the Indian Journal of Pharmacy最新文献_第3页

Cosmeceuticals: A transit state from synthetic to natural. 药妆：从合成到天然的过渡状态。

IF 2.4 4区医学

the Indian Journal of Pharmacy Pub Date : 2024-01-01 Epub Date: 2024-03-08 DOI: 10.4103/ijp.ijp_244_21

Sathyabama Sathyaseelan, Bhavana Hemantha Rao, S Anushmati

{"title":"Cosmeceuticals: A transit state from synthetic to natural.","authors":"Sathyabama Sathyaseelan, Bhavana Hemantha Rao, S Anushmati","doi":"10.4103/ijp.ijp_244_21","DOIUrl":"10.4103/ijp.ijp_244_21","url":null,"abstract":"Cosmeceuticals are topically applied cosmetic products containing a biologically active ingredient with a pharmaceutical effect that improves, nourishes, and treats the skin appearance. The trend of cosmeceuticals began during the mid-20th century due to its potent ingredients with therapeutic effects for various skin ailments. Even though there is a great advancement in cosmetics, which shows the risk of cosmetic linked melanoma, endocrine disorders, and birth defects which was one in 1500 people during 1935 have increased to one in 75 people in 2000. Hence, as a part of reducing the harmful effect, natural ingredients were added to the formulation to give the pharmaceutical effect. Thus, natural/herbal cosmeceuticals were introduced. Due to the awareness of the side effects such as photo-toxicity, mutagenicity, irritation by these synthetic products, people started preferring herbal/natural cosmetic products. Moreover, natural cosmeceuticals were proven to be effective against various dermatological conditions as well as have fewer side effects marked the natural/herbal cosmeceuticals in the market. Unlike a drug, cosmeceutical products undergo safety, toxicity, and efficacy tests, but these are not classified under Food and Drug Administration. This review will give an insight into different natural ingredients used in natural/herbal cosmeceutical formulation and their function challenges faced during formulation, advantages of natural cosmeceuticals over regular cosmeceuticals, and regulatory aspects in India.","PeriodicalId":49189,"journal":{"name":"the Indian Journal of Pharmacy","volume":"56 1","pages":"42-51"},"PeriodicalIF":2.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11001171/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140060967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of Alpha-Synuclein protein model against therapeutic aspects of Parkinson's disease. 开发针对帕金森病治疗的 Alpha-Synuclein 蛋白模型。

IF 2.4 4区医学

the Indian Journal of Pharmacy Pub Date : 2024-01-01 Epub Date: 2024-03-08 DOI: 10.4103/ijp.ijp_325_23

Kanika Bhardwaj, Neelu Kanwar Rajawat, Nupur Mathur

引用次数: 0

Fixed drug combination (levosulpiride and rabeprazole)-induced atypical Parkinsonian's disorders with associated anxiety and low-lying depression. 固定联合用药（左旋舒必利和雷贝拉唑）诱发非典型帕金森氏症，并伴有焦虑和低度抑郁。

IF 2.4 4区医学

the Indian Journal of Pharmacy Pub Date : 2024-01-01 Epub Date: 2024-03-08 DOI: 10.4103/ijp.ijp_929_21

Vishal R Tandon, Sheikh Hanan Ismail, Amarjeet Singh

引用次数: 0

Drug-induced Stevens-Johnson syndrome in Post traumatic facial injury. 面部外伤后药物诱发的史蒂文斯-约翰逊综合征。

IF 2.4 4区医学

the Indian Journal of Pharmacy Pub Date : 2024-01-01 Epub Date: 2024-03-08 DOI: 10.4103/ijp.ijp_485_23

Asfiya Samar, G N Sahana, P Deepak, Jayashree V Nagaral, M Saranyaa

引用次数: 0

Dolutegravir-induced hand-foot skin reaction in a seropositive male: A rare presentation. 一名血清反应呈阳性的男性因多替拉韦引起手足皮肤反应：罕见病例。

IF 2.4 4区医学

the Indian Journal of Pharmacy Pub Date : 2024-01-01 Epub Date: 2024-03-08 DOI: 10.4103/ijp.ijp_258_23

Tirthankar Gayen, Subhasmita Baisya, Devansi Sarawgi, Sumit Sen

引用次数: 0

Real-world safety and effectiveness of Pistacia lentiscus (mastic gum) in patients with diabetic gastroparesis: 24-week interim analysis postintervention. Pistacia lentiscus（桉树胶）对糖尿病胃轻瘫患者的实际安全性和有效性：干预后 24 周中期分析。

IF 2.4 4区医学

the Indian Journal of Pharmacy Pub Date : 2024-01-01 Epub Date: 2024-03-08 DOI: 10.4103/ijp.ijp_555_23

Ravi Kant, Ajaypal Singh, Rohit Raina, Vandana Dhingra, Mukesh Bairwa, Varsha Kanwar

{"title":"Real-world safety and effectiveness of Pistacia lentiscus (mastic gum) in patients with diabetic gastroparesis: 24-week interim analysis postintervention.","authors":"Ravi Kant, Ajaypal Singh, Rohit Raina, Vandana Dhingra, Mukesh Bairwa, Varsha Kanwar","doi":"10.4103/ijp.ijp_555_23","DOIUrl":"10.4103/ijp.ijp_555_23","url":null,"abstract":"Introduction: Gastrointestinal neuropathies are frequently found in diabetic patients.Aim: The aim of this study was to find out the safety, adverse reactions, and long-term effectiveness of Pistacia lentiscus plant extract (mastic gum) in diabetic gastroparesis (DG) with respect to sustainable improvement in gastroparesis symptoms (Gastrointestinal Cardinal Symptom Index [GCSI] score) by observational follow-up study of a single-centric double-blind noninferiority randomized control trial.Materials and methods: Thirty-eight individuals were recruited and equally randomized in two study groups based on GCSI score and TC99 radionuclide gastric emptying scintigraphy (GES), i.e. the mastic gum group and the levosulpiride group. After 24 weeks, the GCSI score was recalculated in both the groups, and patients were evaluated for the safety, adverse reactions, and long-term effectiveness of mastic gum and the standard drug levosulpiride.Results: In the extended study, mean GCSI score changes at 24 weeks were statistically significant (P < 0.001) (t-test) between the two groups. In the mastic gum arm, the change in mean GCSI score at 24 weeks was statistically nonsignificant mean ± (standard deviation [SD]) 16.7± (3.81) compared to the GCSI score at 2-month postintervention mean (SD) 16.35± (2.27) (intragroup P = 0.89) (repeated measures ANOVA). It strongly indicates that mastic gum provided a sustainable improvement in DG symptoms in comparison to levosulpiride, with excellent subjective well-being postintervention, without any obvious significant adverse effects.Conclusion: Six-month (24-week) interim analysis of patients suggests that mastic gum gives a sustainable improvement in DG symptoms without any obvious adverse effects as compared to levosulpiride.","PeriodicalId":49189,"journal":{"name":"the Indian Journal of Pharmacy","volume":"56 1","pages":"4-9"},"PeriodicalIF":2.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11001183/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140060974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Safety evaluation of 5-hydroxytryptophan and S-(2-aminoethyl)isothiouronium bromide hydrobromide on rodent lungs. 5-hydroxytryptophan and S-(2-aminoethyl)isothiouronium bromide hydrobromide 对啮齿动物肺部的安全性评估。

IF 2.4 4区医学

the Indian Journal of Pharmacy Pub Date : 2024-01-01 Epub Date: 2024-03-08 DOI: 10.4103/ijp.ijp_176_23

Suresh Kumar Thokchom, Namita Indracanti, Anoushka Khanna, Prem Kumar Indraganti

{"title":"Safety evaluation of 5-hydroxytryptophan and S-(2-aminoethyl)isothiouronium bromide hydrobromide on rodent lungs.","authors":"Suresh Kumar Thokchom, Namita Indracanti, Anoushka Khanna, Prem Kumar Indraganti","doi":"10.4103/ijp.ijp_176_23","DOIUrl":"10.4103/ijp.ijp_176_23","url":null,"abstract":"Objectives: During the past few decades, various compounds have been researched for their potential as radioprotectants, and many of them were found to be safe and effective in several preclinical models. However, many of these compounds were found to have serious adverse effects when evaluated in clinical settings, thereby making them unsuitable for human applications. 5-hydroxytryptophan (5-HTP) and S-(2-aminoethyl) isothiouronium bromide hydrobromide (AET) act in a synergistic fashion to promote radioprotection. The present study primarily emphasizes the safety of fixed dose of 5-HTP + AET in the lungs of C57BL/6 mice, a well-known model used in drug safety studies.Materials and methods: Post-administration of the combination of HTP+AET at specific time points, blood and bronchoalveolar lavage fluid (BALF) were collected for the analysis of inflammatory and oxidative stress markers of the lungs. Thereafter, the mice were sacrificed and the lungs were dissected out, weighed, and fixed in formalin for histopathological studies.Results: The inflammatory biomarkers: tumor necrosis factor-alpha and interleukin-10 and oxidative stress biomarkers: 8-isoprostane and 8-hydroxy-2'-deoxyguanosine were found to have normal levels in blood and BALF in both control and treatment groups, which was further supported by normal histological findings. In addition, other endpoints such as food and water intake were found to be within normal limits.Conclusion: The present safety study reflects that the combination has no adverse effects on the lungs of the experimental mouse. Further, evaluation in higher mammals including nonhuman primates is essential prior to validation of the safety of the combination in humans.","PeriodicalId":49189,"journal":{"name":"the Indian Journal of Pharmacy","volume":"56 1","pages":"28-36"},"PeriodicalIF":2.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11001180/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140060976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Topical antibiotics in the prevention of port-site infection after elective day care laparoscopic cholecystectomy. 日间护理腹腔镜胆囊切除术后局部使用抗生素预防手术口感染。

IF 2.4 4区医学

the Indian Journal of Pharmacy Pub Date : 2024-01-01 Epub Date: 2024-03-08 DOI: 10.4103/ijp.ijp_882_20

Nipun Sharma, Lileswar Kaman, Siddhant Khare, Divya Dahiya, Ashish Gupta, Uttam Kumar Thakur, Sameer Sethi

{"title":"Topical antibiotics in the prevention of port-site infection after elective day care laparoscopic cholecystectomy.","authors":"Nipun Sharma, Lileswar Kaman, Siddhant Khare, Divya Dahiya, Ashish Gupta, Uttam Kumar Thakur, Sameer Sethi","doi":"10.4103/ijp.ijp_882_20","DOIUrl":"10.4103/ijp.ijp_882_20","url":null,"abstract":"Background: Wound-related infections and complications are rare after day care laparoscopic cholecystectomy (LC). They can have a significant adverse impact on the postoperative course after an uneventful elective LC. The use of topical antibiotics over the port site may prevent such complications.Materials and methods: This trial was conducted from January 2018 to June 2019. Two hundred and fifty patients who met the inclusion and exclusion criteria were included in the study. They were randomized into the topical antibiotic group (Group A, n = 125) and control group (Group B, n = 125). All patients underwent four-port LC. Mupirocin 2% topical antibiotic ointment was applied to all four-port sites in Group A, whereas no topical antibiotic was used in Group B. One dose of prophylactic systemic antibiotics was given to all patients in both groups.Results: The mean age was 43.22 ± 12.7 years in Group A and 43.44 ± 12.5 years in Group B. The comorbidities and the other variables were comparable between the two groups. The port-site infection (PSI) was observed in one patient in Group A and three patients in Group B, which was statistically nonsignificant (P = 0.622). The mean time of detection of infection was 4.75 ± 1.7 days. All the infections were superficial surgical site infections. Microbiological swabs culture of the infected wounds yielded no growth of bacteria.Conclusion: The PSI after LC is very less. The use of topical antibiotics to prevent PSIs after LC could not be established.","PeriodicalId":49189,"journal":{"name":"the Indian Journal of Pharmacy","volume":"56 1","pages":"16-19"},"PeriodicalIF":2.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11001178/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140060890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stability problems with some vitamins in pharmaceuticals. 药品中某些维生素的稳定性问题。

IF 2.4 4区医学

the Indian Journal of Pharmacy Pub Date : 1961-06-01

T J MACEK

引用次数: 0

A note on the pharmacopeial characteristics of injection of sodium antimony V gluconate (concentrated). 葡萄糖酸锑钒钠(浓缩)注射液药典特征的说明。

IF 2.4 4区医学

the Indian Journal of Pharmacy Pub Date : 1949-09-01

A N BOSE, T N GHOSH

引用次数: 0