Cellular Oncology最新文献

{"title":"METTL7A inhibits progression of colorectal cancer through the SREBP1 / FDFT1 / SQLE / CYP51A1 / cholesterol metabolic pathway.","authors":"Sha Li, Xiangyin Chi, Xiaoxue Li, Wan Li, Hong Yang, Wanxin Cao, Yuxuan Zhao, Xu Zhang, Rui Meng, Guanhua Du, Dan Zhang, Jinhua Wang","doi":"10.1007/s13402-026-01209-2","DOIUrl":"10.1007/s13402-026-01209-2","url":null,"abstract":"<p><strong>Background: </strong>Colorectal cancer (CRC) incidence and mortality rates are steadily on the rise, which brings significant public health concern worldwide, especially in China. Methyltransferase-like 7 A (METTL7A), a member of the methyltransferase-like family, is associated with various cancers including CRC. Notably, CRC progression is closely linked to metabolic reprogramming. However, its precise role in CRC, particularly metabolic reprogramming of CRC, remains unclear.</p><p><strong>Methods: </strong>METTL7A was identified as a pivotal gene closely associated with CRC by bioinformatics analyses. Through a series of cellular functional assays and several animal experiments, such as in situ tumor and spontaneous tumor in C57BL/6 mice, the role of METTL7A in the development of colorectal cancer was evaluated. Transcriptomics and proteomics were used to analyze the effects of METTL7A on the expression of numerous genes, especially those involved in metabolic processes including cholesterol synthesis pathway within CRC cells. Western-blotting, co-immunoprecipitation and immunofluorescence were used to elucidate the relationship of METTL7A and the cholesterol metabolic pathway.</p><p><strong>Results: </strong>METTL7A exhibited low expression in CRC cell lines and CRC tissues and it was demonstrated to function as a tumor suppressor in CRC. Transcriptomic and proteomic analyses indicated that METTL7A affects genes related to the cholesterol metabolism pathway. METTL7A was further proven to directly bind to Sterol Regulatory Element-Binding Protein1 (SREBP1) and SREBP Cleavage-Activating Protein (SCAP), hindering the nuclear translocation of SREBP1 and thereby reducing intracellular cholesterol content.</p><p><strong>Conclusions: </strong>This study provides valuable insights into the role of METTL7A in CRC and its impact on metabolic reprogramming, particularly cholesterol synthesis, and identifies METTL7A as a potential therapeutic target of CRC.</p>","PeriodicalId":49223,"journal":{"name":"Cellular Oncology","volume":"49 3","pages":""},"PeriodicalIF":4.8,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13096364/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147730688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of DDX39A in modulating the tumor progression and radiosensitivity in esophageal squamous cell carcinoma.","authors":"Beina Hui, Weibin Hu, Xin Chen, Ying Wang, Jing Li, Yuchen Sun, Xuanzi Sun, Juan Ren","doi":"10.1007/s13402-026-01206-5","DOIUrl":"10.1007/s13402-026-01206-5","url":null,"abstract":"","PeriodicalId":49223,"journal":{"name":"Cellular Oncology","volume":"49 2","pages":""},"PeriodicalIF":4.8,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13083710/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147693068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Next-generation neoantigen mRNA vaccines: Immuno-engineering strategies for precision cancer immunotherapy.","authors":"Xiaoping Li, Parham Jabbarzadeh Kaboli, Ghazaal Roozitalab, Shanli Salahi, Hongbo Qian, Xinyi Zhang, Keda Chen, Saber Imani","doi":"10.1007/s13402-026-01199-1","DOIUrl":"10.1007/s13402-026-01199-1","url":null,"abstract":"","PeriodicalId":49223,"journal":{"name":"Cellular Oncology","volume":"49 2","pages":""},"PeriodicalIF":4.8,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13083697/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147693073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A CREM-ITGA2B-MAPK axis drives proliferation and invasiveness in gastric cancer: insights from single-cell analysis.","authors":"Hongmei Wu, Mengnan Ye, Lisheng Zheng, Yaoyao Zhang, Yan Mei, Yi Lu, Bing Li, Wei Xue, Di Peng, Feiyan Feng, Yue Qiu, Jingbo Sun, Xuegang Sun, Xiuwu Bian, Qingling Zhang","doi":"10.1007/s13402-026-01189-3","DOIUrl":"10.1007/s13402-026-01189-3","url":null,"abstract":"","PeriodicalId":49223,"journal":{"name":"Cellular Oncology","volume":"49 2","pages":""},"PeriodicalIF":4.8,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13057087/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147629215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ADAMDEC1-driven CCL2-CCR2-PD-1 axis in esophageal squamous cell carcinoma: a dual threat of O-GlcNAcylation and m⁶A methylation in neoadjuvant therapy resistance and immune evasion.","authors":"Jiwei Cheng, Haibo Ma, Xin Qian, Wenqun Xing","doi":"10.1007/s13402-026-01204-7","DOIUrl":"10.1007/s13402-026-01204-7","url":null,"abstract":"","PeriodicalId":49223,"journal":{"name":"Cellular Oncology","volume":"49 2","pages":""},"PeriodicalIF":4.8,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13057036/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147629218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lactate and lactylation: metabolic architects of tumor progression and metastasis.","authors":"Hanyue Ma, Zhuo Gu, Zhenxin Wang","doi":"10.1007/s13402-026-01182-w","DOIUrl":"10.1007/s13402-026-01182-w","url":null,"abstract":"","PeriodicalId":49223,"journal":{"name":"Cellular Oncology","volume":"49 2","pages":""},"PeriodicalIF":4.8,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13057061/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147629251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcriptional repression of TGFB2-AS1 by GATA6 drives triple-negative breast cancer metastasis.","authors":"Chang Liu, Qianru Yu, Difei Wang, Zheng Duan, Xin Zhang, Jiao Wang, Xiaoyu Qi, Jiayin Ye, Qian Zhao, Jianrong He, Cixiang Zhou","doi":"10.1007/s13402-026-01195-5","DOIUrl":"10.1007/s13402-026-01195-5","url":null,"abstract":"","PeriodicalId":49223,"journal":{"name":"Cellular Oncology","volume":"49 2","pages":""},"PeriodicalIF":4.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13043960/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147595889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TBC1D23 drives lymphatic metastasis in pancreatic ductal adenocarcinoma by altering EGFR cell surface dynamics and signaling.","authors":"Ying-Jui Chao, Hao-Chen Wang, Yu-Lun Chen, Chih-Jung Wang, Ya-Chin Hou, Yu-Ting Kuo, Jyh-Wei Shin, Yan-Shen Shan","doi":"10.1007/s13402-026-01203-8","DOIUrl":"10.1007/s13402-026-01203-8","url":null,"abstract":"<p><strong>Background: </strong>Pancreatic ductal adenocarcinoma (PDAC) is among the most devastating malignancies worldwide, characterized by late diagnosis, rapid progression, and dismal survival rates. The discovery of reliable biomarkers for early detection and disease monitoring remains an urgent clinical need. Owing to its proximity to tumor cells and protein-rich composition, pancreatic juice represents a compelling reservoir for biomarker discovery.</p><p><strong>Methods: </strong>We performed comprehensive proteomic profiling of pancreatic juice using mass spectrometry to uncover PDAC-associated biomarkers. The expression and prognostic relevance of candidate proteins were validated in patient-derived tumor tissues, sera, and tissue microarrays (TMAs). Functional roles were interrogated through RNA interference-mediated knockdown in PDAC cell lines and an orthotopic PANC-1 xenograft model.</p><p><strong>Results: </strong>Our analyses revealed TBC1D23 as a previously unrecognized oncogenic driver in PDAC. TBC1D23 was markedly upregulated in pancreatic juice, tumor specimens, and patient sera, with elevated expression correlating strongly with lymphatic metastasis and inferior overall survival. Functionally, silencing TBC1D23 curtailed PDAC cell proliferation, migration, and invasion in vitro, and significantly attenuated tumor growth and peritoneal dissemination in vivo. Transcriptomic and biochemical analyses demonstrated that TBC1D23 depletion led to profound downregulation of VEGF-C, diminishing its secretion, and consequently impairing tumor-driven lymphangiogenesis. This effect was rescued by VEGF-C supplementation and abolished by the VEGFR3 inhibitor MAZ51, underscoring VEGF-C as a principal downstream effector. Mechanistically, TBC1D23 orchestrated EGFR trafficking, enhancing receptor recycling and membrane localization while suppressing lysosomal degradation, thereby sustaining EGFR/ERK signaling and driving VEGF-C upregulation.</p><p><strong>Conclusions: </strong>These findings uncover TBC1D23 as a novel regulator of EGFR dynamics and a pivotal mediator of PDAC lymphatic metastasis. By delineating the TBC1D23/EGFR/VEGF-C signaling axis, this study not only identifies a promising biomarker for PDAC detection and prognosis but also highlights an actionable therapeutic target for intercepting metastatic progression.</p>","PeriodicalId":49223,"journal":{"name":"Cellular Oncology","volume":"49 2","pages":""},"PeriodicalIF":4.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13043878/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147595861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The histone acylation network: emerging therapeutic targets for remodeling the epigenetic landscape in pancreatic ductal adenocarcinoma.","authors":"Deju Anna Kong, Huang Wang, Mingzhen Wang, Siyu Chen, Dingge Cao, Xujun Liu, Liyan Cui, Wenzhe Si","doi":"10.1007/s13402-026-01191-9","DOIUrl":"10.1007/s13402-026-01191-9","url":null,"abstract":"","PeriodicalId":49223,"journal":{"name":"Cellular Oncology","volume":"49 2","pages":""},"PeriodicalIF":4.8,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13013902/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147516189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated analysis identifies a CXCR6/CD45/PD-1-based risk model for melanoma prognosis and intratumoral CD8+/CD69 + T-cell infiltration correlation.","authors":"Hai-Yun Wang, Hao-Yang Cai, Ling Deng, Yi Lu, Jiali Huang, Ting Hou, Ye Liu, Xin-Yang Huang, Ze-Meng Wang, Yue Li, Fang Wang","doi":"10.1007/s13402-026-01188-4","DOIUrl":"10.1007/s13402-026-01188-4","url":null,"abstract":"","PeriodicalId":49223,"journal":{"name":"Cellular Oncology","volume":"49 2","pages":""},"PeriodicalIF":4.8,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12996583/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147476031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}