Autogenous Bilateral Cleft Alveolar Bone Grafting with rhBMP-2 and Cellular Bone Matrix.

IF 1.3 4区 医学 Q2 Dentistry
Cleft Palate-Craniofacial Journal Pub Date : 2025-10-01 Epub Date: 2024-08-06 DOI:10.1177/10556656241271672
Lucas M Harrison, Rami R Hallac, James Seaward, Alex A Kane, Yong-Jong Park
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引用次数: 0

Abstract

Alveolar bone grafting (ABG) in bilateral cleft lip and palate (BCLP) patients provides a reconstructive challenge. We present a novel technique of combining autologous iliac crest bone graft (ICBG) with recombinant human bone morphogenic protein 2 (rhBMP-2) and cellular bone matrix (CBM) for ABG in BCLP patients. Complete bone fill occurred in 90% of patients, with 100% having bilateral canine eruption. No patients required repeat ABG, and no significant complications were reported. The alveolar cleft gap volume significantly decreased with an improvement of 75.87%. ABG with autologous ICBG with rhBMP-2 and CBM is an effective technique for patients with BCLP.

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使用 rhBMP-2 和细胞骨基质进行自体双侧齿槽裂骨移植。
双侧唇腭裂(BCLP)患者的牙槽骨移植(ABG)是一项整形挑战。我们介绍了一种将自体髂嵴骨移植(ICBG)与重组人骨形态发生蛋白 2(rhBMP-2)和细胞骨基质(CBM)相结合的新技术,用于 BCLP 患者的牙槽骨移植。90%的患者实现了完全骨填充,100%的患者实现了双侧犬齿萌出。没有患者需要再次进行 ABG,也没有重大并发症的报告。牙槽裂间隙体积明显缩小,改善率达 75.87%。使用自体 ICBG 与 rhBMP-2 和 CBM 进行 ABG 是治疗 BCLP 患者的有效技术。
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来源期刊
Cleft Palate-Craniofacial Journal
Cleft Palate-Craniofacial Journal DENTISTRY, ORAL SURGERY & MEDICINE-SURGERY
CiteScore
2.20
自引率
36.40%
发文量
0
审稿时长
4-8 weeks
期刊介绍: The Cleft Palate-Craniofacial Journal (CPCJ) is the premiere peer-reviewed, interdisciplinary, international journal dedicated to current research on etiology, prevention, diagnosis, and treatment in all areas pertaining to craniofacial anomalies. CPCJ reports on basic science and clinical research aimed at better elucidating the pathogenesis, pathology, and optimal methods of treatment of cleft and craniofacial anomalies. The journal strives to foster communication and cooperation among professionals from all specialties.
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