Serum Erythropoietin Level in Polycythemia Vera: Is a New Cut-Off Possible?

IF 0.6 4区医学 Q4 HEMATOLOGY

Indian Journal of Hematology and Blood Transfusion Pub Date : 2025-10-01 Epub Date: 2025-02-24 DOI:10.1007/s12288-025-01990-4

Rafet Eren, Abdulkadir Karismaz, Ceyda Arslan, Esra Terzi Demirsoy, Aliihsan Gemici, Istemi Serin

{"title":"Serum Erythropoietin Level in Polycythemia Vera: Is a New Cut-Off Possible?","authors":"Rafet Eren, Abdulkadir Karismaz, Ceyda Arslan, Esra Terzi Demirsoy, Aliihsan Gemici, Istemi Serin","doi":"10.1007/s12288-025-01990-4","DOIUrl":null,"url":null,"abstract":"Polycythemia vera (PV) is a myeloproliferative disease characterized by hemoglobin/hematocrit levels above 16.5 g/dL or 49% in men, and 16 g/dL or 48% in women and accompanied by JAK2 mutations. It is aimed to prevent false negative and false positive results with simultaneous serum erythropoietin (EPO) measurements. The importance of sensitivity and specificity of low EPO level for PV is known; determining a more sensitive cut-off may reduce the need for further analyzes and invasive procedures. In our study, we aimed to reveal the sensitivity and specificity of serum EPO level in patients diagnosed with PV and to determine a new cut-off value that would show higher diagnostic performance instead of low serum EPO level. In this study, patients who were examined because of polycythemia between 01.01.2018-01.01.2022 at the hematology clinics of 5 different centers from xxx were included. A total of 468 patients (90 females, 378 males) were included in the study. One hundred seventy-five (37.4%) patients met the criteria for PV. In the ROC analysis performed to reveal the effectiveness of serum EPO level for predicting the diagnosis of PV, the sensitivity for ≤ 4.68 cut-off value was 89%, specificity 92%, AUC = 0.934 (95% CI: 0.91-0.96, p < 0.05), positive predictive value 87% and negative predictive value was 93.1%. Serum EPO level is an effective and easy method for predicting the diagnosis of PV, and it would be more predictive for the new cut-off level in this study.Supplementary information: The online version contains supplementary material available at 10.1007/s12288-025-01990-4.","PeriodicalId":49188,"journal":{"name":"Indian Journal of Hematology and Blood Transfusion","volume":"41 4","pages":"951-955"},"PeriodicalIF":0.6000,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12515172/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Indian Journal of Hematology and Blood Transfusion","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s12288-025-01990-4","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/2/24 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"HEMATOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Polycythemia vera (PV) is a myeloproliferative disease characterized by hemoglobin/hematocrit levels above 16.5 g/dL or 49% in men, and 16 g/dL or 48% in women and accompanied by JAK2 mutations. It is aimed to prevent false negative and false positive results with simultaneous serum erythropoietin (EPO) measurements. The importance of sensitivity and specificity of low EPO level for PV is known; determining a more sensitive cut-off may reduce the need for further analyzes and invasive procedures. In our study, we aimed to reveal the sensitivity and specificity of serum EPO level in patients diagnosed with PV and to determine a new cut-off value that would show higher diagnostic performance instead of low serum EPO level. In this study, patients who were examined because of polycythemia between 01.01.2018-01.01.2022 at the hematology clinics of 5 different centers from xxx were included. A total of 468 patients (90 females, 378 males) were included in the study. One hundred seventy-five (37.4%) patients met the criteria for PV. In the ROC analysis performed to reveal the effectiveness of serum EPO level for predicting the diagnosis of PV, the sensitivity for ≤ 4.68 cut-off value was 89%, specificity 92%, AUC = 0.934 (95% CI: 0.91-0.96, p < 0.05), positive predictive value 87% and negative predictive value was 93.1%. Serum EPO level is an effective and easy method for predicting the diagnosis of PV, and it would be more predictive for the new cut-off level in this study.

Supplementary information: The online version contains supplementary material available at 10.1007/s12288-025-01990-4.

查看原文本刊更多论文

真性红细胞增多症患者血清促红细胞生成素水平：是否可能有新的临界值？

真性红细胞增多症（PV）是一种骨髓增生性疾病，其特征是血红蛋白/红细胞比容水平在男性高于16.5 g/dL或49%，在女性高于16 g/dL或48%，并伴有JAK2突变。它的目的是防止假阴性和假阳性结果与同时血清促红细胞生成素（EPO）测量。低EPO水平对PV的敏感性和特异性的重要性是已知的；确定一个更敏感的分界点可以减少进一步分析和侵入性手术的需要。在我们的研究中，我们旨在揭示诊断为PV的患者血清EPO水平的敏感性和特异性，并确定一个新的临界值，以显示更高的诊断效能，而不是低血清EPO水平。本研究纳入了2018年1月1日至2022年1月1日在xxx的5个不同中心的血液科诊所因红细胞增多症接受检查的患者。共纳入468例患者，其中女性90例，男性378例。175例（37.4%）患者符合PV标准。在ROC分析中，血清EPO水平预测PV诊断的有效性，灵敏度≤4.68临界值为89%，特异性为92%，AUC = 0.934 （95% CI: 0.91-0.96, p）。补充信息：在线版本包含补充资料，可在10.1007/s12288-025-01990-4获得。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Indian Journal of Hematology and Blood Transfusion HEMATOLOGY-

CiteScore

1.70

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Indian Journal of Hematology and Blood Transfusion is a medium for propagating and exchanging ideas within the medical community. It publishes peer-reviewed articles on a variety of aspects of clinical hematology, laboratory hematology and hemato-oncology. The journal exists to encourage scientific investigation in the study of blood in health and in disease; to promote and foster the exchange and diffusion of knowledge relating to blood and blood-forming tissues; and to provide a forum for discussion of hematological subjects on a national scale. The Journal is the official publication of The Indian Society of Hematology & Blood Transfusion.