the Indian Journal of Pharmacy最新文献_第4页

Evaluation of anthelmintic activity of medicinal plants: Why earthworm? 评估药用植物的驱虫活性：为什么是蚯蚓？

IF 2.4 4区医学

the Indian Journal of Pharmacy Pub Date : 2024-01-01 Epub Date: 2024-03-08 DOI: 10.4103/ijp.ijp_554_23

Sanjib Bhattacharya

引用次数: 0

The effective dose of remimazolam in adult gastroscopy. 成人胃镜检查中瑞马唑仑的有效剂量。

IF 2.4 4区医学

the Indian Journal of Pharmacy Pub Date : 2024-01-01 Epub Date: 2024-03-08 DOI: 10.4103/ijp.ijp_425_22

Rongyan Zhang, Gang Zhao, Zhangjun Yan, Hongmei Xuan, Yan Chen

{"title":"The effective dose of remimazolam in adult gastroscopy.","authors":"Rongyan Zhang, Gang Zhao, Zhangjun Yan, Hongmei Xuan, Yan Chen","doi":"10.4103/ijp.ijp_425_22","DOIUrl":"10.4103/ijp.ijp_425_22","url":null,"abstract":"Objectives: The objectives of this study were to explore the median effective dose (ED50) and the dose required for successful anesthesia in 95% of the patients (ED95) of remimazolam for intravenous anesthesia in adult outpatients undergoing gastroscopy.Methods: This pilot study was conducted in patients scheduled to undergo painless gastroscopy at the authors' hospital between March 15, 2022 and March 25, 2022. The ED of remimazolam was determined using the modified Dixon sequential method, using an initial induction dose of 0.2 mg/kg. With successful or failed anesthesia, the remimazolam dose was decreased or increased by 0.05 mg/kg for the next patient, respectively.Results: Twenty-two patients (43.6 ± 10.5 years of age) were enrolled. During gastroscopy, the remimazolam induction dose was 19.93 ± 2.96 mg (0.2-0.45 mg/kg). Eighteen patients could complete anesthesia with remimazolam alone, and four patients needed propofol to complete anesthesia. The induction time after the injection of remimazolam was 20.8 ± 8.4 s, the gastroscopy time was 5.1 ± 1.3 min, and the anesthesia recovery time was 17.5 ± 5.6 min. The ED50 and the ED95 of remimazolam were 0.362 mg/kg (95% confidence interval [CI]: 0.313-0.455 mg/kg) and 0.464 mg/kg (95% CI: 0.403-2.242 mg/kg), respectively. The vital signs of all patients remained within the predefined acceptable limits. No patients required antagonist rescue.Conclusion: The ED50 and ED95 of remimazolam for adult gastroscopy were 0.362 mg/kg and 0.464 mg/kg, respectively. Additional anesthetics might be required during gastroscopy in some patients.Trial registration: The trial was registered. The number is ChiCTR2200057446.","PeriodicalId":49189,"journal":{"name":"the Indian Journal of Pharmacy","volume":"56 1","pages":"10-15"},"PeriodicalIF":2.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11001170/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140060977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Amelioration by Withania somnifera of neurobehavioural and immunological markers in time dependent sensitization induced post traumatic stress disorder in rats. 在时间依赖性敏化诱导的创伤后应激障碍中，睡茄可改善大鼠的神经行为和免疫标记。

IF 2.4 4区医学

the Indian Journal of Pharmacy Pub Date : 2024-01-01 Epub Date: 2024-03-08 DOI: 10.4103/ijp.ijp_825_22

Sana Rehman, Mohammad Faizan, Nafaa Hasan Ali, Kavita Gulati, Arunabha Ray

{"title":"Amelioration by Withania somnifera of neurobehavioural and immunological markers in time dependent sensitization induced post traumatic stress disorder in rats.","authors":"Sana Rehman, Mohammad Faizan, Nafaa Hasan Ali, Kavita Gulati, Arunabha Ray","doi":"10.4103/ijp.ijp_825_22","DOIUrl":"10.4103/ijp.ijp_825_22","url":null,"abstract":"Aims and objectives: Posttraumatic stress disorder (PTSD) is a complex neuropsychiatric pathophysiology with an unmet need for safe, effective, and sustainable therapeutic modalities. Thus, the present study evaluated the effects of Withaniasomnifera (WS, Ashwagandha) on an experimental model of PTSD in rats.Materials and methods: Wistar rats (200-250 g) were used and time-dependent sensitization (TDS) was used as the experimental model of PTSD. Standardized WS root extract (100 and 300 mg/kg, p.o. for 15 days) was administered with TDS and their effects were observed on neurobehavioral (anxiety) and brain cytokines, corticosterone, and oxidative stress markers.Results: Exposure to TDS resulted in anxiogenic behavior in the elevated plus maze (EPM) test, i.e., reductions in open arm entries and open arm time, as compared to the control group. Pretreatment with WS extract (100 and 300 mg/kg × 14 days) attenuated the TDS-induced anxiogenic activity in a dose-related manner, and these WS effects were comparable to those seen after the comparator drug fluoxetine (10 mg/kg). Assay of brain homogenates showed that TDS also resulted in elevations in brain interleukin-6 and reduction in corticosterone levels in both the hippocampus and prefrontal cortex (PFC), which were reversed after WS pretreatments. Further, WS pretreatment also reversed the TDS-induced changes in brain oxidative stress markers, namely elevated malondialdehyde and reduced glutathione levels in both the hippocampus and PFC.Conclusion: These results suggest that WS could have potential as a therapeutic agent for treating PTSD by attenuating anxiogenesis, neuroimmune axis activation, and oxidative stress.","PeriodicalId":49189,"journal":{"name":"the Indian Journal of Pharmacy","volume":"56 1","pages":"20-27"},"PeriodicalIF":2.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11001169/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140060966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cosmeceuticals: A transit state from synthetic to natural. 药妆：从合成到天然的过渡状态。

IF 2.4 4区医学

the Indian Journal of Pharmacy Pub Date : 2024-01-01 Epub Date: 2024-03-08 DOI: 10.4103/ijp.ijp_244_21

Sathyabama Sathyaseelan, Bhavana Hemantha Rao, S Anushmati

{"title":"Cosmeceuticals: A transit state from synthetic to natural.","authors":"Sathyabama Sathyaseelan, Bhavana Hemantha Rao, S Anushmati","doi":"10.4103/ijp.ijp_244_21","DOIUrl":"10.4103/ijp.ijp_244_21","url":null,"abstract":"Cosmeceuticals are topically applied cosmetic products containing a biologically active ingredient with a pharmaceutical effect that improves, nourishes, and treats the skin appearance. The trend of cosmeceuticals began during the mid-20th century due to its potent ingredients with therapeutic effects for various skin ailments. Even though there is a great advancement in cosmetics, which shows the risk of cosmetic linked melanoma, endocrine disorders, and birth defects which was one in 1500 people during 1935 have increased to one in 75 people in 2000. Hence, as a part of reducing the harmful effect, natural ingredients were added to the formulation to give the pharmaceutical effect. Thus, natural/herbal cosmeceuticals were introduced. Due to the awareness of the side effects such as photo-toxicity, mutagenicity, irritation by these synthetic products, people started preferring herbal/natural cosmetic products. Moreover, natural cosmeceuticals were proven to be effective against various dermatological conditions as well as have fewer side effects marked the natural/herbal cosmeceuticals in the market. Unlike a drug, cosmeceutical products undergo safety, toxicity, and efficacy tests, but these are not classified under Food and Drug Administration. This review will give an insight into different natural ingredients used in natural/herbal cosmeceutical formulation and their function challenges faced during formulation, advantages of natural cosmeceuticals over regular cosmeceuticals, and regulatory aspects in India.","PeriodicalId":49189,"journal":{"name":"the Indian Journal of Pharmacy","volume":"56 1","pages":"42-51"},"PeriodicalIF":2.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11001171/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140060967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of Alpha-Synuclein protein model against therapeutic aspects of Parkinson's disease. 开发针对帕金森病治疗的 Alpha-Synuclein 蛋白模型。

IF 2.4 4区医学

the Indian Journal of Pharmacy Pub Date : 2024-01-01 Epub Date: 2024-03-08 DOI: 10.4103/ijp.ijp_325_23

Kanika Bhardwaj, Neelu Kanwar Rajawat, Nupur Mathur

引用次数: 0

Fixed drug combination (levosulpiride and rabeprazole)-induced atypical Parkinsonian's disorders with associated anxiety and low-lying depression. 固定联合用药（左旋舒必利和雷贝拉唑）诱发非典型帕金森氏症，并伴有焦虑和低度抑郁。

IF 1.5 4区医学

the Indian Journal of Pharmacy Pub Date : 2024-01-01 Epub Date: 2024-03-08 DOI: 10.4103/ijp.ijp_929_21

Vishal R Tandon, Sheikh Hanan Ismail, Amarjeet Singh

引用次数: 0

Dolutegravir-induced hand-foot skin reaction in a seropositive male: A rare presentation. 一名血清反应呈阳性的男性因多替拉韦引起手足皮肤反应：罕见病例。

IF 2.4 4区医学

the Indian Journal of Pharmacy Pub Date : 2024-01-01 Epub Date: 2024-03-08 DOI: 10.4103/ijp.ijp_258_23

Tirthankar Gayen, Subhasmita Baisya, Devansi Sarawgi, Sumit Sen

引用次数: 0

Drug-induced Stevens-Johnson syndrome in Post traumatic facial injury. 面部外伤后药物诱发的史蒂文斯-约翰逊综合征。

IF 2.4 4区医学

the Indian Journal of Pharmacy Pub Date : 2024-01-01 Epub Date: 2024-03-08 DOI: 10.4103/ijp.ijp_485_23

Asfiya Samar, G N Sahana, P Deepak, Jayashree V Nagaral, M Saranyaa

引用次数: 0

Topical antibiotics in the prevention of port-site infection after elective day care laparoscopic cholecystectomy. 日间护理腹腔镜胆囊切除术后局部使用抗生素预防手术口感染。

IF 2.4 4区医学

the Indian Journal of Pharmacy Pub Date : 2024-01-01 Epub Date: 2024-03-08 DOI: 10.4103/ijp.ijp_882_20

Nipun Sharma, Lileswar Kaman, Siddhant Khare, Divya Dahiya, Ashish Gupta, Uttam Kumar Thakur, Sameer Sethi

{"title":"Topical antibiotics in the prevention of port-site infection after elective day care laparoscopic cholecystectomy.","authors":"Nipun Sharma, Lileswar Kaman, Siddhant Khare, Divya Dahiya, Ashish Gupta, Uttam Kumar Thakur, Sameer Sethi","doi":"10.4103/ijp.ijp_882_20","DOIUrl":"10.4103/ijp.ijp_882_20","url":null,"abstract":"Background: Wound-related infections and complications are rare after day care laparoscopic cholecystectomy (LC). They can have a significant adverse impact on the postoperative course after an uneventful elective LC. The use of topical antibiotics over the port site may prevent such complications.Materials and methods: This trial was conducted from January 2018 to June 2019. Two hundred and fifty patients who met the inclusion and exclusion criteria were included in the study. They were randomized into the topical antibiotic group (Group A, n = 125) and control group (Group B, n = 125). All patients underwent four-port LC. Mupirocin 2% topical antibiotic ointment was applied to all four-port sites in Group A, whereas no topical antibiotic was used in Group B. One dose of prophylactic systemic antibiotics was given to all patients in both groups.Results: The mean age was 43.22 ± 12.7 years in Group A and 43.44 ± 12.5 years in Group B. The comorbidities and the other variables were comparable between the two groups. The port-site infection (PSI) was observed in one patient in Group A and three patients in Group B, which was statistically nonsignificant (P = 0.622). The mean time of detection of infection was 4.75 ± 1.7 days. All the infections were superficial surgical site infections. Microbiological swabs culture of the infected wounds yielded no growth of bacteria.Conclusion: The PSI after LC is very less. The use of topical antibiotics to prevent PSIs after LC could not be established.","PeriodicalId":49189,"journal":{"name":"the Indian Journal of Pharmacy","volume":"56 1","pages":"16-19"},"PeriodicalIF":2.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11001178/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140060890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Real-world safety and effectiveness of Pistacia lentiscus (mastic gum) in patients with diabetic gastroparesis: 24-week interim analysis postintervention. Pistacia lentiscus（桉树胶）对糖尿病胃轻瘫患者的实际安全性和有效性：干预后 24 周中期分析。

IF 2.4 4区医学

the Indian Journal of Pharmacy Pub Date : 2024-01-01 Epub Date: 2024-03-08 DOI: 10.4103/ijp.ijp_555_23

Ravi Kant, Ajaypal Singh, Rohit Raina, Vandana Dhingra, Mukesh Bairwa, Varsha Kanwar

{"title":"Real-world safety and effectiveness of Pistacia lentiscus (mastic gum) in patients with diabetic gastroparesis: 24-week interim analysis postintervention.","authors":"Ravi Kant, Ajaypal Singh, Rohit Raina, Vandana Dhingra, Mukesh Bairwa, Varsha Kanwar","doi":"10.4103/ijp.ijp_555_23","DOIUrl":"10.4103/ijp.ijp_555_23","url":null,"abstract":"Introduction: Gastrointestinal neuropathies are frequently found in diabetic patients.Aim: The aim of this study was to find out the safety, adverse reactions, and long-term effectiveness of Pistacia lentiscus plant extract (mastic gum) in diabetic gastroparesis (DG) with respect to sustainable improvement in gastroparesis symptoms (Gastrointestinal Cardinal Symptom Index [GCSI] score) by observational follow-up study of a single-centric double-blind noninferiority randomized control trial.Materials and methods: Thirty-eight individuals were recruited and equally randomized in two study groups based on GCSI score and TC99 radionuclide gastric emptying scintigraphy (GES), i.e. the mastic gum group and the levosulpiride group. After 24 weeks, the GCSI score was recalculated in both the groups, and patients were evaluated for the safety, adverse reactions, and long-term effectiveness of mastic gum and the standard drug levosulpiride.Results: In the extended study, mean GCSI score changes at 24 weeks were statistically significant (P < 0.001) (t-test) between the two groups. In the mastic gum arm, the change in mean GCSI score at 24 weeks was statistically nonsignificant mean ± (standard deviation [SD]) 16.7± (3.81) compared to the GCSI score at 2-month postintervention mean (SD) 16.35± (2.27) (intragroup P = 0.89) (repeated measures ANOVA). It strongly indicates that mastic gum provided a sustainable improvement in DG symptoms in comparison to levosulpiride, with excellent subjective well-being postintervention, without any obvious significant adverse effects.Conclusion: Six-month (24-week) interim analysis of patients suggests that mastic gum gives a sustainable improvement in DG symptoms without any obvious adverse effects as compared to levosulpiride.","PeriodicalId":49189,"journal":{"name":"the Indian Journal of Pharmacy","volume":"56 1","pages":"4-9"},"PeriodicalIF":2.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11001183/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140060974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0