Indian Journal of Hematology and Blood Transfusion最新文献_第4页

C-Reactive Protein/Albumin Ratio (CAR) Predicts Early Posttransplant Complications and Survival in Allogeneic Hematopoietic Stem Cell Transplantation Recipients. c反应蛋白/白蛋白比（CAR）预测异体造血干细胞移植受者早期移植后并发症和生存率。

IF 0.6 4区医学

Indian Journal of Hematology and Blood Transfusion Pub Date : 2025-10-01 Epub Date: 2024-12-18 DOI: 10.1007/s12288-024-01942-4

Şeyma Yıldız, Zeynep Arzu Yegin, Gonca Gül Gündem, Sema Yaşar, Seda Çiçekli, Zübeyde Nur Özkurt, Münci Yağcı

{"title":"C-Reactive Protein/Albumin Ratio (CAR) Predicts Early Posttransplant Complications and Survival in Allogeneic Hematopoietic Stem Cell Transplantation Recipients.","authors":"Şeyma Yıldız, Zeynep Arzu Yegin, Gonca Gül Gündem, Sema Yaşar, Seda Çiçekli, Zübeyde Nur Özkurt, Münci Yağcı","doi":"10.1007/s12288-024-01942-4","DOIUrl":"https://doi.org/10.1007/s12288-024-01942-4","url":null,"abstract":"C reactive protein/albumin ratio (CAR) is considered as a predictor for prognosis in a variety of systemic disorders including malignancies. We aimed to investigate the potential impact of pretransplant CAR on transplant related complications and clinical outcomes in patients undergoing allogeneic hematopoietic stem cell transplantation (alloHSCT). A total of 430 alloHSCT recipients [median age: 44(18-72) years; male/female: 258/172] were included in this retrospective study. Median follow-up period was 761(1-5910) days. The study population was divided into two subgroups as low- (< 0.312) and high-CAR (≥ 0.312) [AUC: 0.61 (95%CI: 0.55-0.67); p < 0.001]. The probability of overall survival (OS) was significantly lower in CARhigh group (27.7% vs. 32.1%, p < 0.001). The frequency of posttransplant early complications including Cytomeglovirus reactivation (p = 0.04), sinusoidal obstruction syndrome (p = 0.042), sepsis (p = 0.004), nephrotoxicity (p = 0.011), dialysis requirement (p = 0.001) and acute GvHD (p = 0.026) were found to be significantly higher in CARhigh group. Pretransplant CAR was shown to have a significant impact on OS (p = 0.009) in multivariate analysis. Pretransplant CAR may be a feasible and cost effective marker to predict alloHSCT outcome for better management of early transplant related toxicity and complications.","PeriodicalId":49188,"journal":{"name":"Indian Journal of Hematology and Blood Transfusion","volume":"41 4","pages":"800-808"},"PeriodicalIF":0.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12515177/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145287472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Detection of Hemoglobin Twin Peaks (HBA2:c.341T > A) in a Family During Antenatal Work-Up: A Case Report Documenting a Rare Entity and its Diagnostic Dilemma. 在产前检查中检测血红蛋白双峰（HBA2:c.341T . > A）：一个记录罕见实体的病例报告及其诊断困境。

IF 0.6 4区医学

Indian Journal of Hematology and Blood Transfusion Pub Date : 2025-10-01 Epub Date: 2024-11-21 DOI: 10.1007/s12288-024-01904-w

Tanvi Jha, Garima Baweja Madaan, Anuj Chachra, Prashant Sharma, Reena Das, Vijay Kumar

引用次数: 0

Exploring the Relationship Between Daratumumab Treatment and Stem Cell Collection in Newly Diagnosed Multiple Myeloma (NDMM) Patients Undergoing Transplantation: Insights From a Single-Center Investigation. 探索达拉单抗治疗与接受移植的新诊断多发性骨髓瘤（NDMM）患者干细胞收集之间的关系：来自单中心研究的见解

IF 0.6 4区医学

Indian Journal of Hematology and Blood Transfusion Pub Date : 2025-10-01 Epub Date: 2024-11-14 DOI: 10.1007/s12288-024-01914-8

Durga Chougule, Geet Aggarwal, Nitin Sood, Aseem Kumar Tiwari, Padam Singh, Manish Kumar Singh

{"title":"Exploring the Relationship Between Daratumumab Treatment and Stem Cell Collection in Newly Diagnosed Multiple Myeloma (NDMM) Patients Undergoing Transplantation: Insights From a Single-Center Investigation.","authors":"Durga Chougule, Geet Aggarwal, Nitin Sood, Aseem Kumar Tiwari, Padam Singh, Manish Kumar Singh","doi":"10.1007/s12288-024-01914-8","DOIUrl":"https://doi.org/10.1007/s12288-024-01914-8","url":null,"abstract":"Purpose: Daratumumab-induction regimen has benefitted the multiple myeloma patients with long-lasting effective response. However, studies have showed daratumumab induction therapy reduced CD34+ stem cell yield and increased dependence on plerixafor use during mobilization therapy for subsequent autologous stem cell transplantation (ASCT). Here, we aim to explore the influence of daratumumab-based induction therapy on CD34+ stem cell yield in Indian multiple myeloma patients.Methods: In this retrospective study, electronic medical records of transplant eligible multiple myeloma patients (n = 91) between December 2015 and February 2023 were considered. Clinical information about induction therapy, mobilization therapy, stem cell collection and transplant status were collected. Data analysis was done using SPSS v.26, with statistical significance at p < 0.05.Results: Among the 91 patients, 8 received daratumumab induction regimen. The CD34+ stem cell yield among daratumumab and non-daratumumab induction groups did not show significant difference (5.29 ± 1.64 × 106 versus 6.08 ± 3.11 × 106 CD34+ cells/kg; p = 0.101). Patients on daratumumab induction regimen exhibited an increased use of plerixafor when compared to non-daratumumab induction regimen (p < 0.001).Conclusion: The addition of daratumumab in induction therapy of multiple myeloma did not affect stem cell yield but increased dependence on plerixafor during mobilization therapy.","PeriodicalId":49188,"journal":{"name":"Indian Journal of Hematology and Blood Transfusion","volume":"41 4","pages":"942-946"},"PeriodicalIF":0.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12515134/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145287480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum Erythropoietin Level in Polycythemia Vera: Is a New Cut-Off Possible? 真性红细胞增多症患者血清促红细胞生成素水平：是否可能有新的临界值？

IF 0.6 4区医学

Indian Journal of Hematology and Blood Transfusion Pub Date : 2025-10-01 Epub Date: 2025-02-24 DOI: 10.1007/s12288-025-01990-4

Rafet Eren, Abdulkadir Karismaz, Ceyda Arslan, Esra Terzi Demirsoy, Aliihsan Gemici, Istemi Serin

{"title":"Serum Erythropoietin Level in Polycythemia Vera: Is a New Cut-Off Possible?","authors":"Rafet Eren, Abdulkadir Karismaz, Ceyda Arslan, Esra Terzi Demirsoy, Aliihsan Gemici, Istemi Serin","doi":"10.1007/s12288-025-01990-4","DOIUrl":"https://doi.org/10.1007/s12288-025-01990-4","url":null,"abstract":"Polycythemia vera (PV) is a myeloproliferative disease characterized by hemoglobin/hematocrit levels above 16.5 g/dL or 49% in men, and 16 g/dL or 48% in women and accompanied by JAK2 mutations. It is aimed to prevent false negative and false positive results with simultaneous serum erythropoietin (EPO) measurements. The importance of sensitivity and specificity of low EPO level for PV is known; determining a more sensitive cut-off may reduce the need for further analyzes and invasive procedures. In our study, we aimed to reveal the sensitivity and specificity of serum EPO level in patients diagnosed with PV and to determine a new cut-off value that would show higher diagnostic performance instead of low serum EPO level. In this study, patients who were examined because of polycythemia between 01.01.2018-01.01.2022 at the hematology clinics of 5 different centers from xxx were included. A total of 468 patients (90 females, 378 males) were included in the study. One hundred seventy-five (37.4%) patients met the criteria for PV. In the ROC analysis performed to reveal the effectiveness of serum EPO level for predicting the diagnosis of PV, the sensitivity for ≤ 4.68 cut-off value was 89%, specificity 92%, AUC = 0.934 (95% CI: 0.91-0.96, p < 0.05), positive predictive value 87% and negative predictive value was 93.1%. Serum EPO level is an effective and easy method for predicting the diagnosis of PV, and it would be more predictive for the new cut-off level in this study.Supplementary information: The online version contains supplementary material available at 10.1007/s12288-025-01990-4.","PeriodicalId":49188,"journal":{"name":"Indian Journal of Hematology and Blood Transfusion","volume":"41 4","pages":"951-955"},"PeriodicalIF":0.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12515172/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145287488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Successful Treatment of Paraneoplastic Mesangioproliferative Glomerulonephritis in Mantle Cell Lymphoma Using Acalabrutinib and Rituximab. 阿卡鲁替尼联合利妥昔单抗治疗套细胞淋巴瘤伴副肿瘤性间血管增殖性肾小球肾炎成功。

IF 0.6 4区医学

Indian Journal of Hematology and Blood Transfusion Pub Date : 2025-10-01 Epub Date: 2024-11-14 DOI: 10.1007/s12288-024-01922-8

Sarthak Wadhera, Rudra Narayan Swain, Shashikant Saini, Arvind Sekar, Praveen Sharma, Jasmine Sethi, Man Updesh Sachdeva, Pankaj Malhotra

引用次数: 0

The Association Study of Targeted DNA Methylation and Thrombophilia. 靶向DNA甲基化与血栓形成的相关性研究。

IF 0.6 4区医学

Indian Journal of Hematology and Blood Transfusion Pub Date : 2025-10-01 Epub Date: 2024-12-11 DOI: 10.1007/s12288-024-01936-2

Xiang Kui, Junfei Feng, Jing Leng, Cong Sun, Qiuheng Tang, Haifeng Li

{"title":"The Association Study of Targeted DNA Methylation and Thrombophilia.","authors":"Xiang Kui, Junfei Feng, Jing Leng, Cong Sun, Qiuheng Tang, Haifeng Li","doi":"10.1007/s12288-024-01936-2","DOIUrl":"https://doi.org/10.1007/s12288-024-01936-2","url":null,"abstract":"Objective: The aim of this study is to investigate the relationship of leukocytes DNA methylation in targeted sites and thrombophilia.Methods: Eight thrombophilia patients and their kin-related individuals as the healthy control. Targeted DNA methylation from peripheral leukocytes were examined with MassArray. Multivariate correlation analysis was used to estimate targeted gene methylation as an independent risk factor of thrombophilia. Receiver operating characteristic curve analysis was used to calculate the accuracy of biomarkers in the prediction of thrombophilia.Results: The age of thrombophilia group was higher than control group (P < 0.001). F5.24.CpG.10 and Protein S.44.CpG.29-33 methylation were significantly associated with thrombophilia negatively and positively (r = -0.7289, P < 0.01 and r = 0.5667, P < 0.05). F5.24.CpG.10 methylation was higher in control group (P < 0.01), but Protein S.44.CpG.29-33 methylation increased in thrombophilia group (P < 0.05). The areas under curve of ROC were 0.9297 and 0.8437, respectively.Conclusion: Target DNA methylation in Protein S.44.CpG.29-33 island is associated with an elevated risk of thrombophilia.","PeriodicalId":49188,"journal":{"name":"Indian Journal of Hematology and Blood Transfusion","volume":"41 4","pages":"878-885"},"PeriodicalIF":0.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12515139/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145287490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

NPM1 Mutation Detected: Does Blast Count Matter? 检测到NPM1突变：爆炸计数重要吗？

IF 0.6 4区医学

Indian Journal of Hematology and Blood Transfusion Pub Date : 2025-10-01 Epub Date: 2024-11-13 DOI: 10.1007/s12288-024-01918-4

M Kumar Nikhil, Nathany Shrinidhi, Swaminathan Anusha, Yadav Chitresh, Gupta Aastha, Kothari Akriti, Garg Paritosh, Panda Rastogi Neha, Dua Vikas, Danewa Arun, Bhargava Rahul

引用次数: 0

Prevalence of Anemia of Chronic Disease/Inflammation at a Tertiary Care Hospital in North India. 印度北部三级保健医院慢性疾病/炎症贫血的流行情况。

IF 0.6 4区医学

Indian Journal of Hematology and Blood Transfusion Pub Date : 2025-10-01 Epub Date: 2025-01-27 DOI: 10.1007/s12288-024-01954-0

Sidheshwar Vishnu Bhendekar, Jay Kirtani, Rahul Naithani

{"title":"Prevalence of Anemia of Chronic Disease/Inflammation at a Tertiary Care Hospital in North India.","authors":"Sidheshwar Vishnu Bhendekar, Jay Kirtani, Rahul Naithani","doi":"10.1007/s12288-024-01954-0","DOIUrl":"https://doi.org/10.1007/s12288-024-01954-0","url":null,"abstract":"There is a lack of data from India on the prevalence of anemia of chronic disease or inflammation. This was a prospective observational cross-sectional prevalence study. Anemic patients underwent investigations namely a complete blood count with peripheral smear, serum ferritin level, iron, total iron binding capacity, transferrin saturation, vitamin B12 and folic acid level, reticulocyte count and stool for occult blood. Other investigations were performed as required according to the patient's clinical profile. Three hundred fifty-five patients were enrolled. A total of 109 patients (30.7%) had anemia of chronic disease (ACD) (30.7%). Sixty-three/263 (24%) females had ACD compared to 46/95 (48.4%) males. ACD was four times more common in the age group 80 years and above (56.5%) compared to the age group 18 to 39 years (13.9%). Seventy-two (66%) patients had mild anemia, 19 patients (17%) had moderate anemia and 18 patients (16%) had severe anemia. Diabetes mellitus (44%), hypertension (39%) and chronic kidney disease (25%) were the commonest underlying morbidity. Thirty-six patients (33%) had no underlying comorbidity or cause. The prevalence of anemia of chronic disease increases with age. The majority of anemia of chronic disease patients have mild anemia.","PeriodicalId":49188,"journal":{"name":"Indian Journal of Hematology and Blood Transfusion","volume":"41 4","pages":"983-986"},"PeriodicalIF":0.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12515173/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145287328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pericardial Effusion Post Hematopoietic Stem Cell Transplant: A Life-Threatening Complication with Myriad Causes. 造血干细胞移植后心包积液：一种有多种原因的危及生命的并发症。

IF 0.6 4区医学

Indian Journal of Hematology and Blood Transfusion Pub Date : 2025-10-01 Epub Date: 2025-01-08 DOI: 10.1007/s12288-024-01951-3

Sidharth Totadri, Shobha Badiger, Pooja Mallya, Ravi Joshi, Deepika Tedakapalli, Sweta Mohanty, Sunil Bhat

{"title":"Pericardial Effusion Post Hematopoietic Stem Cell Transplant: A Life-Threatening Complication with Myriad Causes.","authors":"Sidharth Totadri, Shobha Badiger, Pooja Mallya, Ravi Joshi, Deepika Tedakapalli, Sweta Mohanty, Sunil Bhat","doi":"10.1007/s12288-024-01951-3","DOIUrl":"https://doi.org/10.1007/s12288-024-01951-3","url":null,"abstract":"Pericardial effusion is an infrequent but life-threatening complication that occurs after hematopoietic stem cell transplant (HSCT). The present study aimed to analyze the etiology and outcome of patients who developed the entity. A retrospective analysis of patients who underwent allogeneic HSCT and developed symptomatic pericardial effusion between 2017 and 2023 was performed. Of 749 patients who underwent HSCT, 22 (3%) developed symptomatic pericardial effusion. The median age was 85 months (range: 26-252). The commonest indication for HSCT was transfusion-dependent thalassemia, which was more common than in patients who did not develop pericardial effusion (82% vs. 56%, P = 0.016). All the patients who developed effusion received myeloablative conditioning. The mean duration from transplant to effusion diagnosis was 98 days (range: 22-195). Sinusoidal obstruction syndrome was observed in a higher proportion of patients who developed pericardial effusion, compared to those who did not (41% vs. 17%, P = 0.002). Fast breathing with/without dyspnea was the commonest clinical presentation, observed in 16 (73%) patients. There was evidence of cardiac tamponade in 9 (41%) patients. Calcineurin-inhibitor was withheld in 12 (54%) patients followed by a short course of glucocorticoid therapy. Sixteen (73%) patients had a complete resolution of the effusion after a mean duration of 12 days. Five patients succumbed to unrelated causes. Pericardial effusion is an infrequent but severe complication post-HSCT and tachypnea is the commonest presentation. Early identification of the etiology and appropriate management can lead to a complete resolution in most cases.Supplementary information: The online version contains supplementary material available at 10.1007/s12288-024-01951-3.","PeriodicalId":49188,"journal":{"name":"Indian Journal of Hematology and Blood Transfusion","volume":"41 4","pages":"791-799"},"PeriodicalIF":0.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12515182/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145287380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of High-Altitude Polycythemia with JAK2V617F Mutation in Pakistani Population. 高原红细胞增多症与巴基斯坦人群JAK2V617F突变的关系

IF 0.6 4区医学

Indian Journal of Hematology and Blood Transfusion Pub Date : 2025-10-01 Epub Date: 2024-12-10 DOI: 10.1007/s12288-024-01937-1

Faiqa Fayyaz, Waseem Shahani, Nida Anwar, Muhammad Nizamuddin, Sidra Zafar, Ayesha Rafiq, Uzma Zaidi

{"title":"Association of High-Altitude Polycythemia with JAK2V617F Mutation in Pakistani Population.","authors":"Faiqa Fayyaz, Waseem Shahani, Nida Anwar, Muhammad Nizamuddin, Sidra Zafar, Ayesha Rafiq, Uzma Zaidi","doi":"10.1007/s12288-024-01937-1","DOIUrl":"https://doi.org/10.1007/s12288-024-01937-1","url":null,"abstract":"To assessthe prevalence of the JAK2V617F mutation in polycythemia patients living at high altitude. This was a cross-sectional study, conducted at the National Institute of Blood Diseasesand Bone Marrow Transplantation (NIBD-BMT), KarachifromJuly 2022 to July 2023. A total of 132 patients with polycythemia (male, hemoglobin ≥ 16.5 g/dl; female, hemoglobin ≥ 16 g/dl) were enrolled in the study. The patients were categorized on the basis of high and low altitude living and further categorization of those living at high-altitude was done on the basis of JAK2 positive and negative status and characteristics. Blood sample of each patient was collected in aseptic environment and sent to laboratory for complete blood count. PCR was used to detect JAK2V617F mutation. Data was analyzed by SPSS version 24. Among 132 polycythemia patients, 94 (71.2%) were high altitude residents whereas 38(28.7%) resided at non-high altitude. Out of 94(71.2%) patients of high altitude, 49(52.1%) harbored the JAK2V617F mutation whereas no mutation was identified in 45(48%) patients. The difference in gender distribution, median age, Hb, TLC, platelet count and ANC was statistically significant in the JAK2 positive group (p < 0.05). Moreover, palpable spleen and presence of ischemic heart was also found to be statistically significant in JAK 2 positive patients. Other characteristics such as hypertension, diabetes mellitus, smoking, and other symptoms (headache, body aches, chest pain, itching, abdominal pain, blurring of vision, burning soles, and cough) showed no significant differences between the two groups (p > 0.05). JAK2V617F mutation was observed in 52.1% ofpolycythemiapatients living at high altitude.","PeriodicalId":49188,"journal":{"name":"Indian Journal of Hematology and Blood Transfusion","volume":"41 4","pages":"843-848"},"PeriodicalIF":0.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12515146/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145287460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0