Embracing cancer immunotherapy with manganese particles.

IF 4.9 2区医学 Q2 CELL BIOLOGY

Cellular Oncology Pub Date : 2025-05-21 DOI:10.1007/s13402-025-01070-9

Ali Moosavi Zenooz, Majid Eterafi, Soheil Azarmi Giglou, Elham Safarzadeh

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引用次数: 0

Abstract

A substance integral to the sustenance and functionality of virtually all forms of life is manganese (Mn), classified as an essential trace metal. Its significance lies in its pivotal role in facilitating metabolic processes crucial for survival. Additionally, Mn exerts influence over various biological functions including bone formation and maintenance, as well as regulation within systems governing immunity, nervous signaling, and digestion. Manganese nanoparticles (Mn-NP) stand out as a beacon of promise within the realm of immunotherapy, their focus honed on intricate mechanisms such as triggering immune pathways, igniting inflammasomes, inducing immunogenic cell death (ICD), and sculpting the nuances of the tumor microenvironment. These minuscule marvels have dazzled researchers with their potential in reshaping the landscape of cancer immunotherapy - serving as potent vaccine enhancers, efficient drug couriers, and formidable allies when paired with immune checkpoint inhibitors (ICIs) or cutting-edge photodynamic/photothermal therapies. Herein, we aim to provide a comprehensive review of recent advances in the application of Mn and Mn-NP in the immunotherapy of cancer. We hope that this review will display an insightful view of Mn-NPs and provide guidance for design and application of them in immune-based cancer therapies.

查看原文本刊更多论文

用锰颗粒进行癌症免疫治疗。

锰（Mn）是一种基本的微量金属，对几乎所有形式的生命的维持和功能都是不可或缺的。它的意义在于它在促进对生存至关重要的代谢过程中起着关键作用。此外，锰还影响多种生物功能，包括骨形成和维持，以及免疫、神经信号和消化系统的调节。锰纳米颗粒（Mn-NP）在免疫治疗领域中脱颖而出，成为一个有希望的灯塔，它们的重点是复杂的机制，如触发免疫途径，点燃炎症小体，诱导免疫原性细胞死亡（ICD），以及塑造肿瘤微环境的细微差别。这些微小的奇迹让研究人员眼花缭乱，因为它们具有重塑癌症免疫治疗前景的潜力-作为有效的疫苗增强剂，有效的药物信使，以及与免疫检查点抑制剂（ICIs）或尖端光动力/光热疗法配对时的强大盟友。在此，我们旨在提供锰和锰- np在癌症免疫治疗中的应用的最新进展的综合综述。我们希望这篇综述能够揭示Mn-NPs的深刻见解，并为Mn-NPs在免疫肿瘤治疗中的设计和应用提供指导。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cellular Oncology ONCOLOGY-CELL BIOLOGY

CiteScore

10.30

自引率

1.50%

发文量

审稿时长

12 months

期刊介绍： The Official Journal of the International Society for Cellular Oncology Focuses on translational research Addresses the conversion of cell biology to clinical applications Cellular Oncology publishes scientific contributions from various biomedical and clinical disciplines involved in basic and translational cancer research on the cell and tissue level, technical and bioinformatics developments in this area, and clinical applications. This includes a variety of fields like genome technology, micro-arrays and other high-throughput techniques, genomic instability, SNP, DNA methylation, signaling pathways, DNA organization, (sub)microscopic imaging, proteomics, bioinformatics, functional effects of genomics, drug design and development, molecular diagnostics and targeted cancer therapies, genotype-phenotype interactions. A major goal is to translate the latest developments in these fields from the research laboratory into routine patient management. To this end Cellular Oncology forms a platform of scientific information exchange between molecular biologists and geneticists, technical developers, pathologists, (medical) oncologists and other clinicians involved in the management of cancer patients. In vitro studies are preferentially supported by validations in tumor tissue with clinicopathological associations.