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Valproate-induced disabling tremor in a case of Rasmussen's encephalitis. 在一例拉斯穆森脑炎患者中，丙戊酸钠诱发了致残性震颤。
IF 2.4 4区 医学
the Indian Journal of Pharmacy Pub Date : 2024-01-01 Epub Date: 2024-03-08 DOI: 10.4103/ijp.ijp_76_23
Rajesh Verma, Rajarshi Chakraborty
{"title":"Valproate-induced disabling tremor in a case of Rasmussen's encephalitis.","authors":"Rajesh Verma, Rajarshi Chakraborty","doi":"10.4103/ijp.ijp_76_23","DOIUrl":"10.4103/ijp.ijp_76_23","url":null,"abstract":"","PeriodicalId":49189,"journal":{"name":"the Indian Journal of Pharmacy","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11001175/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140060891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reduction of COVID-19 vaccine-induced neutralizing antibody and changing of molecular epidemiology pattern of omicron SARS-CoV-2 subvariant: Observed interrelationship. COVID-19 疫苗诱导的中和抗体减少与 SARS-CoV-2 子变异体分子流行病学模式的变化：观察到的相互关系
IF 2.4 4区 医学
the Indian Journal of Pharmacy Pub Date : 2024-01-01 Epub Date: 2024-03-08 DOI: 10.4103/ijp.ijp_362_23
Beuy Joob, Pathum Sookaromdee, Viroj Wiwanitkit
{"title":"Reduction of COVID-19 vaccine-induced neutralizing antibody and changing of molecular epidemiology pattern of omicron SARS-CoV-2 subvariant: Observed interrelationship.","authors":"Beuy Joob, Pathum Sookaromdee, Viroj Wiwanitkit","doi":"10.4103/ijp.ijp_362_23","DOIUrl":"10.4103/ijp.ijp_362_23","url":null,"abstract":"","PeriodicalId":49189,"journal":{"name":"the Indian Journal of Pharmacy","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11001174/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140060975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Expected usefulness of the third dose of COVID-19 vaccine for adolescents living with underlying HIV infection. COVID-19第三剂疫苗对潜在艾滋病毒感染青少年的预期效用。
IF 2.4 4区 医学
the Indian Journal of Pharmacy Pub Date : 2024-01-01 Epub Date: 2024-03-08 DOI: 10.4103/ijp.ijp_17_23
Sora Yasri, Viroj Wiwanitkit
{"title":"Expected usefulness of the third dose of COVID-19 vaccine for adolescents living with underlying HIV infection.","authors":"Sora Yasri, Viroj Wiwanitkit","doi":"10.4103/ijp.ijp_17_23","DOIUrl":"10.4103/ijp.ijp_17_23","url":null,"abstract":"","PeriodicalId":49189,"journal":{"name":"the Indian Journal of Pharmacy","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11001181/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140060972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The pivotal role of artificial intelligence in enhancing experimental animal model research: A machine learning perspective. 人工智能在加强实验动物模型研究中的关键作用：机器学习的视角。
IF 2.4 4区 医学
the Indian Journal of Pharmacy Pub Date : 2024-01-01 Epub Date: 2024-03-08 DOI: 10.4103/ijp.ijp_81_24
Anushka Ghosh, Gajendra Choudhary, Bikash Medhi
{"title":"The pivotal role of artificial intelligence in enhancing experimental animal model research: A machine learning perspective.","authors":"Anushka Ghosh, Gajendra Choudhary, Bikash Medhi","doi":"10.4103/ijp.ijp_81_24","DOIUrl":"10.4103/ijp.ijp_81_24","url":null,"abstract":"","PeriodicalId":49189,"journal":{"name":"the Indian Journal of Pharmacy","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11001179/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140060978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of anthelmintic activity of medicinal plants: Why earthworm? 评估药用植物的驱虫活性：为什么是蚯蚓？
IF 2.4 4区 医学
the Indian Journal of Pharmacy Pub Date : 2024-01-01 Epub Date: 2024-03-08 DOI: 10.4103/ijp.ijp_554_23
Sanjib Bhattacharya
{"title":"Evaluation of anthelmintic activity of medicinal plants: Why earthworm?","authors":"Sanjib Bhattacharya","doi":"10.4103/ijp.ijp_554_23","DOIUrl":"10.4103/ijp.ijp_554_23","url":null,"abstract":"","PeriodicalId":49189,"journal":{"name":"the Indian Journal of Pharmacy","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11001177/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140060971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effective dose of remimazolam in adult gastroscopy. 成人胃镜检查中瑞马唑仑的有效剂量。
IF 2.4 4区 医学
the Indian Journal of Pharmacy Pub Date : 2024-01-01 Epub Date: 2024-03-08 DOI: 10.4103/ijp.ijp_425_22
Rongyan Zhang, Gang Zhao, Zhangjun Yan, Hongmei Xuan, Yan Chen
{"title":"The effective dose of remimazolam in adult gastroscopy.","authors":"Rongyan Zhang, Gang Zhao, Zhangjun Yan, Hongmei Xuan, Yan Chen","doi":"10.4103/ijp.ijp_425_22","DOIUrl":"10.4103/ijp.ijp_425_22","url":null,"abstract":"<p><strong>Objectives: </strong>The objectives of this study were to explore the median effective dose (ED50) and the dose required for successful anesthesia in 95% of the patients (ED95) of remimazolam for intravenous anesthesia in adult outpatients undergoing gastroscopy.</p><p><strong>Methods: </strong>This pilot study was conducted in patients scheduled to undergo painless gastroscopy at the authors' hospital between March 15, 2022 and March 25, 2022. The ED of remimazolam was determined using the modified Dixon sequential method, using an initial induction dose of 0.2 mg/kg. With successful or failed anesthesia, the remimazolam dose was decreased or increased by 0.05 mg/kg for the next patient, respectively.</p><p><strong>Results: </strong>Twenty-two patients (43.6 ± 10.5 years of age) were enrolled. During gastroscopy, the remimazolam induction dose was 19.93 ± 2.96 mg (0.2-0.45 mg/kg). Eighteen patients could complete anesthesia with remimazolam alone, and four patients needed propofol to complete anesthesia. The induction time after the injection of remimazolam was 20.8 ± 8.4 s, the gastroscopy time was 5.1 ± 1.3 min, and the anesthesia recovery time was 17.5 ± 5.6 min. The ED50 and the ED95 of remimazolam were 0.362 mg/kg (95% confidence interval [CI]: 0.313-0.455 mg/kg) and 0.464 mg/kg (95% CI: 0.403-2.242 mg/kg), respectively. The vital signs of all patients remained within the predefined acceptable limits. No patients required antagonist rescue.</p><p><strong>Conclusion: </strong>The ED50 and ED95 of remimazolam for adult gastroscopy were 0.362 mg/kg and 0.464 mg/kg, respectively. Additional anesthetics might be required during gastroscopy in some patients.</p><p><strong>Trial registration: </strong>The trial was registered. The number is ChiCTR2200057446.</p>","PeriodicalId":49189,"journal":{"name":"the Indian Journal of Pharmacy","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11001170/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140060977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Amelioration by Withania somnifera of neurobehavioural and immunological markers in time dependent sensitization induced post traumatic stress disorder in rats. 在时间依赖性敏化诱导的创伤后应激障碍中，睡茄可改善大鼠的神经行为和免疫标记。
IF 2.4 4区 医学
the Indian Journal of Pharmacy Pub Date : 2024-01-01 Epub Date: 2024-03-08 DOI: 10.4103/ijp.ijp_825_22
Sana Rehman, Mohammad Faizan, Nafaa Hasan Ali, Kavita Gulati, Arunabha Ray
{"title":"Amelioration by Withania somnifera of neurobehavioural and immunological markers in time dependent sensitization induced post traumatic stress disorder in rats.","authors":"Sana Rehman, Mohammad Faizan, Nafaa Hasan Ali, Kavita Gulati, Arunabha Ray","doi":"10.4103/ijp.ijp_825_22","DOIUrl":"10.4103/ijp.ijp_825_22","url":null,"abstract":"<p><strong>Aims and objectives: </strong>Posttraumatic stress disorder (PTSD) is a complex neuropsychiatric pathophysiology with an unmet need for safe, effective, and sustainable therapeutic modalities. Thus, the present study evaluated the effects of Withaniasomnifera (WS, Ashwagandha) on an experimental model of PTSD in rats.</p><p><strong>Materials and methods: </strong>Wistar rats (200-250 g) were used and time-dependent sensitization (TDS) was used as the experimental model of PTSD. Standardized WS root extract (100 and 300 mg/kg, p.o. for 15 days) was administered with TDS and their effects were observed on neurobehavioral (anxiety) and brain cytokines, corticosterone, and oxidative stress markers.</p><p><strong>Results: </strong>Exposure to TDS resulted in anxiogenic behavior in the elevated plus maze (EPM) test, i.e., reductions in open arm entries and open arm time, as compared to the control group. Pretreatment with WS extract (100 and 300 mg/kg × 14 days) attenuated the TDS-induced anxiogenic activity in a dose-related manner, and these WS effects were comparable to those seen after the comparator drug fluoxetine (10 mg/kg). Assay of brain homogenates showed that TDS also resulted in elevations in brain interleukin-6 and reduction in corticosterone levels in both the hippocampus and prefrontal cortex (PFC), which were reversed after WS pretreatments. Further, WS pretreatment also reversed the TDS-induced changes in brain oxidative stress markers, namely elevated malondialdehyde and reduced glutathione levels in both the hippocampus and PFC.</p><p><strong>Conclusion: </strong>These results suggest that WS could have potential as a therapeutic agent for treating PTSD by attenuating anxiogenesis, neuroimmune axis activation, and oxidative stress.</p>","PeriodicalId":49189,"journal":{"name":"the Indian Journal of Pharmacy","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11001169/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140060966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cosmeceuticals: A transit state from synthetic to natural. 药妆：从合成到天然的过渡状态。
IF 2.4 4区 医学
the Indian Journal of Pharmacy Pub Date : 2024-01-01 Epub Date: 2024-03-08 DOI: 10.4103/ijp.ijp_244_21
Sathyabama Sathyaseelan, Bhavana Hemantha Rao, S Anushmati
{"title":"Cosmeceuticals: A transit state from synthetic to natural.","authors":"Sathyabama Sathyaseelan, Bhavana Hemantha Rao, S Anushmati","doi":"10.4103/ijp.ijp_244_21","DOIUrl":"10.4103/ijp.ijp_244_21","url":null,"abstract":"<p><p>Cosmeceuticals are topically applied cosmetic products containing a biologically active ingredient with a pharmaceutical effect that improves, nourishes, and treats the skin appearance. The trend of cosmeceuticals began during the mid-20th century due to its potent ingredients with therapeutic effects for various skin ailments. Even though there is a great advancement in cosmetics, which shows the risk of cosmetic linked melanoma, endocrine disorders, and birth defects which was one in 1500 people during 1935 have increased to one in 75 people in 2000. Hence, as a part of reducing the harmful effect, natural ingredients were added to the formulation to give the pharmaceutical effect. Thus, natural/herbal cosmeceuticals were introduced. Due to the awareness of the side effects such as photo-toxicity, mutagenicity, irritation by these synthetic products, people started preferring herbal/natural cosmetic products. Moreover, natural cosmeceuticals were proven to be effective against various dermatological conditions as well as have fewer side effects marked the natural/herbal cosmeceuticals in the market. Unlike a drug, cosmeceutical products undergo safety, toxicity, and efficacy tests, but these are not classified under Food and Drug Administration. This review will give an insight into different natural ingredients used in natural/herbal cosmeceutical formulation and their function challenges faced during formulation, advantages of natural cosmeceuticals over regular cosmeceuticals, and regulatory aspects in India.</p>","PeriodicalId":49189,"journal":{"name":"the Indian Journal of Pharmacy","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11001171/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140060967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of Alpha-Synuclein protein model against therapeutic aspects of Parkinson's disease. 开发针对帕金森病治疗的 Alpha-Synuclein 蛋白模型。
IF 2.4 4区 医学
the Indian Journal of Pharmacy Pub Date : 2024-01-01 Epub Date: 2024-03-08 DOI: 10.4103/ijp.ijp_325_23
Kanika Bhardwaj, Neelu Kanwar Rajawat, Nupur Mathur
{"title":"Development of Alpha-Synuclein protein model against therapeutic aspects of Parkinson's disease.","authors":"Kanika Bhardwaj, Neelu Kanwar Rajawat, Nupur Mathur","doi":"10.4103/ijp.ijp_325_23","DOIUrl":"10.4103/ijp.ijp_325_23","url":null,"abstract":"<p><p>JOURNAL/ijpha/04.03/01363791-202456010-00007/figure1/v/2024-03-07T095025Z/r/image-tiff Parkinson's disease (PD) is the most common neurodegenerative disease caused by the steady depletion of dopamine in the striatum due to the loss of dopaminergic neurons. Most of the current therapeutics work on rebuilding the striatal dopamine level through oral administration of levodopa which stops the symptoms of PD. But there is a long-term motor complication with these dopamine precursors. Moreover, no preventive treatment is available for PD. Thus, before finding a therapeutic treatment for PD, it is necessary to first understand the basic cause of PD. Moreover, alpha-synuclein oligomerization can be the major factor in PD. From the UniProt database, protein information was extracted, and the model was designed by homology modeling technique and validated by the model validation server. Hence, the designed model has 96.5% most favored region and 0% disallowed region. Therefore, the model is stable based on RC plot parameters.</p>","PeriodicalId":49189,"journal":{"name":"the Indian Journal of Pharmacy","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11001172/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140060968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fixed drug combination (levosulpiride and rabeprazole)-induced atypical Parkinsonian's disorders with associated anxiety and low-lying depression. 固定联合用药（左旋舒必利和雷贝拉唑）诱发非典型帕金森氏症，并伴有焦虑和低度抑郁。
IF 2.4 4区 医学
the Indian Journal of Pharmacy Pub Date : 2024-01-01 Epub Date: 2024-03-08 DOI: 10.4103/ijp.ijp_929_21
Vishal R Tandon, Sheikh Hanan Ismail, Amarjeet Singh
{"title":"Fixed drug combination (levosulpiride and rabeprazole)-induced atypical Parkinsonian's disorders with associated anxiety and low-lying depression.","authors":"Vishal R Tandon, Sheikh Hanan Ismail, Amarjeet Singh","doi":"10.4103/ijp.ijp_929_21","DOIUrl":"10.4103/ijp.ijp_929_21","url":null,"abstract":"<p><p>We hereby describe a rare case of levosulpiride-induced atypical parkinsonism presenting with sluggish movements, atypical kinetic tremors (tremors with voluntary movement), periorbital tremors, dystonia, difficulty in speech and coordination, postural imbalance, with additional features of difficulty in swallowing and drooling with associated recent onset psychiatric disturbances such as anxiety and low-lying depression. The dechallenge of levosulpiride and medications for associated anxiety and low-lying depression caused a complete remission of the disease within 2 ½ months.</p>","PeriodicalId":49189,"journal":{"name":"the Indian Journal of Pharmacy","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11001173/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140060973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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