{"title":"The role of Botulinum Toxin for the Management of post Parotidectomy Sialocele: A Randomized Controlled Trial.","authors":"Maryam Sheykhveisi, Ehsan Khaauthori, Leila Mashhadi, Habibollah Esmaily, Kamran Khazaeni","doi":"10.1007/s12070-024-05226-1","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Parotid fistula or Sialocele is a general consequence of a penetrating injury of parotid gland or parotidectomy surgery which may be caused serious complications. Studies show different approaches had various effects on management of sialocele complications after parotidectomy. The purpose of this study is to evaluate the effects of botulinum toxin (BTX) on total/ partial and partial superficial parotidectomy complications.</p><p><strong>Methods: </strong>Patients with benign parotid gland tumors were included in this bicentric, double-blind, parallel, randomized clinical trial from 2021 to 2023. One hundred subjects underwent parotidectomy with/ without BTX injection were randomly assigned into two groups including the intervention (BTX group) (<i>n</i> = 50) and control group (<i>n</i> = 50) then the clinical information of all mentioned patients was assessed.</p><p><strong>Results: </strong>Hematoma, infection, opening of the wound, warmth or swelling was not observed in either group. BTX group had significantly lower Postoperative drainage volume versus control group on both 24 and 48 h after surgery (23 vs. 19 mL, <i>P</i> < 0.02 at first day and 27 vs. 12, <i>p</i> = 0.003 at second day). Although the incidence of sialocele was lower in the BTX group than the control group (2/50 [4%] vs. 6/50 [12%]) with (<i>p</i> = 0.269) but it wasn't significant.</p><p><strong>Conclusion: </strong>The study results demonstrated that botulinum toxin may be safe and effective therefore BTX injection in improving parotidectomy complications like sialocele was recommended.</p>","PeriodicalId":49190,"journal":{"name":"Indian Journal of Otolaryngology and Head and Neck Surgery","volume":"77 3","pages":"1215-1219"},"PeriodicalIF":0.6000,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11909307/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Indian Journal of Otolaryngology and Head and Neck Surgery","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s12070-024-05226-1","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/16 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"SURGERY","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Parotid fistula or Sialocele is a general consequence of a penetrating injury of parotid gland or parotidectomy surgery which may be caused serious complications. Studies show different approaches had various effects on management of sialocele complications after parotidectomy. The purpose of this study is to evaluate the effects of botulinum toxin (BTX) on total/ partial and partial superficial parotidectomy complications.
Methods: Patients with benign parotid gland tumors were included in this bicentric, double-blind, parallel, randomized clinical trial from 2021 to 2023. One hundred subjects underwent parotidectomy with/ without BTX injection were randomly assigned into two groups including the intervention (BTX group) (n = 50) and control group (n = 50) then the clinical information of all mentioned patients was assessed.
Results: Hematoma, infection, opening of the wound, warmth or swelling was not observed in either group. BTX group had significantly lower Postoperative drainage volume versus control group on both 24 and 48 h after surgery (23 vs. 19 mL, P < 0.02 at first day and 27 vs. 12, p = 0.003 at second day). Although the incidence of sialocele was lower in the BTX group than the control group (2/50 [4%] vs. 6/50 [12%]) with (p = 0.269) but it wasn't significant.
Conclusion: The study results demonstrated that botulinum toxin may be safe and effective therefore BTX injection in improving parotidectomy complications like sialocele was recommended.
期刊介绍：
Indian Journal of Otolaryngology and Head & Neck Surgery was founded as Indian Journal of Otolaryngology in 1949 as a scientific Journal published by the Association of Otolaryngologists of India and was later rechristened as IJOHNS to incorporate the changes and progress.
IJOHNS, undoubtedly one of the oldest Journals in India, is the official publication of the Association of Otolaryngologists of India and is about to publish it is 67th Volume in 2015. The Journal published quarterly accepts articles in general Oto-Rhino-Laryngology and various subspecialities such as Otology, Rhinology, Laryngology and Phonosurgery, Neurotology, Head and Neck Surgery etc.
The Journal acts as a window to showcase and project the clinical and research work done by Otolaryngologists community in India and around the world. It is a continued source of useful clinical information with peer review by eminent Otolaryngologists of repute in their respective fields. The Journal accepts articles pertaining to clinical reports, Clinical studies, Research articles in basic and applied Otolaryngology, short Communications, Clinical records reporting unusual presentations or lesions and new surgical techniques. The journal acts as a catalyst and mirrors the Indian Otolaryngologist’s active interests and pursuits. The Journal also invites articles from senior and experienced authors on interesting topics in Otolaryngology and allied sciences from all over the world.
The print version is distributed free to about 4000 members of Association of Otolaryngologists of India and the e-Journal shortly going to make its appearance on the Springer Board can be accessed by all the members.
Association of Otolaryngologists of India and M/s Springer India group have come together to co-publish IJOHNS from January 2007 and this bondage is going to provide an impetus to the Journal in terms of international presence and global exposure.
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