Indian Journal of Hematology and Blood Transfusion最新文献

Chronic Myeloid Leukemia in Resource Limited Settings: Treatment Free Remission and Tyrosine Kinase Resistance. 资源有限环境中的慢性粒细胞白血病：无治疗缓解和酪氨酸激酶抗药性。

IF 0.7 4区医学

Indian Journal of Hematology and Blood Transfusion Pub Date : 2024-10-01 Epub Date: 2024-10-04 DOI: 10.1007/s12288-024-01899-4

Sanjeev Kumar Gupta, Sanjeevan Sharma

引用次数: 0

Haploidentical Hematopoietic Stem Cell Transplantation in India-Bridging the Gap. 印度的同种异体造血干细胞移植--缩小差距。

IF 0.7 4区医学

Indian Journal of Hematology and Blood Transfusion Pub Date : 2024-07-01 Epub Date: 2024-06-25 DOI: 10.1007/s12288-024-01812-z

Kundan Mishra, Rahul Naithani

引用次数: 0

Potential Role of Positivity Percentage of CD200 in the Mature B Cell Neoplasms CD200 阳性率在成熟 B 细胞肿瘤中的潜在作用

IF 0.9 4区医学

Indian Journal of Hematology and Blood Transfusion Pub Date : 2024-01-05 DOI: 10.1007/s12288-023-01727-1

Can Yan, Weichu Dai, Na Shi, Wei Pan

引用次数: 0

Short-Term Impact of Hematopoietic Stem Cell Transplantation on Depressive Behavior, Cognition and Quality of Life in Leukemia Patients. 造血干细胞移植对白血病患者抑郁行为、认知和生活质量的短期影响

IF 0.7 4区医学

Indian Journal of Hematology and Blood Transfusion Pub Date : 2024-01-01 Epub Date: 2023-04-04 DOI: 10.1007/s12288-023-01653-2

Rhythm Joshi, Aakriti Garg, Zehva Khan, Dinesh Bhurani, Nidhi, Mohd Ashif Khan

{"title":"Short-Term Impact of Hematopoietic Stem Cell Transplantation on Depressive Behavior, Cognition and Quality of Life in Leukemia Patients.","authors":"Rhythm Joshi, Aakriti Garg, Zehva Khan, Dinesh Bhurani, Nidhi, Mohd Ashif Khan","doi":"10.1007/s12288-023-01653-2","DOIUrl":"10.1007/s12288-023-01653-2","url":null,"abstract":"Hematopoietic stem cell transplantation (HSCT) or Bone Marrow Transplantation (BMT) has significantly improved the survival rates of patients suffering from hematological malignancies. However, the cure can only be achieved at the price of morbidity and long-term complications. Thus, this study aimed to evaluate the short-term effect of HSCT on depressive behavior, cognition, and quality of life (QoL) in leukemia patients. Sixty patients were included in this prospective observational study. The current study assessed depression using Patient Health Questionnaire (PHQ-9) scale, cognition using Montreal Cognitive Assessment (MOCA) scale and QoL using European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ C30) before 7 days of the therapy i.e., preconditioning/baseline (TP1) and after 30 days of the treatment (TP2) in leukemia patients undergoing HSCT. At TP2, there was a significant improvement in PHQ-9 (p = 0.001), MOCA (p < 0.0001), functional scale (p < 0.0001) and global health & QoL scale (p = 0.001) of EORTC QLQ C30 scores whereas there was a significant decrease in symptom scale of EORTC QLQ C30 score (p = 0.005). Furthermore, at TP2 a statistically significant (p < 0.05) negative correlation was observed between MOCA and symptom scale of EORTC QLQ C30 after Pearson correlation analysis. In conclusion, post-30 days of HSCT there was alleviation in depressive behavior, cognition, and QoL in leukemia patients compared to before therapy.Graphical abstract: ","PeriodicalId":49188,"journal":{"name":"Indian Journal of Hematology and Blood Transfusion","volume":"1 1","pages":"83-90"},"PeriodicalIF":0.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10831021/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41707076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

AML With HIV Infection in The Era of Precision Oncology – Do We See The Light At The End of The Tunnel? 精准肿瘤学时代感染艾滋病毒的急性髓细胞白血病--我们看到隧道尽头的曙光了吗？

IF 0.9 4区医学

Indian Journal of Hematology and Blood Transfusion Pub Date : 2023-12-08 DOI: 10.1007/s12288-023-01715-5

S. Mailankody, Ananth Pai, Ram Bhat, Karthik Udupa

引用次数: 0

Biclonal Low-Grade B Cell Lymphoma as Detected by Multiparametric Flow Cytometry in Blood and Marrow. 血液和骨髓多参数流式细胞术检测双克隆低级别B细胞淋巴瘤。

IF 0.7 4区医学

Indian Journal of Hematology and Blood Transfusion Pub Date : 2023-10-01 Epub Date: 2023-01-02 DOI: 10.1007/s12288-022-01625-y

Thulasi Raman Ramalingam, Srikanth Muralikrishnan, Jose Easow, Lakshman Vaidhyanathan

{"title":"Biclonal Low-Grade B Cell Lymphoma as Detected by Multiparametric Flow Cytometry in Blood and Marrow.","authors":"Thulasi Raman Ramalingam, Srikanth Muralikrishnan, Jose Easow, Lakshman Vaidhyanathan","doi":"10.1007/s12288-022-01625-y","DOIUrl":"10.1007/s12288-022-01625-y","url":null,"abstract":"Biclonal B cell lymphomas (BCL) of two different low-grade components are rare. Multiparametric flow cytometry (MFC) is an integral tool in lymphoma diagnosis and very efficient in picking up BCL cases, especially when the associated second component is small. We studied the incidence of BCL in the routine blood and marrow samples sent for immunophenotyping by MFC. A total of 376 cases were analyzed retrospectively. We studied their clinical, immunophenotypic, molecular, and cytogenetic findings with literature review. We found five cases of BCL with two different clonal low-grade B cell components at an incidence of 1.3%. All cases were males with a median age of 68 years. The chronic lymphocytic leukemia (CLL) clone was present in all 5 cases. The other associated component in cases 1 to 5 were lymphoplasmacytic lymphoma, follicular lymphoma, splenic marginal zone lymphoma, hairy cell leukemia, and monoclonal B cell population of non-CLL type respectively. Diagnosing BCL may be challenging and may also go undiagnosed when the second component is petite and overshadowed by the more significant component. It may be critical if the small, unnoticed lymphoma component is of a more aggressive type.Supplementary information: The online version contains supplementary material available at 10.1007/s12288-022-01625-y.","PeriodicalId":49188,"journal":{"name":"Indian Journal of Hematology and Blood Transfusion","volume":"39 4","pages":"691-698"},"PeriodicalIF":0.7,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10542050/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41167397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effective and Elaborative Induction Program for Mitigating Myths and Misconceptions Linked to Hematopoietic Stem Cell Transplantation in a Resource Limited Setting. 在资源有限的环境中缓解与造血干细胞移植相关的神话和误解的有效和精细的诱导计划。

IF 0.9 4区医学

Indian Journal of Hematology and Blood Transfusion Pub Date : 2023-10-01 Epub Date: 2023-03-16 DOI: 10.1007/s12288-023-01634-5

Safaa A A Khaled, Mahmoud M Elzembely, Asmaa M A Soliman, Nahed Shwakat, Nashwa Rafaat, Mohamed A Malek, Esmat S Abdelmageed

{"title":"Effective and Elaborative Induction Program for Mitigating Myths and Misconceptions Linked to Hematopoietic Stem Cell Transplantation in a Resource Limited Setting.","authors":"Safaa A A Khaled, Mahmoud M Elzembely, Asmaa M A Soliman, Nahed Shwakat, Nashwa Rafaat, Mohamed A Malek, Esmat S Abdelmageed","doi":"10.1007/s12288-023-01634-5","DOIUrl":"https://doi.org/10.1007/s12288-023-01634-5","url":null,"abstract":"Since the first transplant in 1957 and hematopoietic stem cell transplantation (HSCT) is the curative modality for numerous hematological disorders. Nevertheless, it is not available for all patients. Besides unavailability of matched donors a lot of factors could hinder HSCT in a resource limited setting, as financial and administrative factors. In our daily practice we noticed other factors that hinder HSCT in our center, the common myths and misconceptions about HSCT and donation. This quasi-experimental study assessed, for the first time, common myths and misconceptions about HSCT among 218 medical and nursing students before and after an interventional educational program. The study tool was an investigators' developed self-administered questionnaire. Participants' male to female ratio was 1:2.5, and FAS was middle in 52.7%. Pretest high myths scores were reported in 53.4% and 90% of medical and nursing students that was reduced to 0% and 4% post-test, respectively. Pretest, 26.3% and 7% of medical and nursing students welling to donate HSC, that increased to 66% and 39% post-test, respectively. Rural residency, low and middle FAS associated with higher myths scores. Myths score is an independent effector of willingness to donate HSC among participants. In conclusion medical/nursing students had significant myths and misconceptions about HSCT that was corrected with the educational program. Thus, wide based educational programs about HSCT are mandatory to correct myths and augment HSC donation. www.clinicaltrrial.gov: clinical trial ID NCT05151406.Supplementary information: The online version contains supplementary material available at 10.1007/s12288-023-01634-5.","PeriodicalId":49188,"journal":{"name":"Indian Journal of Hematology and Blood Transfusion","volume":"39 4","pages":"598-609"},"PeriodicalIF":0.9,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10542043/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41122486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In-vitro Modulation of mTOR-HIF-1α Axis by TLR7/8 Agonist (Resiquimod) in B-Chronic Lymphocytic Leukemia. TLR7/8激动剂（雷喹莫特）对慢性B淋巴细胞白血病mTOR-HIF-1α轴的体外调节作用。

IF 0.9 4区医学

Indian Journal of Hematology and Blood Transfusion Pub Date : 2023-10-01 Epub Date: 2023-04-07 DOI: 10.1007/s12288-023-01649-y

Rana M Hanafy, Soheir R Demian, Lobna A Abou-Shamaa, O Ghallab, Eman M Osman

{"title":"In-vitro Modulation of mTOR-HIF-1α Axis by TLR7/8 Agonist (Resiquimod) in B-Chronic Lymphocytic Leukemia.","authors":"Rana M Hanafy, Soheir R Demian, Lobna A Abou-Shamaa, O Ghallab, Eman M Osman","doi":"10.1007/s12288-023-01649-y","DOIUrl":"https://doi.org/10.1007/s12288-023-01649-y","url":null,"abstract":"Targeting toll-like receptors (TLRs), via TLR agonists, has been implicated in the regulation of immunometabolism. B-chronic lymphocytic leukemia (B-CLL) represents a suitable model for B-cell derived malignancies with shifted metabolic adaptations. Several signaling pathways have been found to be critical in metabolic reprogramming of CLL, including mechanistic target of rapamycin- hypoxia inducible factor-1α (mTOR- HIF-1α) pathway, the main metabolic regulator of glycolysis. Here, we investigated the effect of TLR7/8 agonist (Resiquimod) on the expression of mTOR and HIF-1α in patients with CLL. B cells were purified using Rosettesep Human B cell Enrichment Cocktail (Stem cell Technologies, Vancouver, BC, Canada#15,024) from peripheral venous blood of CLL patients (n = 20) and healthy individuals (n = 15). Isolated B cells were then cultured in both presence and absence of Resiquimod. Gene expression of mTOR and HIF-1α were assessed using qRT-PCR. Resiquimod significantly decreased mTOR and HIF-1α gene expression in both CLL (p < 0.001and p < 0.001, respectively) and Normal B cells (p = 0.004 and p = 0.001, respectively). Resiquimod may reprogram immunometabolism of malignant B-CLL cells via down-regulation of key glycolytic metabolic actors, mTOR and HIF-1α genes. Accordingly, Resiquimod may be an adjuvant as a therapeutic tool for CLL, which needs to be studied further.Supplementary information: The online version contains supplementary material available at 10.1007/s12288-023-01649-y.","PeriodicalId":49188,"journal":{"name":"Indian Journal of Hematology and Blood Transfusion","volume":"39 4","pages":"537-545"},"PeriodicalIF":0.9,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10542076/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41155527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cell Death Markers in Children with Immune Thrombocytopenic Purpura: A Preliminary Study. 免疫性血小板减少性紫癜患儿细胞死亡标志物的初步研究。

IF 0.9 4区医学

Indian Journal of Hematology and Blood Transfusion Pub Date : 2023-10-01 Epub Date: 2023-02-25 DOI: 10.1007/s12288-023-01639-0

Sohier Yahia, Waleed Eldars, Heba Eldegla, Ahmed K Mansour, Mouna Guaida, Mohamed S A Abdelkader, Yahya Wahba

{"title":"Cell Death Markers in Children with Immune Thrombocytopenic Purpura: A Preliminary Study.","authors":"Sohier Yahia, Waleed Eldars, Heba Eldegla, Ahmed K Mansour, Mouna Guaida, Mohamed S A Abdelkader, Yahya Wahba","doi":"10.1007/s12288-023-01639-0","DOIUrl":"https://doi.org/10.1007/s12288-023-01639-0","url":null,"abstract":"Immune thrombocytopenic purpura (ITP) is an autoimmune disease with possible dysregulation of the apoptotic pathways. We aimed to evaluate the possible role of some apoptotic markers (caspase 3, caspase 8 and BCL2) in the pathogenesis and course of ITP. We investigated some apoptotic markers (caspase 3, caspase 8 and BCL2) using the flow cytometry in 60 children with newly diagnosed ITP, 20 children with chemotherapy-related thrombocytopenia (CRT) and 20 healthy children. We also assessed the effects of intravenous immunoglobulin (IVIG) and methyl prednisolone therapies on the platelet apoptosis in children with newly diagnosed ITP. We demonstrated significantly higher values of caspase 3 in the newly diagnosed ITP group than control and CRT groups, and non-significantly higher values of caspase 8 in the ITP group than the healthy group. After IVIG treatment, the platelet count increased in all patients, and there was a significant decrease in caspase 3 and caspase 8 levels while BCL2 level increased. Regarding methylprednisolone treatment, there was a significant decrease in BCL2 and caspase 8 levels while caspase 3 levels did not significantly decrease. There is a possible role of the caspase dependent cell death pathway of the platelets in the occurrence of newly diagnosed ITP. There is heterogeneity in the apoptotic changes of newly diagnosed ITP children who received IVIG versus those who received methylprednisolone.","PeriodicalId":49188,"journal":{"name":"Indian Journal of Hematology and Blood Transfusion","volume":"39 4","pages":"635-641"},"PeriodicalIF":0.9,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10542074/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41162254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Depolarized Mitochondrial Membrane Potential and Elevated Calcium in Platelets of Sickle Cell Disease. 镰状细胞病血小板中线粒体膜电位的去极化和钙的升高。

IF 0.7 4区医学

Indian Journal of Hematology and Blood Transfusion Pub Date : 2023-10-01 Epub Date: 2023-03-04 DOI: 10.1007/s12288-023-01640-7

Samarjit Maharana, Chitrali Laha Roy, Kamal Kishor, Ravi Ranjan, Firdos Ahmad, Manoranjan Mahapatra, Renu Saxena, Meganathan Kannan

{"title":"Depolarized Mitochondrial Membrane Potential and Elevated Calcium in Platelets of Sickle Cell Disease.","authors":"Samarjit Maharana, Chitrali Laha Roy, Kamal Kishor, Ravi Ranjan, Firdos Ahmad, Manoranjan Mahapatra, Renu Saxena, Meganathan Kannan","doi":"10.1007/s12288-023-01640-7","DOIUrl":"10.1007/s12288-023-01640-7","url":null,"abstract":"Hemolysis, a crucial feature of Sickle cell disease (SCD), is a key player for cellular activation leading to various complications including thrombosis. In response to hemolysis, platelets get activated and release components that are necessary for further platelet activation and aggregation. Thus, it is believed that platelets contribute to the development of thrombotic complications. Platelets in SCD are expected to be affected due to common cause of hemolysis. To measure the surface markers of platelets including P-Selectin, Phosphatidyl Serine and integrin αIIbβ3 in SCD patients and healthy controls in order to understand the status of the platelets in SCD. To measure the surface markers of activated platelets using flow cytometry. Since mitochondria and calcium play an important role in cellular functions, the mitochondrial membrane potential and calcium content of platelets in SCD were also evaluated using flow cytometry. In the present study, we have observed significant increase of calcium level in SCD platelets. Further, the loss of mitochondrial membrane potential in SCD platelets was found to be significantly higher when compared to platelets of healthy controls. Though the surface markers of activated platelets in SCD remain unchanged, increased level of calcium and mitochondrial membrane potential loss suggest that the platelets in SCD are more prone to become activated. In order to understand the status of the platelets in SCD, apart from the surface markers, it is also important to assess the calcium levels and mitochondrial membrane potential of platelets.","PeriodicalId":49188,"journal":{"name":"Indian Journal of Hematology and Blood Transfusion","volume":"39 4","pages":"565-571"},"PeriodicalIF":0.7,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10542052/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41155733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0