the Indian Journal of Pharmacy最新文献

{"title":"Exploring the mechanism of sunflower seed oil against Alzheimer's disease through experimental and network pharmacology studies.","authors":"Yashodhan Desai, Deepak Karunakaran, Juhi Singh, Alric Raul Noronha, Gagan Poojary, Bijaya Chettri, Rekha Shenoy, Madhavan Nampoothiri, Sree Lalitha Bojja","doi":"10.4103/ijp.ijp_761_23","DOIUrl":"10.4103/ijp.ijp_761_23","url":null,"abstract":"<p><strong>Objectives: </strong>With the prevalence of Alzheimer's disease (AD) increasing exponentially, there has been a shift in the focus of drug discovery for AD from treating the symptoms to preventing the development of the disease. Several natural compounds are extensively studied as neuroprotectives in preventing disease progression. Helianthus annuus seed oil (HA) is widely used as cooking oil and is abundant in antioxidant activity. Therefore, we evaluated the effect of HA in mice model of scopolamine-induced amnesia and explored the potential underlying mechanisms.</p><p><strong>Methods: </strong>Twenty-four male mice were administered orally with either distilled water (control and scopolamine groups) or treatment groups (HA 100 and HA 200 mg/kg) for 8 consecutive days. All groups, except the control group, received an intraperitoneal injection of scopolamine at a dose of 1 mg/kg. Subsequently, novel object recognition task for cognition assessment and open field tests for locomotory activity were performed. In addition, network analysis was performed to identify the key bioactives and targets of HA against AD. Further, the binding affinity of HA bioactives to the key targets was verified by molecular docking analysis.</p><p><strong>Results: </strong>HA (100 mg/kg and 200 mg/kg) significantly ameliorated recognition memory compared to the scopolamine group, suggesting the protective effect of HA against cognitive impairment. Network analysis indicated that the key bioactives of HA, chlorogenic acid, and oleic acid act through multiple targets and pathways, particularly the mitogen-activated protein kinase (MAPK) pathway, to ameliorate AD symptoms. Importantly, chlorogenic acid showed good binding affinity with MAPKs, TP53, and EP300.</p><p><strong>Conclusion: </strong>HA has therapeutic benefits in AD acting through the MAPK pathway. However, further studies need to be done to confirm the results derived and translate the potential use of HA as a dietary supplement for preventing AD.</p>","PeriodicalId":49189,"journal":{"name":"the Indian Journal of Pharmacy","volume":"56 6","pages":"396-404"},"PeriodicalIF":2.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11913338/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143460255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using the Physitrack telehealth platform for enhancing pharmacology education in pain management.","authors":"Ankit K Badge, Rashi Lahoti, Nandkishor J Bankar, Gulshan Bandre","doi":"10.4103/ijp.ijp_717_24","DOIUrl":"10.4103/ijp.ijp_717_24","url":null,"abstract":"","PeriodicalId":49189,"journal":{"name":"the Indian Journal of Pharmacy","volume":"56 6","pages":"442-443"},"PeriodicalIF":2.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11913331/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143460284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Putrescine can inhibit germinal center B cell differentiation by inducing reactive oxygen species generation.","authors":"Yuqiang Zhang, Peijia Cong, Bin Wang, Haifeng Lian, Yuming Zhou","doi":"10.4103/ijp.ijp_531_24","DOIUrl":"10.4103/ijp.ijp_531_24","url":null,"abstract":"<p><strong>Abstract: </strong>Polyamine synthesis and abnormal regulation of B cell differentiation occur concurrently in various diseases. We investigated whether putrescine could suppress germinal center B cell (GCB) differentiation by inducing reactive oxygen species (ROS) generation. The results of flow cytometry analysis revealed that putrescine did not affect B cell apoptosis and cell cycle. The results of RT-qPCR and western blotting revealed that putrescine could inhibit CD79a phosphorylation rather than total expression. Using an O2K high-resolution respirometer, we illustrated that putrescine increased the oxygen consumption rate in the basal mitochondrial respiration stage, ATP-coupled respiration stage, and maximum respiration stage. Similarly, it also elevated ROS generation across stages in B cells and reduced the proportion of GCB cells. Meanwhile, ROS scavenging by SOD could reverse such inhibitory effects on GCB cells. We concluded that putrescine could inhibit the differentiation of GCB cells by reducing CD79a phosphorylation and increasing ROS levels in GCB cells.</p>","PeriodicalId":49189,"journal":{"name":"the Indian Journal of Pharmacy","volume":"56 6","pages":"430-436"},"PeriodicalIF":2.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11913330/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143460281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Valproate-induced disabling tremor in a case of Rasmussen's encephalitis.","authors":"Rajesh Verma, Rajarshi Chakraborty","doi":"10.4103/ijp.ijp_76_23","DOIUrl":"10.4103/ijp.ijp_76_23","url":null,"abstract":"","PeriodicalId":49189,"journal":{"name":"the Indian Journal of Pharmacy","volume":"56 1","pages":"61-63"},"PeriodicalIF":2.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11001175/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140060891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reduction of COVID-19 vaccine-induced neutralizing antibody and changing of molecular epidemiology pattern of omicron SARS-CoV-2 subvariant: Observed interrelationship.","authors":"Beuy Joob, Pathum Sookaromdee, Viroj Wiwanitkit","doi":"10.4103/ijp.ijp_362_23","DOIUrl":"10.4103/ijp.ijp_362_23","url":null,"abstract":"","PeriodicalId":49189,"journal":{"name":"the Indian Journal of Pharmacy","volume":"56 1","pages":"66-67"},"PeriodicalIF":2.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11001174/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140060975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expected usefulness of the third dose of COVID-19 vaccine for adolescents living with underlying HIV infection.","authors":"Sora Yasri, Viroj Wiwanitkit","doi":"10.4103/ijp.ijp_17_23","DOIUrl":"10.4103/ijp.ijp_17_23","url":null,"abstract":"","PeriodicalId":49189,"journal":{"name":"the Indian Journal of Pharmacy","volume":"56 1","pages":"68-70"},"PeriodicalIF":2.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11001181/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140060972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The pivotal role of artificial intelligence in enhancing experimental animal model research: A machine learning perspective.","authors":"Anushka Ghosh, Gajendra Choudhary, Bikash Medhi","doi":"10.4103/ijp.ijp_81_24","DOIUrl":"10.4103/ijp.ijp_81_24","url":null,"abstract":"","PeriodicalId":49189,"journal":{"name":"the Indian Journal of Pharmacy","volume":"56 1","pages":"1-3"},"PeriodicalIF":2.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11001179/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140060978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of anthelmintic activity of medicinal plants: Why earthworm?","authors":"Sanjib Bhattacharya","doi":"10.4103/ijp.ijp_554_23","DOIUrl":"10.4103/ijp.ijp_554_23","url":null,"abstract":"","PeriodicalId":49189,"journal":{"name":"the Indian Journal of Pharmacy","volume":"56 1","pages":"64-65"},"PeriodicalIF":2.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11001177/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140060971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effective dose of remimazolam in adult gastroscopy.","authors":"Rongyan Zhang, Gang Zhao, Zhangjun Yan, Hongmei Xuan, Yan Chen","doi":"10.4103/ijp.ijp_425_22","DOIUrl":"10.4103/ijp.ijp_425_22","url":null,"abstract":"<p><strong>Objectives: </strong>The objectives of this study were to explore the median effective dose (ED50) and the dose required for successful anesthesia in 95% of the patients (ED95) of remimazolam for intravenous anesthesia in adult outpatients undergoing gastroscopy.</p><p><strong>Methods: </strong>This pilot study was conducted in patients scheduled to undergo painless gastroscopy at the authors' hospital between March 15, 2022 and March 25, 2022. The ED of remimazolam was determined using the modified Dixon sequential method, using an initial induction dose of 0.2 mg/kg. With successful or failed anesthesia, the remimazolam dose was decreased or increased by 0.05 mg/kg for the next patient, respectively.</p><p><strong>Results: </strong>Twenty-two patients (43.6 ± 10.5 years of age) were enrolled. During gastroscopy, the remimazolam induction dose was 19.93 ± 2.96 mg (0.2-0.45 mg/kg). Eighteen patients could complete anesthesia with remimazolam alone, and four patients needed propofol to complete anesthesia. The induction time after the injection of remimazolam was 20.8 ± 8.4 s, the gastroscopy time was 5.1 ± 1.3 min, and the anesthesia recovery time was 17.5 ± 5.6 min. The ED50 and the ED95 of remimazolam were 0.362 mg/kg (95% confidence interval [CI]: 0.313-0.455 mg/kg) and 0.464 mg/kg (95% CI: 0.403-2.242 mg/kg), respectively. The vital signs of all patients remained within the predefined acceptable limits. No patients required antagonist rescue.</p><p><strong>Conclusion: </strong>The ED50 and ED95 of remimazolam for adult gastroscopy were 0.362 mg/kg and 0.464 mg/kg, respectively. Additional anesthetics might be required during gastroscopy in some patients.</p><p><strong>Trial registration: </strong>The trial was registered. The number is ChiCTR2200057446.</p>","PeriodicalId":49189,"journal":{"name":"the Indian Journal of Pharmacy","volume":"56 1","pages":"10-15"},"PeriodicalIF":2.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11001170/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140060977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amelioration by Withania somnifera of neurobehavioural and immunological markers in time dependent sensitization induced post traumatic stress disorder in rats.","authors":"Sana Rehman, Mohammad Faizan, Nafaa Hasan Ali, Kavita Gulati, Arunabha Ray","doi":"10.4103/ijp.ijp_825_22","DOIUrl":"10.4103/ijp.ijp_825_22","url":null,"abstract":"<p><strong>Aims and objectives: </strong>Posttraumatic stress disorder (PTSD) is a complex neuropsychiatric pathophysiology with an unmet need for safe, effective, and sustainable therapeutic modalities. Thus, the present study evaluated the effects of Withaniasomnifera (WS, Ashwagandha) on an experimental model of PTSD in rats.</p><p><strong>Materials and methods: </strong>Wistar rats (200-250 g) were used and time-dependent sensitization (TDS) was used as the experimental model of PTSD. Standardized WS root extract (100 and 300 mg/kg, p.o. for 15 days) was administered with TDS and their effects were observed on neurobehavioral (anxiety) and brain cytokines, corticosterone, and oxidative stress markers.</p><p><strong>Results: </strong>Exposure to TDS resulted in anxiogenic behavior in the elevated plus maze (EPM) test, i.e., reductions in open arm entries and open arm time, as compared to the control group. Pretreatment with WS extract (100 and 300 mg/kg × 14 days) attenuated the TDS-induced anxiogenic activity in a dose-related manner, and these WS effects were comparable to those seen after the comparator drug fluoxetine (10 mg/kg). Assay of brain homogenates showed that TDS also resulted in elevations in brain interleukin-6 and reduction in corticosterone levels in both the hippocampus and prefrontal cortex (PFC), which were reversed after WS pretreatments. Further, WS pretreatment also reversed the TDS-induced changes in brain oxidative stress markers, namely elevated malondialdehyde and reduced glutathione levels in both the hippocampus and PFC.</p><p><strong>Conclusion: </strong>These results suggest that WS could have potential as a therapeutic agent for treating PTSD by attenuating anxiogenesis, neuroimmune axis activation, and oxidative stress.</p>","PeriodicalId":49189,"journal":{"name":"the Indian Journal of Pharmacy","volume":"56 1","pages":"20-27"},"PeriodicalIF":2.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11001169/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140060966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}