Air Quality Atmosphere and Health最新文献

{"title":"Cardiopulmonary health effects of oil- and gas-related environmental pollution in the Niger Delta, Nigeria: a systematic review of observational studies","authors":"Ogechi Peter Obute,&nbsp;Chiara Frazzoli,&nbsp;Kenechi Adachi Aliche,&nbsp;Chika Maurine Ossai,&nbsp;Baridoo Donatus Dooka,&nbsp;Beatrice Bocca,&nbsp;Orish Ebere Orisakwe","doi":"10.1007/s11869-026-01989-4","DOIUrl":"10.1007/s11869-026-01989-4","url":null,"abstract":"<div>\u0000 \u0000 <p>This systematic review synthesises available evidence on the association between environmental pollution and cardiopulmonary diseases among populations residing in the Niger Delta region of Nigeria. Electronic databases were searched from inception to October 2025 following PRISMA guidelines. Twenty‑one observational studies met the inclusion criteria. Environmental exposures were primarily related to gas flaring, oil spills, artisanal refining, traffic emissions, and industrial pollution. Reported outcomes included respiratory symptoms, asthma, chronic obstructive pulmonary disease, reduced lung function indices, and hypertension. Due to substantial heterogeneity in exposure measurements and outcome reporting across studies, a quantitative meta‑analysis was not feasible; therefore, findings were synthesised narratively. The available evidence suggests a possible association between environmental pollution and cardiopulmonary health outcomes in the Niger Delta, although the certainty of the evidence remains low to moderate and should be interpreted with caution due to methodological limitations across the included studies.</p>\u0000 </div>","PeriodicalId":49109,"journal":{"name":"Air Quality Atmosphere and Health","volume":"19 5","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147738130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Airborne particulate matter exposure modulates humoral immune response and systemic inflammation in allergic individuals","authors":"José Francisco Zambrano Zaragoza ,&nbsp;Juan C. Hernandez,&nbsp;Iris Celeste Tovar Ocampo,&nbsp;Aurora Elizabeth Rojas García ,&nbsp;Irma Martha Medina Díaz,&nbsp;Yael Yvette Bernal Hernández,&nbsp;Cyndia Azucena González Arias,&nbsp;Briscia Socorro Barrón Vivanco,&nbsp;Bruno Daniel Bañuelos Pacheco,&nbsp;Juan Manuel Agraz Cibrian","doi":"10.1007/s11869-026-01991-w","DOIUrl":"10.1007/s11869-026-01991-w","url":null,"abstract":"<div>\u0000 \u0000 <p>This study explored the immunological effects of particulate matter (PM) exposure in individuals with allergies. It aimed to assess how ambient particulate matter influences humoral immunity and systemic inflammation. A total of 37 non-smoking allergic volunteers participated, grouped by high and low PM exposure periods. Peripheral blood samples were analyzed for antibodies against non-specific PM-components and inflammatory markers. IgE levels against non-specific PM components were significantly elevated during high PM periods, indicating acute immune activation. Conversely, IgG levels against non-specific PM components were higher at lower PM exposure levels. Among inflammation markers, PLR and SII increased with higher PM, while NLPR decreased. However, hsCRP showed a positive correlation with several indices under high PM conditions. The study also highlights PM role in immune system dysregulation and inflammation in allergic individuals. Monitoring antibody and inflammatory profiles may help identify individuals at greater risk. Further studies are needed to confirm these findings and clarify the mechanisms involved.</p>\u0000 </div>","PeriodicalId":49109,"journal":{"name":"Air Quality Atmosphere and Health","volume":"19 5","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147737755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of air flow pattern and distribution on indoor air quality using computational fluid dynamics","authors":"Gowtham Sarella,&nbsp;Ajey Kumar Patel","doi":"10.1007/s11869-026-01990-x","DOIUrl":"10.1007/s11869-026-01990-x","url":null,"abstract":"<div>\u0000 \u0000 <p>Most of the time, we live in indoor environments. So, it is very important to have a good indoor environment especially in terms of air quality. The major factors affecting Indoor Air Quality (IAQ) are airflow pattern, velocity gradient, air distribution. All the above factors can be collectively categorized as ventilation. In this study, indoor air ventilation has been studied and analyzed using Computational Fluid Dynamics (CFD). The velocity of air at different positions and heights was analyzed with uniform inlet velocity for two ventilation layouts i.e. L1 (single inlet and outlet) &amp; L2 (dual inlet and outlet). The results of L1 were compared with available experimental data in the literature and was found to be in good agreement with the experimental values. Using the optimized parameters of L1, the simulations of L2 were performed, analyzed, and compared. In L1 the jet-dominated airflow failed to sufficiently reach mid and far-end zones, with velocities as low as 0.008 m/s, risking pollutant accumulation and thermal discomfort. Whereas in L2 the dual inlet ensured airflow reach all zones, maintaining a minimum velocity of 0.03 m/s. The height-velocity relationship provides valuable insight into the effectiveness of air circulation in an indoor space. The simulations also help in identifying better layout for a minimal air stagnation zone within the indoor space thereby identify safe receptor position. Out of nine receptor positions (P1 to P9) examined at 0.5 m height, P8 has the highest velocity (0.023 m/s for L2 and 0.007 m/s for L1). L2 demonstrated superior performance of air velocity distribution, IAQ, and occupant health outcomes as compared to L1. It minimizes low-flow regions, supports uniform contaminant removal, and enhances occupant comfort.</p>\u0000 </div>","PeriodicalId":49109,"journal":{"name":"Air Quality Atmosphere and Health","volume":"19 5","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147682725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of an hourly bottom-up emission inventory to assess air pollution dispersion with GRAMM/GRAL in complex terrain","authors":"Petra Dolšak Lavrič,&nbsp;Damijan Bec,&nbsp;Don Ciglenečki,&nbsp;Matej Ogrin,&nbsp;Janja Turšič,&nbsp;Gašper Stegnar,&nbsp;Jibran Khan,&nbsp;Andreja Kukec","doi":"10.1007/s11869-026-01992-9","DOIUrl":"10.1007/s11869-026-01992-9","url":null,"abstract":"<div>\u0000 \u0000 <p>The detailed spatial and temporal emission inventory, prepared on an hourly basis and at a 250 × 250-meter grid, coupled with the local dispersion modeling system GRAMM/GRAL, helps to identify the impact of primary emission sources on air pollution. Our study was conducted in the complex subalpine city of Ljubljana. We prepared a detailed emission inventory for the most contributive sectors, which are industry, transport, small combustion, and agriculture for NO_x, PM₁₀, PM_2.5, NMVOCs, and NH₃ emissions in the year 2021. The total estimated annual emissions for Ljubljana were 1,935 tons of NOₓ, 393 tons of PM₁₀, 315 tons of PM_2.5, 1,847 tons of NMVOCs, and 168 tons of NH₃. A comprehensive uncertainty analysis was conducted to assess the reliability of the emission inventory. Results from the GRAMM/GRAL dispersion model illustrate the spatial distribution of pollutants, which closely follows the geographical patterns of emission sources. Statistical comparison between modeled and observed concentrations indicates moderate agreement for PM₁₀ and stronger agreement for NO₂. Additionally, PMF analysis at the Vič monitoring station shows a consistent representation of primary emission sources compared with the model results. Overall, the results of this study improve understanding of atmospheric emission dynamics and provide a scientific basis for evidence-based decision-making aimed at reducing pollutant concentrations and protecting public health.</p>\u0000 </div>","PeriodicalId":49109,"journal":{"name":"Air Quality Atmosphere and Health","volume":"19 5","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11869-026-01992-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147682705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on the temporal and spatial characteristics, health risks, and targeted control strategies of volatile organic compounds (VOCs) exposure in China-specific indoor air","authors":"Jingwen Liu,&nbsp;Zhengzheng Zhang,&nbsp;Yuan Yang,&nbsp;Jiaxin Wang,&nbsp;Jian Song,&nbsp;Lisha Jing,&nbsp;Junling Li,&nbsp;Hao Zhang","doi":"10.1007/s11869-026-01985-8","DOIUrl":"10.1007/s11869-026-01985-8","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 &lt;p&gt;With rapid urbanization in China and evolving residents’ lifestyles, indoor air quality (IAQ) has become a growing concern across various sectors of society. Among indoor pollutants, volatile organic compounds (VOCs) are ubiquitous contaminants with varied and complex sources, posing potential health risks that represent a pressing public health issue. This study aims to provide a systematic critical review of VOC exposure characteristics in China-specific indoor environments, evaluate their health risks through comparative analysis, and develop evidence-based control strategies. This study conducts a systematic review following PRISMA guidelines of peer-reviewed literature on indoor VOCs in China published between 2000 and 2024. We searched Web of Science, PubMed, CNKI, Wanfang, and VIP databases, ultimately including 246 studies meeting quality criteria. VOC concentration data from various indoor environments including residences, public spaces, and vehicles were systematically analyzed using meta-analytical techniques. Health risk assessments were synthesized using EPA-established methodologies adapted with China-specific exposure factors, focusing on both carcinogenic and non-carcinogenic risks. The analysis examined unique contributions of China-specific factors including building materials, household products, Chinese-style cooking, and human activities to indoor VOC emissions through an analytical framework linking sources, pathways, and receptors. The review reveals significant spatiotemporal heterogeneity in VOC concentrations within Chinese indoor environments, with substantial methodological considerations affecting reported values. Formaldehyde, benzene homologues, and TVOCs frequently exceed national standards, with exceedance rates reaching 88.29–96.43% in some residential areas. Meta-analysis shows formaldehyde concentrations demonstrate temperature-dependent emission following modified Arrhenius kinetics (activation energy = 45.2 ± 3.8 kJ/mol), with summer levels 2.3 times higher than winter. Regional analysis reveals BTX concentrations in northeastern China exceed southern regions by 2–3 fold, correlating with heating degree days (&lt;i&gt;r&lt;/i&gt; = 0.76) and economic development indices (&lt;i&gt;r&lt;/i&gt; = 0.68). Health risk assessments indicate lifetime cancer risks exceed acceptable thresholds by 10–100 fold even at concentrations meeting national standards. Children show elevated vulnerability with adjusted odds ratios for asthma of 11.985 for formaldehyde exposure, substantially higher than Western populations. Occupational groups face extreme exposures, with renovation workers’ cumulative cancer risk reaching 1.2 × 10&lt;sup&gt;− 4&lt;/sup&gt;. Mixture effects analysis reveals synergistic interactions increasing hazard indices by 40–90% above additive models. Indoor VOC pollution in China presents unique public health challenges requiring targeted interventions beyond Western models. The fundamental disconnect bet","PeriodicalId":49109,"journal":{"name":"Air Quality Atmosphere and Health","volume":"19 4","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147737950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of indoor air quality, thermal comfort, and airborne microbiology in school buildings in Uruguay: a transdisciplinary approach","authors":"Martín Draper,&nbsp;Paola Scavone,&nbsp;Mariana Mendina,&nbsp;Juan Pablo Oliver,&nbsp;Mauro D’Angelo,&nbsp;María Noel López,&nbsp;Daniela Arredondo,&nbsp;María José González,&nbsp;Jonathan Florez,&nbsp;Magdalena Camacho,&nbsp;Lucía Pereira,&nbsp;Germán Pérez,&nbsp;Luciana Robino,&nbsp;Ana Paula Gómez,&nbsp;Leandro Díaz,&nbsp;Julia Azziz,&nbsp;Germán Capdehourat,&nbsp;Lorena Pardo Casaretto","doi":"10.1007/s11869-026-01963-0","DOIUrl":"10.1007/s11869-026-01963-0","url":null,"abstract":"<div>\u0000 \u0000 <p>The relevance of indoor air quality has increased during the last decade, mainly as a consequence of the SARS-CoV-2 pandemic. The academic community has shown growing interest regarding the effects of indoor air quality on health, and this became a global concern in educational buildings as children spent long periods of time indoors. Also, they could be exposed to different agents and could decrease cognitive performance and reduced productivity caused by poor indoor air quality. This initiative aims to evaluate air quality, ventilation, thermal comfort, and microbial loads in elementary schools in Uruguay in a transdisciplinary manner under local winter and spring climate conditions. To achieve this goal, different types of data were collected during 2023 and 2024, including measurements of bacteria and fungi concentrations, air temperature, relative humidity, criteria pollutants, carbon dioxide, as well as surveys on comfort conditions. Results revealed a strong correlation between carbon dioxide, bacterial counts and particulate matter. Interestingly, a discrepancy was found between predicted thermal comfort and actual user-reported comfort. This report represents the first assessment of indoor air quality in Uruguayan schools</p>\u0000 </div>","PeriodicalId":49109,"journal":{"name":"Air Quality Atmosphere and Health","volume":"19 4","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147737770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metagenomic analysis of bioaerosols (bacteria and fungi) associated with PM10 in the Mezquital Valley, Hidalgo, Mexico: Implications for public health","authors":"María del Carmen Calderón-Ezquerro,&nbsp;César Guerrero-Guerra,&nbsp;Carolina Brunner-Mendoza,&nbsp;Hilda Adriana Guerrero-Parra","doi":"10.1007/s11869-026-01979-6","DOIUrl":"10.1007/s11869-026-01979-6","url":null,"abstract":"<div>\u0000 \u0000 <p>The Mezquital Valley (Hidalgo, Mexico) faces a severe environmental crisis driven by intense industrial activity and chronic wastewater pollution, factors historically associated with high rates of respiratory and gastrointestinal morbidity. This study assessed the integral biological quality of the air through monitoring and metagenomic profiling of bioaerosols physically associated with PM₁₀ mass, using high-throughput sequencing of the 16 S rRNA gene (for bacteria) and Internal Transcribed Spacer (ITS) region (for fungi). The results revealed a high diversity of airborne microbiota with distinct taxonomic signatures reflecting a multi-source origin, including soil resuspension, hydro-aerosolization from contaminated water bodies, and industrial emissions. Multiple genera with significant pathogenic potential were identified, notably bacteria such as <i>Clostridium</i> and <i>Pseudomonas</i>, and fungi such as <i>Aspergillus</i>, <i>Penicillium</i>, <i>Alternaria</i>, and <i>Cladosporium</i>. The observed physical adhesion of inorganic particles to these biological propagules suggests a dangerous synergy; exposure to this complex mixture may enhance allergenicity and facilitate the deep penetration of pathogens into the respiratory system, thereby exacerbating health risks. These findings demonstrate that the airborne microbiome in industrial basins is a heterogeneous complex shaped by diverse local loads. Our study highlights the need for multifactorial environmental monitoring strategies that consider the interaction between chemical and biological agents to protect public health in the region.</p>\u0000 </div>","PeriodicalId":49109,"journal":{"name":"Air Quality Atmosphere and Health","volume":"19 4","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11869-026-01979-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147737768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantification of inhaled and deposited particulate matter from biomass fuel combustion in rural households of Assam, Northeast India","authors":"Pratibha Deka,&nbsp;Mebaaibok L Nonglait,&nbsp;Mayuri Chabukdhara,&nbsp;Raza Rafiqul Hoque","doi":"10.1007/s11869-026-01983-w","DOIUrl":"10.1007/s11869-026-01983-w","url":null,"abstract":"<div>\u0000 \u0000 <p>Understanding particulate matter (PM) dose and its deposition within the human respiratory tract is essential for evaluating exposure-related health risks and formulating effective mitigation strategies. The present study was structured around two objectives: (i) to quantify PM deposition across various age groups resulting from the use of different biomass fuels, specifically wood with bamboo, wood, mixed biomass fuels, bamboo, and cow dung; (ii) to estimate the inhaled PM mass generated during cooking activities. Real-time measurements of PM₁₀ (PM with an aerodynamic diameter of 10 µm or less), PM_2.5 (2.5 µm or less), and PM₁ (1 µm or less) were collected from 35 rural households of Assam, Northeast India. The Multiple-Path Particle Dosimetry (MPPD) model was then employed to simulate age-specific deposition patterns. The integration of field-based measurements of PM with MPPD model represents a key strength of the study, enabling more realistic and reliable estimation of age-specific PM deposition. Inhalation doses were calculated by integrating individual physiological parameters and activity levels. Results revealed that biomass fuel combustion produced PM concentrations 2.3 to 4.8 times higher than LPG. Among the various PM fractions, PM₁₀ showed the highest deposition in the respiratory tract, followed by PM_2.5 and PM₁. According to the MPPD model, PM₁ deposition was highest in children, while adult women were estimated to have elevated levels of PM₁₀ and PM₂.₅ deposition. </p>\u0000 </div>","PeriodicalId":49109,"journal":{"name":"Air Quality Atmosphere and Health","volume":"19 4","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147737769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ambient fine particulate matter, constituents, and ischemic heart disease mortality: a time-stratified case-crossover analysis in Central China","authors":"Ling-Shuang Lv,&nbsp;Xiu-Ying Liu,&nbsp;Yuan Liu,&nbsp;Zi-Tong Zhuang,&nbsp;Xin-Ye Zhang,&nbsp;Yue-Hua Hu,&nbsp;Ji Hu,&nbsp;Te-Hui Zeng,&nbsp;Li-Dong Gao,&nbsp;Xin Xia,&nbsp;Li Yin","doi":"10.1007/s11869-026-01947-0","DOIUrl":"10.1007/s11869-026-01947-0","url":null,"abstract":"<div>\u0000 \u0000 <p>Exposure to fine particulate matter (PM_2.5) and its constituents has been associated with disease-specific mortality, but the impact on ischemic heart disease (IHD) mortality remains unclear. This study aimed to evaluate the short-term effect of PM_2.5, its constituents on the risk of IHD mortality. We employed a time-stratified case-crossover design to evaluate the short-term effect between PM_2.5, its constituents and IHD deaths in Hunan Province, Central China, from January 2013 to December 2019. The PM_2.5 and its constituents, including black carbon (BC), organic matter (OM), sulfate (SO₄²⁻), ammonium (NH₄⁺), and nitrate (NO₃⁻), were estimated based on geocoded residential address. A distributed lag nonlinear model (DLNM) combined with conditional logistic regression model was employed to assess the associations of PM_2.5 and its constituents with IHD mortality. A total of 387,832 IHD deaths were recorded. The risk of IHD mortality increases with the elevation of PM_2.5 and its constituents. The strongest cumulative associations specific to the median concentrations of PM_2.5 and SO₄²⁻ were observed at Lag07, with odds ratios (ORs) of 1.115 (95% CI: 1.070, 1.161) and 1.120 (95% CI: 1.082, 1.159), respectively. For acute myocardial infarction (AMI), the cumulative associations of PM_2.5 and BC were strongest at Lag02, with OR values of 1.122 (95% CI: 1.042, 1.208) and 1.136 (95% CI: 1.054, 1.224), respectively. Subgroup analyses revealed that stronger associations between PM_2.5 exposure and IHD mortality were observed in elderly populations and during cold-month periods. If the median concentration of PM_2.5 decreases to WHO-recommended Air Quality Guidelines (AQG) level, the attributable IHD-related mortality risk would be reduced to 6.80%, 3.51% and 3.57%, respectively. Short-term exposure to PM_2.5 and its constituents showed significant associations with IHD-related mortality. Our findings have implications for optimizing air quality management policies to alleviate the influence of PM_2.5 and its constituents on IHD mortality.</p>\u0000 </div>","PeriodicalId":49109,"journal":{"name":"Air Quality Atmosphere and Health","volume":"19 4","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11869-026-01947-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147642890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiscale computational modeling reveals arrhythmogenic effects of combined atmospheric pollutants in human atria","authors":"Laura C. Palacio,&nbsp;Juan P. Ugarte,&nbsp;Javier Saiz,&nbsp;Catalina Tobón","doi":"10.1007/s11869-026-01982-x","DOIUrl":"10.1007/s11869-026-01982-x","url":null,"abstract":"<div>\u0000 \u0000 <p>Air pollution increases mortality and the risk of atrial arrhythmias through electrical and structural remodeling, including fibrosis, although the underlying mechanisms remain unclear. In this study, a human-based multiscale in silico framework was applied, integrating a human atrial myocyte model in two- and three-dimensional (2D and 3D) atrial models with varying degrees of fibrosis, to evaluate the impact of main atmospheric pollutants at different concentrations on atrial electrophysiology and arrhythmia generation. Pollutant-specific modulation of ionic currents was implemented to represent pollutant exposure. Electrogram signals were recorded using a virtual basket catheter. Pollutant exposure altered ionic currents, shortening the action potential plateau and duration in a concentration-dependent manner by up to 62% in the left atrium and 61% in the right atrium. In 2D models, vulnerability to reentry increased with pollutant concentration. In 3D models, pollutants promoted reentrant activity, producing more reentries and chaotic propagation as pollutant levels and fibrosis rose. Electrogram analysis revealed higher activation rates of up to 115% in the left atrium and 125% in the right atrium, particularly under structurally vulnerable conditions, accompanied by marked disorganization in the left atrium, which reinforces its dominant role in maintaining the rapid, irregular conduction characteristic of atrial fibrillation. Overall, air pollution can destabilize atrial electrical activity, enhancing susceptibility to reentry and irregular rhythms, particularly with fibrosis. These findings suggest that air pollutants may act as silent proarrhythmic modifiers, facilitating the initiation and maintenance of reentrant and irregular atrial rhythms, particularly in fibrotic atria.</p>\u0000 </div>","PeriodicalId":49109,"journal":{"name":"Air Quality Atmosphere and Health","volume":"19 4","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147642857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}