Journal of Developmental Origins of Health and Disease最新文献

{"title":"Trimester-specific associations of methyl-donor nutrients and prenatal dietary patterns with adolescent blood leukocyte circadian gene DNA methylation.","authors":"Jennifer Ting-Yun Lee, Jaclyn M Goodrich, Dana C Dolinoy, Karen E Peterson, Martha M Téllez-Rojo, Alejandra Cantoral, Libni Torres-Olascoaga, Edward A Ruiz-Narváez, Erica C Jansen","doi":"10.1017/S2040174426100786","DOIUrl":"https://doi.org/10.1017/S2040174426100786","url":null,"abstract":"<p><p>The prenatal period is critical for the development of the circadian system, with maternal diet potentially influencing its regulation through DNA methylation of circadian genes. This study examined the associations between prenatal dietary patterns and methyl-donor nutrient intake with DNA methylation of circadian genes in adolescents in the Early Life Exposure in Mexico to ENvironmental Toxicants cohort. Among 392 participants, trimester-specific dietary intake was assessed using food frequency questionnaire. Dietary patterns were derived from energy-adjusted food groups. Blood leukocyte DNA methylation was measured in adolescence using the Infinium MethylationEPIC BeadChip. Linear regression estimated associations at 707 cytosine-guanine sites across 18 circadian genes and in an epigenome-wide association study (EWAS) of 745,797 sites. False discovery rate of 5% was applied using the Benjamini-Hochberg method. First-trimester riboflavin intake was positively associated with DNA methylation at loci in <i>RORA</i> (probe ID cg08700690) and <i>NR1D2</i> (cg21029468), while vitamin B12 intake was negatively associated with <i>RORA</i> (cg13576304). Second-trimester <i>Transitioning Mexican Diet</i> was positively associated with <i>RORA</i> (cg27391826). Third-trimester methionine intake was negatively associated with DNA methylation near the promoter region of <i>RORA</i> (cg10133825) and positively associated with a locus in <i>PER1</i> (cg27004243), and the <i>High Meat & Fat Diet</i> was negatively associated with <i>CLOCK</i> (cg07327568). More associations were observed with gestational dietary patterns in males than females. EWAS identified multiple associations with methionine and vitamin B6 intake, including two circadian genes (<i>BHLHE40</i> and <i>RORA</i>). Trimester-specific maternal intake of riboflavin, vitamin B12, and methionine were associated with DNA methylation at circadian gene loci assessed during adolescence.</p>","PeriodicalId":49167,"journal":{"name":"Journal of Developmental Origins of Health and Disease","volume":"17 ","pages":"e43"},"PeriodicalIF":1.6,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149041706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In-utero exposure to maternal hyperinsulinemia impacts glucose homeostasis in male offspring transiently.","authors":"Tracy Her, Grace Chung, Ron Regal, Brigid Ellen Gregg, Ernesto Bernal Mizrachi, Sarah Wernimont, Emilyn Alejandro","doi":"10.1017/S2040174426100671","DOIUrl":"https://doi.org/10.1017/S2040174426100671","url":null,"abstract":"<p><p>Fetal in-utero exposures are known to impact the long-term metabolic health of offspring. Insulin is the primary treatment to manage glucose concentrations in mothers with gestational diabetes. However, adverse offspring outcomes persist, such as macrosomia and increased risk of early obesity in offspring with potential metabolic consequences in adulthood. Here, we developed two novel mouse models to investigate the effects of maternal insulin on offspring health. In the first model, RIP-βAkt dams exhibited hyperinsulinemia, normoglycemia, and insulin resistance without obesity. Their wild-type offspring are referred to as βAkt-HIP. The second model involved RIP-Cre; βTSC2 dams, which displayed hyperinsulinemia and hypoglycemia without insulin resistance or obesity; their wild-type offspring are termed βTSC2KO-HIP. Male βAkt-HIP offspring exposed to hyperinsulinemia with normoglycemia and insulin resistance during gestation showed increased body weight on a normal chow diet (NCD) but limited weight gain when challenged with a high-fat diet (HFD). No significant changes in body weight were observed in female βAkt-HIP or βTSC2KO-HIP offspring or in male βTSC2KO-HIP under either diet relative to the age-matched controls. Both male βAkt-HIP and βTSC2KO-HIP offspring exhibited transient glucose intolerance at 6-8 weeks of age relative to the age-matched controls. Glucose homeostasis remained unaffected in female offspring of both models under NCD and HFD relative to controls. Maternal hyperinsulinemia without obesity, regardless of the presence of hypoglycemia, does not significantly impair glucose homeostasis in offspring. However, when hyperinsulinemia is accompanied by insulin resistance, it results in increased body weight in male offspring, a known risk factor for type 2 diabetes.</p>","PeriodicalId":49167,"journal":{"name":"Journal of Developmental Origins of Health and Disease","volume":"17 ","pages":"e42"},"PeriodicalIF":1.6,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149018390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of maternal diet quality in early pregnancy on infant anthropometry at birth and at six months of age.","authors":"Izabela da Silva Santos, Mariana Rinaldi Carvalho, Naiara Franco Baroni, Maria Carolina de Lima, Natalia Posses Carreira, Livia Castro Crivellenti, Daniela Saes Sartorelli","doi":"10.1017/S2040174426100749","DOIUrl":"10.1017/S2040174426100749","url":null,"abstract":"<p><p>The aim was to investigate the association between maternal diet quality in early pregnancy and infant anthropometric outcomes at birth and at six months of age among Brazilian women with overweight. Secondary analysis of a randomized clinical trial included 238 pregnant women and 192 mother-infant pairs with data at birth and six months, respectively. 24-h dietary recalls were obtained between 3 and 15 gestational weeks. Diet quality was evaluated using the <i>Diet Quality Index Adapted for Pregnant Women (IQDaG</i>). Linear regression models adjusted for potential confounding factors, including treatment group (control/intervention) were used to investigate the associations. Higher maternal diet quality (I<i>QDaG</i> score) was positively associated with birth weight (<i>β</i> = 12.311; 95% CI: 5.163, 19.458; <i>p</i> = 0.001), birth weight <i>Z</i>-score (<i>β</i> = 0.024; 95% CI: 0.007, 0.041; <i>p</i> = 0.007), birth length (<i>β</i> = 0.050; 95% CI: 0.015, 0.084; <i>p</i> = 0.005), birth length <i>Z</i>-score (<i>β</i> = 0.030; 95% CI: 0.008, 0.052; <i>p</i> = 0.008), and ponderal index (<i>β</i> = 0.044; 95% CI: 0.010, 0.078; <i>p</i> = 0.011), and inversely associated with small for gestational age (<i>β</i> = -0.006; 95% CI: -0.009, -0.002; <i>p</i> = 0.002) and low birth weight (<i>β</i> = -0.007; 95% CI: -0.010, -0.003; <i>p</i> < 0.001). No significant associations were observed with others neonatal indicators. At six months of age, I<i>QDaG</i> score was positively associated with infant length (<i>β</i> = 0.061; 95% CI: 0.019, 0.103; <i>p</i> = 0.004) and length-for-age <i>Z</i>-score (<i>β</i> = 0.204; 95% CI: 0.007, 0.401; <i>p</i> = 0.006), but not with weight-related indicators. These findings suggest that better maternal diet quality in early pregnancy is associated with more favorable fetal growth and may be particularly related to linear growth during infancy.</p>","PeriodicalId":49167,"journal":{"name":"Journal of Developmental Origins of Health and Disease","volume":"17 ","pages":"e41"},"PeriodicalIF":1.6,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148992155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between second-trimester maternal physical activity and neonatal body composition: findings from the ORIGINS birth cohort.","authors":"Kristjana Einarsdottir, Natasha Bear, Ayla Sogutluoglu, Desiree Silva, Lisa Gibson","doi":"10.1017/S2040174426100750","DOIUrl":"https://doi.org/10.1017/S2040174426100750","url":null,"abstract":"<p><p>The impact of maternal physical activity on infant body composition remains understudied. This study aimed to investigate the association between maternal activity levels during pregnancy and infant body fat percentage, utilising data from the Western Australian ORIGINS birth cohort. A total of 323 pregnant women and their male (148) and female (175) infants born during 2016-2024 were included in the analysis. Maternal physical activity was measured with the International Physical Activity Questionnaire (IPAQ) and the Godin Leisure-Time Exercise (Godin) questionnaire during the second trimester. Infant body composition was measured within 7 d of birth using infant air displacement plethysmography (PEA POD). Associations were calculated using linear regression models adjusted for confounders. A significant difference in neonatal body fat percentage was observed between sexes, with males averaging 11.7% and females 13.0% (p = 0.005). Analyses of maternal physical activity during the second trimester demonstrated sex-specific effects on infant body fat percentage. High maternal activity levels were associated with lower body fat percentage for female infants (IPAQ: -3.23, 95% CI: -5.22, -1.23 and Godin: -1.73, 95% CI: -3.26, -0.22), while for males, no association was observed. These results suggest that tailored prenatal care strategies that promote exercise and a healthy diet would be beneficial to pregnant women. Further research is needed to explore additional factors that could influence infant body fat percentage, which in turn could enhance prenatal care recommendations.</p>","PeriodicalId":49167,"journal":{"name":"Journal of Developmental Origins of Health and Disease","volume":"17 ","pages":"e40"},"PeriodicalIF":1.6,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148882200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of paternal obesity in fetal development, pregnancy complications, and childhood outcomes: a systematic review.","authors":"Tuba Güner Emül, Emine Kaplan Serin","doi":"10.1017/S2040174426100737","DOIUrl":"https://doi.org/10.1017/S2040174426100737","url":null,"abstract":"<p><p>The Developmental Origins of Health and Disease theory proposes that environmental influences during early life have long-term effects on health outcomes. Although maternal factors have been extensively studied, the impact of paternal obesity on fetal development and pregnancy outcomes has received limited attention. This systematic review aimed to evaluate the effects of paternal obesity on fetal development and pregnancy complications within the DOHaD framework. English-language studies published between 2020 and 2025 were searched in PubMed, Scopus, Web of Science, and the Cochrane Library databases. Studies were selected according to the PICOS criteria, and methodological quality was assessed using the Joanna Briggs Institute (JBI) critical appraisal tools. The study selection process followed PRISMA 2020 guidelines, and the protocol was prospectively registered in PROSPERO. A total of sevenprimary studies met the inclusion criteria and were included in the final review. Paternal overweight and obesity were associated with increased risks of macrosomia, large-for-gestational-age infants, low birth weight, preterm birth, preeclampsia, and cesarean delivery. In addition, paternal obesity was found to be potentially associated with childhood obesity and neurodevelopmental disorders. However, the effect of paternal body mass index (BMI) on birth weight was more limited compared to maternal factors. Paternal obesity represents a significant risk factor for fetal development and pregnancy outcomes and should be considered in preconception care strategies.</p>","PeriodicalId":49167,"journal":{"name":"Journal of Developmental Origins of Health and Disease","volume":"17 ","pages":"e39"},"PeriodicalIF":1.6,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148814735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary tooth emergence in young children is associated with a stress biomarker.","authors":"Dorota Kopycka-Kedzierawski, Changyong Feng, Patricia G Ragusa, Kim Flint, Gene Watson, Cynthia Wong, Ronald J Billings, Thomas G O'Connor","doi":"10.1017/S2040174426100762","DOIUrl":"10.1017/S2040174426100762","url":null,"abstract":"<p><p>Early tooth emergence may reflect developmental stress exposures and compose part of a broader set of growth measures that may be accelerated in response to early stress exposure. We test the hypothesis that timing of primary tooth emergence is associated with stress exposure and stress biology in young children. Tooth emergence was tracked prospectively in a diverse sample of initially caries-free 1-3 year-olds; socio-economic and psychosocial determinants of oral health, oral microbiology, and salivary stress markers were assessed at baseline and at 6-monthly intervals for 2 years. The number of tooth surfaces observed at the initial assessment in caries-free children was associated with a stress-related pattern of salivary cortisol reactivity: diminished cortisol response to a laboratory stressor was strongly associated with the number of surfaces (estimate -6.51 [SE 1.90], 95% CI -10.23--2.79, p < 0.001), after adjusting for covariates. This effect was also found in longitudinal analyses across the two-year study period. The findings provide novel evidence that a marker of stress biology is positively associated with tooth emergence in young children and may reflect additional developmental and biological influences that underlie oral health in children.</p>","PeriodicalId":49167,"journal":{"name":"Journal of Developmental Origins of Health and Disease","volume":"17 ","pages":"e38"},"PeriodicalIF":1.6,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13628187/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148714080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developmental perfluorobutanesulfonic acid (PFBS) exposure alters exocrine pancreas function in zebrafish (<i>Danio rerio</i>).","authors":"Charlotte Gridley, Kelsey Rodrigues, Isabella Boyack, Marjorie Graham, Madeline Tompach, Alicia R Timme-Laragy","doi":"10.1017/S2040174426100683","DOIUrl":"10.1017/S2040174426100683","url":null,"abstract":"<p><p>Embryonic exposures to perfluorobutanesulfonic acid (PFBS) in zebrafish have been shown to impair pancreas growth. This study investigated the persistence of the truncated pancreas phenotype, functional impacts on digestive enzyme production, and the hypothesis that redox stress contributes to these outcomes. Transgenic ptf1a:GFP zebrafish were exposed to 0 (0.01% dimethyl sulfoxide (DMSO)), 16, and 32 µM PFBS from 24 to 96 h post-fertilization (hpf) and raised in clean water to 15 days post-fertilization (dpf). Confocal microscopy revealed the pancreata regained normal size, suggesting \"catch-up\" growth. To evaluate the importance of redox stress in this recovery and acinar cell function, wild-type or mutant zebrafish embryos with a mutation in the DNA-binding domain of the Nrf2a transcription factor were exposed to PFBS from 3 to 96 hpf and raised to 9 dpf in clean water. At 9 dpf, Nrf2a mutants had shorter exocrine pancreases than wild-types with the same treatment, indicating this phenotype likely involves redox stress. Expression of pancreatic proteases and Trypsin were examined to assess functional changes. Although protease gene expression did not differ significantly at 4 or 9 dpf, Trypsin levels decreased with increasing PFBS concentrations in wild-type larvae at 6 and 9 dpf. Lipid analysis showed no change in cholesterol but lower triglycerides in Nrf2a mutants. Assessment of glutathione utilization using monochlorobimane fluorescence indicated more robust antioxidant responses in wild-type fish. This study increases understanding of how Nrf2a modulates the response to PFBS exposure, impacts on exocrine pancreas function, and has implications for understanding \"catch-up\" growth in response to embryonic toxicant exposures.</p>","PeriodicalId":49167,"journal":{"name":"Journal of Developmental Origins of Health and Disease","volume":"17 ","pages":"e37"},"PeriodicalIF":1.6,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148702525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Linking prenatal exposure to temperature intensity and variability to child mortality: evidence from 31 low-and middle-income countries.","authors":"Rafi Amir-Ud-Din, Rasheed Ahmed, Fatima Irfan, Sameen Zafar","doi":"10.1017/S2040174426100701","DOIUrl":"https://doi.org/10.1017/S2040174426100701","url":null,"abstract":"<p><p>High child mortality in low-and middle-income countries is compounded by rising temperatures and climate variability. We conducted a retrospective cohort study of singleton live births from DHS birth histories (IPUMS-DHS) linked to gridded climate reanalysis across 31 countries in sub-Saharan Africa, South Asia, and the Middle East and North Africa. The analytical sample comprised births to mothers aged 15-49 years from 1990 to 2018. Using survey-weighted multilevel logistic regression with cluster-level random intercepts, we examined associations between prenatal exposure to average maximum temperature (°C) and its variability with neonatal, infant, and under-5 mortality. Each additional degree of cumulative exposure was associated with 2.7% higher under-5 mortality odds (OR = 1.027; 95% CI: 1.023-1.030; <i>p</i> < 0.001). A dose-response pattern emerged, with the highest temperature quintile associated with 38.3% higher under-5 odds (OR = 1.383; 95% CI: 1.330-1.437; <i>p</i> < 0.001). Infant mortality showed similar trimester-specific associations (from OR = 1.008; 95% CI: 1.005-1.011; <i>p</i> < 0.001 to OR: 1.013; 95% CI: 1.006-1.012; <i>p</i> < 0.001), and neonatal mortality smaller but significant ones. Variability showed divergent associations: positive deviations (>0.5σ) with higher under-5 mortality (OR = 1.033; 95% CI: 1.016-1.051; <i>p</i> < 0.001) but lower neonatal odds (OR = 0.966; 95% CI: 0.941-0.991; <i>p</i> < 0.01). Prenatal heat was consistently associated with higher child mortality, with the first and third trimesters as critical windows and risk intensifying at upper quintiles. These findings underscore the limitations of mean-temperature metrics and support embedding heat-alert counseling and affordable cooling within maternal and child health services.</p>","PeriodicalId":49167,"journal":{"name":"Journal of Developmental Origins of Health and Disease","volume":"17 ","pages":"e36"},"PeriodicalIF":1.6,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148632466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The maternal microbiome-epigenome axis in gestational diabetes: pathogenesis, diagnosis, and emerging therapies.","authors":"Aliya Abbas Rizvi, Mohammad Abbas, Asma Imran Ansari, Sushma Verma, Akanksha Sinha, Farzana Mahdi","doi":"10.1017/S2040174426100695","DOIUrl":"https://doi.org/10.1017/S2040174426100695","url":null,"abstract":"<p><p>Gestational diabetes mellitus (GDM) is a common pregnancy complication with profound short- and long-term consequences for both mother and offspring. Beyond transient hyperglycemia, GDM represents a multifactorial metabolic condition shaped by the interplay of genetic predisposition, epigenetic regulation, and alterations in the maternal microbiome. Dysbiosis of the gut and reproductive tract microbiota contributes to inflammation, insulin resistance, and dyslipidemia during pregnancy, while microbial metabolites influence placental physiology and epigenetic remodeling of key metabolic and imprinted genes. These modifications, including changes in DNA methylation and non-coding RNA expression, link maternal hyperglycemia and microbial shifts to persistent alterations in gene expression that affect trophoblast activity, fetal growth trajectories, and long-term metabolic risk in offspring. Vertical transmission of maternal microbiota further imprints the neonatal microbiome, establishing an early-life foundation for reproductive and metabolic health. Although current diagnostic criteria and biomarkers remain inconsistent across populations, recent advances highlight the microbiome-epigenome axis as a promising source of predictive markers and therapeutic targets. Interventions such as probiotics, prebiotics, synbiotics, and dietary modulation show potential for improving maternal glycemic control, shaping placental function, and modulating fetal programming, although evidence for long-term efficacy is still emerging. Viewing GDM as both a metabolic stress test and a window of reproductive opportunity underscores the importance of early diagnosis and precision strategies. Integrating microbiome research and epigenetic insights into clinical practice offers new avenues to improve maternal outcomes, optimize fetal development, and reduce the intergenerational transmission of reproductive and metabolic disease risk.</p>","PeriodicalId":49167,"journal":{"name":"Journal of Developmental Origins of Health and Disease","volume":"17 ","pages":"e35"},"PeriodicalIF":1.6,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148622179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Art of Creation: arts-based approaches to translating the Developmental Origins of Health and Disease science for public health impact.","authors":"Jordan Chin, Sara Dickinson, Luseadra McKerracher, Mary Barker, Gursimran Deol, Deborah M Sloboda","doi":"10.1017/S2040174426100658","DOIUrl":"https://doi.org/10.1017/S2040174426100658","url":null,"abstract":"<p><p>Public understanding of the Developmental Origins of Health and Disease (DOHaD) remains limited, hindering efforts to shift health behaviours and policy. Arts-based knowledge translation (ABKT) offers a promising approach to engage the public with complex health science. We evaluated the feasibility, acceptability, and impact of a multi-site exhibition co-developed by scientists, artists, and community members to convey DOHaD concepts. The Art of Creation Exhibition, shown in a mid-sized Canadian city in gallery and community settings, featured professional and community-created artworks and interactive activities. Using a parallel convergent mixed methods design, we collected and analysed observational notes, written reflections, analytics from QR codes linked to information about the artworks and DOHaD, and structured activity responses. Quantitative data were analysed using Firth-penalised logistic regression and descriptive statistics. Qualitative data underwent conventional content analysis. Findings were integrated narratively. The Exhibition was successfully installed at all sites, although space and security constraints in community settings required adaptation. 93% of observed individuals at the gallery site engaged with the exhibition, compared to 3%-17% at community sites. Gallery visitors engaged with more artworks for longer. Viewing over half of the artworks was associated with higher odds of endorsing Social Determinants of Health (SDoH) (OR = 6.63, 95% CI [1.22, 68.34]). Written and verbal feedback demonstrated increased awareness, emotional engagement, and interest in further learning. Despite some misinterpretation and low fidelity of interactive activities, the Exhibition was well received and evoked critical reflection. Using ABKT for DOHaD can enhance health literacy, foster dialogue about the SDoH, and support equitable health communication.</p>","PeriodicalId":49167,"journal":{"name":"Journal of Developmental Origins of Health and Disease","volume":"17 ","pages":"e34"},"PeriodicalIF":1.6,"publicationDate":"2026-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148563463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}