the Indian Journal of Pharmacy最新文献

Null result: Inconvenient, underreported, and indispensable! 无效结果：不方便，少报，但不可或缺！

IF 1.5 4区医学

the Indian Journal of Pharmacy Pub Date : 2026-05-01 DOI: 10.4103/ijp.ijp_464_26

Rituparna Maiti, Archana Mishra, Debasish Hota

引用次数: 0

Effect of adding ketamine to etomidate infusion on serum cortisol levels for anesthetic induction compared to etomidate infusion alone in elective surgical patients: A randomized controlled trial. 选择性手术患者麻醉诱导时加入氯胺酮与单独输注依托咪酯相比对血清皮质醇水平的影响：一项随机对照试验。

IF 1.5 4区医学

the Indian Journal of Pharmacy Pub Date : 2026-05-01 DOI: 10.4103/ijp.ijp_1319_25

M V S Satya Prakash, L Jency, Sakthirajan Panneerselvam, Prashant Shankarrao Adole

{"title":"Effect of adding ketamine to etomidate infusion on serum cortisol levels for anesthetic induction compared to etomidate infusion alone in elective surgical patients: A randomized controlled trial.","authors":"M V S Satya Prakash, L Jency, Sakthirajan Panneerselvam, Prashant Shankarrao Adole","doi":"10.4103/ijp.ijp_1319_25","DOIUrl":"https://doi.org/10.4103/ijp.ijp_1319_25","url":null,"abstract":"Purpose: This study aimed to evaluate whether the addition of ketamine to an etomidate infusion could attenuate the reduction in serum cortisol levels compared to etomidate alone in patients undergoing elective surgical procedures.Subjects and methods: Eighty patients aged 18-60 years undergoing elective surgery were randomized into two groups. Group E (n = 40) received etomidate infusion 50 mcg/kg/min till the patient was induced. Group KE (n = 40) received a combined infusion of etomidate (1 mg/dL) + ketamine (5 mg/mL) at a rate of 50 mcg/kg/min of etomidate. The primary aim was to estimate serum cortisol levels at baseline, 4 h, 12 h, and 24 h postinduction.Results: The mean post-induction cortisol levels were significantly lower (p-value < 0.001) in Group E (8 ± 2.54 mcg/dL at 4 hours, 7.06 ± 2.57 mcg/dL at 12 hours, and 8.23 ± 3.1 mcg/dL at 24 hours) compared to Group KE (10.14 ± 1.96 mcg/dL at 4 hours, 10.07 ± 2.48 mcg/dL at 12 hours, and 11.27 ± 2.14 mcg/dL at 24 hours) with a comparable baseline cortisol concentrations (12.95 ± 2.64 mcg/dL) in Group E and (11.74 ± 2.11 mcg/dL) in Group KE. The serum cortisol levels decreased by approximately 39% in Group E and by around 17% in Group KE at 4 h postinduction.Conclusion: The addition of ketamine to an etomidate induction regimen decreases etomidate-induced adrenal suppression while preserving anesthetic efficacy and maintaining hemodynamic stability.","PeriodicalId":49189,"journal":{"name":"the Indian Journal of Pharmacy","volume":"58 3","pages":"259-265"},"PeriodicalIF":1.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147822732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Torsemide and warfarin: A cautionary case of altered international normalized ratio and bleeding risk. 托尔塞米和华法林：一个改变国际标准化比例和出血风险的警示案例。

IF 1.5 4区医学

the Indian Journal of Pharmacy Pub Date : 2026-05-01 DOI: 10.4103/ijp.ijp_1300_25

V H Mohammed, S R Ranjana, Arya S Kumar

{"title":"Torsemide and warfarin: A cautionary case of altered international normalized ratio and bleeding risk.","authors":"V H Mohammed, S R Ranjana, Arya S Kumar","doi":"10.4103/ijp.ijp_1300_25","DOIUrl":"https://doi.org/10.4103/ijp.ijp_1300_25","url":null,"abstract":"Abstract: Warfarin is a widely used oral anticoagulant with a narrow therapeutic index and multiple drug-drug interactions that may significantly alter its anticoagulant effect. Torsemide, a loop diuretic commonly prescribed for heart failure and fluid overload, shares metabolic pathways with warfarin, raising the possibility of clinically significant interactions. However, the evidence regarding this interaction remains limited and inconsistent. A 66-year-old male with a history of type 2 diabetes mellitus, hypertension, chronic kidney disease, and prior aortic valve replacement on chronic warfarin therapy presented with extensive soft tissue necrosis of the left leg following minor trauma. During hospitalization, warfarin (3 mg once daily) and Torsemide (20 mg once daily) were initiated concurrently. Subsequently, the patient developed a progressive elevation in international normalized ratio (INR), necessitating repeated fresh frozen plasma transfusions due to increased bleeding risk. Despite supportive management, INR remained elevated. Torsemide was discontinued and replaced with furosemide, after which a gradual stabilization of INR levels was observed. The patient later required left above-knee amputation due to worsening necrosis but recovered following multidisciplinary management. Assessment using the Naranjo Adverse Drug Reaction Probability Scale suggested a possible interaction between warfarin and Torsemide. This case highlights a potential interaction between warfarin and Torsemide resulting in elevated INR and increased bleeding risk. Clinicians should exercise caution and ensure close INR monitoring when initiating Torsemide in patients receiving warfarin therapy.","PeriodicalId":49189,"journal":{"name":"the Indian Journal of Pharmacy","volume":"58 3","pages":"283-286"},"PeriodicalIF":1.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147822733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Semaglutide in obesity and type 2 diabetes: A review of clinical trial evidence from 1 to 5 semaglutide treatment effect in people with obesity program. 西马鲁肽治疗肥胖症和2型糖尿病：1 ~ 5例西马鲁肽治疗肥胖症的临床试验证据综述

IF 1.5 4区医学

the Indian Journal of Pharmacy Pub Date : 2026-05-01 DOI: 10.4103/ijp.ijp_686_25

Aastha Khanna, Vipin Kumar, Sahil Gola

{"title":"Semaglutide in obesity and type 2 diabetes: A review of clinical trial evidence from 1 to 5 semaglutide treatment effect in people with obesity program.","authors":"Aastha Khanna, Vipin Kumar, Sahil Gola","doi":"10.4103/ijp.ijp_686_25","DOIUrl":"https://doi.org/10.4103/ijp.ijp_686_25","url":null,"abstract":"Abstract: Obesity and type 2 diabetes mellitus (T2DM) are widespread health concerns that often coexist, contributing to increased cardiometabolic risks and premature death. Despite advancements in both lifestyle interventions and medical treatments, achieving lasting weight reduction and stable glycemic control remains a major clinical challenge. This review examines findings from the semaglutide treatment effect in people with obesity 1 (STEP) 1-5 trials, which assessed the effectiveness, safety, and long-term outcomes of once-weekly semaglutide 2.4 mg for weight management in adults. These trials included individuals with and without T2DM, enabling comparison across different populations and interventions. In nondiabetic participants (STEP 1, 3, and 4), semaglutide led to average weight reductions between 10% and 17%, while in patients with T2DM (STEP 2), the reduction was around 10%. The inclusion of intensive behavioral therapy in STEP 3 further enhanced weight loss outcomes. Results from STEP 4 highlighted notable weight regain following treatment withdrawal, reflecting the relapsing nature of obesity. STEP 5 confirmed semaglutide's ability to maintain significant weight loss (~15%) and improve metabolic health over a 2-year period. The most common side effects were gastrointestinal in nature but were generally manageable and nonsevere. Collectively, these trials support semaglutide 2.4 mg as an effective and sustainable option for managing obesity and overweight, including in people with T2DM. The data also emphasize the importance of combining pharmacological therapy with lifestyle modifications and recognize obesity as a long-term condition that necessitates continuous treatment.","PeriodicalId":49189,"journal":{"name":"the Indian Journal of Pharmacy","volume":"58 3","pages":"166-175"},"PeriodicalIF":1.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147822746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comment on Bellapu, Dhanush, et al., sodium glucose co-transporter 2 inhibitors safety depending on their adverse drug reactions and glucose monitoring parameters in type 2 diabetes mellitus. Bellapu， Dhanush等，葡萄糖共转运蛋白2钠抑制剂对2型糖尿病患者药物不良反应和血糖监测参数的安全性评价

IF 1.5 4区医学

the Indian Journal of Pharmacy Pub Date : 2026-05-01 DOI: 10.4103/ijp.ijp_986_25

Priti Dhande, Sanjay Jaiswal, Jayshree S Dawane, Chandra Dhar Shukla

引用次数: 0

Discovery of the protective effect of glutamine on acute alcoholic liver injury. 谷氨酰胺对急性酒精性肝损伤保护作用的研究。

IF 1.5 4区医学

the Indian Journal of Pharmacy Pub Date : 2026-05-01 DOI: 10.4103/ijp.ijp_26_24

Huan Yang, Wei Guo, San-Qiang Li, Bing-Bing Zhang, Dan Wang, Wei-Gang Cheng, Shuning Chen

{"title":"Discovery of the protective effect of glutamine on acute alcoholic liver injury.","authors":"Huan Yang, Wei Guo, San-Qiang Li, Bing-Bing Zhang, Dan Wang, Wei-Gang Cheng, Shuning Chen","doi":"10.4103/ijp.ijp_26_24","DOIUrl":"https://doi.org/10.4103/ijp.ijp_26_24","url":null,"abstract":"Objective: Our research aims to evaluate the important role of glutamine (Gln) in alcohol (ethanol)-induced liver damage.Materials and methods: In our study, the mice were simultaneously divided into normal group, alcohol group, and Gln+alcohol group. After different treatments, we detected alanine aminotransferase (ALT), aspartate aminotransferase (AST), and liver index. Then, some histopathological examination was used to observe the damage of liver tissue, glycogen, and liver cell apoptosis in mice. In addition, the expression of apoptosis-related proteins Bcl-2, Bax, Caspase3, heat stress protein 70 (HSP70), cytochrome cytochrome P450-2E1, NFκB pathway-related proteins IkB-a, NFκB-p65, and tumor necrosis factor-α were detected in different groups by western blotting. The experiment in vitro, we used normal hepatocytes L02, after treatment with alcohol and Gln for 24 h, carried out CCK-8 cell proliferation detection and western blotting to detect the expression of related proteins.Results: Our results showed that, in serological testing, Gln can significantly reduce the levels of ALT, AST, and liver index in Gln+alcohol group; and in the histopathological examination, Gln can increase the glycogen content and decrease the apoptosis rate in Gln+alcohol group. In addition, the differential expression of IκBα, NFκB-p65, and other factors in Western blotting shows that the NFκB signaling pathway plays important role in acute alcoholic liver injury.Conclusions: Our results showed that Gln played an important protective role in alcohol-induced liver injury in mice by regulating glycogen stores, apoptosis, anti-oxidative stress and inhibiting NF-κB signaling pathways in liver cells.","PeriodicalId":49189,"journal":{"name":"the Indian Journal of Pharmacy","volume":"58 3","pages":"215-223"},"PeriodicalIF":1.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147822743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Suzetrigine: A promising analgesic targeting voltage-gated sodium channel. 苏泽三嗪：一种有前景的靶向电压门控钠通道的镇痛药。

IF 1.5 4区医学

the Indian Journal of Pharmacy Pub Date : 2026-05-01 DOI: 10.4103/ijp.ijp_854_25

Samarjit Dey, M V Eeshwar, Vamshidhar Chamala, Sunit Kumar Gupta

引用次数: 0

Hepatic adverse effects of valproic acid: Management strategies. 丙戊酸对肝脏的不良反应：管理策略。

IF 1.5 4区医学

the Indian Journal of Pharmacy Pub Date : 2026-05-01 DOI: 10.4103/ijp.ijp_1224_25

Imen Bouaziz, Rim Atheymen, Rym Sahnoun, Kamilia Ksouda, Hanen Affes, Serria Hammami, Khaled Zghal

{"title":"Hepatic adverse effects of valproic acid: Management strategies.","authors":"Imen Bouaziz, Rim Atheymen, Rym Sahnoun, Kamilia Ksouda, Hanen Affes, Serria Hammami, Khaled Zghal","doi":"10.4103/ijp.ijp_1224_25","DOIUrl":"https://doi.org/10.4103/ijp.ijp_1224_25","url":null,"abstract":"Introduction: Valproic acid (VPA) is a widely prescribed first-generation antiepileptic drug. It can induce different liver adverse effects (AEs) which range from mild to severe.Materials and methods: A retrospective study was conducted by collecting 9-year reports (from January 2015 to June 2023) of VPA-associated hepatic AEs. It was collected in the Regional Center of Pharmacovigilance of Sfax (Tunisia). Causality was evaluated with the French Bégaud et al. imputability method. Plasma VPA concentrations were measured using an automated enzyme immunoassay (INDIKO).Results: We collected the eight cases of hepatic cytolysis with varying severity: Six had mild elevations of liver enzymes, one presented with moderately severe cytolysis and one case was fatal. There management strategies were guided by both transaminase levels and VPA concentrations. For those with alanine aminotransferase levels ≥5 times the upper limit of normal (ULN), we conducted the drug discontinuation. However, for patients with lower levels of transaminases, plasma VPA level measurement was recommended. The concentrations were within or near the ULN. Management consisted of either withdrawal or dose reduction, depending on associated clinical symptoms. Additional investigations to rule out nondrug-related causes performed in five cases were negatives. Most patients recovered favorable outcome after discontinuation or VPA dose reduction.Conclusion: Management of VPA-induced hepatic cytolysis requires integrating the severity of liver enzyme elevations, plasma drug level measurements, and the results of etiological investigation to guide the clinical decisions.","PeriodicalId":49189,"journal":{"name":"the Indian Journal of Pharmacy","volume":"58 3","pages":"266-271"},"PeriodicalIF":1.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147822819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tapentadol-induced urticarial rash in a patient with acute pancreatitis. 急性胰腺炎患者的他他多诱发的荨麻疹。

IF 1.5 4区医学

the Indian Journal of Pharmacy Pub Date : 2026-05-01 DOI: 10.4103/ijp.ijp_1081_25

Srinu Deshidi, Vinod Hanumanthu, Gaurav Mahajan, Sreekanth Appasani

引用次数: 0

Nivolumab-induced folliculitis: A case of immune-related cutaneous adverse reaction. 尼沃鲁单抗诱导的毛囊炎：一例免疫相关皮肤不良反应。

IF 1.5 4区医学

the Indian Journal of Pharmacy Pub Date : 2026-05-01 DOI: 10.4103/ijp.ijp_818_25

P Akshay Sankar, Neel Prabha

引用次数: 0