Indian Journal of Hematology and Blood Transfusion最新文献_第2页

F18-FDG PET/CT Imaging in a Rare Case of Solitary Primary Iliac Bone Lymphoma. F18-FDG PET/CT在罕见的孤立性原发性髂骨淋巴瘤中的表现。

IF 0.7 4区医学

Indian Journal of Hematology and Blood Transfusion Pub Date : 2025-07-01 Epub Date: 2024-09-26 DOI: 10.1007/s12288-024-01862-3

Ritwik Wakankar, Jaspriya Bal, Pankaj Dougall

引用次数: 0

ABO-Mismatch Hematopoietic Stem Cell Transplantation with Pre-existing Red Cell Alloantibody Resembling a Case of Post-transplant Autoimmune Hemolytic Anemia. abo -错配造血干细胞移植与预先存在的红细胞同种抗体类似移植后自身免疫性溶血性贫血的病例。

IF 0.7 4区医学

Indian Journal of Hematology and Blood Transfusion Pub Date : 2025-07-01 Epub Date: 2024-09-20 DOI: 10.1007/s12288-024-01883-y

Ayesha Sinha, Arijit Nag, Debapriya Basu, Suvro Sankha Datta

引用次数: 0

Glial Tumor Metastasizing to Bone Marrow: A Rare Journey. 神经胶质肿瘤转移到骨髓：一个罕见的旅程。

IF 0.7 4区医学

Indian Journal of Hematology and Blood Transfusion Pub Date : 2025-07-01 Epub Date: 2024-10-17 DOI: 10.1007/s12288-024-01866-z

Apeksha Bhat, Anab Sayyada, Somya Choubey, Udayakumar Ds, Bhaarat Folbs, Ankur Nandan Varshney

引用次数: 0

Outcome of Childhood and Adolescents and Young Adults ALL Treated with ALL IC-BFM 2009 Protocol-A Single-Center Experience in India. 儿童、青少年和青年接受ALL - IC-BFM 2009方案治疗的结果——印度的单中心经验。

IF 0.7 4区医学

Indian Journal of Hematology and Blood Transfusion Pub Date : 2025-07-01 Epub Date: 2024-10-18 DOI: 10.1007/s12288-024-01898-5

Karthik Kumar, Sashi Kant Singh, Jhasaketan Nayak, Kanimozhi Rajamani, Adamya Gupta, Paras Satadeve, Vinod Kumar, Priyavadhana Balasubramanian, Puneet Dhamija, Harish Chandra, Uttam Kumar Nath

{"title":"Outcome of Childhood and Adolescents and Young Adults ALL Treated with ALL IC-BFM 2009 Protocol-A Single-Center Experience in India.","authors":"Karthik Kumar, Sashi Kant Singh, Jhasaketan Nayak, Kanimozhi Rajamani, Adamya Gupta, Paras Satadeve, Vinod Kumar, Priyavadhana Balasubramanian, Puneet Dhamija, Harish Chandra, Uttam Kumar Nath","doi":"10.1007/s12288-024-01898-5","DOIUrl":"https://doi.org/10.1007/s12288-024-01898-5","url":null,"abstract":"ALL is a biologically heterogeneous disease. Risk and response adapted therapy improved the survival of childhood ALL above 90%. Early response parameters independently predicted the survival and relapse. This study was a single-center, prospective, randomized study conducted in AIIMS Rishikesh from April 2021 to February 2023. The objectives were to assess the efficacy and toxicity of two steroid groups in Induction and overall survival of patients treated with ALL IC-BFM 2009 protocol. The study enrolled 75 ALL patients in the age group of 1-24 years. Forty-one patients received dexamethasone and thirty-four patients received prednisolone. Of evaluable patients, 83% completed induction therapy. Of enrolled patients, 86% achieved good steroid response, 73% had day 15 BM M1 and 38% had day 15 BM MRD below 0.1%. Complete remission was achieved in 97% of participants with 77% MRD below 0.01%. There was no statistically significant difference in efficacy between the two groups. There was a significantly higher incidence of neutropenia in the Dexa group compared to the Pred group [Dexa- 97%, Pred- 60%; p < 0.001]. The incidence of Induction mortality in the study was 12% [Dexa-14.6%; Pred-8.8%] (p 0.449). There was no statistically significant difference in other toxicities between the groups. The overall survival and event-free survival were 74.24% (dexa- 76.3%; pred-71.4%) and 65.3% [dexa- 70.7%, Pred- 58.8%] respectively. The subgroup analysis demonstrated an overall survival of 80% for SR, 84% for IR & 64% for HR groups. The overall incidence of relapse was 6.4%. Prospective studies are needed from LMIC to correlate combined day 15 and post-induction MRD.","PeriodicalId":49188,"journal":{"name":"Indian Journal of Hematology and Blood Transfusion","volume":"41 3","pages":"494-503"},"PeriodicalIF":0.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12267799/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144676308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Eosinophils- the Misconstrue behind Platelet Dysfunction! 嗜酸性粒细胞-血小板功能障碍背后的误解！

IF 0.7 4区医学

Indian Journal of Hematology and Blood Transfusion Pub Date : 2025-07-01 Epub Date: 2024-10-05 DOI: 10.1007/s12288-024-01890-z

Surbhi Dahiya, Pallavi Prakhar, Jyoti Kotwal, Amrita Saraf, Nitin Gupta

引用次数: 0

Recurrent Hypoglycemia during Sorafenib Maintenance Post-Allogeneic Hematopoietic Stem Cell Transplantation. 异基因造血干细胞移植后索拉非尼维持期间复发性低血糖。

IF 0.7 4区医学

Indian Journal of Hematology and Blood Transfusion Pub Date : 2025-07-01 Epub Date: 2024-10-10 DOI: 10.1007/s12288-024-01893-w

Nihar Desai, Auro Viswabandya

引用次数: 0

Scarring Cutaneous Tubercular Abscess in a Patient with Lymphoblastic Lymphoma. 淋巴母细胞淋巴瘤患者的瘢痕性皮肤结核脓肿。

IF 0.7 4区医学

Indian Journal of Hematology and Blood Transfusion Pub Date : 2025-07-01 Epub Date: 2024-10-17 DOI: 10.1007/s12288-024-01907-7

Sarthak Wadhera, Sudipto Banerjee, Rajinder Kumar Basher, Charanpreet Singh, Arihant Jain, Gaurav Prakash, Alka Khadwal, Pankaj Malhotra

引用次数: 0

Characterisation of β-thalassemia mutations in a tertiary care referral hospital in southern India- A descriptive study. 表征β-地中海贫血突变在印度南部三级保健转诊医院-描述性研究。

IF 0.7 4区医学

Indian Journal of Hematology and Blood Transfusion Pub Date : 2025-07-01 Epub Date: 2024-09-28 DOI: 10.1007/s12288-024-01886-9

Dheebika Kuppusamy, Angalena Ramachandran, Nivedita Nanda, Chinnaiah Govindareddy Delhi Kumar, Rakhee Kar

{"title":"Characterisation of β-thalassemia mutations in a tertiary care referral hospital in southern India- A descriptive study.","authors":"Dheebika Kuppusamy, Angalena Ramachandran, Nivedita Nanda, Chinnaiah Govindareddy Delhi Kumar, Rakhee Kar","doi":"10.1007/s12288-024-01886-9","DOIUrl":"10.1007/s12288-024-01886-9","url":null,"abstract":"Purpose: Thalassemia is the most prevalent autosomal single-gene disorder. More than 250 mutations that impact β-globin gene expression levels through diverse mechanisms are known to cause β-thalassemia. Regional variations in β-thalassemia mutations are common. This study was undertaken to study the common β-thalassemia mutations in a tertiary care hospital in Puducherry, southern India.Methods: The study was conducted over two years (2020-2021). Patients with β-thalassemia, their carrier parents and siblings, mainly from Puducherry and various districts of Tamil Nadu, were included to screen prevalent mutations. The genomic DNA isolated from whole blood samples was hybridized using a strip assay kit by reverse dot blot hybridization. For a few samples, DNA sequencing was done from a referral lab.Results: Among the 92 cases, comprising 40 index cases and 52 family members, IVS I-5(G > C) was the most common mutation detected, accounting for 78%, followed by Cd 15(G > A) at 5.3% of all mutant alleles. Additional β-thalassemia mutations identified included - 28 (A > G) and Poly A site (T > C) through sequencing, along with FS Cd 41/42 (-TCTT) and Cd 8/9 (+ G) detected via strip assay. One index case of Sickle-β thalassemia with IVS I-5(G > C) + Cd 6(A > T) and another case of HbE-β thalassemia with Cd8/9(+ G) + Cd 26(G > A) mutant alleles was also identified. Uncharacterized mutant alleles in the study accounted for 4.5%.Conclusion: This study helped us to identify the common mutation patterns in our hospital population. Additional mutations could be detected by sequencing beyond those identified through strip assay. Mutation screening plays a crucial role in genetic counselling and prenatal diagnosis.","PeriodicalId":49188,"journal":{"name":"Indian Journal of Hematology and Blood Transfusion","volume":"41 3","pages":"551-557"},"PeriodicalIF":0.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12267716/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144676218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mutation Analysis for Hemoglobinopathies in Eastern Jharkhand. 贾坎德邦东部血红蛋白病的突变分析。

IF 0.7 4区医学

Indian Journal of Hematology and Blood Transfusion Pub Date : 2025-07-01 Epub Date: 2024-10-10 DOI: 10.1007/s12288-024-01894-9

Shambhavi, Umesh Kumar Ojha, Mahino Fatima, Rani Manisha, Mohammed Faruq, Vivek Kumar

{"title":"Mutation Analysis for Hemoglobinopathies in Eastern Jharkhand.","authors":"Shambhavi, Umesh Kumar Ojha, Mahino Fatima, Rani Manisha, Mohammed Faruq, Vivek Kumar","doi":"10.1007/s12288-024-01894-9","DOIUrl":"10.1007/s12288-024-01894-9","url":null,"abstract":"Thalassemia is the commonest monogenic disorder worldwide and India is home to significant proportion of these patients. The prevalence of beta-thalassemia trait varies around the country ranging from 0.35 to 37.5%. Data regarding mutation spectrum of beta thalassemia from Jharkhand are scanty, though this state has high prevalence of thalassemia. The Aim of study was to explore different mutations prevalent in transfusion-dependent-thalassemia patients in age group of 6 months to 18 years, coming to our centre over period of one month for regular transfusion. Basic characteristics were noted and blood sample were sent for genetic analysis. We studied 51 patients. Their mean age was 9 years. Severe β+/ severe β + was most common genotype found in 78.4% patients followed by severe β+/β0. We found that c.92 + 5 C > G was the commonest mutation. We also report one patient with extremely rare mutation called as Hb Monroe (c.92G > C). The mutation c.92 + 5 C > G has been reported as the commonest mutation in various regions of our country but its frequency varies from 55 to about 71.4%. We found even greater frequency of this mutation (88.2%) in our sample. This study serves to fill the gap in knowledge of mutation spectrum in this under-represented area of our country.","PeriodicalId":49188,"journal":{"name":"Indian Journal of Hematology and Blood Transfusion","volume":"41 3","pages":"694-697"},"PeriodicalIF":0.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12267758/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144676306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lenalidomide Induced Conjunctivitis in a Patient with Multiple Myeloma. 来那度胺致多发性骨髓瘤结膜炎1例。

IF 0.7 4区医学

Indian Journal of Hematology and Blood Transfusion Pub Date : 2025-07-01 Epub Date: 2024-09-23 DOI: 10.1007/s12288-024-01874-z

Paras Gupta, Sarthak Wadhera, Charanpreet Singh, Arihant Jain, Sreejesh Sreedharanuni, Gaurav Prakash, Alka Rani Khadwal, Pankaj Malhotra

引用次数: 0