybe there is!","authors":"Manuel Muñoz, Jens Meier, Anna Falanga","doi":"10.2450/BloodTransfus.1024","DOIUrl":"10.2450/BloodTransfus.1024","url":null,"abstract":"","PeriodicalId":49260,"journal":{"name":"Blood Transfusion","volume":"23 1","pages":"1-4"},"PeriodicalIF":2.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11841954/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143469662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Which should be the target for preoperative hemoglobin optimization?","authors":"Daniel Ariza-Villanueva, Donat R Spahn, Andrés Cobos-Díaz","doi":"10.2450/BloodTransfus.945","DOIUrl":"10.2450/BloodTransfus.945","url":null,"abstract":"","PeriodicalId":49260,"journal":{"name":"Blood Transfusion","volume":" ","pages":"33-36"},"PeriodicalIF":2.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11841947/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142774059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reversal of oral anticoagulation in emergency conditions.","authors":"Anna Falanga, Chiara Ambaglio, Luca Barcella","doi":"10.2450/BloodTransfus.993","DOIUrl":"10.2450/BloodTransfus.993","url":null,"abstract":"","PeriodicalId":49260,"journal":{"name":"Blood Transfusion","volume":"23 1","pages":"64-69"},"PeriodicalIF":2.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11841934/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143469670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coagulation Factor XIII - Last to think about?","authors":"Tina Tomić Mahečić, Sanja Konosić, Matthias Noitz, Mirna Bobinac","doi":"10.2450/BloodTransfus.902","DOIUrl":"10.2450/BloodTransfus.902","url":null,"abstract":"","PeriodicalId":49260,"journal":{"name":"Blood Transfusion","volume":" ","pages":"70-74"},"PeriodicalIF":2.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11841952/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142980314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implementing first pillar of PBM in the Emergency Area: a missed opportunity?","authors":"Ivo Beverina, Carlos Jericó, Manuel Quintana-Díaz","doi":"10.2450/BloodTransfus.984","DOIUrl":"10.2450/BloodTransfus.984","url":null,"abstract":"","PeriodicalId":49260,"journal":{"name":"Blood Transfusion","volume":" ","pages":"50-54"},"PeriodicalIF":2.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11841948/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142980342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tranexamic acid in hip fracture repair surgery: safe and effective?","authors":"Sigismond Lasocki, Maëva Campfort, Maxime Léger, Emmanuel Rineau","doi":"10.2450/BloodTransfus.933","DOIUrl":"10.2450/BloodTransfus.933","url":null,"abstract":"","PeriodicalId":49260,"journal":{"name":"Blood Transfusion","volume":" ","pages":"83-86"},"PeriodicalIF":2.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11841949/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142980351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}