Indian Journal of Hematology and Blood Transfusion最新文献_第10页

Evaluation of Erythroid Maturation Patterns in Unexplained anemia in the Elderly. 老年人不明原因性贫血中红细胞成熟模式的评价。

IF 0.7 4区医学

Indian Journal of Hematology and Blood Transfusion Pub Date : 2025-07-01 Epub Date: 2024-10-29 DOI: 10.1007/s12288-024-01879-8

Shrinza Gupta, Mrinalini Kotru, Ashish Goel, Richa Gupta

{"title":"Evaluation of Erythroid Maturation Patterns in Unexplained anemia in the Elderly.","authors":"Shrinza Gupta, Mrinalini Kotru, Ashish Goel, Richa Gupta","doi":"10.1007/s12288-024-01879-8","DOIUrl":"10.1007/s12288-024-01879-8","url":null,"abstract":"In the elderly, a sizeable proportion of anemia remains unexplained. Erythroid maturation patterns may provide clues to underlying pathophysiology. Hence, this study was conducted to identify unique erythroid maturation patterns in unexplained anemia (UA) and their usefulness in providing a clue to the underlying cause of anemia. Immunophenotyping by flow cytometry was performed on bone marrow (BM) aspirates. The maturation patterns of erythroid precursors were studied, and erythroid cells were classified into early erythroid precursors (CD34+/CD117+/CD71-), proerythroblasts (CD45neg-dim/CD71+/CD117+/CD235a-), erythroblasts (CD117-/CD71+/CD235a+) and mature erythrocytes (CD235a+). Three different patterns were observed based on CD71 expression (heterogeneous, homogeneous, and negative to dim), the percentage of CD117 + erythroid cells, and MFI CD71 (increased or decreased). Three of these cases also showed mild CD117+/CD235a + copositive aberrant/asynchronous pattern. UA cases in the elderly demonstrated three different maturation patterns. These patterns need to be validated along with a cytogenetic work-up in further studies with larger sample size and longer follow-ups to gain a better understanding of the progression of UA.Supplementary information: The online version contains supplementary material available at 10.1007/s12288-024-01879-8.","PeriodicalId":49188,"journal":{"name":"Indian Journal of Hematology and Blood Transfusion","volume":"41 3","pages":"571-578"},"PeriodicalIF":0.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12267786/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144676296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cervical Lymphadenopathy as Sole Presentation in a Case of Chronic Myeloid Leukemia at the Outset. 宫颈淋巴结病是慢性髓性白血病的唯一表现。

IF 0.7 4区医学

Indian Journal of Hematology and Blood Transfusion Pub Date : 2025-07-01 Epub Date: 2024-10-15 DOI: 10.1007/s12288-024-01900-0

Shaad Vali, Bembem Khuraijam, Nimisha Dhankar, Sarika Singh, Priyanka Munjal, Ravi Meher

引用次数: 0

Outcomes after Immunosuppressive Therapy for Aplastic Anemia: A Single Centre Experience from Northern India. 再生障碍性贫血免疫抑制治疗后的结果：来自印度北部的单一中心经验。

IF 0.7 4区医学

Indian Journal of Hematology and Blood Transfusion Pub Date : 2025-07-01 Epub Date: 2024-10-29 DOI: 10.1007/s12288-024-01913-9

Nitish Kumar, Alok Hemal, Aditya Sangwan, Shilpa Khanna Arora

{"title":"Outcomes after Immunosuppressive Therapy for Aplastic Anemia: A Single Centre Experience from Northern India.","authors":"Nitish Kumar, Alok Hemal, Aditya Sangwan, Shilpa Khanna Arora","doi":"10.1007/s12288-024-01913-9","DOIUrl":"https://doi.org/10.1007/s12288-024-01913-9","url":null,"abstract":"Purpose: Aplastic anemia (AA) in children is a life-threatening disorder with very few therapeutic options. This study was carried out to assess the response of Immunosuppressive therapy (IST) in children with non-inherited AA.Methods: It was a prospective observational study carried out among 35 children aged less than 18 years, recently diagnosed with AA by bone marrow biopsy. Those suffering from inherited bone marrow failure syndromes and secondary AA were excluded. IST included equine anti-thymocyte globulin (eATG), steroids, and cyclosporine. Response to immunosuppressive therapy was assessed after four months.Results: The mean age was 10.77 ± 3.6 years. Non-severe AA was diagnosed in 65.71% of children with severe and very severe AA in 17.14%. The overall response rate was found to be 65.7%, with 54.28% of children achieving a partial response and 11.42% of children achieving a complete response. Whereas 17.14% did not respond to treatment, and another 17.14% of children expired before the time point of response assessment. Hemoglobin levels, total leucocyte count, platelet count, and reticulocyte count showed statistically significant elevation following IST.Conclusion: IST can be safely and effectively used as the first-line treatment option in children with non-inherited aplastic anemia, especially when stem cell transplant is not a feasible option.","PeriodicalId":49188,"journal":{"name":"Indian Journal of Hematology and Blood Transfusion","volume":"41 3","pages":"579-584"},"PeriodicalIF":0.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12267709/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144676282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of Modified Blood Components in Patient with History of Allergic Reactions Undergoing Liver Transplantation. 改良血液成分在肝移植有过敏史患者中的作用。

IF 0.7 4区医学

Indian Journal of Hematology and Blood Transfusion Pub Date : 2025-07-01 Epub Date: 2024-10-15 DOI: 10.1007/s12288-024-01901-z

Deepti Sachan, Deepthi Krishna G, Naresh Shanmugam, Mohamed Rela

引用次数: 0

Approaches To Managing Relapsed Myeloma: Switching Drug Class or Retreatment With Same Drug Class? 治疗复发性骨髓瘤的方法：转换药物类别还是用相同药物类别再治疗？

IF 0.7 4区医学

Indian Journal of Hematology and Blood Transfusion Pub Date : 2025-07-01 Epub Date: 2025-03-29 DOI: 10.1007/s12288-025-02008-9

R Vijjhalwar, A Kannan, C Fuentes-Lacouture, K Ramasamy

{"title":"Approaches To Managing Relapsed Myeloma: Switching Drug Class or Retreatment With Same Drug Class?","authors":"R Vijjhalwar, A Kannan, C Fuentes-Lacouture, K Ramasamy","doi":"10.1007/s12288-025-02008-9","DOIUrl":"10.1007/s12288-025-02008-9","url":null,"abstract":"Multiple myeloma (MM) is the second most common haematological malignancy characterised by clonal proliferation of plasma cells within the bone marrow. Despite advances in treatment options, myeloma remains incurable. Relapsed MM poses significant challenges due to clonal evolution, drug resistance, patient comorbidities and therefore complexities of therapeutic decision-making. A critical question in managing relapsed MM is whether to switch drug classes or retreat with agents within the same class. The question is present with the recent addition of three new drug classes (XPO1 inhibitors, BCMA targeted agents, GPRC5d targeted agents) to clinical practice. Switching drug classes offers the potential to target alternative disease pathways and introduce new mechanisms of action, which can be particularly beneficial in cases of limited response to previous therapies. On the other hand, retreatment within the same drug class remains an effective strategy for some patients, particularly those who previously achieved durable responses and known tolerability profile. Both approaches require careful consideration on a background of patient-specific factors such as age, comorbidities, disease burden, and quality of life. We discuss the clinical vignette of a 71-year-old male with biochemical relapse after lenalidomide maintenance; this review explores the nuanced decision-making process involved in selecting the most appropriate treatment. By taking a personalised approach and integrating the evolving therapeutic landscape with real-world considerations, this review highlights strategies to optimise outcomes while maintaining tolerability and quality of life in patients with relapsed MM.","PeriodicalId":49188,"journal":{"name":"Indian Journal of Hematology and Blood Transfusion","volume":"41 3","pages":"478-493"},"PeriodicalIF":0.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12267815/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144676211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Etiology, Diagnosis, and Genetic Analysis of Polycythemia in Pediatric Population. 儿童红细胞增多症的病因、诊断和遗传分析。

IF 0.6 4区医学

Indian Journal of Hematology and Blood Transfusion Pub Date : 2025-07-01 Epub Date: 2024-09-28 DOI: 10.1007/s12288-024-01887-8

Yaşar Cihad Kilinç, Ahmet Bolat, Orhan Gürsel, Cengiz Zeybek, Bülent Ünay

引用次数: 0

Cerium Interferes Iron Binding to Human Serum Apo-Transferrin Which can Affect Iron Metabolism. 铈干扰铁与人血清载铁转铁蛋白结合，影响铁代谢。

IF 0.7 4区医学

Indian Journal of Hematology and Blood Transfusion Pub Date : 2025-04-01 Epub Date: 2024-09-19 DOI: 10.1007/s12288-024-01850-7

Fereshteh Hematyar Tabatabaie, Seyed Ali Asghar Moshtaghie, Ali Asghar Rastegari, Hashem Nayeri

{"title":"Cerium Interferes Iron Binding to Human Serum Apo-Transferrin Which can Affect Iron Metabolism.","authors":"Fereshteh Hematyar Tabatabaie, Seyed Ali Asghar Moshtaghie, Ali Asghar Rastegari, Hashem Nayeri","doi":"10.1007/s12288-024-01850-7","DOIUrl":"10.1007/s12288-024-01850-7","url":null,"abstract":"Iron (Fe) is one of the most abundant metallic elements on the earth and is vital for human health. Some trace elements such as cerium may interfere with iron metabolism. In the present study, the effect of cerium (Ce) interference on intestinal absorption of iron in the first stage of iron metabolism was studied. The spectrophotometry and equilibrium dialysis were used to investigate the interaction of iron and cerium. The interaction of cerium with iron metabolism by interaction with apo-transferrin was investigated. The maximum absorption wavelength of iron-transferrin and cerium-transferrin were obtained 240 nm and 465 nm, respectively. The results showed that cerium was able to bind to apo-transferrin, which binds to transferrin like saturated iron. By obtaining the iron and cerium binding constants in equilibrium dialysis (6.66 × 106 M-1 and 3.51 × 106 M-1, respectively), it was determined that the site of interaction of these two ions on apo-transferrin is probably the same and cerium reduces the binding of iron to apotransferrin by 14%. Based on the results obtained in this project, it was found that cerium interferes with iron metabolism so that it can be altered through impaired intestinal absorption, plasma transport, and biochemical processes required for iron. As serum iron levels in humans are tightly regulated, the interference of cerium with iron metabolism may affect human blood functions.","PeriodicalId":49188,"journal":{"name":"Indian Journal of Hematology and Blood Transfusion","volume":"41 2","pages":"257-266"},"PeriodicalIF":0.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11992286/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144028054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Iron Deficiency anemia Therapy: Hepcidin, Dosing, Formulations and Adjuvants. 缺铁性贫血治疗：Hepcidin，剂量，配方和佐剂。

IF 0.7 4区医学

Indian Journal of Hematology and Blood Transfusion Pub Date : 2025-04-01 Epub Date: 2025-03-29 DOI: 10.1007/s12288-025-02018-7

Mukul Aggarwal, Rakhee Kar

引用次数: 0

Six Cases of 'Asia Type' DEL Detected via Serological Testing. 经血清学检测发现6例亚洲型DEL。

IF 0.7 4区医学

Indian Journal of Hematology and Blood Transfusion Pub Date : 2025-04-01 Epub Date: 2024-08-23 DOI: 10.1007/s12288-024-01847-2

Jingyi Liu, Qiaolin Zhang

引用次数: 0

Sesame Jaggery Ball Supplementation as a Dietary Adjunct Therapy in Treating Moderate Iron Deficiency Anemia Among Children Aged 6-11 Years in South India: An Open-Labeled Randomized Controlled Trial. 芝麻杂碎球补充剂作为治疗印度南部6-11岁儿童中度缺铁性贫血的膳食辅助疗法：一项开放标签随机对照试验。

IF 0.7 4区医学

Indian Journal of Hematology and Blood Transfusion Pub Date : 2025-04-01 Epub Date: 2024-09-28 DOI: 10.1007/s12288-024-01880-1

Yenduri Naimisha, Dhandapany Gunasekaran, Ramasamy Ramesh, D Madhavi Massilamani

{"title":"Sesame Jaggery Ball Supplementation as a Dietary Adjunct Therapy in Treating Moderate Iron Deficiency Anemia Among Children Aged 6-11 Years in South India: An Open-Labeled Randomized Controlled Trial.","authors":"Yenduri Naimisha, Dhandapany Gunasekaran, Ramasamy Ramesh, D Madhavi Massilamani","doi":"10.1007/s12288-024-01880-1","DOIUrl":"10.1007/s12288-024-01880-1","url":null,"abstract":"The prevalence of iron deficient anemia in Indian children has continued to be high for decades, despite drastic measures. Natural food dietary diversification with foodstuffs prepared at home using locally available ingredients could be helpful to counter childhood anemia. In this open-labelled randomized controlled trial, 82 consecutive children aged 6-11 years diagnosed with moderate iron deficiency anemia were randomized into two groups. Children in the control group received 3 mg/kg/day of elemental iron orally in a syrup form, for eight weeks. In addition to the oral iron syrup in the same dose, the intervention group received one sesame jaggery ball (containing 60 g of sesame seeds and jaggery each) for eight weeks. The increases in hemoglobin (Hb) at 4 and 8 weeks were estimated as the primary outcomes. The increases in serum ferritin and body weight at eight weeks were measured as the secondary outcomes. The increase in the median Hb levels of the intervention group at four weeks [0.9 (0.6, 1.5) Vs 0.8 (0.4, 1.2), p-0.045] and eight weeks [1.7 (1.0, 2.4) Vs 1.3 (0.6, 2.0), p-0.013] were statistically more significant than the control group. Likewise, the increase in the serum ferritin levels [10.7 (6.4, 16.7) Vs 6.2 (4.6, 13.3), p-0.015] and body weight [0.8 (0.3, 1.4) Vs 0.1 (-0.4, 0.6)] in the intervention group were significantly more than in the control group. Besides routine oral iron syrup, daily supplementation of sesame jaggery balls in moderate iron-deficient anemic children improves their iron status.","PeriodicalId":49188,"journal":{"name":"Indian Journal of Hematology and Blood Transfusion","volume":"41 2","pages":"267-273"},"PeriodicalIF":0.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11992248/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0