the Indian Journal of Pharmacy最新文献

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Safety evaluation of 5-hydroxytryptophan and S-(2-aminoethyl)isothiouronium bromide hydrobromide on rodent lungs. 5-hydroxytryptophan and S-(2-aminoethyl)isothiouronium bromide hydrobromide 对啮齿动物肺部的安全性评估。
IF 2.4 4区 医学
the Indian Journal of Pharmacy Pub Date : 2024-01-01 Epub Date: 2024-03-08 DOI: 10.4103/ijp.ijp_176_23
Suresh Kumar Thokchom, Namita Indracanti, Anoushka Khanna, Prem Kumar Indraganti
{"title":"Safety evaluation of 5-hydroxytryptophan and S-(2-aminoethyl)isothiouronium bromide hydrobromide on rodent lungs.","authors":"Suresh Kumar Thokchom, Namita Indracanti, Anoushka Khanna, Prem Kumar Indraganti","doi":"10.4103/ijp.ijp_176_23","DOIUrl":"10.4103/ijp.ijp_176_23","url":null,"abstract":"<p><strong>Objectives: </strong>During the past few decades, various compounds have been researched for their potential as radioprotectants, and many of them were found to be safe and effective in several preclinical models. However, many of these compounds were found to have serious adverse effects when evaluated in clinical settings, thereby making them unsuitable for human applications. 5-hydroxytryptophan (5-HTP) and S-(2-aminoethyl) isothiouronium bromide hydrobromide (AET) act in a synergistic fashion to promote radioprotection. The present study primarily emphasizes the safety of fixed dose of 5-HTP + AET in the lungs of C57BL/6 mice, a well-known model used in drug safety studies.</p><p><strong>Materials and methods: </strong>Post-administration of the combination of HTP+AET at specific time points, blood and bronchoalveolar lavage fluid (BALF) were collected for the analysis of inflammatory and oxidative stress markers of the lungs. Thereafter, the mice were sacrificed and the lungs were dissected out, weighed, and fixed in formalin for histopathological studies.</p><p><strong>Results: </strong>The inflammatory biomarkers: tumor necrosis factor-alpha and interleukin-10 and oxidative stress biomarkers: 8-isoprostane and 8-hydroxy-2'-deoxyguanosine were found to have normal levels in blood and BALF in both control and treatment groups, which was further supported by normal histological findings. In addition, other endpoints such as food and water intake were found to be within normal limits.</p><p><strong>Conclusion: </strong>The present safety study reflects that the combination has no adverse effects on the lungs of the experimental mouse. Further, evaluation in higher mammals including nonhuman primates is essential prior to validation of the safety of the combination in humans.</p>","PeriodicalId":49189,"journal":{"name":"the Indian Journal of Pharmacy","volume":"56 1","pages":"28-36"},"PeriodicalIF":2.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11001180/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140060976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stability problems with some vitamins in pharmaceuticals. 药品中某些维生素的稳定性问题。
IF 2.4 4区 医学
the Indian Journal of Pharmacy Pub Date : 1961-06-01
T J MACEK
{"title":"Stability problems with some vitamins in pharmaceuticals.","authors":"T J MACEK","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":49189,"journal":{"name":"the Indian Journal of Pharmacy","volume":"23 ","pages":"150-61"},"PeriodicalIF":2.4,"publicationDate":"1961-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"23358384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A note on the pharmacopeial characteristics of injection of sodium antimony V gluconate (concentrated). 葡萄糖酸锑钒钠(浓缩)注射液药典特征的说明。
IF 2.4 4区 医学
the Indian Journal of Pharmacy Pub Date : 1949-09-01
A N BOSE, T N GHOSH
{"title":"A note on the pharmacopeial characteristics of injection of sodium antimony V gluconate (concentrated).","authors":"A N BOSE,&nbsp;T N GHOSH","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":49189,"journal":{"name":"the Indian Journal of Pharmacy","volume":"11 5","pages":"155-7"},"PeriodicalIF":2.4,"publicationDate":"1949-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32123197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Labile nature of the kurchi bases; assay of kurchi-bismuth-iodide. 库尔奇基地的不稳定性;碘化钾铋的测定。
IF 2.4 4区 医学
the Indian Journal of Pharmacy Pub Date : 1949-09-01
N K BASU, N N BATTACHARYA
{"title":"Labile nature of the kurchi bases; assay of kurchi-bismuth-iodide.","authors":"N K BASU,&nbsp;N N BATTACHARYA","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":49189,"journal":{"name":"the Indian Journal of Pharmacy","volume":"11 5","pages":"157-60"},"PeriodicalIF":2.4,"publicationDate":"1949-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32123170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Some observations on the deterioration of ascorbic acid solution. 抗坏血酸溶液变质的一些观察。
IF 2.4 4区 医学
the Indian Journal of Pharmacy Pub Date : 1949-09-01
S K GANGULY
{"title":"Some observations on the deterioration of ascorbic acid solution.","authors":"S K GANGULY","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":49189,"journal":{"name":"the Indian Journal of Pharmacy","volume":"11 5","pages":"145-7"},"PeriodicalIF":2.4,"publicationDate":"1949-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32123169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Studies in the stability of compressed tablets of ascorbic acid. 抗坏血酸压缩片的稳定性研究。
IF 2.4 4区 医学
the Indian Journal of Pharmacy Pub Date : 1949-09-01
S B SENGUPTA, M BOSE
{"title":"Studies in the stability of compressed tablets of ascorbic acid.","authors":"S B SENGUPTA,&nbsp;M BOSE","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":49189,"journal":{"name":"the Indian Journal of Pharmacy","volume":"11 5","pages":"160"},"PeriodicalIF":2.4,"publicationDate":"1949-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32123175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Extraction of quinine from cinchona barks. 金鸡纳树皮中奎宁的提取。
IF 2.4 4区 医学
the Indian Journal of Pharmacy Pub Date : 1949-09-01
N B BHUNVARA, M L KHORANA
{"title":"Extraction of quinine from cinchona barks.","authors":"N B BHUNVARA,&nbsp;M L KHORANA","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":49189,"journal":{"name":"the Indian Journal of Pharmacy","volume":"11 5","pages":"148-55"},"PeriodicalIF":2.4,"publicationDate":"1949-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32123171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of different branches of science in pharmaceutics. 不同科学分支在药剂学中的作用。
IF 2.4 4区 医学
the Indian Journal of Pharmacy Pub Date : 1948-01-01
P C GUHA
{"title":"Role of different branches of science in pharmaceutics.","authors":"P C GUHA","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":49189,"journal":{"name":"the Indian Journal of Pharmacy","volume":"10 1","pages":"10-5"},"PeriodicalIF":2.4,"publicationDate":"1948-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27762274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A note on the Indian pharmacopoeial list. 印度药典目录上的注释。
IF 2.4 4区 医学
the Indian Journal of Pharmacy Pub Date : 1948-01-01
S S SUBRAMANIAN
{"title":"A note on the Indian pharmacopoeial list.","authors":"S S SUBRAMANIAN","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":49189,"journal":{"name":"the Indian Journal of Pharmacy","volume":"10 1","pages":"4"},"PeriodicalIF":2.4,"publicationDate":"1948-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27762265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Industrial aspects of pharmaceutics. 制药工业方面。
IF 2.4 4区 医学
the Indian Journal of Pharmacy Pub Date : 1948-01-01
S B SEN GUPTA
{"title":"Industrial aspects of pharmaceutics.","authors":"S B SEN GUPTA","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":49189,"journal":{"name":"the Indian Journal of Pharmacy","volume":"10 1","pages":"16"},"PeriodicalIF":2.4,"publicationDate":"1948-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27762276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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