Journal of Developmental Origins of Health and Disease最新文献

{"title":"Neonatal handling modifies maternal care and lactational adaptations to gestational protein restriction.","authors":"Carla da Silva Benetti, Andre Krumel Portella, Hellena Gonçalves Vido, Fernanda Urruth Fontella, Cristie Noschang, Carla Dalmaz, Marcelo Zubaran Goldani, Patricia Pelufo Silveira","doi":"10.1017/S2040174426100828","DOIUrl":"https://doi.org/10.1017/S2040174426100828","url":null,"abstract":"<p><p>Prenatal nutritional conditions influence offspring metabolic health and may also program maternal physiology and caregiving during lactation. Early postnatal experience can modify maternal-infant interactions and thus modulate maternal physiological and behavioral adaptations induced by gestational undernutrition. Although species differences must be considered, this early postnatal window in rodents approximates human early infancy. We tested whether neonatal handling, an early-life manipulation that increases maternal care, modifies the effects of maternal protein restriction during gestation and early lactation on maternal behavior, milk composition, and lactogenic hormones. Wistar rat dams received a control (22% protein) or low-protein (8%, isoenergetic) diet throughout gestation and the first week of lactation. Litters were assigned to either neonatal handling (10 min/day, postnatal days 1-6) or undisturbed rearing with their dams. We measured maternal caloric intake, gestational weight gain, pup growth, maternal licking and grooming, milk macronutrients on postnatal day 6, and maternal serum prolactin, corticosterone, and insulin. Thirty-seven dams were included (8-10 per treatment group), and litter size did not differ between groups. Maternal low-protein diet significantly reduced pup body weight and milk protein content, while neonatal handling significantly increased maternal licking/grooming in low-protein dams and reversed the reduction in milk protein concentration. Additionally, neonatal handling decreased insulin levels in control dams, but had no effect in low protein dams, while prolactin and corticosterone were not altered between groups. Together, these findings indicate that early postnatal experience can modify a maternal phenotype induced by gestational undernutrition, including maternal care and lactational composition, with a metabolic signature involving insulin.</p>","PeriodicalId":49167,"journal":{"name":"Journal of Developmental Origins of Health and Disease","volume":"17 ","pages":"e53"},"PeriodicalIF":1.6,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149197317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subclinical neonatal hypoxic stress: a hypothesis on transitional oxygen instability.","authors":"Tareef Fadhil Raham","doi":"10.1017/S2040174426100889","DOIUrl":"10.1017/S2040174426100889","url":null,"abstract":"<p><p>The transition from fetal to neonatal life requires rapid adjustments in respiratory, cardiovascular, and autonomic regulation as the newborn establishes independent oxygenation. Although most infants achieve stable physiological adaptation, transient fluctuations in oxygen saturation and respiratory control are frequently observed during early neonatal life and are generally considered benign once stability is restored. However, the physiological implications of such transient instability have rarely been systematically examined.This article proposes the concept of subclinical neonatal hypoxic stress (SNHS) as a theoretical framework describing mild and transient oxygen-related physiological stress that may occur during neonatal transition without producing overt manifestations of clinically significant hypoxia or hypoxic injury. SNHS is conceptualized as a hypothesized subclinical physiological vulnerability state within the continuum of neonatal adaptation, distinct from both ordinary physiological variability and clinically significant hypoxic conditions. Episodes potentially consistent with SNHS may include brief transitional instability that resolves rapidly, sometimes following minimal supportive measures, after which infants are considered clinically normal.The paper outlines the physiological basis of neonatal oxygen variability, differentiates SNHS from established hypoxic disorders, and proposes empirically testable approaches for investigating this potential transitional state within early-life physiology. If validated, the SNHS framework could support more precise characterization of transient oxygen instability during neonatal transition and inform future monitoring strategies aimed at distinguishing benign physiological variability from potentially meaningful subclinical physiological stress.</p>","PeriodicalId":49167,"journal":{"name":"Journal of Developmental Origins of Health and Disease","volume":"17 ","pages":"e52"},"PeriodicalIF":1.6,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149197460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal protein restriction during lactation programs peripheral insulin sensitivity and reduces UCP1 abundance in interscapular brown adipose tissue of adult male Wistar rats.","authors":"Willian do Nascimento de Souza Rodrigues, Lucas Paulo Jacinto Saavedra, Paulo Cezar de Freitas Mathias","doi":"10.1017/S204017442610083X","DOIUrl":"https://doi.org/10.1017/S204017442610083X","url":null,"abstract":"<p><p>Maternal protein restriction during lactation is associated with stunted growth and hyperphagia in adult offspring, yet its long-term effects on mitochondrial uncoupling-related proteins in interscapular brown adipose tissue (iBAT) remain unknown. This study investigated how postnatal protein undernutrition affects thermogenic regulators and metabolic programming in adult males. Dams received either a low-protein (LP; 4% protein) or normal-protein (NP; 20.5% protein) diet during the first two weeks of lactation. Thereafter, the NP diet was provided to LP dams until weaning and to all offspring from weaning to PND 90. Male offspring were euthanized at postnatal day 90 for somatic, biochemical, hormonal, and iBAT UCP1 and β3-AR protein analyses. Compared with NP controls, LP offspring exhibited reduced body mass, length, and visceral adiposity, despite increased food consumption (all <i>p</i> < 0.0001). They also showed reduced glycemia, insulin, HOMA-β, TyG index, albumin, and HDL-c (all <i>p</i> < 0.05), together with increased peripheral insulin sensitivity assessed by ipITT (<i>p</i> < 0.05). Conversely, LP offspring exhibited increased AST activity and AST/ALT ratio (both <i>p</i> < 0.05) and higher hepatic cholesterol content (<i>p</i> < 0.01). In iBAT, UCP1 protein content was reduced (<i>p</i> < 0.05), whereas β3-AR remained unchanged (<i>p</i> > 0.05). These findings indicate that maternal protein undernutrition during lactation programmed a persistent metabolic phenotype characterized by hyperphagia, reduced somatic growth and visceral adiposity, increased peripheral insulin sensitivity, and lower iBAT UCP1 protein abundance. Collectively, these results suggest long-term alterations in energy partitioning and the iBAT molecular phenotype, although functional thermogenesis was not assessed.</p>","PeriodicalId":49167,"journal":{"name":"Journal of Developmental Origins of Health and Disease","volume":"17 ","pages":"e45"},"PeriodicalIF":1.6,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149117412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mothers' and partners' changes in health behaviours during pregnancy: observations from the <i>Growing Up in New Zealand Cohort</i>.","authors":"Teresa Gontijo de Castro, Angela Lee, Beng In Loh, Nicola Gillies, Clare Wall","doi":"10.1017/S2040174426100798","DOIUrl":"https://doi.org/10.1017/S2040174426100798","url":null,"abstract":"<p><p>Improving modifiable health behaviours during pregnancy may benefit parental health and offspring outcomes. Although pregnancy may motivate lifestyle change in both mothers and partners, evidence on partner health behaviour change and within-couple alignment remains limited. Antenatal data from the Growing Up in New Zealand cohort were used to describe health behaviour changes among mothers <i>(n</i> = 6822) and partners (<i>n</i> = 4401), and to examine associations between selected dietary changes within mother-partner dyads <i>(n</i> = 1195). Measures included changes in physical activity, alcohol use, smoking, and diet [avoidance of sugar-sweetened beverages (SSBs) and fast foods, and the addition of fruits and vegetables]. Associations were examined using multivariate Poisson regression models with robust variance. Most mothers (73.7%) remained consistently active or inactive during pregnancy, while 43.4% of partners reported changes in activity. Around 43% of both mothers and partners reduced or stopped alcohol use. Nearly half of smoking mothers quit, and two-thirds of smoking partners reduced or quit smoking. For diet, 22.9% and 30.7% of mothers avoided SSBs and fast foods, respectively, and 15.8% added fruits and/or vegetables; respective figures for partners were 13.2%, 9.9%, and 19.2%. Significant dyadic associations were observed for avoiding SSBs (Prevalence ratio [PR]: 1.37, 95% confidence interval [CI]: 1.04-1.79) and for adding fruits and/or vegetables to diets (PR: 2.05, 95% CI: 1.59-2.65). These findings indicate that pregnancy may represent a shared context for health behaviour change within households and highlight the potential value of partner-inclusive antenatal approaches.</p>","PeriodicalId":49167,"journal":{"name":"Journal of Developmental Origins of Health and Disease","volume":"17 ","pages":"e51"},"PeriodicalIF":1.6,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149128745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DOHaD ANZPac: bringing together the DOHaD community across Australia, New Zealand, and the Pacific.","authors":"Beverly Mühlhäusler, Deanne Hryciw","doi":"10.1017/S2040174426100841","DOIUrl":"https://doi.org/10.1017/S2040174426100841","url":null,"abstract":"","PeriodicalId":49167,"journal":{"name":"Journal of Developmental Origins of Health and Disease","volume":"17 ","pages":"e50"},"PeriodicalIF":1.6,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149117377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Repositioning oral health within DOHaD: linking early childhood caries to life-course NCD prevention.","authors":"Seema Lal-Kumar, Anand Marya, Bob Williams, Metua Bates, Abiola Adeniyi","doi":"10.1017/S2040174426100713","DOIUrl":"https://doi.org/10.1017/S2040174426100713","url":null,"abstract":"<p><p>The Developmental Origins of Health and Disease (DOHaD) paradigm has transformed our understanding of how early-life biological and social environments shape lifelong health trajectories. While DOHaD research across Oceania has focused primarily on metabolic, cardiovascular, and nutritional outcomes, oral health, particularly early childhood caries (ECC), remains largely absent from life course research and policy despite its early onset, shared risk factors with childhood obesity and other noncommunicable diseases (NCDs), and strong social and intergenerational patterning. This conceptual paper synthesises the DOHaD paradigm, First 1000 Days approaches, common risk factor theory, and Pacific relational worldviews to propose a Pacific-centred framework that explicitly integrates oral health. Using the Cook Islands as a regional exemplar, the paper demonstrates how oral health can be aligned with existing maternal and child health, nutrition, and NCD policy priorities. The proposed framework reframes ECC as both a biologically embedded developmental outcome and an early indicator of broader NCD risk trajectories. It highlights the interconnected influence of biological, family, community, health system, and policy environments on oral health across the life course. Integrating oral health within a Pacific centred DOHaD framework addresses an important gap in research and policy and provides a culturally grounded and policy relevant model to strengthen early-life prevention, improve health equity, and guide future research and implementation across Oceania.</p>","PeriodicalId":49167,"journal":{"name":"Journal of Developmental Origins of Health and Disease","volume":"17 ","pages":"e46"},"PeriodicalIF":1.6,"publicationDate":"2026-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149117398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal obesity induces sex-specific gut microbiota changes associated with reduced fecal levels of endocannabinoid-like molecules in rat offspring at weaning.","authors":"Marcella Augusta Falci, Gabriela de Cássia Ávila Alpino, Julliane Dutra Medeiros, Poliana Guiomar de Almeida Brasiel, Vinicius Vieira Lima, Thiago Vinicius Ávila, Carmen Cabanelas Pazos-Moura, Sheila Cristina Potente Dutra Luquetti, Isis Hara Trevenzoli, Mariana Macedo Almeida","doi":"10.1017/S2040174426100865","DOIUrl":"https://doi.org/10.1017/S2040174426100865","url":null,"abstract":"<p><p>Maternal obesity alters the gut microbiota of offspring, although sex-specific effects remain poorly assessed before puberty. An interplay has emerged between the gut microbiota and fecal endocannabinoids, including oleoylethanolamide (OEA) and palmitoylethanolamide (PEA), which exert anti-inflammatory and anti-obesity effects. We have demonstrated that maternal obesogenic diet induces early obesity associated with low fecal PEA and OEA levels and sex-specific changes on the gut endocannabinoid signaling of offspring at weaning. We hypothesized that maternal obesity induces sex-specific gut microbiota. Progenitor female rats were divided maternal control group (received control diet) or maternal obesity group (received obesogenic diet, high-fat high-sugar diet) during perinatal period. Gut microbiota analysis was performed using feces from offspring at weaning. There was no sexual dimorphism in the gut microbiota between control female offspring and control male offspring. Maternal obesity increased the <i>Blautia</i> abundance and decreased <i>Mucispirillum</i> abundance in the gut microbiota in males compared to control male offspring. <i>Blautia</i> abundance showed a negative correlation, while <i>Mucispirillum</i> abundance showed a positive correlation with PEA and OEA fecal levels. There were no correlations between gut microbiota and offspring adiposity, which was negatively correlated with PEA and OEA fecal levels. In conclusion, only in male offspring, maternal obesity-induced gut microbiota changes, which could contribute to low PEA and OEA fecal levels and early obesity. Fecal endocannabinoids could reflect the biological mechanism by which gut microbiota impacts adiposity in early life. Our findings provide molecular insights into the sex-specific crosstalk between gut microbiota and fecal endocannabinoids underlying intergenerational metabolic disorders.</p>","PeriodicalId":49167,"journal":{"name":"Journal of Developmental Origins of Health and Disease","volume":"17 ","pages":"e49"},"PeriodicalIF":1.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149117321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal exposure to fluorotelomer ethoxylates: magnetic resonance spectroscopy and imaging to study bioaccumulation during pregnancy and the long-term impact on offspring neuroanatomy.","authors":"Haley M Adams, Jenna Hanrahan, Shoshana Spring, Céline M Schneider, John G Sled, Karl J Jobst, Lindsay S Cahill","doi":"10.1017/S2040174426100804","DOIUrl":"https://doi.org/10.1017/S2040174426100804","url":null,"abstract":"<p><p>Fluorotelomer ethoxylates (FTEOs) are a new and unregulated class of per-/polyfluoroalkyl substances (PFAS) recognized to be persistent in the environment and known in the laboratory setting to have important health effects, such as causing placental dysfunction in the mouse. The bioaccumulation potential and the long-term impacts for offspring health following maternal exposure to FTEOs are not known. In the present study, we exposed pregnant CD-1 mice to FTEOs (50 mg/L for nuclear magnetic resonance experiments and 100 ng/L for the magnetic resonance imaging study) through their drinking water during gestation and lactation. Using ¹⁹F solid-state nuclear magnetic resonance, we detected FTEOs in a maternal liver and placenta tissue sample. ¹H three-dimensional high-resolution ex vivo magnetic resonance imaging revealed that offspring exposed to FTEOs had focal neuroanatomical differences compared to controls in multiple brain structures including the cortex, hippocampus, medulla, midbrain, striatum, thalamus, and cerebellum. Many of these MRI-detectable changes in brain volume differed by sex, with the female offspring the most impacted by FTEO exposure. This study demonstrates that FTEOs are bioaccumulative and cause postnatal neurotoxicity in mice, highlighting the importance of understanding their impact on long-term human health.</p>","PeriodicalId":49167,"journal":{"name":"Journal of Developmental Origins of Health and Disease","volume":"17 ","pages":"e48"},"PeriodicalIF":1.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149117368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Growth faltering in infants: a contemporary review.","authors":"Mohamed A Hendaus, Fatima Jomha","doi":"10.1017/S2040174426100816","DOIUrl":"10.1017/S2040174426100816","url":null,"abstract":"<p><p>Growth faltering, often referred to as failure to thrive (FTT), is a significant and frequently encountered issue in pediatric care. It denotes inadequate growth resulting from a lack of sufficient caloric intake, impaired nutrient absorption, increased metabolic demands, or a complex interplay of biological and psychosocial factors. In this review, we will explore contemporary understanding of growth faltering in infants, addressing definitions, epidemiology, diagnostic evaluations, management strategies, and long-term outcomes. A comprehensive assessment should encompass consistent growth monitoring, detailed nutritional evaluations, developmental assessments, psychosocial screenings, and identification of possible medical causes. Many cases of growth faltering are complex and can be effectively managed through outpatient multidisciplinary care. Hospitalization should only be considered for severe malnutrition, dehydration, suspected abuse or neglect, or when outpatient interventions have failed. Emphasizing a family-centered, multidisciplinary approach is essential to ensure effective management and support for the child's overall well-being.</p>","PeriodicalId":49167,"journal":{"name":"Journal of Developmental Origins of Health and Disease","volume":"17 ","pages":"e47"},"PeriodicalIF":1.6,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149082708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal overnutrition during pregnancy: impacts on pancreatic proteome of the offspring.","authors":"Lindsey Eileen, David Townson, Maria L Peterson","doi":"10.1017/S2040174426100774","DOIUrl":"https://doi.org/10.1017/S2040174426100774","url":null,"abstract":"<p><p>Maternal obesity, resulting from high caloric intake during pregnancy, can impair pancreatic development in the offspring and lead to an increased risk of diabetes. We hypothesized that maternal obesity during pregnancy results in reduced expression of proteins associated with pancreatic <i>β</i> cell function and increased expression of proteins associated with apoptosis. C57BL/6J (<i>N</i> = 6) female mice were fed either a control (CON; <i>n</i> = 3) or a high-fat (HFD; <i>n</i> = 3) diet for fourteen weeks prior to pregnancy, diets were continued throughout gestation and lactation. Offspring were weaned at four weeks and then maintained on a control diet. At eight weeks of age, the offspring were euthanized (<i>N</i> = 20; 4-6/treatment/sex) and pancreas tissue samples were collected. Protein was isolated and analyzed using ultra-high performance liquid chromatography and tandem mass spectrometry. A total of 2,329 proteins were identified across both male and female mice in the comparison between the control and HFD groups, with 165 differentially expressed (DE) proteins (CON vs HFD males: 145; CON vs HFD females: 20; <i>P</i> ≤ 0.05). In male offspring, 131 DE proteins were down regulated, and 14 were upregulated, while in females 13 were upregulated and seven were down regulated. Four DE proteins (Mgat2, Lama2, Isyna1, Got2) were common to both sexes. However, only Lama2 exhibited a similar pattern of expression, with both HFD males and females having greater expression than CON. Alternatively, HFD males exhibited reduced expression of Mgat2, Got2, and Isyna1 when compared with CON. HFD females exhibited increased gene expression for the DEPs.</p>","PeriodicalId":49167,"journal":{"name":"Journal of Developmental Origins of Health and Disease","volume":"17 ","pages":"e44"},"PeriodicalIF":1.6,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149082703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}