Journal of Developmental Origins of Health and Disease最新文献_第2页

Population-based assessment of major congenital malformations in the United States: smoking risk association. 美国主要先天性畸形基于人群的评估：吸烟风险关联。

IF 1.8 4区医学

Journal of Developmental Origins of Health and Disease Pub Date : 2025-02-27 DOI: 10.1017/S2040174425000054

Diancarlos P de Andrade, Camila M Marques, Dayane C R Andrade, Henrique Laureano, Luana Lenzi, Cláudia S Oliveira, Meire E Pereira, Bonald C Figueiredo

{"title":"Population-based assessment of major congenital malformations in the United States: smoking risk association.","authors":"Diancarlos P de Andrade, Camila M Marques, Dayane C R Andrade, Henrique Laureano, Luana Lenzi, Cláudia S Oliveira, Meire E Pereira, Bonald C Figueiredo","doi":"10.1017/S2040174425000054","DOIUrl":"10.1017/S2040174425000054","url":null,"abstract":"The incidence of congenital malformations (CM) among non-Hispanic White American (NHWA) mothers was reviewed to identify and evaluate the geographic differences in the most frequent CM subtypes associated with smoking and other risk factors. Data on CM were obtained from 150,775 children (2000-2004) from the Centers for Disease Control and Prevention. Risk factors associated with CM development were the mother's age < 21 and > 35 years, body weight gain during pregnancy, anemia, diabetes mellitus, eclampsia (cases of preeclampsia were omitted), smoking, and alcohol use during pregnancy. Among smoking mothers, the most common CM was omphalocele, club foot, cleft lip, and polydactyly. The highest incidences (CM/10,000 births/year) of observed CM in children of smoking mothers were clubfoot, 25.51 cases (Utah), cleft lip, 22.47 (South Dakota), polydactyly, 21.23 (North Dakota), and omphalocele, 13.14 (Montana). The presence of maternal comorbidities, tobacco and alcohol consumption, and their association with other environmental factors can affect the incidence of CM in NHWA mothers. Further comparisons among the American states regarding the overall changes in CM over the last two decades should uncover crucial outcomes in terms of CM and smoking.","PeriodicalId":49167,"journal":{"name":"Journal of Developmental Origins of Health and Disease","volume":"16 ","pages":"e13"},"PeriodicalIF":1.8,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143517261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differential associations between birthweight and cardiometabolic characteristics among persons with and without type 2 diabetes in the UK Biobank. 英国生物银行中2型糖尿病患者和非2型糖尿病患者出生体重和心脏代谢特征之间的差异关联

IF 1.8 4区医学

Journal of Developmental Origins of Health and Disease Pub Date : 2025-02-27 DOI: 10.1017/S2040174425000066

Aleksander L Hansen, Christina Ji-Young Lee, Aldis H Björgvinsdóttir, Tarunveer S Ahluwalia, Charlotte Brøns, Christian Torp-Pedersen, Allan Vaag

{"title":"Differential associations between birthweight and cardiometabolic characteristics among persons with and without type 2 diabetes in the UK Biobank.","authors":"Aleksander L Hansen, Christina Ji-Young Lee, Aldis H Björgvinsdóttir, Tarunveer S Ahluwalia, Charlotte Brøns, Christian Torp-Pedersen, Allan Vaag","doi":"10.1017/S2040174425000066","DOIUrl":"10.1017/S2040174425000066","url":null,"abstract":"Low birthweight is a risk factor for type 2 diabetes. We hypothesised that differential associations between birthweight and clinical characteristics in persons with and without type 2 diabetes may provide novel insights into the role of birthweight in type 2 diabetes and its progression. We analysed UK Biobank data from 9,442 persons with and 254,446 without type 2 diabetes. Associations between birthweight, clinical traits, and genetic predisposition were assessed using adjusted linear and logistic regression, comparing the lowest and highest 25% of birthweight to the middle 50%. Each kg increase in birthweight was associated with higher BMI, waist, and hip circumference, with stronger effects in persons with versus without type 2 diabetes (BMI: 0.74 [0.58, 0.90] vs. 0.21 [0.18, 0.24] kg/m2; waist: 2.15 [1.78, 2.52] vs. 1.04 [0.98, 1.09] cm; hip: 1.65 [1.33, 1.97] vs. 1.04 [1.04, 1.09] cm). Family history of diabetes was associated with higher birthweight regardless of diabetes status, albeit with a twofold higher effect estimate in type 2 diabetes. Low birthweight was further associated with prior myocardial infarction regardless of type 2 diabetes status (OR 1.33 [95% CI 1.11, 1.60] for type 2 diabetes; 1.23 [95% CI 1.13, 1.33] without), and hypertension (OR 1.25 [1.23, 1.28] and stroke 1.24 [1.14, 1.34]) only among persons without type 2 diabetes. Differential associations between birthweight and cardiometabolic traits in persons with and without type 2 diabetes illuminate potential causal inferences reflecting the roles of pre- and postnatal environmental versus genetic aetiologies and disease mechanisms.","PeriodicalId":49167,"journal":{"name":"Journal of Developmental Origins of Health and Disease","volume":"16 ","pages":"e12"},"PeriodicalIF":1.8,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143517258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Maternal hyperglycemia and postnatal high-fat diet impair metabolic regulation and autophagy response in the liver of adult female rats. 母体高血糖和产后高脂饮食对成年雌性大鼠肝脏代谢调节和自噬反应的影响。

IF 1.8 4区医学

Journal of Developmental Origins of Health and Disease Pub Date : 2025-02-20 DOI: 10.1017/S204017442400045X

Larissa Lopes da Cruz, Yuri Karen Sinzato, Verônyca Gonçalves Paula, Matheus Naia Fioretto, Franciane Quintanilha Gallego, Vinícius Soares Barco, Ana Carolina Lima Camargo, José Eduardo Corrente, Luis Antonio Justulin, Tiago Rodrigues, Gustavo Tadeu Volpato, Débora Cristina Damasceno

{"title":"Maternal hyperglycemia and postnatal high-fat diet impair metabolic regulation and autophagy response in the liver of adult female rats.","authors":"Larissa Lopes da Cruz, Yuri Karen Sinzato, Verônyca Gonçalves Paula, Matheus Naia Fioretto, Franciane Quintanilha Gallego, Vinícius Soares Barco, Ana Carolina Lima Camargo, José Eduardo Corrente, Luis Antonio Justulin, Tiago Rodrigues, Gustavo Tadeu Volpato, Débora Cristina Damasceno","doi":"10.1017/S204017442400045X","DOIUrl":"10.1017/S204017442400045X","url":null,"abstract":"This study aimed to investigate the mechanisms by which the association between maternal hyperglycemia and postnatal high-fat diet (HFD) exposure compromises metabolic parameters and hepatic autophagy in adult female pups. For this, Sprague Dawley rats, female pups from nondiabetic (control = FC) or diabetic (FD) mothers, were fed a standard diet (SD) or HFD from weaning until adulthood (n minimum = 5 rats/group): FC/SD, FC/HFD, FD/SD, and FD/HFD. In adulthood, these rats were tested with the oral glucose tolerance test, euthanized, and serum biochemistry parameters were analyzed. Liver samples were collected to evaluate cytokines, redox status, and protein expression autophagy and apoptosis markers. Histomorphometric analyses and an assessment of lipofuscin accumulation were also performed to reflect incomplete autolysosomal digestion. The FC/HFD, FD/SD, and FD/HFD groups showed glucose intolerance and an increased number of hepatocytes. Furthermore, FD/SD and FD/HFD rats showed hyperlipidemia and insulin resistance. Adaptations in hepatic redox pathways were observed in the FD/SD group with increased antioxidant defense marker activity. The FD/SD group also exhibited increased autophagy protein expression, such as p-AMPK, LC3-II/LC3-I, and p62/SQSTM1, lipofuscin accumulation, and caspase-3 activation. After exposure to HFD, the adult female pups of diabetic rats had a reduced p-AMPK and LC3-II/LC3-I ratio, the presence of steatosis, oxidative stress, and inflammation. The reduction of autophagy, stimulated by HFD, may be of vital importance for the susceptibility to metabolic dysfunction-associated fatty liver disease induced by maternal diabetes.","PeriodicalId":49167,"journal":{"name":"Journal of Developmental Origins of Health and Disease","volume":"16 ","pages":"e11"},"PeriodicalIF":1.8,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143460227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors associated with attrition in a diverse birth cohort study in Detroit, Michigan. 在密歇根州底特律的一项不同出生队列研究中，与人员流失相关的因素。

IF 1.8 4区医学

Journal of Developmental Origins of Health and Disease Pub Date : 2025-02-18 DOI: 10.1017/S2040174425000029

Audrey Urquhart, Alexandra R Sitarik, Andrea E Cassidy-Bushrow, Amanda Cyrus, Katherine Graham-McNeil, Jennifer K Straughen, Sara Santarossa, Ganesa Wegienka, Christine Cole Johnson

{"title":"Factors associated with attrition in a diverse birth cohort study in Detroit, Michigan.","authors":"Audrey Urquhart, Alexandra R Sitarik, Andrea E Cassidy-Bushrow, Amanda Cyrus, Katherine Graham-McNeil, Jennifer K Straughen, Sara Santarossa, Ganesa Wegienka, Christine Cole Johnson","doi":"10.1017/S2040174425000029","DOIUrl":"10.1017/S2040174425000029","url":null,"abstract":"Long-term birth cohorts are essential for studying health and disease over the life course. The retention of participants remains a challenge in study design. Previous research works on attrition are limited in length of follow-up time and lack of racial/ethnic diversity. Using data from the Wayne County Health, Environment, Allergy, and Asthma Longitudinal Study (WHEALS; United States cohort born between 2004 and 2007, n = 1258), we first performed longitudinal latent class analyses to identify patterns of participation spanning the prenatal period and six follow-up timepoints: 1, 6, 12, and 24 months; 3-6 years; and 10-12 years. Data collection included a combination of in-person visits, home visits, home specimen kits, and staff-administered questionnaires. We examined associations between baseline factors and participation class using multinomial logistic regression modeling, and with conditional inference modeling to identify variables most strongly associated with class. We identified four participation classes: high early participation with gradual loss-to-follow-up, sporadic participation, consistently high participation, and consistently low participation. Multiple baseline characteristics were associated with participation class. The \"consistently high participation\" class was disproportionately composed of participants who were older, were of higher education, had private insurance, had suburban residence, and were with higher income. Conditional inference trees identified maternal education, insurance, and income as most strongly associated with participation class. Through latent class modeling, we show that participants who were lost to follow-up fell into distinct groupings of participation. In the future, preparatory communications with those who are at the highest risk of study discontinuation may improve long-term retention.","PeriodicalId":49167,"journal":{"name":"Journal of Developmental Origins of Health and Disease","volume":"16 ","pages":"e10"},"PeriodicalIF":1.8,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Celebrating 280 birth years of Lamarck: revisiting his legacy in the concept of Developmental Origins of Health and Disease. 庆祝拉马克诞辰280周年：在健康和疾病的发展起源的概念中回顾他的遗产。

IF 1.8 4区医学

Journal of Developmental Origins of Health and Disease Pub Date : 2025-02-14 DOI: 10.1017/S2040174425000030

Elena Zambrano, Carlos A Ibáñez

引用次数: 0

Rainfall shocks and child health in rural Pakistan. 巴基斯坦农村地区的降雨冲击与儿童健康。

IF 1.8 4区医学

Journal of Developmental Origins of Health and Disease Pub Date : 2025-02-14 DOI: 10.1017/S2040174424000424

Hamna Ahmed

{"title":"Rainfall shocks and child health in rural Pakistan.","authors":"Hamna Ahmed","doi":"10.1017/S2040174424000424","DOIUrl":"10.1017/S2040174424000424","url":null,"abstract":"In utero exposure to income shocks has a lasting effect on child well-being. In an agricultural economy, fluctuations in rainfall directly affect household income. In this paper, we investigate the short- and long-run impact of pre-pregnancy, prenatal, and early-life exposure to fluctuations in rainfall on height for a sample of 2290 children in rural Pakistan. Given the widespread canal irrigation system prevalent in the country, we also investigate how fluctuations in river water flows affect child health. We find that fluctuations in rainfall during the pre-pregnancy period have the most lasting effects on the stature of children in the short and long run. Exposure of a mother to a 1 standard deviation reduction in rainfall during the pre-pregnancy period led her child to be 0.17 standard deviations (0.53 cm) shorter by age four. This negative impact of a pre-pregnancy rainfall shock on height persisted over time; the child continued to be 0.12 standard deviations (0.83 cm) shorter, on average, by 13 years of age. However, we find that the effect of pre-pregnancy rainfall fluctuations on children's height is smaller in districts that have access to irrigation facilities.","PeriodicalId":49167,"journal":{"name":"Journal of Developmental Origins of Health and Disease","volume":"16 ","pages":"e9"},"PeriodicalIF":1.8,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143415862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effects of maternal body weight on iodine concentration in breast milk and cord blood and infant growth. 母亲体重对母乳和脐带血碘浓度及婴儿生长的影响。

IF 1.8 4区医学

Journal of Developmental Origins of Health and Disease Pub Date : 2025-01-30 DOI: 10.1017/S2040174425000017

Ceren Şarahman Kahraman, Hasan Basri Savaş, Dilek Erdem, Nurcan Yabancı Ayhan

{"title":"The effects of maternal body weight on iodine concentration in breast milk and cord blood and infant growth.","authors":"Ceren Şarahman Kahraman, Hasan Basri Savaş, Dilek Erdem, Nurcan Yabancı Ayhan","doi":"10.1017/S2040174425000017","DOIUrl":"10.1017/S2040174425000017","url":null,"abstract":"Breast milk (BM) is the only source of iodine and bioactive compounds that influence growth and development in infants. The content of BM may be influenced by maternal body mass index (BMI). The aim of this study was to investigate the effect of maternal weight on BM and cord blood iodine concentrations, growth-related hormones, infant anthropometric measurements. A total of 84 mother-infant pairs participated. Levels of leptin, adiponectin and insulin-like growth factor-I (IGF-I) in postnatal BM and cord blood were analysed by enzyme-linked immunosorbent assay (ELISA), iodine by Sandell-Kolthoff reaction. Dietary iodine intake of women was determined by food frequency questionnaire, and anthropometric measurements of infants at birth and 3 months were evaluated. Dietary iodine intake was found to be similar in normal weight (NW) and overweight/obese (OW/OB) women (p > 0.05). Breast milk iodine concentration (BMIC) was 17.4 μg in NW, 18.2 μg in OB/OW women. Adiponectin in cord blood and IGF-I in BM were higher OB/OW than NW women (p < 0.05). Positive correlations were found between the infant birth weight and adiponectin in BM, between the infant body weight at 3 months and leptin and adiponectin in BM, between the infant birth head circumference and IGF-I in BM (p < 0.05). In multiple linear regression model, leptin and adiponectin in BM had a positive effect on infant body weight (p < 0.05). Maternal BMI may influence infant body weight via leptin and adiponectin in BM and infant head circumference via IGF-I. No relationship was found between maternal BMI and iodine levels and anthropometric measurements of the infant. Longitudinal studies are recommended to understand the effect of BMIC on growth.","PeriodicalId":49167,"journal":{"name":"Journal of Developmental Origins of Health and Disease","volume":"16 ","pages":"e6"},"PeriodicalIF":1.8,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143069138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preventive effects of kefir on colon tumor development in Wistar rats: gut microbiota critical role. 开菲尔对 Wistar 大鼠结肠肿瘤发生的预防作用：肠道微生物群的关键作用。

IF 1.8 4区医学

Journal of Developmental Origins of Health and Disease Pub Date : 2025-01-27 DOI: 10.1017/S2040174424000461

Poliana Guiomar de Almeida Brasiel, Julliane Dutra Medeiros, Thaís Costa de Almeida, Claudio Teodoro de Souza, Gabriela de Cássia Ávila Alpino, Alessandra Barbosa Ferreira Machado, Sheila Cristina Potente Dutra Luquetti

{"title":"Preventive effects of kefir on colon tumor development in Wistar rats: gut microbiota critical role.","authors":"Poliana Guiomar de Almeida Brasiel, Julliane Dutra Medeiros, Thaís Costa de Almeida, Claudio Teodoro de Souza, Gabriela de Cássia Ávila Alpino, Alessandra Barbosa Ferreira Machado, Sheila Cristina Potente Dutra Luquetti","doi":"10.1017/S2040174424000461","DOIUrl":"10.1017/S2040174424000461","url":null,"abstract":"To clarify the effects of kefir in critical periods of development in adult diseases, we study the effects of kefir intake during early life on gut microbiota and prevention of colorectal carcinogenesis in adulthood. Lactating Wistar rats were divided into three groups: control (C), kefir lactation (KL), and kefir puberty (KP) groups. The C and KP groups received 1 mL of water/day; KL dams received kefir milk daily (108 CFU/mL) during lactation. After weaning (postnatal day 21), KP pups received kefir treatment until 60 days. At 67 days old, colorectal carcinogenesis was induced through intraperitoneal injection of 1, 2-dimethylhydrazine. The gut microbiota composition were analyzed by 16S rRNA gene sequencing and DESeq2 (differential abundance method), revealing significant differences in bacterial abundances between the kefir consumption periods. Maternal kefir intake strong anticancer power, suppressed tumors in adult offspring and reduced the relative risk of offspring tumor development. The gut microbiota in cecal samples of the KL group was enriched with Lactobacillus, Romboutsia, and Blautia. In contrast, control animals were enriched with Acinetobacter. The administration of kefir during critical periods of development, with emphasis on lactation, affected the gut microbial community structure to promote host benefits. Pearson analysis indicated positive correlation between tumor number with IL-1 levels. Therefore, the probiotic fermented food intake in early life may be effective as chemopreventive potential against colon tumor development, especially in lactation period.","PeriodicalId":49167,"journal":{"name":"Journal of Developmental Origins of Health and Disease","volume":"16 ","pages":"e5"},"PeriodicalIF":1.8,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143048435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early maternal undernutrition induces sex-related metabolic changes in adult offspring. 母亲早期营养不良会导致成年后代发生与性别相关的代谢变化。

IF 1.8 4区医学

Journal of Developmental Origins of Health and Disease Pub Date : 2025-01-21 DOI: 10.1017/S2040174424000448

Rhauany P Guergolette, Danielly D Aguiar, Larissa R S Stopa, Camila F Souza, Ana Luiza M Wunderlich, Dimas A M Zaia, Cássia Thais B V Zaia, Cristiane M Leite, Ernane T Uchoa

{"title":"Early maternal undernutrition induces sex-related metabolic changes in adult offspring.","authors":"Rhauany P Guergolette, Danielly D Aguiar, Larissa R S Stopa, Camila F Souza, Ana Luiza M Wunderlich, Dimas A M Zaia, Cássia Thais B V Zaia, Cristiane M Leite, Ernane T Uchoa","doi":"10.1017/S2040174424000448","DOIUrl":"10.1017/S2040174424000448","url":null,"abstract":"Nutritional status during the developmental periods leads to predisposition to several diseases and comorbidities, highlighting metabolic and reproductive changes throughout adult life, and in the next generations. One of the experimental models used to induce undernutrition is litter size expansion, which decreases the availability of breast milk to pups and delays development. This work evaluated the effects of maternal undernutrition induced by litter size expansion, a maternal undernutrition preconception model, on the metabolic and reproductive alterations of the offspring. For this, metabolic and reproductive parameters were evaluated in male and female offspring of female rats reared in normal (NL - 10 pups: 5 males and 5 females) and large (LL - 16 pups: 8 males and 8 females) litters. Male and female offspring of LL mothers presented higher food intake than the offspring of NL mothers. Male offspring from undernourished females showed reduced body weight from lactation to adulthood, nasoanal distance in childhood, increased nasoanal distance, and decreased Lee index in adult life, while female offspring showed decreased nasoanal distance in childhood. The male offspring from LL mothers showed increased insulin plasma levels and glucose tolerance, and reduced triglycerides plasma levels, without changes in the female offspring. These results indicate that neonatal undernutrition in females predisposes their male and female offspring to develop metabolic alterations, without reproductive repercussions, and male offspring seems to be more susceptible to present these metabolic changes than females. Thus, there are sexual differences in the metabolic responses of the offspring elicited by maternal preconceptional undernutrition.","PeriodicalId":49167,"journal":{"name":"Journal of Developmental Origins of Health and Disease","volume":"16 ","pages":"e4"},"PeriodicalIF":1.8,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143014794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations among rearing environment and the infant gut microbiome with early-life neurodevelopment and cognitive development in a nonhuman primate model (Macaca mulatta). 在非人类灵长类动物模型（猕猴）中，饲养环境和婴儿肠道微生物组与早期神经发育和认知发育之间的关系。

IF 1.8 4区医学

Journal of Developmental Origins of Health and Disease Pub Date : 2025-01-09 DOI: 10.1017/S2040174424000400

Katherine Daiy, Kyle Wiley, Jacob Allen, Michael T Bailey, Amanda M Dettmer

{"title":"Associations among rearing environment and the infant gut microbiome with early-life neurodevelopment and cognitive development in a nonhuman primate model (Macaca mulatta).","authors":"Katherine Daiy, Kyle Wiley, Jacob Allen, Michael T Bailey, Amanda M Dettmer","doi":"10.1017/S2040174424000400","DOIUrl":"10.1017/S2040174424000400","url":null,"abstract":"Early gut microbiome development may impact brain and behavioral development. Using a nonhuman primate model (Macaca mulatta), we investigated the association between social environments and the gut microbiome on infant neurodevelopment and cognitive function. Infant rhesus monkeys (n = 33) were either mother-peer-reared (MPR) or nursery-reared (NR). Neurodevelopmental outcomes, namely emotional responsivity, visual orientation, and motor maturity, were assessed with the Primate Neonatal Neurobehavioral Assessment (PNNA) at 14-30 days. Cognitive development was assessed through tasks evaluating infant reward association, cognitive flexibility, and impulsivity at 6-8 months. The fecal microbiome was quantified from rectal swabs via 16S rRNA sequencing. Factor analysis was used to identify \"co-abundance factors\" describing patterns of microbial composition. We used multiple linear regressions with AIC Model Selection and differential abundance analysis (MaAsLin2) to evaluate relationships between co-abundance factors, microbiome diversity, and neuro-/cognitive development outcomes. At 30 days of age, a gut microbiome co-abundance factor, or pattern, with high Prevotella and Lactobacillus (β = -0.88, p = 0.04, AIC Weight = 68%) and gut microbiome alpha diversity as measured by Shannon diversity (β = -1.33, p = 0.02, AIC Weight = 80%) were both negatively associated with infant emotional responsivity. At 30 days of age, being NR was also associated with lower emotional responsivity (Factor 1 model: β = -3.13, p < 0.01; Shannon diversity model: β = -3.77, p < 0.01). The infant gut microbiome, along with early-rearing environments, may shape domains of neuro-/cognitive development related to temperament.","PeriodicalId":49167,"journal":{"name":"Journal of Developmental Origins of Health and Disease","volume":"16 ","pages":"e1"},"PeriodicalIF":1.8,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11731890/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142957622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0