Effects of Kanamycin on Hearing and Vestibular Function in Multidrug-Resistant Tuberculosis Patients.

IF 0.6 Q4 SURGERY

Indian Journal of Otolaryngology and Head and Neck Surgery Pub Date : 2025-03-01 Epub Date: 2025-02-18 DOI:10.1007/s12070-025-05362-2

Prakash Kumar Koirala, Sushma Kashyap, Hari Shankar Sharma

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引用次数: 0

Abstract

Kanamycin, an aminoglycoside antibiotic used to treat multidrug-resistant tuberculosis (MDR-TB), poses a significant risk of ototoxicity, potentially affecting hearing and balance. This study aimed to investigate the impact of kanamycin on auditory and vestibular function in MDR-TB patients focusing on the development of Sensorineural Hearing Loss (SNHL), dizziness, and tinnitus. A cohort of primarily young patients (44.4% aged 19-30, 69.4% female) underwent interviews, tuning fork tests, and Pure Tone Audiometry before and after treatment. Statistical analysis revealed significant associations between kanamycin use SNHL, dizziness, and tinnitus. A substantial proportion of participants experienced hearing loss and balance-related symptoms post-treatment. The findings underscore the need for routine auditory and vestibular monitoring in MDR-TB patients, particularly those at higher risk. Further research on minimizing kanamycin-induced ototoxicity, exploring alternative therapies, and conducting longitudinal studies to assess long-term auditory and vestibular outcomes in MDR-TB treatment.

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来源期刊

Indian Journal of Otolaryngology and Head and Neck Surgery Medicine-Otorhinolaryngology

CiteScore

0.80

自引率

0.00%

发文量

226

审稿时长

6-12 weeks

期刊介绍： Indian Journal of Otolaryngology and Head & Neck Surgery was founded as Indian Journal of Otolaryngology in 1949 as a scientific Journal published by the Association of Otolaryngologists of India and was later rechristened as IJOHNS to incorporate the changes and progress. IJOHNS, undoubtedly one of the oldest Journals in India, is the official publication of the Association of Otolaryngologists of India and is about to publish it is 67th Volume in 2015. The Journal published quarterly accepts articles in general Oto-Rhino-Laryngology and various subspecialities such as Otology, Rhinology, Laryngology and Phonosurgery, Neurotology, Head and Neck Surgery etc. The Journal acts as a window to showcase and project the clinical and research work done by Otolaryngologists community in India and around the world. It is a continued source of useful clinical information with peer review by eminent Otolaryngologists of repute in their respective fields. The Journal accepts articles pertaining to clinical reports, Clinical studies, Research articles in basic and applied Otolaryngology, short Communications, Clinical records reporting unusual presentations or lesions and new surgical techniques. The journal acts as a catalyst and mirrors the Indian Otolaryngologist’s active interests and pursuits. The Journal also invites articles from senior and experienced authors on interesting topics in Otolaryngology and allied sciences from all over the world. The print version is distributed free to about 4000 members of Association of Otolaryngologists of India and the e-Journal shortly going to make its appearance on the Springer Board can be accessed by all the members. Association of Otolaryngologists of India and M/s Springer India group have come together to co-publish IJOHNS from January 2007 and this bondage is going to provide an impetus to the Journal in terms of international presence and global exposure.