Nature Reviews Neuroscience最新文献_第9页

Lessons on predictive learning from the honeybee 蜜蜂的预测学习经验

IF 28.7 1区医学

Nature Reviews Neuroscience Pub Date : 2024-06-11 DOI: 10.1038/s41583-024-00835-9

Sabine Krabbe

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Fear, anxiety and the functional architecture of the human central extended amygdala 恐惧、焦虑和人类中央扩展杏仁核的功能结构。

IF 28.7 1区医学

Nature Reviews Neuroscience Pub Date : 2024-06-10 DOI: 10.1038/s41583-024-00832-y

Alexander J. Shackman, Shannon E. Grogans, Andrew S. Fox

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Reply to ‘Fear, anxiety and the functional architecture of the human central extended amygdala’ 对 "恐惧、焦虑和人类中央扩展杏仁核的功能结构 "的答复

IF 28.7 1区医学

Nature Reviews Neuroscience Pub Date : 2024-06-10 DOI: 10.1038/s41583-024-00834-w

Liping Wang, Yu-Ting Tseng, Bernhard Schaefke, Pengfei Wei, Sheng He

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A pas de deux between the hippocampus and the cortex during sleep 睡眠时海马体与大脑皮层的双人舞

IF 28.7 1区医学

Nature Reviews Neuroscience Pub Date : 2024-06-05 DOI: 10.1038/s41583-024-00828-8

Adrien Peyrache

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Pattern recognition using action potential timing 利用动作电位定时进行模式识别

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Nature Reviews Neuroscience Pub Date : 2024-06-03 DOI: 10.1038/s41583-024-00831-z

Izumi Fukunaga

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Common principles for odour coding across vertebrates and invertebrates 脊椎动物和无脊椎动物气味编码的共同原则。

IF 28.7 1区医学

Nature Reviews Neuroscience Pub Date : 2024-05-28 DOI: 10.1038/s41583-024-00822-0

Kara A. Fulton, David Zimmerman, Aravi Samuel, Katrin Vogt, Sandeep Robert Datta

{"title":"Common principles for odour coding across vertebrates and invertebrates","authors":"Kara A. Fulton, David Zimmerman, Aravi Samuel, Katrin Vogt, Sandeep Robert Datta","doi":"10.1038/s41583-024-00822-0","DOIUrl":"10.1038/s41583-024-00822-0","url":null,"abstract":"The olfactory system is an ideal and tractable system for exploring how the brain transforms sensory inputs into behaviour. The basic tasks of any olfactory system include odour detection, discrimination and categorization. The challenge for the olfactory system is to transform the high-dimensional space of olfactory stimuli into the much smaller space of perceived objects and valence that endows odours with meaning. Our current understanding of how neural circuits address this challenge has come primarily from observations of the mechanisms of the brain for processing other sensory modalities, such as vision and hearing, in which optimized deep hierarchical circuits are used to extract sensory features that vary along continuous physical dimensions. The olfactory system, by contrast, contends with an ill-defined, high-dimensional stimulus space and discrete stimuli using a circuit architecture that is shallow and parallelized. Here, we present recent observations in vertebrate and invertebrate systems that relate the statistical structure and state-dependent modulation of olfactory codes to mechanisms of perception and odour-guided behaviour. The detection, discrimination and categorization of odours are essential for survival across the animal kingdom. In this Review, Datta and co-workers describe and compare the neural circuits that mediate the processing of olfactory information and the key principles of olfactory coding in insects and mammals.","PeriodicalId":49142,"journal":{"name":"Nature Reviews Neuroscience","volume":"25 7","pages":"453-472"},"PeriodicalIF":28.7,"publicationDate":"2024-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141162448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The neuropathobiology of multiple sclerosis 多发性硬化症的神经生物学

IF 28.7 1区医学

Nature Reviews Neuroscience Pub Date : 2024-05-24 DOI: 10.1038/s41583-024-00823-z

Marcel S. Woo, Jan Broder Engler, Manuel A. Friese

{"title":"The neuropathobiology of multiple sclerosis","authors":"Marcel S. Woo, Jan Broder Engler, Manuel A. Friese","doi":"10.1038/s41583-024-00823-z","DOIUrl":"10.1038/s41583-024-00823-z","url":null,"abstract":"Chronic low-grade inflammation and neuronal deregulation are two components of a smoldering disease activity that drives the progression of disability in people with multiple sclerosis (MS). Although several therapies exist to dampen the acute inflammation that drives MS relapses, therapeutic options to halt chronic disability progression are a major unmet clinical need. The development of such therapies is hindered by our limited understanding of the neuron-intrinsic determinants of resilience or vulnerability to inflammation. In this Review, we provide a neuron-centric overview of recent advances in deciphering neuronal response patterns that drive the pathology of MS. We describe the inflammatory CNS environment that initiates neurotoxicity by imposing ion imbalance, excitotoxicity and oxidative stress, and by direct neuro-immune interactions, which collectively lead to mitochondrial dysfunction and epigenetic dysregulation. The neuronal demise is further amplified by breakdown of neuronal transport, accumulation of cytosolic proteins and activation of cell death pathways. Continuous neuronal damage perpetuates CNS inflammation by activating surrounding glia cells and by directly exerting toxicity on neighbouring neurons. Further, we explore strategies to overcome neuronal deregulation in MS and compile a selection of neuronal actuators shown to impact neurodegeneration in preclinical studies. We conclude by discussing the therapeutic potential of targeting such neuronal actuators in MS, including some that have already been tested in interventional clinical trials. Slowing neurodegeneration is the most pressing clinical need for multiple sclerosis (MS). In this Review, Woo, Engler and Friese provide a neuron-centric view on inflammation-induced neurodegeneration in MS and discuss key pathways and molecules that can be therapeutically targeted.","PeriodicalId":49142,"journal":{"name":"Nature Reviews Neuroscience","volume":"25 7","pages":"493-513"},"PeriodicalIF":28.7,"publicationDate":"2024-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141092104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Network state transitions during cortical development 大脑皮层发育过程中的网络状态转换

IF 28.7 1区医学

Nature Reviews Neuroscience Pub Date : 2024-05-23 DOI: 10.1038/s41583-024-00824-y

Michelle W. Wu, Nazim Kourdougli, Carlos Portera-Cailliau

{"title":"Network state transitions during cortical development","authors":"Michelle W. Wu, Nazim Kourdougli, Carlos Portera-Cailliau","doi":"10.1038/s41583-024-00824-y","DOIUrl":"10.1038/s41583-024-00824-y","url":null,"abstract":"Mammalian cortical networks are active before synaptogenesis begins in earnest, before neuronal migration is complete, and well before an animal opens its eyes and begins to actively explore its surroundings. This early activity undergoes several transformations during development. The most important of these is a transition from episodic synchronous network events, which are necessary for patterning the neocortex into functionally related modules, to desynchronized activity that is computationally more powerful and efficient. Network desynchronization is perhaps the most dramatic and abrupt developmental event in an otherwise slow and gradual process of brain maturation. In this Review, we summarize what is known about the phenomenology of developmental synchronous activity in the rodent neocortex and speculate on the mechanisms that drive its eventual desynchronization. We argue that desynchronization of network activity is a fundamental step through which the cortex transitions from passive, bottom–up detection of sensory stimuli to active sensory processing with top–down modulation. At early developmental stages, spontaneous activity in the mammalian cortex is characterized by the occurrence of highly synchronous network events. Portera-Cailliau and colleagues describe these activity patterns, their underlying mechanisms and function, and their transition to the desynchronized activity observed in adult individuals.","PeriodicalId":49142,"journal":{"name":"Nature Reviews Neuroscience","volume":"25 8","pages":"535-552"},"PeriodicalIF":28.7,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141087762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Brain functional networks and psychiatric disorders 大脑功能网络与精神疾病

IF 28.7 1区医学

Nature Reviews Neuroscience Pub Date : 2024-05-17 DOI: 10.1038/s41583-024-00827-9

Isobel Leake

引用次数: 0

Mapping the social memory network 绘制社会记忆网络图

IF 28.7 1区医学

Nature Reviews Neuroscience Pub Date : 2024-05-15 DOI: 10.1038/s41583-024-00826-w

Maria Papatriantafyllou

引用次数: 0