Indian Journal of Hematology and Blood Transfusion最新文献

Cerium Interferes Iron Binding to Human Serum Apo-Transferrin Which can Affect Iron Metabolism. 铈干扰铁与人血清载铁转铁蛋白结合，影响铁代谢。

IF 0.7 4区医学

Indian Journal of Hematology and Blood Transfusion Pub Date : 2025-04-01 Epub Date: 2024-09-19 DOI: 10.1007/s12288-024-01850-7

Fereshteh Hematyar Tabatabaie, Seyed Ali Asghar Moshtaghie, Ali Asghar Rastegari, Hashem Nayeri

{"title":"Cerium Interferes Iron Binding to Human Serum Apo-Transferrin Which can Affect Iron Metabolism.","authors":"Fereshteh Hematyar Tabatabaie, Seyed Ali Asghar Moshtaghie, Ali Asghar Rastegari, Hashem Nayeri","doi":"10.1007/s12288-024-01850-7","DOIUrl":"https://doi.org/10.1007/s12288-024-01850-7","url":null,"abstract":"Iron (Fe) is one of the most abundant metallic elements on the earth and is vital for human health. Some trace elements such as cerium may interfere with iron metabolism. In the present study, the effect of cerium (Ce) interference on intestinal absorption of iron in the first stage of iron metabolism was studied. The spectrophotometry and equilibrium dialysis were used to investigate the interaction of iron and cerium. The interaction of cerium with iron metabolism by interaction with apo-transferrin was investigated. The maximum absorption wavelength of iron-transferrin and cerium-transferrin were obtained 240 nm and 465 nm, respectively. The results showed that cerium was able to bind to apo-transferrin, which binds to transferrin like saturated iron. By obtaining the iron and cerium binding constants in equilibrium dialysis (6.66 × 106 M-1 and 3.51 × 106 M-1, respectively), it was determined that the site of interaction of these two ions on apo-transferrin is probably the same and cerium reduces the binding of iron to apotransferrin by 14%. Based on the results obtained in this project, it was found that cerium interferes with iron metabolism so that it can be altered through impaired intestinal absorption, plasma transport, and biochemical processes required for iron. As serum iron levels in humans are tightly regulated, the interference of cerium with iron metabolism may affect human blood functions.","PeriodicalId":49188,"journal":{"name":"Indian Journal of Hematology and Blood Transfusion","volume":"41 2","pages":"257-266"},"PeriodicalIF":0.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11992286/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144028054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Iron Deficiency anemia Therapy: Hepcidin, Dosing, Formulations and Adjuvants. 缺铁性贫血治疗：Hepcidin，剂量，配方和佐剂。

IF 0.7 4区医学

Indian Journal of Hematology and Blood Transfusion Pub Date : 2025-04-01 Epub Date: 2025-03-29 DOI: 10.1007/s12288-025-02018-7

Mukul Aggarwal, Rakhee Kar

引用次数: 0

Six Cases of 'Asia Type' DEL Detected via Serological Testing. 经血清学检测发现6例亚洲型DEL。

IF 0.7 4区医学

Indian Journal of Hematology and Blood Transfusion Pub Date : 2025-04-01 Epub Date: 2024-08-23 DOI: 10.1007/s12288-024-01847-2

Jingyi Liu, Qiaolin Zhang

引用次数: 0

Sesame Jaggery Ball Supplementation as a Dietary Adjunct Therapy in Treating Moderate Iron Deficiency Anemia Among Children Aged 6-11 Years in South India: An Open-Labeled Randomized Controlled Trial. 芝麻杂碎球补充剂作为治疗印度南部6-11岁儿童中度缺铁性贫血的膳食辅助疗法：一项开放标签随机对照试验。

IF 0.7 4区医学

Indian Journal of Hematology and Blood Transfusion Pub Date : 2025-04-01 Epub Date: 2024-09-28 DOI: 10.1007/s12288-024-01880-1

Yenduri Naimisha, Dhandapany Gunasekaran, Ramasamy Ramesh, D Madhavi Massilamani

{"title":"Sesame Jaggery Ball Supplementation as a Dietary Adjunct Therapy in Treating Moderate Iron Deficiency Anemia Among Children Aged 6-11 Years in South India: An Open-Labeled Randomized Controlled Trial.","authors":"Yenduri Naimisha, Dhandapany Gunasekaran, Ramasamy Ramesh, D Madhavi Massilamani","doi":"10.1007/s12288-024-01880-1","DOIUrl":"https://doi.org/10.1007/s12288-024-01880-1","url":null,"abstract":"The prevalence of iron deficient anemia in Indian children has continued to be high for decades, despite drastic measures. Natural food dietary diversification with foodstuffs prepared at home using locally available ingredients could be helpful to counter childhood anemia. In this open-labelled randomized controlled trial, 82 consecutive children aged 6-11 years diagnosed with moderate iron deficiency anemia were randomized into two groups. Children in the control group received 3 mg/kg/day of elemental iron orally in a syrup form, for eight weeks. In addition to the oral iron syrup in the same dose, the intervention group received one sesame jaggery ball (containing 60 g of sesame seeds and jaggery each) for eight weeks. The increases in hemoglobin (Hb) at 4 and 8 weeks were estimated as the primary outcomes. The increases in serum ferritin and body weight at eight weeks were measured as the secondary outcomes. The increase in the median Hb levels of the intervention group at four weeks [0.9 (0.6, 1.5) Vs 0.8 (0.4, 1.2), p-0.045] and eight weeks [1.7 (1.0, 2.4) Vs 1.3 (0.6, 2.0), p-0.013] were statistically more significant than the control group. Likewise, the increase in the serum ferritin levels [10.7 (6.4, 16.7) Vs 6.2 (4.6, 13.3), p-0.015] and body weight [0.8 (0.3, 1.4) Vs 0.1 (-0.4, 0.6)] in the intervention group were significantly more than in the control group. Besides routine oral iron syrup, daily supplementation of sesame jaggery balls in moderate iron-deficient anemic children improves their iron status.","PeriodicalId":49188,"journal":{"name":"Indian Journal of Hematology and Blood Transfusion","volume":"41 2","pages":"267-273"},"PeriodicalIF":0.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11992248/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anemia Management in Pediatric Chronic Kidney Disease: Current Challenges and Treatment Strategies. 儿童慢性肾脏疾病贫血管理：当前的挑战和治疗策略。

IF 0.7 4区医学

Indian Journal of Hematology and Blood Transfusion Pub Date : 2025-04-01 Epub Date: 2025-01-08 DOI: 10.1007/s12288-024-01955-z

Altaf Jamil, Barbara Gruner, Javairia Jamil, Alicia Bach, Tyler Severance, Kim Ebersol, Laura E Hesemann

{"title":"Anemia Management in Pediatric Chronic Kidney Disease: Current Challenges and Treatment Strategies.","authors":"Altaf Jamil, Barbara Gruner, Javairia Jamil, Alicia Bach, Tyler Severance, Kim Ebersol, Laura E Hesemann","doi":"10.1007/s12288-024-01955-z","DOIUrl":"https://doi.org/10.1007/s12288-024-01955-z","url":null,"abstract":"A prevalent complication of chronic kidney disease (CKD), iron deficiency anemia (IDA) continues to be underdiagnosed and undertreated. Anemia in CKD in children is associated with a reduced quality of life, and an increased morbidity and mortality. The multifaceted etiology of anemia in CKD involves factors such as diminished endogenous erythropoietin (EPO) production, absolute or functional iron deficiency, and heightened inflammation characterized by elevated hepcidin levels. This paper reviews the complexities of anemia management in pediatric CKD, emphasizing the pivotal role of iron supplementation and erythropoiesis-stimulating agents (ESAs) in ameliorating erythropoiesis and optimizing patient outcomes. While intravenous (IV) iron supplementation effectively addresses iron-restricted erythropoiesis and enhances ESA response, challenges persist in accurately defining anemia in pediatric CKD patients and establishing appropriate treatment targets.","PeriodicalId":49188,"journal":{"name":"Indian Journal of Hematology and Blood Transfusion","volume":"41 2","pages":"228-237"},"PeriodicalIF":0.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11992271/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144036185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of Autoimmune Hemolytic Anemia During Ruxolitinib Treatment for Myelofibrosis: A Case Series. 鲁索利替尼治疗骨髓纤维化期间自身免疫性溶血性贫血的发展：一个病例系列

IF 0.7 4区医学

Indian Journal of Hematology and Blood Transfusion Pub Date : 2025-04-01 Epub Date: 2024-08-24 DOI: 10.1007/s12288-024-01845-4

Atakan Turgutkaya, Ali Zahit Bolaman, İrfan Yavaşoğlu

引用次数: 0

Azacytidine and Venetoclax as a Salvage Therapy for Relapsed/Refractory Acute Myeloid Leukemia: A Single Centre Experience. 阿扎胞苷和Venetoclax作为复发/难治性急性髓性白血病的补救性治疗：单中心经验。

IF 0.7 4区医学

Indian Journal of Hematology and Blood Transfusion Pub Date : 2025-01-01 Epub Date: 2024-06-18 DOI: 10.1007/s12288-024-01802-1

Saikat Mondal, Deepika Gupta, Naveen Vairamoorthy, Priyanka Moule, Jyoti Kotwal, Nitin Gupta

引用次数: 0

Management of CML and Pregnancy in Low-and Middle-income Countries. 中低收入国家慢性粒细胞白血病和妊娠的管理。

IF 0.7 4区医学

Indian Journal of Hematology and Blood Transfusion Pub Date : 2025-01-01 Epub Date: 2024-11-19 DOI: 10.1007/s12288-024-01930-8

Nitya Malhotra, Rimpy Tandon, Pankaj Malhotra

{"title":"Management of CML and Pregnancy in Low-and Middle-income Countries.","authors":"Nitya Malhotra, Rimpy Tandon, Pankaj Malhotra","doi":"10.1007/s12288-024-01930-8","DOIUrl":"10.1007/s12288-024-01930-8","url":null,"abstract":"Chronic myeloid leukemia (CML) is one of the most common types of leukemia observed in adults in low- and middle-income countries (LMICs). While the life expectancy of CML patients in the chronic phase in high-income countries (HIC) countries has nearly matched that of the general population, this is not the case for CML patients in LMICs. Several factors contribute to this disparity, including delayed presentation, delayed diagnosis, poor socioeconomic background, illiteracy, lack of insurance, long travel distances to healthcare facilities, limited availability of CML specialists, and the prevalence of tropical infections such as dengue and malaria. Consequently, management guidelines developed for CML patients in HIC are not always applicable to those in LMICs. The same hold true for CML patients who are pregnant or wish to conceive. This manuscript explores these differences and offers tailored recommendations for pregnancy and CML. Male patients with CML can safely father children, as neither the disease nor tyrosine kinase inhibitors (TKIs) impact pregnancy or affect newborns. However, managing CML in female patients is more complex. Although physicians advise planned pregnancies for CML patients, most pregnancies in LMICs are unplanned. Issues such as whether to continue or stop TKI treatment and which TKI to use are critical considerations. Interferon is regarded as safe during pregnancy but is seldom prescribed due to its high cost. This manuscript aims to address these complexities and provide recommendations for pregnant CML patients in LMICs including India.","PeriodicalId":49188,"journal":{"name":"Indian Journal of Hematology and Blood Transfusion","volume":"41 1","pages":"1-9"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11794896/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chronic Myeloid Leukemia in Resource Limited Settings: Treatment Free Remission and Tyrosine Kinase Resistance. 资源有限环境中的慢性粒细胞白血病：无治疗缓解和酪氨酸激酶抗药性。

IF 0.7 4区医学

Indian Journal of Hematology and Blood Transfusion Pub Date : 2024-10-01 Epub Date: 2024-10-04 DOI: 10.1007/s12288-024-01899-4

Sanjeev Kumar Gupta, Sanjeevan Sharma

引用次数: 0

Haploidentical Hematopoietic Stem Cell Transplantation in India-Bridging the Gap. 印度的同种异体造血干细胞移植--缩小差距。

IF 0.7 4区医学

Indian Journal of Hematology and Blood Transfusion Pub Date : 2024-07-01 Epub Date: 2024-06-25 DOI: 10.1007/s12288-024-01812-z

Kundan Mishra, Rahul Naithani

引用次数: 0