Indian Journal of Otolaryngology and Head and Neck Surgery最新文献

{"title":"Response to Induction Chemotherapy as a Predictor of Clinical Outcome After Chemoradiation in Locally Advanced Head and Neck Squamous Cell Carcinoma Patients: A Retrospective Study.","authors":"Mayank Soni, Sweety Gupta, Abhishek Chakravarty, Aviral Rastogi, Nitin Kumar, Shrutikant Bhatia, Deepa M Joseph, Manoj Gupta","doi":"10.1007/s12070-025-05538-w","DOIUrl":"10.1007/s12070-025-05538-w","url":null,"abstract":"<p><strong>Introduction: </strong>Concurrent chemo-radiotherapy is standard of care for locally advanced Head and Neck squamous cell carcinoma. Induction chemotherapy is given to reduce locoregional relapse, distant metastases and tumor shrinkage. Response to induction chemotherapy can predict response to radiotherapy, but impact of IC response to survival benefit after radical treatment is less studied.</p><p><strong>Materials and methods: </strong>We conducted a retrospective study of patients with locally advanced Head and Neck squamous cell carcinoma receiving induction chemotherapy followed by radical chemoradiotherapy. Clinico-radiological response to induction chemotherapy was recorded and further subjected to chemoradiotherapy. Overall, Disease free and distant metastasis free survival were analysed.</p><p><strong>Results: </strong>116 patients received induction chemotherapy followed by radical chemoradiotherapy. Post induction chemotherapy, response(down-stage) was, 48(41.37%) for T-stage, 46(36.65%) for N-stage and 45(38.79%) for Stage group, respectively. On follow up after chemoradiotherapy, 52(44.8%) had complete response, 61(52.6%) had failure of treatment, and 3(2.6%) died within three months. With median overall survival of 18.89 months, median follow up was of 10.8 months. Univariate analysis indicated significant benefits in Disease free survival for T-stage response (<i>p</i> < 0.04), but not for N-stage (<i>p</i> = 0.25) or stage group (<i>p</i> = 0.11). However, multivariate analysis identified stage group response as statistically significant predictor overall survival (<i>p - </i>0.04, HR<i> - </i>0.538). In subset analysis, younger population (< 50 year), despite being non-responder had significant benefit in distant metastasis free survival status (<i>p - </i>0.04). For subsite, hypopharyngeal malignancies had significant benefit in overall survival status for N-stage (<i>p - </i>0.002) and stage group (<i>p - </i>0.008), and for laryngeal malignancies significant benefit in disease free survival status for T-stage response (<i>p - </i>0.03).</p><p><strong>Conclusion: </strong>In locally advanced Head and Neck squamous cell carcinoma, response to induction chemotherapy can be viewed as an indicator of potential survival benefit. Role of induction chemotherapy is recommended for laryngeal and hypopharyngeal malignancies, to preserve organ-function along with enhanced survival rates. In younger patients, even if they are non-responders, induction chemotherapy combined with concurrent chemoradiation is a viable option that may improve locoregional, and distant control of the disease.</p>","PeriodicalId":49190,"journal":{"name":"Indian Journal of Otolaryngology and Head and Neck Surgery","volume":"77 7","pages":"2514-2522"},"PeriodicalIF":0.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12149041/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144276418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sinonasal Small Cell Neuroendocrine Carcinoma Invading to Skull Base in a Young Female.","authors":"Thuruthiath Nisha, Gopinatha Menon Arjun, Antony Febin, Chakramakkal Joesph Andrews","doi":"10.1007/s12070-025-05514-4","DOIUrl":"10.1007/s12070-025-05514-4","url":null,"abstract":"<p><p>An uncommon and aggressive tumour, sinonasal small cell neuroendocrine carcinoma (SCNEC) typically presents with a little male predominance. SCNEC in a 23-year-old woman is described here. A multidisciplinary therapy was done comprising surgery followed by chemo-radiation therapy. After being monitored, the patient was confirmed to be disease-free.</p>","PeriodicalId":49190,"journal":{"name":"Indian Journal of Otolaryngology and Head and Neck Surgery","volume":"77 7","pages":"2618-2621"},"PeriodicalIF":0.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12149345/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144276420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing Diagnostic Accuracy of BRAF Marker with Surgery Findings in Detecting the Type of Lesion in Patients with Thyroid Nodules with Suspected Fine Needle Aspiration (AUS).","authors":"Vahid Zand, Mehdi Kalantar, Mohammadhossein Baradaranfar, Sedighe Vaziribozorg, Mahya Ebrahiminasab, Ahmad Mohammadi, Fatemeh Khabri","doi":"10.1007/s12070-025-05564-8","DOIUrl":"10.1007/s12070-025-05564-8","url":null,"abstract":"<p><strong>Introduction: </strong>In this study we compared diagnostic accuracy of BRAF marker with histopathology findings in detecting the type of lesion in patients with thyroid nodules with suspected fine needle aspiration (AUS).</p><p><strong>Methods: </strong>In this cross-sectional study, 70 patients with thyroid nodules and AUS cytology undergoing surgery were involved. Demographic data (age, gender), type of lesion based on histopathology findings (malignant, benign), and type of cancer in malignant lesions (Papillary Thyroid Carcinoma and Follicular Thyroid Carcinoma) was recorded in a checklist. In order to evaluate the BRAF mutation, PCR test was performed on samples obtained from the thyroid nodule site through thyroid surgery. The PCR results were compared with the histopathology findings as a pathology report. The sensitivity, specificity, positive predictive value, and negative predictive value were evaluated and analyzed.</p><p><strong>Results: </strong>Sixty patients were females and 10 were males. Forty one (58.57%) had multinodular goiter, 20 (28.57%) had PTC, 3 (4.28%) had Hashimoto's and 6 (8.58%) were diagnosed with thyroiditis. PCR test results showed that only two cases in the PTC group were heterozygous for BRAF mutation and the rest of the samples were normal. Sensitivity and specificity and positive and negative predictive value of BRAF marker showed that this marker had low sensitivity and high specificity. The positive predictive value was 91.3 and the negative predictive value was 33.4.</p><p><strong>Conclusions: </strong>The results showed that the BRAF marker had low sensitivity and high specificity in diagnosing the type of thyroid lesions. In addition, this study was conducted to compare BRAF with standard PCR method and considering the cost-effectiveness of this method, this method could be used for AUS patients.</p>","PeriodicalId":49190,"journal":{"name":"Indian Journal of Otolaryngology and Head and Neck Surgery","volume":"77 7","pages":"2543-2547"},"PeriodicalIF":0.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12149372/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144276424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thyroid Malignancy with Tracheal Invasion: Evaluating Process and Outcomes.","authors":"Ananth S Mathad, Surbhi Varshney, Nawaz Usman, Akhil Palod, Preethi S Shetty, Naveena An Kumar","doi":"10.1007/s12070-025-05580-8","DOIUrl":"10.1007/s12070-025-05580-8","url":null,"abstract":"<p><strong>Aim: </strong>Tracheal invasion by thyroid cancers poses significant surgical challenges. In this case series, we present our experience of tracheal resection and reconstruction in eight patients. This study highlights the importance of a coordinated multidisciplinary approach and technique of partial tracheal resection as well as evaluates the outcomes of this complex surgical intervention.</p><p><strong>Materials and methods: </strong>This study is the retrospective analysis of prospectively maintained data base of Thyroid cancer.</p><p><strong>Results: </strong>The tracheal resection and reconstruction was performed in eight patients, including five males and three females, with a median age of 51 years. Seven patients had papillary thyroid carcinoma, while one had medullary thyroid carcinoma. Seven underwent partial tracheal resection, and one had full-thickness resection with anastomosis, achieving negative margins in all cases. No major complications related to tracheal resection and reconstruction except one patient had mortality due to carotid blow out. Over a median follow-up of 24 months (12-28 months), 6 patients remained disease-free.</p><p><strong>Conclusion: </strong>Tracheal resection and reconstruction for thyroid cancer with tracheal invasion is a viable approach, offering favourable outcomes in carefully selected patients. While the procedure is associated with inherent risks, a multidisciplinary approach and technical expertise are pivotal in minimizing complications and optimizing survival.</p>","PeriodicalId":49190,"journal":{"name":"Indian Journal of Otolaryngology and Head and Neck Surgery","volume":"77 7","pages":"2591-2595"},"PeriodicalIF":0.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12149030/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144276437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unravelling the Hidden Complication: Costal Osteomyelitis of the PMMC Donor Site.","authors":"Pranav Mohan Singhal, Manikandan Venkatasubramaniyan, Viswamadesh Ramachandran, Arvind Krishnamurthy","doi":"10.1007/s12070-025-05553-x","DOIUrl":"10.1007/s12070-025-05553-x","url":null,"abstract":"<p><p>The Pectoralis Major Myocutaneous Flap (PMMC) has been an essential part of the armamentarium of surgeons reconstructing oral cavity defects after resection for malignancies. Ease of harvest, reliability and versatility coupled with minimal donor site and flap related morbidities have made the PMMC a favorite of reconstructive surgeons and surgical oncologist, especially in situations where a free flap reconstruction is either not possible or expertise and logistics don't support such a procedure. But like any other surgical procedure, the PMMC also suffers from various complications. This case report describes a rather unusual complication of Costal Osteomyelitis of the 5-8th rib of the donor site following harvest of the PMMC for reconstructing the ipsilateral buccal mucosa defect after resection for oral cavity.</p>","PeriodicalId":49190,"journal":{"name":"Indian Journal of Otolaryngology and Head and Neck Surgery","volume":"77 7","pages":"2670-2673"},"PeriodicalIF":0.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12149350/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144276439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laryngopharyngeal Reflux Prevalence and Predictors Among Doctors.","authors":"Dianitta Devapriya Veronica, Shyam Sudhakar Sudarsan, Prem Kumar, Allen John","doi":"10.1007/s12070-025-05535-z","DOIUrl":"10.1007/s12070-025-05535-z","url":null,"abstract":"<p><p>Laryngopharyngeal reflux (LPR) refers to the retrograde flow of stomach contents into the larynx due to an abnormality involving the upper oesophageal sphincter. It presents with symptoms like frequent hawking, nocturnal cough, globus pharyngeus and unresolving throat discomfort. Studies have focused on LPR in the general population. However, certain cohorts may be more susceptible or silently suffering from LPR. A PubMed search on \"laryngopharyngeal reflux in doctors\" derived 118 results between 1998 and 2025 with no study on cohorts comprising doctors though general population and non-healthcare cohorts have been researched. Only Google Gemini's Generative Artificial Intelligence suggests that there is a possibility. To estimate the prevalence of LPR among doctors and derive a predictor model. A cross-sectional study was done among 822 doctors. Survey-based. Demographics, data related to work and RSI scoring were collected. Thorough ear, nose and throat examination with videolaryngoscopy was done. Descriptive statistics, prevalence rate, correlation and regression analysis were done. Variables satisfying assumptions for regression were filtered and a suitable model was developed to observe factors with most weightage causing LPR and estimate the medico's chances of suffering from it. Higher prevalence rate noted. Work related data provided a meaningful insight on finding factors with significant influence causing LPR in medicos. 1st predictor model with variables explaining the risk weightage derived. Age and gender did not have a statistically significant impact on the model. Impactful outcomes particularly noted in those who do shift work(8.292), take irregular diet(4.455), have habits(2.918), and work for extended hours(0.981) with values in parentheses showing how prone a candidate is, in developing LPR. LPR is more prevalent than expected in cohort comprising doctors when compared to general population, suggesting a possible silent disease among doctors. Revising work timing / improving diet hygiene / reducing stress by easing administrative delays apart from clinical suspicion, early recognition and management may help the healthcare professionals tide over the wave of LPR. The predictor model helps to categorise factors on weightage and predict how influential a role it can play in causing LPR.</p>","PeriodicalId":49190,"journal":{"name":"Indian Journal of Otolaryngology and Head and Neck Surgery","volume":"77 7","pages":"2500-2507"},"PeriodicalIF":0.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12149064/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144276359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Misleading Stone: Case Report of a Giant Sialolithiasis and Review of Literature.","authors":"Nadia Romdhane, Ameni Amri, Dorra Chiboub, Asma Ayadi, Emna Rjab, Imen Zoghlami, Safa Nefzaoui, Ines Hariga, Chiraz Chaouch Mbarek","doi":"10.1007/s12070-025-05507-3","DOIUrl":"10.1007/s12070-025-05507-3","url":null,"abstract":"<p><p>Sialolithiasis is defined as the presence of calculi inside salivary glands. This affection can either be located in the gland's duct, or inside the glandular parenchyma. This issue is considered as one of the most frequent non-neoplasic salivary gland diseases. Salivary gland stones are a relatively frequent affection and are estimated to affect up to 12 out of 1,000 subjects in the adult population. Sialoliths form in the secretory system of the submandibular gland and can range in dimension from less than a millimeter to a few centimeters in diameter. Calculi are usually less than 10 mm large and giant sialoliths are defined as those measuring 1.5 cm or larger in any dimension. Our aim is to report a case of giant sialolithiasis of the submandibular gland in a male adult, and to describe its clinical, radiological, and pathological presentation. The submandibular gland stone was treated surgically through a transcervical approach. Along with our case report, this work carries an exhaustive review of literature on all documented cases of giant salivary gland calculi.</p>","PeriodicalId":49190,"journal":{"name":"Indian Journal of Otolaryngology and Head and Neck Surgery","volume":"77 7","pages":"2704-2710"},"PeriodicalIF":0.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12149081/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144276407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of Modified ITBCC Criteria of Tumor Budding in Oral Squamous Cell Carcinoma and its Correlation with Clinicopathological Parameters and Overall Survival.","authors":"Gaurav Thoke, Deepak Pandiar, Reshma Poothakulath Krishnan","doi":"10.1007/s12070-025-05575-5","DOIUrl":"10.1007/s12070-025-05575-5","url":null,"abstract":"<p><strong>Aim: </strong>To apply and correlate clinicopathological parameters and survival in oral squamous cell carcinoma (OSCC) with tumor budding using the modified International Tumor Budding Consensus Conference (ITBCC) criteria for colorectal cancer.</p><p><strong>Materials and methods: </strong>Ethical clearance was sought from the institutional ethical clearance committee, and 121 consecutive cases of excised cases OSCC (with neck dissection and adequate follow-up) were included in the present study. The cases were divided into two groups- with tumor budding (TB) and without TB and were correlated with clinicopathological features. The TB-positive cases were further classified into four classes using modified ITBCC criteria as TB0, TB1, TB2 and TB3. IBM SPSS version 26 was used for analysis, and any value less than or equal to 0.05 was considered statistically significant.</p><p><strong>Result: </strong>Cases with tumor budding showed more nodal metastasis (p-value: <0.001) and lower overall survival (p-value: 0.038). No significant difference was found between tumor budding and any other clinical and histopathological parameter (p-value: >0.05).</p><p><strong>Conclusion: </strong>Tumor budding is an independent predictor of nodal metastasis and poorer overall survival in OSCC. Tumor budding at the invasive tumor front should be included in the pathological report and deserves inclusion in staging and grading.</p>","PeriodicalId":49190,"journal":{"name":"Indian Journal of Otolaryngology and Head and Neck Surgery","volume":"77 7","pages":"2568-2574"},"PeriodicalIF":0.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12149060/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144276411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship Between Personality Patterns and General Health of Rhinoplasty Applicants with Satisfaction After Rhinoplasty.","authors":"Gholamreza Bazmandegan, Mahboubeh Vtaanparast, Leila Pourhossenali, Masoud Radman, Farid Soltani","doi":"10.1007/s12070-025-05475-8","DOIUrl":"10.1007/s12070-025-05475-8","url":null,"abstract":"<p><p>Satisfaction level after cosmetic surgery, creating unrealistic expectations, and hiding other complications of the surgery. The present study aims to investigate the relationship between personality patterns and the general health of rhinoplasty applicants with the post-operative satisfaction of clients. His cross-sectional study was conducted on 57 applicants for rhinoplasty and 57 control subjects after age and gender matching. The control group was selected from relatives of rhinoplasty applicants to control cultural and genetic factors. Data was collected using general health questionnaire-28 (GHQ-28), NEO Five-Factor Inventory (NEO-FFI) questionnaire, and satisfaction with surgery. The data were analyzed using SPSS.24 software and a significance level of 0.05. The mean age of rhinoplasty applicants was 29.84 ± 8.02 years and for the control group was 30.49 ± 7.75 years (<i>P</i> = 0.661). The frequency of women applying for rhinoplasty was 71.9% (<i>P</i> = 0.836). The odds ratio for rhinoplasty decreased by increasing agreeableness (OR: 0.741, 95% CI: 0.598-0.917) and by increasing levels of neuroticism (OR: 1.523, 95% CI: 1.225-1.894) and extraversion (OR: 1.291, 95% CI: 1.091-1.527) increased. By increasing anxiety, the odds ratio of rhinoplasty surgery decreased (OR: 0.823, 95% CI: 0.696-0.975). Those who had higher neuroticism had lower satisfaction with rhinoplasty by 0.679 (<i>P</i> < 0.001). Different dimensions of personality and general health of people affect the action and tendency towards rhinoplasty. It is necessary to check the health level of applicants for rhinoplasty and also perform psychiatric consultations to check the causes of performing rhinoplasty and prevent unnecessary surgeries.</p>","PeriodicalId":49190,"journal":{"name":"Indian Journal of Otolaryngology and Head and Neck Surgery","volume":"77 7","pages":"2443-2448"},"PeriodicalIF":0.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12149347/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144276417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical Outcomes in Chronic Otitis Media: Hearing and Quality of Life Improvements.","authors":"Deepak Jaglan, Divya Gupta, Divya Aggarwal","doi":"10.1007/s12070-025-05578-2","DOIUrl":"10.1007/s12070-025-05578-2","url":null,"abstract":"<p><p>Chronic Otitis Media (COM) is a persistent middle ear infection that can cause hearing impairment and significantly impact a patient's quality of life (QoL). While surgical interventions such as tympanoplasty are well-recognized for improving hearing, their broader effects on QoL remain less thoroughly investigated. To evaluate the impact of ear surgery on both audiometric outcomes and QoL in patients with COM, using validated patient-reported outcome measures. This prospective analytical study was conducted in the Department of ENT at a tertiary care hospital, involving 120 adult patients diagnosed with COM. Changes in QoL were assessed using validated tools: the Chronic Ear Survey (CES) and the Chronic Otitis Media Outcome Test-15 (COMOT-15) questionnaires, administered both pre- and post-surgery. Audiometric outcomes were measured using Pure Tone Audiometry (PTA). Post-operative evaluations demonstrated significant improvements in both audiometric outcomes and QoL. The mean air-bone (AB) gap decreased from 28.92 ± 8.83 dB pre-operatively to 16.47 ± 5.86 dB post-operatively. CES scores increased from 58.45 ± 9.01 to 76.19 ± 8.33, while COMOT-15 scores improved from 56.65 ± 12.16 to 22.81 ± 8.52. These improvements were statistically significant (<i>p</i> < 0.001). Ear surgery in patients with COM significantly enhances both hearing function and QoL. These findings emphasize the necessity of incorporating patientreported outcome measures, such as QoL assessments, in evaluating surgical success and underscore the importance of timely surgical interventions for comprehensive patient care.</p>","PeriodicalId":49190,"journal":{"name":"Indian Journal of Otolaryngology and Head and Neck Surgery","volume":"77 7","pages":"2585-2590"},"PeriodicalIF":0.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12149384/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144276421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}