Maternal birth experience and DNA methylation.

IF 1.8 4区医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Journal of Developmental Origins of Health and Disease Pub Date : 2025-05-21 DOI:10.1017/S2040174425000133

Cyrielle Holuka, Alessia Melacca, Giorgia Menta, Conchita D'Ambrosio, Sandra Morano, Jasminka Štefulj, Jean Calleja-Agius, Laura Bordoni, Rosita Gabbianelli, Jonathan D Turner

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Abstract

Childbirth influences maternal and new-born's future health, with the Epigenetic Impact of Childbirth (EPIIC) hypothesis proposing that labour stress affects foetal gene expression. This study explores how birth experiences relate to DNA methylation in infants, breastfeeding and mother-infant bonding. Data from the Avon Longitudinal Study of Parents and Children was used, including 14,541 pregnant women. The ARIES subset of 1,022 mother-child pairs provided DNA methylation profiles. Maternal birth experience (MBE) was evaluated, with mother-infant bonding and breastfeeding. Statistical analysis involved linear regression and epigenome-wide association study. Half of the mothers reported at least one negative childbirth event, with 7% experiencing three or more adverse events. Negative MBE correlated with shorter breastfeeding duration and weaker mother-infant bonding. No significant CpG associations with MBE were found. While positive MBE is linked to improved mother-infant bonding and breastfeeding, no significant changes in DNA methylation profiles were observed in the offspring. Further research is needed to understand MBE's long-term impact on child health.

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产妇分娩经历和DNA甲基化。

分娩影响母亲和新生儿未来的健康，分娩的表观遗传影响（EPIIC）假说提出，劳动压力影响胎儿基因表达。本研究探讨了出生经历与婴儿DNA甲基化、母乳喂养和母婴结合之间的关系。数据来自雅芳父母和孩子的纵向研究，包括14541名孕妇。1,022对母子的白羊座子集提供了DNA甲基化谱。评估产妇分娩经验（MBE），母婴结合和母乳喂养。统计分析采用线性回归和全表观基因组关联研究。一半的母亲报告了至少一次负面分娩事件，7%的母亲经历了三次或更多的不良事件。负的MBE与较短的母乳喂养时间和较弱的母婴关系相关。未发现CpG与MBE有显著关联。虽然MBE阳性与改善母婴关系和母乳喂养有关，但在后代中没有观察到DNA甲基化谱的显著变化。需要进一步的研究来了解MBE对儿童健康的长期影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Developmental Origins of Health and Disease PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-

CiteScore

3.80

自引率

0.00%

发文量

145

审稿时长

6-12 weeks

期刊介绍： JDOHaD publishes leading research in the field of Developmental Origins of Health and Disease (DOHaD). The Journal focuses on the environment during early pre-natal and post-natal animal and human development, interactions between environmental and genetic factors, including environmental toxicants, and their influence on health and disease risk throughout the lifespan. JDOHaD publishes work on developmental programming, fetal and neonatal biology and physiology, early life nutrition, especially during the first 1,000 days of life, human ecology and evolution and Gene-Environment Interactions. JDOHaD also accepts manuscripts that address the social determinants or education of health and disease risk as they relate to the early life period, as well as the economic and health care costs of a poor start to life. Accordingly, JDOHaD is multi-disciplinary, with contributions from basic scientists working in the fields of physiology, biochemistry and nutrition, endocrinology and metabolism, developmental biology, molecular biology/ epigenetics, human biology/ anthropology, and evolutionary developmental biology. Moreover clinicians, nutritionists, epidemiologists, social scientists, economists, public health specialists and policy makers are very welcome to submit manuscripts. The journal includes original research articles, short communications and reviews, and has regular themed issues, with guest editors; it is also a platform for conference/workshop reports, and for opinion, comment and interaction.