{"title":"A Study to Compare the Relationship Between Tissue Eosinophilia and Radiological Findings in Nasal Polyposis.","authors":"Devendra Kumar Gupta, Parasuraman Mayandi, Amit Sood, Santosh Kumar, Biswajit Das, Rahul Naga","doi":"10.1007/s12070-024-05234-1","DOIUrl":"https://doi.org/10.1007/s12070-024-05234-1","url":null,"abstract":"<p><p>Nasal polyps are benign inflammatory growth of sinonasal mucosa, often associated with chronic rhinosinusitis. This condition prevalent among adults, significantly impacts the quality of life. Eosinophil plays a crucial role in the pathogenesis of nasal polyposis. Hence, this study was carried out to compare the relationship between tissue eosinophilia and radiological findings in nasal polyposis. This observational study was conducted at a tertiary care centre, involving 30 patients with nasal polyposis underwent endoscopic sinus surgery. All patients underwent pre operative CT scan and Lund MacKay score were calculated. Excised polyp tissues were examined, and eosinophil count was calculated per high power field (400 X). Eosinophil count was categorized as low (≤ 10 E/HPF) and high (> 10 E/HPF). The study population had a mean age of 41.65 ± 11.43 years, with a male predominance (80%). Hypertension was the most common comorbidity (26.67%). The mean Lund MacKay score was 18.03 ± 4.3 with the majority of patients (60%) had Lund-Mackay scores between 17-24, indicating significant sinus involvement. Patients with higher eosinophil counts (> 10 E/HPF) showed more severe disease, reflected by higher Lund-Mackay scores (<i>p</i> < 0.0001). A moderate positive correlation (<i>r</i> = 0.005) was observed between tissue eosinophil count and Lund-Mackay scores. This study found moderate positive correlation between the Lund Mackay score and tissue eosinophil count. The correlation between tissue eosinophil count and disease severity underscores its potential as a prognostic marker in nasal polyposis.</p>","PeriodicalId":49190,"journal":{"name":"Indian Journal of Otolaryngology and Head and Neck Surgery","volume":"77 3","pages":"1220-1224"},"PeriodicalIF":0.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11908989/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Optimal Frequency for cVEMP in Users of Personal Listening Devices.","authors":"Teja Deepak Dessai, Annapurna G Parameswaran, Rashmi J Bhat, Kaushlendra Kumar","doi":"10.1007/s12070-025-05356-0","DOIUrl":"https://doi.org/10.1007/s12070-025-05356-0","url":null,"abstract":"<p><p>The use of PLDs is linked to negative effects on the inner ear. Thus, the aim of this study is to identify the optimal frequency to test cVEMP in individuals using PLDs. A cross sectional comparative study was conducted on 128 individuals who were between the ages of 15-24 years with PLD exposure were divided into two groups: control group (history of PLD exposure for at least 1 h per day at a volume less than 60% of the PLD) and an experimental group (history of PLD exposure for at least 1 h per day at a volume greater than 60% for more than 1 year). Participants underwent MIRE and cVEMP testing using tone bursts of three different frequencies (500, 750, and 1000 Hz). Further, Latency, Peak-Peak Amplitude and Asymmetric Ratio of cVEMP responses were compared between the two groups. The data were analyzed using statistical tests such as Mann-Whitney U test and Kruskal-Walli's test. The findings revealed no statistically significant difference across frequencies in both groups. However, experimental group used higher output dBA values (75.4 ± 7.77 dBA). Similarly, reduced amplitudes, increased latencies and Asymmetric Ratio values were observed in experimental group suggesting a negative influence of PLDs on the vestibular system. A 500 Hz tone burst stimuli is observed to be the optimal frequency for cVEMP. However, higher values for all compared parameters of cVEMP in experimental group may depict the negative influence of PLD on the vestibular system.</p>","PeriodicalId":49190,"journal":{"name":"Indian Journal of Otolaryngology and Head and Neck Surgery","volume":"77 3","pages":"1429-1438"},"PeriodicalIF":0.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11909322/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Sphenopalatine Artery Pseudoaneurysm Managed with Endovascular Embolization: A Case Report.","authors":"Ritesh Kumar Tapadiya, Adity Prakash, Chinmaya Deepak Patro, Basanta Manjari Swain","doi":"10.1007/s12070-025-05329-3","DOIUrl":"https://doi.org/10.1007/s12070-025-05329-3","url":null,"abstract":"<p><p>Epistaxis caused by Sphenopalatine artery (SpA) pseudoaneurysms are rare and have been reported after trauma, infection, radiation, surgery and tumor invasion. Surgical ligation of SpA pseudoaneurysms have traditionally been done to control epistaxis. However, endovascular embolisation offers a minimally invasive technique to treat them. We report a case of a 28 year old male with post-traumatic SpA pseudoaneurysm. The patient was managed by endovascular embolization. Epistaxis ceased after embolization and the patient was discharged in stable condition.</p>","PeriodicalId":49190,"journal":{"name":"Indian Journal of Otolaryngology and Head and Neck Surgery","volume":"77 3","pages":"1615-1617"},"PeriodicalIF":0.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11908987/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vandhana Murugesan, Geetha Kishan Siddapur, R Venkataramanan, S Ganesh, Ram Kumar, Balaji Venkatesan
{"title":"Prevalence of Depression in Patients with Subjective Chronic Tinnitus in Rural Population of Puducherry: An Observational Cross-Sectional Study.","authors":"Vandhana Murugesan, Geetha Kishan Siddapur, R Venkataramanan, S Ganesh, Ram Kumar, Balaji Venkatesan","doi":"10.1007/s12070-025-05322-w","DOIUrl":"https://doi.org/10.1007/s12070-025-05322-w","url":null,"abstract":"<p><p>Tinnitus, the perception of sound without an external source, is a prevalent auditory disorder that can have a significant psychological impact, particularly in the form of depression. While the association between tinnitus and depression is well-documented in Western populations, limited research exists within the Indian context, especially in rural settings. This study aims to determine the prevalence of depression in patients with subjective chronic tinnitus in a rural population of Puducherry. A hospital-based cross-sectional study was conducted over four months, from February 2023 to May 2023, among 100 patients visiting the ENT outpatient department at Sri Lakshmi Narayana Institute of Medical Sciences. Participants, aged 18 and above with a history of tinnitus for at least one year, were selected using a convenience sampling technique. Those with a prior psychiatric history were excluded. Data collection included demographic information, tinnitus duration, hearing loss, and assessment using the Beck's Depression Inventory scale. Statistical analysis was performed using IBM SPSS V22.0, with chi-square tests to assess the association between tinnitus, hearing loss, and depression. The mean age of the participants was 44.40 ± 5.03 years, with 59 males and 41 females. Tinnitus duration was less than five years in 65% of patients and more than five years in 35%. Tinnitus with normal hearing was present in 73% of participants, while 27% had hearing impairment. Depression was prevalent in 31% of patients, with 8% exhibiting mild, 14% moderate, and 9% severe depression. A significant association was found between depression and tinnitus sufferers with and without hearing impairment (<i>p</i> = 0.024). The study highlights a 31% prevalence of depression among tinnitus patients in rural Puducherry. Given the significant association between tinnitus and depression, routine psychological assessment should be integrated into tinnitus management, especially in rural areas. Early detection and intervention, including mental health counseling and community support initiatives, are crucial for improving patient outcomes.</p>","PeriodicalId":49190,"journal":{"name":"Indian Journal of Otolaryngology and Head and Neck Surgery","volume":"77 3","pages":"1289-1293"},"PeriodicalIF":0.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11909289/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"To Evaluate the Impact of Uncontrolled HbA1C Levels on Hearing in Patients of Type 1 Diabetes Mellitus.","authors":"Garima Katewa, Tarun Ojha, Priyanshi Gupta, Atul Kumar Nimawat, Jyoti Kumawat, Sayed Sazeed Khan, Kritika Arora","doi":"10.1007/s12070-025-05326-6","DOIUrl":"https://doi.org/10.1007/s12070-025-05326-6","url":null,"abstract":"<p><p>To study the prevalence of SNHL in type 1 diabetes mellitus with uncontrolled HbA1c. Prospective study. 72 patients in the age group < 18 yrs were taken for study, who were diagnosed with type 1 diabetes mellitus in department of medicine, paediatrics and endocrinology and willing to undergo ENT examination. The patients with type 2 diabetes mellitus, a history of ear disease, head or ear trauma, history of use of ototoxic drugs, with family history of congenital deafness or previously operated ear and exposure to excessive noise were excluded. A complete ENT examination was done. Written consent was taken from the parents. A note was made of the HbA1c values of the patient of last 1 year in order to classify them as controlled diabetics with regular insulin therapy and uncontrolled diabetics with irregular insulin therapy. The cut off value of HbA1c was taken as 7%. On the basis is glycemic control, the patients were divided in 2 categories, controlled (HbA1C less than 7%) and uncontrolled (HbA1C greater than 7%). The type, degree and frequency of hearing impairement were determined by pure tone audiometry (PTA) (at 500, 1000, 2000 and 4000 Hz).The degree of hearing impairement was classified according to the WHO classification. 72 patients who had type 1 diabetes mellitus were evaluated using pure tone audiometry for hearing assessment. The factors taken into consideration for studying the impact on hearing loss was gender of the patients and HbA1c value. A <i>P</i> value of > 0.05 was seen in case of gender of the patients and a <i>P</i> value of < 0.05 was seen in regard to HbA1c value. Type 1 diabetes mellitus patients with deranged HbA1c and uncontrolled diabetes have higher incidence of hearing loss as compared to the Type 1 diabetes mellitus patients with controlled disease. Therefore if patients have a controlled sugar levels with regular HbA1C monitoring, this can have a preventive action on the SNHL as compared to the patients with uncontrolled HbA1C.</p>","PeriodicalId":49190,"journal":{"name":"Indian Journal of Otolaryngology and Head and Neck Surgery","volume":"77 3","pages":"1307-1311"},"PeriodicalIF":0.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11909370/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cricotracheal Separation with Esophageal Laceration in Blunt Neck Trauma: A Case Report.","authors":"Annanya Soni, Dhruv Kapoor, Arijit Jotdar, Pranabh Kushwaha, Amit Kumar Gupta","doi":"10.1007/s12070-025-05382-y","DOIUrl":"https://doi.org/10.1007/s12070-025-05382-y","url":null,"abstract":"<p><p>Survival from laryngotracheal separation injuries depends on appropriate airway treatment, these injuries are uncommon but dangerous. consequently, expert opinion and brief case studies have served as the foundation for managerial recommendations. In the present case, the airway was first obtained by awake tracheostomy followed by urgent neck exploration and repair of cricotracheal defect and esophageal laceration under general anaesthesia. at four months after surgery, patient had an occluded tracheostomy with cords in paramedian position, eating a regular diet, and had a decent voice quality. patients can regain a patent airway, a functional voice, and normal swallowing with a high index of suspicion and prompt reconstruction that restores the laryngotracheal framework and mucosal integrity.</p>","PeriodicalId":49190,"journal":{"name":"Indian Journal of Otolaryngology and Head and Neck Surgery","volume":"77 3","pages":"1673-1677"},"PeriodicalIF":0.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11909331/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P S Suhaima, Arun Srinivaasan, Bhartendu Bharti, Kranti Bhavana
{"title":"Diagnostic and Surgical Challenges in External Auditory Canal Cholesteatoma: Experience from a Tertiary Care Centre.","authors":"P S Suhaima, Arun Srinivaasan, Bhartendu Bharti, Kranti Bhavana","doi":"10.1007/s12070-025-05330-w","DOIUrl":"https://doi.org/10.1007/s12070-025-05330-w","url":null,"abstract":"<p><p>External auditory canal cholesteatoma is an uncommon disease. Its severity can range from limited superficial erosion and minimal debris accumulation to extensive involvement of surrounding structures. It is important to diagnose and intervene the disease at the right time keeping in mind the important structures in ear which could be involved during the disease progression. In this paper we share our experience with canal cholesteatoma from our tertiary care Centre.</p>","PeriodicalId":49190,"journal":{"name":"Indian Journal of Otolaryngology and Head and Neck Surgery","volume":"77 3","pages":"1316-1323"},"PeriodicalIF":0.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11909350/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mojtaba Meybodian, Mohammad Mandegari, Mohammadhossein Baradaranfar, Sedighe Vaziribozorg, Fatemeh Khabri
{"title":"Middle Turbinate Resection Versus its Preservation in Patients with Chronic Polypoid Rhinosinusitis Undergoing Endoscopic Sinus Surgery.","authors":"Mojtaba Meybodian, Mohammad Mandegari, Mohammadhossein Baradaranfar, Sedighe Vaziribozorg, Fatemeh Khabri","doi":"10.1007/s12070-024-05188-4","DOIUrl":"https://doi.org/10.1007/s12070-024-05188-4","url":null,"abstract":"<p><p>The present study compared middle turbinate resection versus its preservation in patients with chronic polypoid rhinosinusitis undergoing FESS. In this clinical trial study, 105 patients with chronic polypoid rhinosinusitis undergoing endoscopic sinus surgery were involved. In the study group, patients underwent endoscopic sinus surgery along with partial middle turbinate resection, while in the control group only endoscopic sinus surgery was performed. SNOT-22 test results (Sino-Nasal Outcome Test) and CT scan of paranasal sinuses results (Lund- Mackay), quality of life, the smell status and nasal congestion were recorded before the operation and then 6 months after the surgery. The average quality of life score did not have a statistically significant difference between the two groups (<i>p</i>-value > 0.05). There was a statistically significant difference in the quality of life score before and after the intervention in each studied group, (without resection = 0.03 and with resection = 0.001). The quality of life score after the intervention was higher in the sinus endoscopy group without resection than the sinus endoscopy group with resection (36.29 versus 33.04). There was no statistically significant difference in the average score of smell reduction between the two study groups (<i>p</i>-value > 0.05). The two groups had no statistically significant difference in terms of nasal congestion (<i>p</i>-value > 0.05). Our results showed that resection or preservation of the middle turbinate in ESS had no significant effect on the patient's outcomes, although the improvement of quality of life and nasal congestion were better in the resection group. Therefore middle turbinate resection is recommended in ESS without worrying about increasing complications.</p>","PeriodicalId":49190,"journal":{"name":"Indian Journal of Otolaryngology and Head and Neck Surgery","volume":"77 3","pages":"1209-1214"},"PeriodicalIF":0.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11909363/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The role of Botulinum Toxin for the Management of post Parotidectomy Sialocele: A Randomized Controlled Trial.","authors":"Maryam Sheykhveisi, Ehsan Khaauthori, Leila Mashhadi, Habibollah Esmaily, Kamran Khazaeni","doi":"10.1007/s12070-024-05226-1","DOIUrl":"https://doi.org/10.1007/s12070-024-05226-1","url":null,"abstract":"<p><strong>Background: </strong>Parotid fistula or Sialocele is a general consequence of a penetrating injury of parotid gland or parotidectomy surgery which may be caused serious complications. Studies show different approaches had various effects on management of sialocele complications after parotidectomy. The purpose of this study is to evaluate the effects of botulinum toxin (BTX) on total/ partial and partial superficial parotidectomy complications.</p><p><strong>Methods: </strong>Patients with benign parotid gland tumors were included in this bicentric, double-blind, parallel, randomized clinical trial from 2021 to 2023. One hundred subjects underwent parotidectomy with/ without BTX injection were randomly assigned into two groups including the intervention (BTX group) (<i>n</i> = 50) and control group (<i>n</i> = 50) then the clinical information of all mentioned patients was assessed.</p><p><strong>Results: </strong>Hematoma, infection, opening of the wound, warmth or swelling was not observed in either group. BTX group had significantly lower Postoperative drainage volume versus control group on both 24 and 48 h after surgery (23 vs. 19 mL, <i>P</i> < 0.02 at first day and 27 vs. 12, <i>p</i> = 0.003 at second day). Although the incidence of sialocele was lower in the BTX group than the control group (2/50 [4%] vs. 6/50 [12%]) with (<i>p</i> = 0.269) but it wasn't significant.</p><p><strong>Conclusion: </strong>The study results demonstrated that botulinum toxin may be safe and effective therefore BTX injection in improving parotidectomy complications like sialocele was recommended.</p>","PeriodicalId":49190,"journal":{"name":"Indian Journal of Otolaryngology and Head and Neck Surgery","volume":"77 3","pages":"1215-1219"},"PeriodicalIF":0.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11909307/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Robin Singh, Nikita Chatterjee, Indranil Chatterjee
{"title":"Exploring P300 Responses in Tinnitus: Linking Cognitive and Audiological Assessments.","authors":"Robin Singh, Nikita Chatterjee, Indranil Chatterjee","doi":"10.1007/s12070-025-05350-6","DOIUrl":"https://doi.org/10.1007/s12070-025-05350-6","url":null,"abstract":"<p><strong>Aim: </strong>The study aimed to evaluate the effect of tinnitus masking on cognitive functioning and the efficacy of tinnitus retraining therapy in reducing the severity of tinnitus handicap.</p><p><strong>Method: </strong>The study recruited 15 subjects (mean age = 47.1 ± 11.5) with unilateral chronic tinnitus (6 participants with right-ear tinnitus and 9 participants with left-ear tinnitus); and mild to moderate sensorineural hearing loss. Conducted in two phases, Phase 1 comprised case history, audiometric testing, tinnitus matching, and THI-Bangla assessment. Phase 2 involved P300 administration followed by a 60-session tinnitus retraining therapy (online-offline modality), concluding with post-therapy P300 and THI-Bangla assessments. Therapy outcomes were evaluated by improvements in P300 latency and amplitude and THI-Bangla scores.</p><p><strong>Results: </strong>A significant improvement observed post-therapy, with reductions in mean P300 latency for both left (<i>p</i> < 0.001) and right (<i>p</i> < 0.001) ears. Mean P300 amplitude also increased significantly post-therapy for left (<i>p</i> < 0.001) and right (<i>p</i> < 0.001) ears. THI scores also declined substantially (<i>p</i> < 0.001), with a post-therapy mean THI score of 17.80 (SD = 4.64) for males and 12.20 (SD = 3.42) for females, revealing a significant difference (<i>p</i> = 0.033).</p><p><strong>Conclusion: </strong>These findings support the efficacy of tinnitus retraining therapy in reducing tinnitus related distress and enhancing cognitive processing, as evidenced by P300 improvements.</p>","PeriodicalId":49190,"journal":{"name":"Indian Journal of Otolaryngology and Head and Neck Surgery","volume":"77 3","pages":"1392-1400"},"PeriodicalIF":0.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11909348/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}