the Indian Journal of Pharmacy最新文献

Comments on "Efficacy and safety of different doses of apremilast in mild to moderate psoriasis". 关于“不同剂量阿普米司特治疗轻中度牛皮癣的疗效和安全性”的评论。

IF 1.5 4区医学

the Indian Journal of Pharmacy Pub Date : 2026-09-01 Epub Date: 2026-09-02 DOI: 10.4103/ijp.ijp_1055_26

Nitin Chintaman Gawari, Aishwarya Rudrabhate, Abhijeet Tilak, B T Rane

引用次数: 0

Levocetirizine-induced paradoxical fixed drug eruption: A case report with causality assessment. 左西替利嗪引起的矛盾的固定药疹：一例报告和因果关系评估。

IF 1.5 4区医学

the Indian Journal of Pharmacy Pub Date : 2026-09-01 Epub Date: 2026-09-02 DOI: 10.4103/ijp.ijp_276_26

Ambili Remesh, Madhavi S Lekshmi, Subramaniam Reshmi

{"title":"Levocetirizine-induced paradoxical fixed drug eruption: A case report with causality assessment.","authors":"Ambili Remesh, Madhavi S Lekshmi, Subramaniam Reshmi","doi":"10.4103/ijp.ijp_276_26","DOIUrl":"10.4103/ijp.ijp_276_26","url":null,"abstract":"Abstract: Fixed drug eruptions (FDE) are drug-induced skin reactions that repeatedly occur at the same anatomical site. The skin lesions are usually clear hyperpigmented patches that may develop into blisters. The skin response involves type IV delayed hypersensitivity reactions and is caused by drug-specific memory CD8 T-cells located at the affected skin site. Levocetirizine, an H1-selective second-generation piperazine antihistamine, has a good safety profile and is used to treat the skin reactions. Its nonprescription availability leads to self-medication and unrecognised adverse drug reactions (ADR). FDE due to levocetirizine, as well as with cetirizine, is less common in the literature. This case was reported to our ADR Monitoring Center and causality was assessed as probable and preventable. This case shows that antihistamines such as levocetirizine can trigger FDE in susceptible individuals. Improving clinical awareness through robust Pharmacovigilance activities, educating patients about triggers, and discouraging self-medication are crucial for preventing recurrence.","PeriodicalId":49189,"journal":{"name":"the Indian Journal of Pharmacy","volume":"58 5","pages":"602-604"},"PeriodicalIF":1.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13610753/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148876355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quick response-code linked video-based objective structured practical examination: Bridging gaps in pharmacology education. 快速反应代码链接视频为基础的客观结构化实践考试：弥合差距在药理学教育。

IF 1.5 4区医学

the Indian Journal of Pharmacy Pub Date : 2026-09-01 Epub Date: 2026-09-02 DOI: 10.4103/ijp.ijp_1351_25

Anupa Eldhose, Rohini Ann Mathew, Aniket Kumar, Margaret Shanthi

{"title":"Quick response-code linked video-based objective structured practical examination: Bridging gaps in pharmacology education.","authors":"Anupa Eldhose, Rohini Ann Mathew, Aniket Kumar, Margaret Shanthi","doi":"10.4103/ijp.ijp_1351_25","DOIUrl":"10.4103/ijp.ijp_1351_25","url":null,"abstract":"Introduction: Traditional live demonstrations were found to be insufficient in supporting the long-term retention and reproducibility of practical skills among medical students. Thus, we adopted a blended learning approach that included self-created demonstration videos.Study objectives: To determine the effectiveness of using a quick response (QR) code linked to prerecorded demonstration videos for various objective structured practical examination (OSPE) stations by baseline and post innovation test scores and to obtain students' feedback on this innovative teaching approach.Materials and methods: Following IRB approval and informed consent, the students were trained in small-group live demonstrations of OSPE stations. Then, a baseline OSPE assessment (pretest) was done. Instructional demonstration videos on different routes of drug administration were created following a structured checklist. This was linked to a QR code. After 2 months, these videos were uploaded to Google Drive for student access. This was followed by a posttest and students' feedback. Statistical analysis was done using a paired t-test, and a P < 0.05 was considered significant.Results: The posttest scores of 17.54 ± 2.18 (mean ± standard deviation [SD]) demonstrated a significant improvement in student performance compared to the pretest scores of 11.95 ± 6.69 (mean ± SD), with a P < 0.001. In the feedback, a majority (>95%) of students reported that the QR code-linked demonstration videos improved their comprehension of OSPE techniques, agreed that blended learning improved their understanding, and recommended these videos for subsequent batches.Conclusion: This integrated video-assisted model holds promise for broader application across medical curricula, aiming to enhance skill retention and learner autonomy.","PeriodicalId":49189,"journal":{"name":"the Indian Journal of Pharmacy","volume":"58 5","pages":"575-580"},"PeriodicalIF":1.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13610775/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148875546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recurrent severe cutaneous reaction to fluoroquinolones and rifampicin in a human immunodeficiency virus-positive patient with disseminated tuberculosis: A rare case report. 人类免疫缺陷病毒阳性的弥散性肺结核患者对氟喹诺酮类药物和利福平的复发性严重皮肤反应：罕见病例报告。

IF 1.5 4区医学

the Indian Journal of Pharmacy Pub Date : 2026-09-01 Epub Date: 2026-09-02 DOI: 10.4103/ijp.ijp_120_26

Divya Chamariya, Taru Garg, Hitesh Verma, Lalit Kumar Gupta

引用次数: 0

The precipitous selection of postgraduate dissertations: A call to a "reflection window" in medical education. 研究生论文的仓促选择：呼吁在医学教育中建立“反思窗口”。

IF 1.5 4区医学

the Indian Journal of Pharmacy Pub Date : 2026-09-01 Epub Date: 2026-09-02 DOI: 10.4103/ijp.ijp_253_26

Yasir Hassan, Siddhi Patel, Gampa Sarjanya, Prabu Ram

引用次数: 0

Modulation of mineralocorticoid receptor protects tributyltin chloride-induced early neurotoxic anomalies in rats. 调节矿物皮质激素受体对三丁基锡诱发的大鼠早期神经毒性异常的保护作用。

IF 1.5 4区医学

the Indian Journal of Pharmacy Pub Date : 2026-09-01 Epub Date: 2026-09-02 DOI: 10.4103/ijp.ijp_1380_25

Kamendra Singh, Sachin Tyagi, Himanshu Aggarwal

{"title":"Modulation of mineralocorticoid receptor protects tributyltin chloride-induced early neurotoxic anomalies in rats.","authors":"Kamendra Singh, Sachin Tyagi, Himanshu Aggarwal","doi":"10.4103/ijp.ijp_1380_25","DOIUrl":"10.4103/ijp.ijp_1380_25","url":null,"abstract":"Background: Tributyltin chloride (TBTC) is an organotin (OT) compound, a known neurotoxin and an endocrine disruptor, but it is inadequately characterized for its short-term exposure. This study aimed to explore the role of N-acetylcysteine (NAC) and Eplerenone in TBTC induced neurotoxicity in rats.Materials and methods: Rats were exposed to a single dose of TBTC and were behaviorally assessed on open field test, light and dark box, Morris water maze, and rota rod test. Thiobarbituric acid reactive substances (TBARS) and nitrite were estimated as a measure of oxidative and nitrosative stress. Evans blue extravasation was used to assess the blood-brain barrier (BBB) integrity and morphological changes were assessed by histopathology. NAC (50 mg/kg) was used as a standard treatment, and eplerenone (50 and 100 mg/kg) was used as test interventions.Results: Short-term TBTC exposure produced significant anxiety-like behavioral alterations, accompanied by elevated brain TBARS and serum nitrite levels, indicating enhanced oxidative and nitrosative stress. BBB integrity was disrupted, and histopathological examination revealed early structural changes. Treatment with NAC and Eplerenone significantly attenuated behavioral disturbances, oxidative stress markers, BBB disruption, and histopathological damage. In contrast, no significant deficits were observed in spatial memory or motor coordination, likely due to the limited exposure duration.Conclusion: TBTC induced early neurotoxic changes in the brain, which were attenuated by NAC and eplerenone administration. The beneficial effects support for further mechanistic studies on mineralocorticoid receptor modulation as a potential target for OT-induced neurotoxicity.","PeriodicalId":49189,"journal":{"name":"the Indian Journal of Pharmacy","volume":"58 5","pages":"537-544"},"PeriodicalIF":1.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13610759/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148876382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early cutaneous warning signs of compartment syndrome due to iohexol extravasation. 碘己醇外渗引起的筋膜室综合征的早期皮肤警告征象。

IF 1.5 4区医学

the Indian Journal of Pharmacy Pub Date : 2026-09-01 Epub Date: 2026-09-02 DOI: 10.4103/ijp.ijp_1350_25

Diptiranjani Bisoyi, Tapan Kumar Sethi, Prateek Maharana, P Ansuman Abhisek, Aspruha Panda

引用次数: 0

Pharmacological management of obesity: Current landscape and emerging therapies. 肥胖的药理学管理：当前景观和新兴疗法。

IF 1.5 4区医学

the Indian Journal of Pharmacy Pub Date : 2026-09-01 Epub Date: 2026-09-02 DOI: 10.4103/ijp.ijp_37_26

Shubham Atal, Chirag Agrawal, Rahul Gupta, Balakrishnan Sadasivam

{"title":"Pharmacological management of obesity: Current landscape and emerging therapies.","authors":"Shubham Atal, Chirag Agrawal, Rahul Gupta, Balakrishnan Sadasivam","doi":"10.4103/ijp.ijp_37_26","DOIUrl":"10.4103/ijp.ijp_37_26","url":null,"abstract":"Abstract: Obesity is now recognized as a chronic, multifactorial, and progressive disease as opposed to mere excess of body weight. It significantly increases the risk of type 2 diabetes, cardiovascular disease, metabolic-associated fatty liver disease, and mental health disorders. 2022 data reveal that nearly 3 billion individuals worldwide were living with either obesity or overweight. Pharmacological therapy has evolved remarkably. Earlier medications targeted primarily the brain's monoaminergic pathways but they were withdrawn due to safety concerns. Currently, six medications (Orlistat, Phentermine/Topiramate, Naltrexone/Bupropion, Liraglutide, Semaglutide, and Tirzepatide) are approved by the U.S. Food and Drug Administration for long-term obesity management and among these, glucagon-like peptide receptor agonists have revolutionized the therapy. The emerging pipeline is even more promising. It has new dual and triple combinations such as CagriSema, Survodutide, and Retatrutide for better efficacy and metabolic outcomes, as well as long-acting and oral formulations, which will improve adherence and accessibility. India released its new obesity guideline in January 2025, emphasizing on early pharmacotherapy initiation and the adoption of stage-based obesity classification. Together, these developments signify a transformative era in obesity care where pharmacotherapy is a powerful and evidence-based tool that, in many cases, approaches the efficacy and metabolic benefits traditionally associated with bariatric surgeries.","PeriodicalId":49189,"journal":{"name":"the Indian Journal of Pharmacy","volume":"58 5","pages":"505-512"},"PeriodicalIF":1.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13610767/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148876346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Distribution of CYP2C19 polymorphism and predicted metabolizer phenotypes in the Indian population: A systematic review. 印度人群CYP2C19多态性分布和预测代谢表型：一项系统综述。

IF 1.5 4区医学

the Indian Journal of Pharmacy Pub Date : 2026-09-01 Epub Date: 2026-09-02 DOI: 10.4103/ijp.ijp_285_26

Smriti Singh, Chanchal Goyal, Tejas K Patel, Vivek Hada, Chandra Kanta Bhusal, Hira Lal Bhalla, Manoj Kumar Saurabh

{"title":"Distribution of CYP2C19 polymorphism and predicted metabolizer phenotypes in the Indian population: A systematic review.","authors":"Smriti Singh, Chanchal Goyal, Tejas K Patel, Vivek Hada, Chandra Kanta Bhusal, Hira Lal Bhalla, Manoj Kumar Saurabh","doi":"10.4103/ijp.ijp_285_26","DOIUrl":"10.4103/ijp.ijp_285_26","url":null,"abstract":"Abstract: The distribution of CYP2C19 polymorphisms and associated metabolizer phenotypes varies across populations. There is a lack of large scale pooled data on CYP2C19 polymorphisms and associated metabolizer phenotypes in Indian population. This systematic review and meta analysis aimed to determine the prevalence of CYP2C19 loss of function and gain of function polymorphisms (*2, *3, and *17) and their associated genotype predicted metabolizer phenotypes in the Indian population. A systematic literature search was conducted in electronic databases to identify relevant studies reporting CYP2C19 polymorphisms in individuals of Indian origin. Observational studies employing validated genotyping methods were included. Meta analysis was performed using a random effects model with double arcsine transformation to estimate pooled prevalence with 95% confidence intervals (CI). Subgroup analyses were conducted based on geographical regions of India, and heterogeneity was assessed using the I2 statistic. A total of 31 studies were included in the analysis. The pooled prevalence of the CYP2C19*2 allele was 32% (95% CI: 28%-37%), with the highest prevalence observed in South India. The CYP2C19*3 allele was rare, with a pooled prevalence of 1% (95% CI: 0%-1%). The gain of function allele CYP2C19*17 showed a prevalence of 17% (95% CI: 13%-21%), with the highest frequency in North India. The pooled prevalence of poor metabolizers was 16% (95% CI: 11%-22%), whereas ultra rapid metabolizers accounted for 12% (95% CI: 4%-24%) of the population. Substantial regional variability in allele frequencies and metabolizer phenotypes was observed. The distribution of CYP2C19 polymorphisms and metabolizer phenotypes shows considerable regional variability within the Indian population.","PeriodicalId":49189,"journal":{"name":"the Indian Journal of Pharmacy","volume":"58 5","pages":"513-523"},"PeriodicalIF":1.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13610760/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148876377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of atypical antipsychotics on cytokine profiles in schizophrenia: An 8-week longitudinal study. 非典型抗精神病药物对精神分裂症患者细胞因子谱的影响：一项为期8周的纵向研究。

IF 1.5 4区医学

the Indian Journal of Pharmacy Pub Date : 2026-09-01 Epub Date: 2026-09-02 DOI: 10.4103/ijp.ijp_63_26

Aashima Handa, Archana Mishra, Sudhir Chandra Sarangi, Mamta Sood, K H Reeta

{"title":"Impact of atypical antipsychotics on cytokine profiles in schizophrenia: An 8-week longitudinal study.","authors":"Aashima Handa, Archana Mishra, Sudhir Chandra Sarangi, Mamta Sood, K H Reeta","doi":"10.4103/ijp.ijp_63_26","DOIUrl":"10.4103/ijp.ijp_63_26","url":null,"abstract":"Background: Schizophrenia has traditionally been conceptualized through dopaminergic and glutamatergic frameworks. In recent years, attention has increasingly focused on the role of immune dysregulation in its pathophysiology, although conclusive evidence remains limited. In this context, the present study aimed to investigate alterations in cytokine profiles and their association with clinical symptomatology following treatment with atypical antipsychotics for 8 weeks.Materials and methods: Thirty patients aged 18-65 years, diagnosed with schizophrenia as per Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition criteria, were enrolled. Participants received atypical antipsychotic therapy as clinically indicated. Symptom severity was assessed using the Scale for the Assessment of Positive Symptoms (SAPS) and the Scale for the Assessment of Negative Symptoms (SANS). Serum levels of tumor necrosis factor-alpha (TNF-α), interleukin-8 (IL-8), and regulated upon activation, normal T-cell expressed and secreted (RANTES) were measured at baseline and after 8 weeks of therapy.Results: Median SAPS and SANS scores significantly decreased from 39 to 30.5 (P < 0.001) and from 30 to 28 (P < 0.001), respectively. Correspondingly, median serum TNF-α levels declined from 28.55 (6.51-227) to 19.98 (4.56-145) pg/mL (P = 0.033). Reductions were also observed for IL-8 (62.2-50.25 pg/mL; P = 0.171) and RANTES (520-500 pg/mL; P = 0.758).Conclusion: Treatment with atypical antipsychotics significantly attenuated both positive and negative symptoms and reduced TNF-α levels in patients with schizophrenia. The concomitant decline in cytokine concentrations suggests a potential immunomodulatory effect of treatment, highlighting TNF-α, IL-8, and RANTES as possible prognostic biomarkers.","PeriodicalId":49189,"journal":{"name":"the Indian Journal of Pharmacy","volume":"58 5","pages":"558-566"},"PeriodicalIF":1.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13610757/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148876350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0