Journal of Developmental Origins of Health and Disease最新文献_第2页

Four years of the COVID-19 pandemic: how does Brazil deal with the impacts? A DOHaD perspective. COVID-19 大流行四年：巴西如何应对影响？卫生部的观点。

IF 1.8 4区医学

Journal of Developmental Origins of Health and Disease Pub Date : 2024-09-23 DOI: 10.1017/S2040174424000242

Ariana Musa de Aquino, Larissa Lopes da Cruz, Henrique José Cavalcanti Bezerra Gouveia, Márcia Maria da Silva, Maysa Rocha de Souza, Mayara da Nóbrega Baqueiro, Isabelle Tenori Ribeiro, Emanuelle Vasconcellos de Lima, Pedro Vinicius Gonçalves Martins, Carolina Oliveira Gonçalves, Graziela Scalianti Ceravolo, Rosiane Aparecida Miranda

{"title":"Four years of the COVID-19 pandemic: how does Brazil deal with the impacts? A DOHaD perspective.","authors":"Ariana Musa de Aquino, Larissa Lopes da Cruz, Henrique José Cavalcanti Bezerra Gouveia, Márcia Maria da Silva, Maysa Rocha de Souza, Mayara da Nóbrega Baqueiro, Isabelle Tenori Ribeiro, Emanuelle Vasconcellos de Lima, Pedro Vinicius Gonçalves Martins, Carolina Oliveira Gonçalves, Graziela Scalianti Ceravolo, Rosiane Aparecida Miranda","doi":"10.1017/S2040174424000242","DOIUrl":"https://doi.org/10.1017/S2040174424000242","url":null,"abstract":"Over the last few years, during the pandemic, the Brazilian population has suffered several problems, ranging from health to socioeconomic impacts. When we consider Brazilian science, there has been an undeniable scientific delay generated by the pandemic, especially in areas that are not related to the coronavirus. In this context, with the aim of fostering collaboration among researchers in the field of Developmental Origins of Health and Diseases (DOHaD) and enhancing the potential for implementing public health strategies to prevent noncommunicable chronic diseases, the Brazilian Association of Developmental Origins of Health and Diseases (DOHaD Brazil) was established in 2020. In this narrative, we explore the effects of the COVID-19 pandemic in Brazil, focusing on its impacts on scientific research conducted in universities. Additionally, we underscore the significance of the DOHaD Brazil Association, particularly from the perspective of young researchers engaged in DOHaD research in Brazil.","PeriodicalId":49167,"journal":{"name":"Journal of Developmental Origins of Health and Disease","volume":"15 ","pages":"e17"},"PeriodicalIF":1.8,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142299413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fatty acids profile in pregnancies affected by neural tube defects. 受神经管缺陷影响的孕妇的脂肪酸概况。

IF 1.8 4区医学

Journal of Developmental Origins of Health and Disease Pub Date : 2024-09-23 DOI: 10.1017/S2040174424000278

Kaouther Nasri, Hana Fenina, Salma Kloula Ben Ghorbal, Dhouha Maamer, Nadia Ben Jamaa, Moncef Feki, Soumeya Siala Gaigi

{"title":"Fatty acids profile in pregnancies affected by neural tube defects.","authors":"Kaouther Nasri, Hana Fenina, Salma Kloula Ben Ghorbal, Dhouha Maamer, Nadia Ben Jamaa, Moncef Feki, Soumeya Siala Gaigi","doi":"10.1017/S2040174424000278","DOIUrl":"https://doi.org/10.1017/S2040174424000278","url":null,"abstract":"This study aimed to determine if maternal fatty acids (FA) levels during pregnancy are associated with the occurrence of neural tube defects (NTDs) and to explore the correlation between FA and maternal vitamin D, homocysteine, vitamin B12, and folate in cases. Plasma FA composition was assessed using capillary gas chromatography. Comparisons between cases and controls were performed by independent samples t-test for continuous variables. Cases had significantly higher levels of heptadecanoic acid, linolelaidic acid, and arachidonic acid (ARA):(eicosapentaenoic acid+docosahexaenoic acid) ratio than controls (p < 0.05). Nervonic acid, ARA, adrenic acid, eicosapentaenoic acid, docosahexaenoic acid, and omega-3 polyunsaturated fatty acids (n-3 PUFA) levels were significantly lower in cases (p < 0.05). Maternal 25-hydroxyvitamin D (25(OH)D) levels were positively correlated with maternal polyunsaturated fatty acids and omega-6 polyunsaturated fatty acids. RBC folate levels were negatively correlated with n-3 PUFA.Further research is required to clarify the association of FA metabolism with NTDs.","PeriodicalId":49167,"journal":{"name":"Journal of Developmental Origins of Health and Disease","volume":"15 ","pages":"e18"},"PeriodicalIF":1.8,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142299412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early life stress exacerbates the obesogenic and anxiogenic effects of a Western diet without worsening cardiac ischaemic tolerance in male mice 早期生活压力会加剧西方饮食的肥胖和焦虑效应，但不会恶化雄性小鼠的心脏缺血耐受性

IF 1.7 4区医学

Journal of Developmental Origins of Health and Disease Pub Date : 2024-09-18 DOI: 10.1017/s2040174424000205

Kai Robertson, Tia A. Griffith, Tessa J. Helman, Kyle Hatton-Jones, Saba Naghipour, Dylan A. Robertson, Jason N. Peart, John P. Headrick, Eugene F. Du Toit

{"title":"Early life stress exacerbates the obesogenic and anxiogenic effects of a Western diet without worsening cardiac ischaemic tolerance in male mice","authors":"Kai Robertson, Tia A. Griffith, Tessa J. Helman, Kyle Hatton-Jones, Saba Naghipour, Dylan A. Robertson, Jason N. Peart, John P. Headrick, Eugene F. Du Toit","doi":"10.1017/s2040174424000205","DOIUrl":"https://doi.org/10.1017/s2040174424000205","url":null,"abstract":"Early life stress (ELS) and a Western diet (WD) promote mood and cardiovascular disorders, however, how these risks interact in disease pathogenesis is unclear. We assessed effects of ELS with or without a subsequent WD on behaviour, cardiometabolic risk factors, and cardiac function/ischaemic tolerance in male mice. Fifty-six new-born male C57BL/6J mice were randomly allocated to a control group (CON) undisturbed before weaning, or to maternal separation (3h/day) and early (postnatal day 17) weaning (MSEW). Mice consumed standard rodent chow (CON, n = 14; MSEW, n = 15) or WD chow (WD, n = 19; MSEW + WD, n = 19) from week 8 to 24. Fasted blood was sampled and open field test and elevated plus maze (EPM) tests undertaken at 7, 15, and 23 weeks of age, with hearts excised at 24 weeks for Langendorff perfusion (evaluating pre- and post-ischaemic function). MSEW alone transiently increased open field activity at 7 weeks; body weight and serum triglycerides at 4 and 7 weeks, respectively; and final blood glucose levels and insulin resistance at 23 weeks. WD increased insulin resistance and body weight gain, the latter potentiated by MSEW. MSEW + WD was anxiogenic, reducing EPM open arm activity vs. WD alone. Although MSEW had modest metabolic effects and did not influence cardiac function or ischaemic tolerance in lean mice, it exacerbated weight gain and anxiogenesis, and improved ischaemic tolerance in WD fed animals. MSEW-induced increases in body weight (obesity) in WD fed animals in the absence of changes in insulin resistance may have protected the hearts of these mice.","PeriodicalId":49167,"journal":{"name":"Journal of Developmental Origins of Health and Disease","volume":"63 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142254169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigating the IGF axis as a pathway for intergenerational effects 研究作为代际效应途径的 IGF 轴

IF 1.7 4区医学

Journal of Developmental Origins of Health and Disease Pub Date : 2024-09-18 DOI: 10.1017/s2040174424000266

Haley B. Ragsdale, Aaron A. Miller, Thomas W. McDade, Nanette R. Lee, Isabelita N. Bas, Christopher W. Kuzawa

{"title":"Investigating the IGF axis as a pathway for intergenerational effects","authors":"Haley B. Ragsdale, Aaron A. Miller, Thomas W. McDade, Nanette R. Lee, Isabelita N. Bas, Christopher W. Kuzawa","doi":"10.1017/s2040174424000266","DOIUrl":"https://doi.org/10.1017/s2040174424000266","url":null,"abstract":"Early nutritional and growth experiences can impact development, metabolic function, and reproductive outcomes in adulthood, influencing health trajectories in the next generation. The insulin-like growth factor (IGF) axis regulates growth, metabolism, and energetic investment, but whether it plays a role in the pathway linking maternal experience with offspring prenatal development is unclear. To test this, we investigated patterns of maternal developmental weight gain (a proxy of early nutrition), young adult energy stores, age, and parity as predictors of biomarkers of the pregnancy IGF axis (n = 36) using data from the Cebu Longitudinal Health and Nutrition Survey in Metro Cebu, Philippines. We analyzed maternal conditional weight measures at 2, 8, and 22 years of age and leptin at age 22 (a marker of body fat/energy stores) in relation to free IGF-1 and IGFBP-3 in mid/late pregnancy (mean age = 27). Maternal IGF axis measures were also assessed as predictors of offspring fetal growth. Maternal age, parity, and age 22 leptin were associated with pregnancy free IGF-1, offspring birth weight, and offspring skinfold thickness. We find that free IGF-1 levels in pregnancy are more closely related to nutritional status in early adulthood than to preadult developmental nutrition and demonstrate significant effects of young adult leptin on offspring fetal fat mass deposition. We suggest that the previously documented finding that maternal developmental nutrition predicts offspring birth size likely operates through pathways other than the maternal IGF axis, which reflects more recent energy status.","PeriodicalId":49167,"journal":{"name":"Journal of Developmental Origins of Health and Disease","volume":"19 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142254170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The interactive effects of gestational obesity and maternal high- and normal-protein diets on food intake, body weight, composition, and glucose metabolism in male offspring of obese Wistar rats 妊娠肥胖与母体高蛋白和正常蛋白饮食对肥胖 Wistar 大鼠雄性后代食物摄入量、体重、成分和糖代谢的交互影响

IF 1.7 4区医学

Journal of Developmental Origins of Health and Disease Pub Date : 2024-09-18 DOI: 10.1017/s2040174424000254

Alireza Jahan-mihan

{"title":"The interactive effects of gestational obesity and maternal high- and normal-protein diets on food intake, body weight, composition, and glucose metabolism in male offspring of obese Wistar rats","authors":"Alireza Jahan-mihan","doi":"10.1017/s2040174424000254","DOIUrl":"https://doi.org/10.1017/s2040174424000254","url":null,"abstract":"More than two-thirds of women during childbearing years (20–39 years old) are overweight or obese in the United States, with protein intake among 20–49-year-old women being 1.6 times higher than recommended (75.4 g/day versus 46 g/day) that can be considered as a relatively high-protein diet (HPD). Both gestational obesity and HPDs during gestation adversely affect offspring health. This study investigates the impact of HPDs fed during gestation and lactation on obese mothers and their offspring in Wistar rats. Dams randomized to either a normal-protein diet (NPD) or HPD (n = 12/group). Pups from each maternal group were weaned to either NPD or HPD for 17 weeks (n = 12/group). No effect of maternal or weaning diet on food intake, body weight, or body fat/weight ratio was observed. However, NPD dams exhibited higher glucose area under the curve compared with HPD dams (p < 0.03). At weaning, offspring born to NPD dams showed higher fasting plasma glucose (P < 0.03) and insulin/glucose ratio (P = 0.05) than those born to HPD dams. The Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) index was higher in offspring born to NPD dams (P < 0.04) and weaned to NPD (P < 0.05) at week 17. These findings underscore the role of high-protein maternal and weaning diets in pregnancy outcomes for obese mothers, particularly in glucose homeostasis, although gestational obesity may overshadow other parameters. Further research is needed to fully understand the impact on both maternal and offspring health and their underlying mechanisms in this context.","PeriodicalId":49167,"journal":{"name":"Journal of Developmental Origins of Health and Disease","volume":"26 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142268983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early-life family meal participation and anthropometric measures at 4 years of age. 早年参与家庭膳食和 4 岁时的人体测量指标。

IF 1.8 4区医学

Journal of Developmental Origins of Health and Disease Pub Date : 2024-09-09 DOI: 10.1017/S2040174424000217

Elisabet Rudjord Hillesund, Linda Reme Sagedal, Nina Cecilie Øverby

{"title":"Early-life family meal participation and anthropometric measures at 4 years of age.","authors":"Elisabet Rudjord Hillesund, Linda Reme Sagedal, Nina Cecilie Øverby","doi":"10.1017/S2040174424000217","DOIUrl":"https://doi.org/10.1017/S2040174424000217","url":null,"abstract":"Early-life family meal participation has been associated with several aspects of nutritional health, but longitudinal associations with linear growth have not yet been investigated. The aim of this study was to investigate whether family meal participation at 12 months of age associates with anthropometric measures 3 years later. We used follow-up data from children born to mothers in the Norwegian Fit for Delivery trial (NFFD) and included 368 first-borns with dietary and anthropometric data at 12 months and 4 years of age. We treated the sample as a cohort and conducted subgroup analyses by randomization status. A family meal participation score was used as exposure, and weight, height, and body mass index (BMI) as outcomes in crude and multivariable linear regression models adjusted for maternal education, randomization status, and child sex.Higher family meal participation score at 12 months was positively associated with length at 12 months (B = 0.198, 95% CI 0.028, 0.367, p = 0.022) and 4 years (B = 0.283, 95% CI 0.011, 0.555, p = 0.042) in multivariable models. After additional adjustment for maternal height the associations attenuated and were no longer significant. An inverse association with BMI at 4 years of age was observed in children born to mothers that had been exposed to the NFFD intervention (B = -0.144, 95% CI -0.275, -0.014, p = 0.030), but attenuated after adjustment for maternal BMI.The longitudinal association observed between early family meal participation and child height was largely explained by maternal height. The relationship with BMI differed according to maternal participation in a lifestyle intervention trial during pregnancy.","PeriodicalId":49167,"journal":{"name":"Journal of Developmental Origins of Health and Disease","volume":"15 ","pages":"e13"},"PeriodicalIF":1.8,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142156455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing the causal relationship of birth weight and childhood obesity on osteoarthritis: a Mendelian randomization study. 评估出生体重和儿童肥胖对骨关节炎的因果关系：孟德尔随机研究。

IF 1.7 4区医学

Journal of Developmental Origins of Health and Disease Pub Date : 2024-06-03 DOI: 10.1017/S2040174424000114

Zengfeng Xin, Lingxiao Xu, Lingling Sun

{"title":"Assessing the causal relationship of birth weight and childhood obesity on osteoarthritis: a Mendelian randomization study.","authors":"Zengfeng Xin, Lingxiao Xu, Lingling Sun","doi":"10.1017/S2040174424000114","DOIUrl":"https://doi.org/10.1017/S2040174424000114","url":null,"abstract":"Obesity is associated with osteoarthritis (OA), but few studies have used fetal origin to explore the association. Our study aims to disentangle the causality between birth weight, childhood obesity, and adult OA using Mendelian randomization (MR). We identified single nucleotide polymorphisms (SNPs) related to birth weight (n = 298,142) and childhood obesity (n = 24,160) from two genome-wide association studies contributed by the Early Growth Genetics Consortium. Summary statistics of OA and its phenotypes (knee, hip, spine, hand, thumb, and finger OA) from the Genetics of Osteoarthritis Consortium (n = 826,690) were used to estimate the effects of SNPs on OA. Multivariable MR (MVMR) was conducted to investigate the independent effects of exposures. It turned out that genetically predicted standard deviation increase in birth weight was not associated with OA. In contrast, there was a marginally positive effect of childhood obesity on total [odds ratio (OR) = 1.07, 95% confidence interval (CI) = 1.00, 1.15 using IVW], knee (OR = 1.13, 95% CI = 1.05, 1.22 using weighted median), hip (OR = 1.13, 95% CI = 1.04, 1.24 using IVW), and spine OA (OR = 1.12, 95% CI = 1.03, 1.22 using IVW), but not hand, thumb, or finger OA. MVMR indicated a potential adulthood body mass index-dependent causal pathway between childhood obesity and OA. In conclusion, no association of birth weight with OA was suggested. Childhood obesity, however, showed a causality with OA in weight-bearing joints, which seems to be a general association of obesity with OA.","PeriodicalId":49167,"journal":{"name":"Journal of Developmental Origins of Health and Disease","volume":"15 ","pages":"e12"},"PeriodicalIF":1.7,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141200941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Maternal birth weight is an indicator of preterm delivery: the Japan environment and children's study. 产妇出生体重是早产的指标：日本环境与儿童研究。

IF 1.7 4区医学

Journal of Developmental Origins of Health and Disease Pub Date : 2024-05-22 DOI: 10.1017/S2040174424000126

Rie Kudo, Noriyuki Iwama, Hirotaka Hamada, Hasumi Tomita, Kazuma Tagami, Natsumi Kumagai, Naoto Sato, Seiya Izumi, Kasumi Sakurai, Zen Watanabe, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Tetsuro Hoshiai, Hirohito Metoki, Masatoshi Saito, Junichi Sugawara, Shinichi Kuriyama, Takahiro Arima, Nobuo Yaegashi

{"title":"Maternal birth weight is an indicator of preterm delivery: the Japan environment and children's study.","authors":"Rie Kudo, Noriyuki Iwama, Hirotaka Hamada, Hasumi Tomita, Kazuma Tagami, Natsumi Kumagai, Naoto Sato, Seiya Izumi, Kasumi Sakurai, Zen Watanabe, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Tetsuro Hoshiai, Hirohito Metoki, Masatoshi Saito, Junichi Sugawara, Shinichi Kuriyama, Takahiro Arima, Nobuo Yaegashi","doi":"10.1017/S2040174424000126","DOIUrl":"https://doi.org/10.1017/S2040174424000126","url":null,"abstract":"This study aimed to investigate the association between maternal birth weight (MBW) with preterm delivery (PTD) in the Japanese population. To this end, a total of 78,972 Japanese pregnant women were included in a prospective birth cohort study. Multiple logistic regression and multinominal logistic regression models were applied to investigate the associations of MBW with PTD (delivery from 22 to < 37 weeks of gestation), early PTD (delivery from 22 to < 34 weeks), and late PTD (delivery from 34 to < 37 weeks). The results showed that MBW was inversely associated with PTD, early PTD, and late PTD (p-for-trend < 0.0001, 0.0014, and < 0.0001, respectively). The adjusted odds ratios per each 500 g of MBW decrease were 1.167 (95% confidence interval [CI]: 1.118-1.218) for PTD, 1.174 (95% CI: 1.070-1.287) for early PTD and 1.151 (95% CI: 1.098-1.206) for late PTD. The effect size of the association of MBW with early PTD was similar to that with late PTD. This study demonstrated for the first time an association of a low MBW with PTD, early PTD, and late PTD in a Japanese nationwide cohort.","PeriodicalId":49167,"journal":{"name":"Journal of Developmental Origins of Health and Disease","volume":"15 ","pages":"e11"},"PeriodicalIF":1.7,"publicationDate":"2024-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141077065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-term outcomes of visual motor integration and motor development children with retinopathy of prematurity. 早产儿视网膜病变患儿视觉运动整合和运动发育的长期结果。

IF 1.7 4区医学

Journal of Developmental Origins of Health and Disease Pub Date : 2024-05-10 DOI: 10.1017/S2040174424000151

Seval Kutlutürk Yıkılmaz, Gokhan Celik, Murat Gunay, Osman Kizilay, Zeliha Candan Algun

{"title":"Long-term outcomes of visual motor integration and motor development children with retinopathy of prematurity.","authors":"Seval Kutlutürk Yıkılmaz, Gokhan Celik, Murat Gunay, Osman Kizilay, Zeliha Candan Algun","doi":"10.1017/S2040174424000151","DOIUrl":"https://doi.org/10.1017/S2040174424000151","url":null,"abstract":"Premature infants have a risk of neurodevelopmental deficits. Little is known, however, about how retinopathy of prematurity (ROP) affects visual motor integration (VMI), which is necessary for both fine motor skills and further school abilities. Due to the systemic escape of bevacizumab in the treatment of ROP, concerns regarding the long-term neurodevelopmental effect of the drug have arisen. The aim is to evaluate VMI and motor development long-term outcomes after intravitreal bevacizumab (IVB) injection and laser treatment for ROP. Two groups of premature children were included: Bevacizumab group - 16 premature children who received IVB treatment and laser group - 23 premature children who underwent laser photocoagulation treatment in this single center cross-sectional study. At 2-6 years of age, VMI (Beery-Buktenica Developmental Test), motor development (Peabody Developmental Motor Scales-2), visual acuity, and refractive status were assessed. The incidence of abnormal visual function was significantly higher in bevacizumab group than in laser group (p = 0.022). The incidence of abnormal VMI skill was significantly higher in bevacizumab group than in laser group (p = 0.024). Incidences of abnormal gross, fine, and total motor skills were significantly higher in bevacizumab group compared to laser group (p < 0.05). Premature children who received bevacizumab for ROP demonstrated significantly lower VMI and motor development features than those with laser treatment at preschool age. Although our results suggest the relevance of bevacizumab injection in impaired VMI and motor development outcomes, general level of sickness rather than treatment might be the cause of delayed motor development.","PeriodicalId":49167,"journal":{"name":"Journal of Developmental Origins of Health and Disease","volume":"15 ","pages":"e10"},"PeriodicalIF":1.7,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140899917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sodium overload during postnatal phases impairs diastolic function and exacerbates reperfusion arrhythmias in adult rats. 出生后钠离子超载会损害成年大鼠的舒张功能并加剧再灌注心律失常。

IF 1.7 4区医学

Journal of Developmental Origins of Health and Disease Pub Date : 2024-05-09 DOI: 10.1017/S204017442400014X

Marina Conceição Dos Santos Moreira, Allancer Divino de Carvalho Nunes, Paulo Ricardo Lopes, Cintia do Carmo Silva, Stefanne Madalena Marques, Lara Marques Naves, Matheus Lobo Perez Dias, Fernanda Cristina Alcântara Santos, Rodrigo Mello Gomes, Carlos Henrique Xavier, Carlos Henrique de Castro, Gustavo Rodrigues Pedrino

{"title":"Sodium overload during postnatal phases impairs diastolic function and exacerbates reperfusion arrhythmias in adult rats.","authors":"Marina Conceição Dos Santos Moreira, Allancer Divino de Carvalho Nunes, Paulo Ricardo Lopes, Cintia do Carmo Silva, Stefanne Madalena Marques, Lara Marques Naves, Matheus Lobo Perez Dias, Fernanda Cristina Alcântara Santos, Rodrigo Mello Gomes, Carlos Henrique Xavier, Carlos Henrique de Castro, Gustavo Rodrigues Pedrino","doi":"10.1017/S204017442400014X","DOIUrl":"https://doi.org/10.1017/S204017442400014X","url":null,"abstract":"Sodium overload during childhood impairs baroreflex sensitivity and increases arterial blood pressure and heart rate in adulthood; these effects persist even after high-salt diet (HSD) withdrawal. However, the literature lacks details on the effects of HSD during postnatal phases on cardiac ischemia/reperfusion responses in adulthood. The current study aimed to elucidate the impact of HSD during infancy adolescence on isolated heart function and cardiac ischemia/reperfusion responses in adulthood. Male 21-day-old Wistar rats were treated for 60 days with hypertonic saline solution (NaCl; 0.3M; experimental group) or tap water (control group). Subsequently, both groups were maintained on a normal sodium diet for 30 days. Subsequently, the rats were euthanized, and their hearts were isolated and perfused according to the Langendorff technique. After 30 min of the basal period, the hearts were subjected to 20 min of anoxia, followed by 20 min of reperfusion. The basal contractile function was unaffected by HSD. However, HSD elevated the left ventricular end-diastolic pressure during reperfusion (23.1 ± 5.2 mmHg vs. 11.6 ± 1.4 mmHg; p < 0.05) and increased ectopic incidence period during reperfusion (208.8 ± 32.9s vs. 75.0 ± 7.8s; p < 0.05). In conclusion, sodium overload compromises cardiac function after reperfusion events, diminishes ventricular relaxation, and increases the severity of arrhythmias, suggesting a possible arrhythmogenic effect of HSD in the postnatal phases.","PeriodicalId":49167,"journal":{"name":"Journal of Developmental Origins of Health and Disease","volume":"15 ","pages":"e9"},"PeriodicalIF":1.7,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140899933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0