{"title":"Nasal Vestibular Expansion in UCLP: A 5- and 10-Year Cephalometric Study.","authors":"Ayano Shiigi, Kiyohide Ishihata, Aya Maeda-Iino, Shoko Nakagawa, Mohamad Farid Ratman, Toshiro Kibe, Masahiro Tezuka, Shouichi Miyawaki, Norifumi Nakamura","doi":"10.1177/10556656261434601","DOIUrl":"10.1177/10556656261434601","url":null,"abstract":"<p><p>ObjectiveTo assess the impact of nasal vestibular expansion (NVE) during primary lip repair on the developmental profiles of hard and soft tissues in individuals with unilateral cleft lip and palate (UCLP).DesignA retrospective analysis of prospectively collected nonrandomized data.SettingTertiary medical center.Patients/ParticipantsWe enrolled patients with complete UCLP who underwent lip repair using the triangular-flap technique with NVE (NVE group) and those who did not (non-NVE group).Main Outcome MeasuresHard and soft tissue profiles were analyzed using lateral cephalometric measurements obtained longitudinally at 5 and 10 years of age.ResultsThirty-five patients were included in each study group. At 5 years of age, the NVE group exhibited significantly smaller SNA and SNB angles compared to the non-NVE group. The non-NVE group had a negative overjet, whereas the NVE group had a significantly larger overjet. At 10 years of age, there were no significant differences in hard tissue measurements between the groups.ConclusionsNVE does not promote the forward growth of the maxilla. However, in 5-year-old children, the degree of reverse overjet of the anterior teeth was smaller in cases where NVE was performed compared to non-NVE cases, suggesting that NVE affects the maxillary anterior teeth.</p>","PeriodicalId":49220,"journal":{"name":"Cleft Palate-Craniofacial Journal","volume":" ","pages":"3953-3962"},"PeriodicalIF":1.3,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147678088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sofia Bachini, Mariska Jorine Hartendorp, Edith Visser, Chantal Mouës-Vink
{"title":"Development and Validation of a Parent-Reported Clinical Screening Instrument for Team Care of Young Children with a Cleft: The CleftChild-8.","authors":"Sofia Bachini, Mariska Jorine Hartendorp, Edith Visser, Chantal Mouës-Vink","doi":"10.1177/10556656261440583","DOIUrl":"10.1177/10556656261440583","url":null,"abstract":"<p><p>ObjectiveThis study aimed to develop and validate a cleft-specific proxy clinical screening instrument for children up to 8 years old with orofacial clefts: the CleftChild-8. Our objective was to implement this questionnaire as a preparatory tool for cleft team consultations, enabling early identification of patient needs, facilitating communication with caregivers, and improving the quality and efficiency of care.DesignThis was a multicenter prospective cohort study to develop an instrument to be interpreted at the item level in an iterative process with relevant domains selection, item pool generation, caregivers and expert feedback, and psychometric testing.SettingThe study took place in 5 orofacial clefts referral centers in the Netherlands.ParticipantsParticipants were parents or caregivers of children born with syndromic and nonsyndromic cleft lip and/or palate and younger than 8 years old.ResultsBetween 2023 and 2025, the CleftChild-8 working version was completed by 414 parents/caregivers. Psychometric analyses supported a four-factor structure with good to excellent internal consistency (<i>α</i> = 0.75-0.92) and demonstrated known-groups validity across cleft types. The final 42-item questionnaire covers feeding and dentition, otology and sleep, speech, and psychosocial functioning.ConclusionThe Cleftchild-8 is a valid instrument to support cleft consultations by prioritizing the needs of patients and their families through reviewing responses to individual items and open-ended questions. The Cleftchild-8 can assist cleft teams to efficiently identify key concerns and tailor consultations accordingly.</p>","PeriodicalId":49220,"journal":{"name":"Cleft Palate-Craniofacial Journal","volume":" ","pages":"3891-3899"},"PeriodicalIF":1.3,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147693093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Usama S Hamdan, Lucille Ridgell, Jose A Garcia-Garcia, Dhruv Ahuja, Kaitlin M Smith, Lizbeth Roman, Beyhan Annan, Giuliana Roggiero, Wassim Najjar, James Liau, Puneet Batra
{"title":"Effect of Single-Stage Posterior Vomerine Ostectomy/Premaxillary Setback on Facial Growth in Bilateral Cleft Lip and Protuberant Premaxilla.","authors":"Usama S Hamdan, Lucille Ridgell, Jose A Garcia-Garcia, Dhruv Ahuja, Kaitlin M Smith, Lizbeth Roman, Beyhan Annan, Giuliana Roggiero, Wassim Najjar, James Liau, Puneet Batra","doi":"10.1177/10556656261436222","DOIUrl":"10.1177/10556656261436222","url":null,"abstract":"<p><p>ObjectiveTo evaluate the impact of single-stage posterior vomerine ostectomy with premaxillary setback (PVPS) on craniofacial development in children with bilateral cleft lip and palate (BCLP) and a protuberant premaxilla.DesignRetrospective pilot study.SettingResource-limited outreach setting.Patients, ParticipantsFifty-two children were included: 22 with BCLP who underwent PVPS before 8 years of age and 30 age-matched non-cleft controls.InterventionsSingle-stage PVPS with bilateral gingivoperiosteoplasties, bilateral cleft lip repair, and primary rhinoplasty.Main Outcome Measure(s)Twenty-two cephalometric parameters assessed post-operatively; intergroup comparisons made using the Mann-Whitney <i>U</i>-test with post-hoc power analysis.ResultsOf 22 cephalometric variables, 16 showed no statistically significant differences between PVPS-treated and control groups, indicating minimal overall impact of PVPS on craniofacial growth. Significant differences were noted in SNA (<i>P</i> = .05), ANB (<i>P</i> = .02), N-A-Pog (<i>P</i> < .01), A-Ptm (<i>P</i> < .01), (ANS-Ptm/M-Me)% (<i>P</i> = .03), and HSTA (<i>P</i> < .01). These differences reflected localized or subtle growth effects rather than global craniofacial alterations.ConclusionsPVPS appears to preserve craniofacial growth in the preadolescent period in BCLP patients with a protruding premaxilla, with limited and localized impact on specific parameters. While not recommended when preoperative orthodontics is available, PVPS provides a valuable alternative in resource-limited settings by achieving adequate results, reducing psychosocial stigma, improving societal integration, and consolidating surgical interventions.</p>","PeriodicalId":49220,"journal":{"name":"Cleft Palate-Craniofacial Journal","volume":" ","pages":"3874-3884"},"PeriodicalIF":1.3,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147576344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Roberta Button, Fiona McFarlane, Alice Farrington, Matthew Hotton
{"title":"The Relationship Between Parent and Child Anxiety: Testing the Intergenerational Model of Anxiety in Children Born with a Cleft.","authors":"Roberta Button, Fiona McFarlane, Alice Farrington, Matthew Hotton","doi":"10.1177/10556656261422883","DOIUrl":"10.1177/10556656261422883","url":null,"abstract":"<p><p>ObjectiveTo compare overprotective parenting and child and parent anxiety between children born with and without a cleft lip and/ or palate (CL/P). To understand correlates of anxiety for children born with a CL/P and their parents.Design, Participants, SettingParents of 8- to 12-year-old children with a CL/P (<i>n</i> = 63, mean age = 10.5 years, male = 68.3%), or without a CL/P (control group; <i>n</i> = 66, mean age = 9.9 years, male = 47%) were recruited from the UK community (2022-2024). Most respondents were mothers (92.2%).Outcome measuresParents completed an online survey assessing overprotective parenting, child anxiety, parent anxiety, and (in the CL/P group) parental appraisals.ResultsParent-reported child anxiety was higher in the CL/P group than the control group (η<sub>p</sub><sup>2</sup> = 0.04, <i>P</i> = .03), while parent anxiety (η<sub>p</sub><sup>2</sup> = 0.01, <i>P</i> = .26) and overprotective parenting (η<sub>p</sub><sup>2</sup> = 0.001, <i>P</i> = .73) did not differ significantly between groups. Within the CL/P group, parent-reported child anxiety was associated (<i>P</i> < .05) with parental anxiety (<i>r<sub>s</sub></i> = .27), overprotective parenting (<i>r<sub>s</sub></i> <i>=</i> .38), and certain parental appraisals (child's self-confidence; <i>r<sub>s</sub></i> <i>=</i> .45, and manageability of the CL/P; <i>r<sub>s</sub></i> <i>=</i> -.25). Parent anxiety was associated with overprotective parenting (<i>r<sub>s</sub></i> = .40), and self-blame appraisals (<i>r<sub>s</sub></i> <i>=</i> .37).ConclusionsChildren born with a CL/P may be at increased risk of anxiety by parent-report, while parental anxiety and overprotection appear comparable to controls. Parental appraisals may be promising targets for intervention. Future longitudinal research is required to draw causal inferences.</p>","PeriodicalId":49220,"journal":{"name":"Cleft Palate-Craniofacial Journal","volume":" ","pages":"3707-3716"},"PeriodicalIF":1.3,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13646421/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147500225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Matthew McCracken, Kristin Delfino, Alaine Nixon, Ashley Manlove, Matthew Johnson
{"title":"Survey of Practice Patterns of Maxillary Distraction Osteogenesis Among Craniofacial Surgeons in Patients With Cleft Lip and Palate.","authors":"Matthew McCracken, Kristin Delfino, Alaine Nixon, Ashley Manlove, Matthew Johnson","doi":"10.1177/10556656261423815","DOIUrl":"10.1177/10556656261423815","url":null,"abstract":"<p><p>ObjectiveWe assess current practices in treatment of maxillary hypoplasia in patients with cleft lip and palate regarding LeFort I osteotomy (LFO) and maxillary distraction osteogenesis (DO).DesignA 27-question survey was distributed to surgeons in the United States via email addresses obtained through the American Cleft Palate Craniofacial Association (ACPA) website, the ACPA online forum, and a surgeons group on WhatsApp.SettingResponses were recorded in the REDCap platform.Patients and ParticipantsSurgeons treating these patients in the United States were included. Surgeons outside the United States, residents, students, and those not caring for these patients were excluded.InterventionsThere were no interventions due to the nature of this study.Main Outcome MeasuresQuestions assessed specialty and experience of respondents, treatment considerations guiding practices (risks of treatment, technique, timing, pre- and post-operative assessment).ResultsFifty-three surgeons responded to the survey. Sixty-six percent would consider DO for severe maxillomandibular discrepancy, 51% for LFO. Relapse (30%), inability to adequately mobilize (47%) are concerns for LFO; vector control (34%), compliance (18.9%) for DO. At ages 16 to 20 81.1% would consider both, whereas age ages 11 to 15 49.1% would consider DO. Lag phase of <7 days (98.1%), activation at 0.6 to 1 mm/day (71.7%), consolidation of at least 10 weeks (66%) are preferred.ConclusionsSurgeons prefer DO for large maxillomandibular discrepancy and scarring from previous surgeries, note less concern for maxillary relapse with DO, but have concern for controlling vector. Surgeons prefer lag phase of <7 days, activation at 0.6 to 1 mm/day, and consolidation of ≥10 weeks.</p>","PeriodicalId":49220,"journal":{"name":"Cleft Palate-Craniofacial Journal","volume":" ","pages":"3669-3676"},"PeriodicalIF":1.3,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146259896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effects of Rapid Maxillary Expansion on Upper Airway Parameters in Children With Unilateral Cleft Lip and Palate: A Cone-Beam Computed Tomography (CBCT) Study.","authors":"Sahal A Alforaidi","doi":"10.1177/10556656261420487","DOIUrl":"10.1177/10556656261420487","url":null,"abstract":"<p><p>ObjectivesTo evaluate the effect of rapid maxillary expansion (RME) on nasopharyngeal dimensions in children with unilateral cleft lip and palate (UCLP).DesignA prospective case-series longitudinal study.SettingOrthodontic Department, School of Dental Sciences.ParticipantsForty-eight children (30 males and 18 females) aged 8 to 10 years old with UCLP who had maxillary transverse constriction and need maxillary expansion.InterventionRME followed by retention phase.Main outcomeChanges in 3-dimensional nasopharyngeal parameters after RME using cephalometric radiographs and cone-beam computed tomography (CBCT).ResultsThe CBCT analysis revealed that the nasal cavity increased by 1907 mm<sup>3</sup> (<i>P</i> < .001), the nasopharynx (NP) increased by 707 mm<sup>3</sup> (<i>P</i> = .027), the minimum cross-sectional area increased by 29.98 mm<sup>2</sup> (<i>P</i> < .001), and the distance between the right and left maxillary sinuses increased by 7.98 mm (<i>P</i> < .001), although the change in the sinus volume was insignificant (<i>P</i> > .05). Cephalometric measurements revealed a statistically significant inferior dislocation of the maxilla after treatment (S-S1, <i>P</i> = .024; N-ANS, <i>P</i> = .017), increase in the inferior anterior and posterior facial height (S-Go, <i>P</i> = .017; ANS-Me, <i>P</i> = .041; N-Me, <i>P</i> = .020).ConclusionRME treatment increased some nasopharyngeal dimensions in children with UCLP and maxillary constriction.</p>","PeriodicalId":49220,"journal":{"name":"Cleft Palate-Craniofacial Journal","volume":" ","pages":"3638-3645"},"PeriodicalIF":1.3,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146133421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Andrade Tanvi Sera Noel, Dilshad Umar, Shafees Koya, Akhter Husain
{"title":"Comprehensive Smile Component Analysis in Unilateral Cleft Lip and Palate Using Akhter-Anne Framework.","authors":"Andrade Tanvi Sera Noel, Dilshad Umar, Shafees Koya, Akhter Husain","doi":"10.1177/10556656261426215","DOIUrl":"10.1177/10556656261426215","url":null,"abstract":"<p><p>ObjectiveThis study aimed to comprehensively compare smile aesthetics between surgically corrected unilateral cleft lip and palate (CUCLP) patients and non-cleft controls, evaluating multiple facial domains to identify persistent deficits.DesignA cross-sectional, comparative study was conducted.SettingThe study was performed in a clinical research setting.Patients/ParticipantsThe cohort consisted of 30 CUCLP patients who had undergone surgical repair and 30 age- and sex-matched non-cleft controls, all aged between 16 and 30 years.InterventionsThe intervention for the patient group was prior surgical correction of CUCLP; no new intervention was administered as part of this observational study.Main Outcome Measure(s)Standardized frontal photographs were analyzed using MAKHTER software and the Akhter-Anne Smile Diagram. Key parameters measured across facial, nasal, labial, nasolabial, and dento-gingival domains included nasal width, commissure width, philtrum height, lip length, and incisor display.ResultsThe facial component showed no significant differences. However, CUCLP patients exhibited significant deficits in other domains: reduced philtrum height (0.58 ± 0.21 mm vs. 0.84 ± 0.31 mm; p = 0.004), shorter upper lip length (0.42 ± 0.14 mm vs. 0.62 ± 0.22 mm; p = 0.001), and narrower commissure width (4.23 ± 0.52 mm vs. 6.95 ± 0.90 mm; p < 0.001). Nasal width was reduced (3.25 ± 0.40 mm vs. 4.56 ± 0.54 mm; p < 0.001) with pronounced nasolabial asymmetry. Dento-gingivally, maxillary incisor show was less (1.80 ± 0.54 mm vs. 3.45 ± 0.63 mm; p < 0.01) while mandibular incisor display was greater (2.75 ± 0.48 mm vs. 1.25 ± 0.36 mm; p < 0.05).ConclusionsDespite surgical repair, CUCLP patients have persistent esthetic impairments, particularly in the nasolabial and dento-gingival regions. A structured, multi-domain smile analysis is crucial for guiding multidisciplinary treatment to optimize final aesthetic and psychosocial outcomes.</p>","PeriodicalId":49220,"journal":{"name":"Cleft Palate-Craniofacial Journal","volume":" ","pages":"3759-3767"},"PeriodicalIF":1.3,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147285977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Morphological Changes Occur in the Brains of Children With Non-Syndromic Cleft Lip and Palate After Speech Therapy.","authors":"Yuxiang Zhai, Xi Zheng, Shenhu Liang, Renji Chen","doi":"10.1177/10556656261427388","DOIUrl":"10.1177/10556656261427388","url":null,"abstract":"<p><p>ObjectiveThe purpose of this study was to investigate the effect of speech therapy on cerebral morphology in patients with non-syndromic cleft palate with or without cleft lip (NSCP ± L) related articulation disorders using structural magnetic resonance imaging technology.DesignA prospective pre-post intervention study.SettingThis study was conducted in the Department of Oral and Maxillofacial Surgery and the Medical Imaging Center of a tertiary hospital.Patients/ParticipantsA total of 24 children with NSCP ± L, aged 6-16 years, who had undergone cleft palate surgery but still presented with articulation disorders.InterventionsThese patients received standardized speech therapy and were divided into the before therapy scans group (bTherapy Scans) and after therapy scans group (aTherapy Scans). By using high-resolution T1-weighted cerebral magnetic resonance imaging scans.Main Outcome Measure(s)Cerebral gray matter volume (GMV), cortical thickness (CT), fractal dimension (FD), and sulcus depth (SD).ResultsCompared with the bTherapy Scans, the aTherapy Scans showed a significant increase in GMV in the left middle frontal gyrus and left medial orbital frontal lobe; a significant increase in CT and FD in the left rostral middle frontal gyrus; and a significant increase in SD in the right lateral orbital frontal lobe region.ConclusionsSpeech therapy not only effectively improves the articulatory function of children with NSCP ± L-related speech disorders, but its effects may also be associated with structural remodeling of brain regions related to speech motor planning and emotional regulation.</p>","PeriodicalId":49220,"journal":{"name":"Cleft Palate-Craniofacial Journal","volume":" ","pages":"3749-3758"},"PeriodicalIF":1.3,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147318733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Samantha Diane Morin, Colton Fernstrum, Laxmi Dhungel, Laura S Humphries, Ian C Hoppe
{"title":"Enhanced Recovery After Surgery Protocols Can Vastly Decrease Rates of Outpatient Opiate Prescribing in Pediatric Plastic Surgery Patients.","authors":"Samantha Diane Morin, Colton Fernstrum, Laxmi Dhungel, Laura S Humphries, Ian C Hoppe","doi":"10.1177/10556656261432956","DOIUrl":"10.1177/10556656261432956","url":null,"abstract":"<p><p>ObjectiveThis study analyzes pediatric plastic surgery outpatient opioid prescribing rates at a single institution that implemented Enhanced Recovery After Surgery (ERAS) protocols with the national average.DesignA retrospective analysis was performed using the 2023 ACS NSQIP Pediatric Opioid Stewardship Report.Setting:The study was conducted at a single academic pediatric hospital participating in the ACS NSQIP Pediatric registry.Patients/ParticipantsPediatric patients who underwent common plastic surgery procedures between January 1 and December 31, 2023, as reported by NSQIP, were included. This comprised 146 patients from the study institution and 10 557 patients from 157 other NSQIP-participating hospitals.InterventionsERAS protocols emphasizing non-opioid multimodal analgesia were implemented in 2018. No outpatient opioids were prescribed for cleft lip repair, cranial spring placement/removal, or mandibular distraction osteogenesis. For more invasive procedures, patients received 3 doses of oral oxycodone.Main Outcome Measure(s)The primary outcome is the rate of outpatient opioid prescribing at the study institution compared to the national average, stratified by age group (adolescents, children, infants/small children, and neonates).ResultsThe study institution had a significantly lower prescribing rate (10.96%) versus the national average (51.81%) (<i>P</i> < .000001). By age group: adolescents (23.81% vs 63.20%), children (5.88% vs 52.82%), and infants/small children (6.45% vs 45.85%), all <i>P</i> < .000001. No neonates at the study site received opioids, compared to 13.83% nationally (<i>P</i> = .566).ConclusionsERAS protocol implementation is associated with a significant reduction in outpatient opioid prescribing. Broader adoption may improve opioid stewardship in pediatric plastic surgery.</p>","PeriodicalId":49220,"journal":{"name":"Cleft Palate-Craniofacial Journal","volume":" ","pages":"3852-3856"},"PeriodicalIF":1.3,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147500247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xuefei Pang, Xinran Zhao, Zuyin Yu, Huilin Wang, Ming Cai
{"title":"Randomized Controlled Trial Comparing Resorption Rates of Mandibular Cortical and Iliac Cancellous Bone Grafts in Alveolar Cleft Repair.","authors":"Xuefei Pang, Xinran Zhao, Zuyin Yu, Huilin Wang, Ming Cai","doi":"10.1177/10556656261432505","DOIUrl":"10.1177/10556656261432505","url":null,"abstract":"<p><p>ObjectiveThe main objective of the randomized controlled trial (RCT) was to evaluate the short-term osteogenic effects of mandibular cortex bone (MCB) versus iliac cancellous bone (ICB) after secondary alveolar bone graft.DesignRCT.SettingDepartment of Oral and Cranio-Maxillofacial Surgery in the Shanghai Ninth People's Hospital from September 1, 2020, to August 31, 2023.PatientsPatients with unilateral alveolar cleft.InterventionsThose who met the inclusion criteria were randomly assigned to receive either MCB or ICB grafting. Clinical and radiographic examinations were performed preoperatively and immediately, as well as at 1, 3, 6, 12, 18, and 24 months postoperatively.Main Outcome Measure(s)The bone resorption rate was measured 6 months postoperatively. Clinical observations included adverse events and hospitalization details including length of surgery, intraoperative bleeding, length of stay, and costs.ResultsA total of 28 patients were included, with 16 allocated to the MCB group and 12 to the ICB group. The bone resorption rate in the MCB group (45.20 ± 29.81%) was significantly lower than that in the ICB group (74.87 ± 18.48%) (P = 0.005). Two adverse events were reported in the MCB group. The MCB group had significantly greater costs (P < 0.001), a significantly shorter length of stay (P < 0.001), and a significantly longer duration of surgery (P = 0.026). However, there were no significant differences in terms of intraoperative bleeding.ConclusionCompared with ICB, MCB demonstrated a slower bone resorption rate in the short term for treating secondary alveolar cleft in this study, albeit with increased surgical time and costs.Trial RegistrationRegistry number: ChiCTR2000034227 [URL: https://www.chictr.org.cn/showprojEN.html?proj=55737].</p>","PeriodicalId":49220,"journal":{"name":"Cleft Palate-Craniofacial Journal","volume":" ","pages":"3737-3748"},"PeriodicalIF":1.3,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147516204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}