Cancer Control最新文献

{"title":"Stage III Non-small Cell Lung Cancer Resectability in a Country With Limited Diagnostic and Therapeutic Resources: A Colombian Expert Consensus.","authors":"Carlos A Carvajal, Stella I Martínez, Diego Pardo, Darwin Padilla, Mauricio Velásquez, Willfredy Castaño, Fernando Alvarado, Ricardo A Zapata-González, Jairo Zuluaga, Ricardo E Bruges, Leonardo Rojas, Clarena Zuluaga, Lucia Viola, Ana M Callejas, Alejandro González-Motta, Eduardo Guerrero, Fernando Rodríguez, José R Pieschacón, Wagner-Gutiérrez Nicolle, Natalia Sánchez, Andrés F Cardona","doi":"10.1177/10732748261457714","DOIUrl":"10.1177/10732748261457714","url":null,"abstract":"<p><p>IntroductionThe role of surgery in stage III non-small cell lung cancer (NSCLC), particularly in the presence of ipsilateral mediastinal lymph node involvement (N2), remains controversial. Criteria for resectability differ among existing clinical guidelines and are particularly difficult to apply in countries with limited access to advanced diagnostic and therapeutic resources. Accordingly, this Colombian expert consensus aimed to define resectability criteria for stage III NSCLC within real-world resource-limited contexts.MethodsThis expert consensus statement was developed by a multidisciplinary panel of Colombian experts following the European Society for Medical Oncology (ESMO) Standardized Operating Procedures. A structured literature review was conducted to inform structured clinical questions addressing resectability across different stage III NSCLC scenarios. Recommendations were formulated through iterative discussion and anonymous voting, with levels of evidence and grades of recommendation assigned according to ESMO methodology.ResultsConsensus was achieved for resectability in selected scenarios of single-station, non-bulky N2 disease, particularly in T1-2 tumors and T3 satellite lesions. Multi-station or bulky N2 disease was more frequently classified as potentially resectable in T1-2 tumors, with greater variability in expert agreement. For T4 disease, resectability depended on the pattern of invasion, nodal burden, and the feasibility of complete resection within a multimodality treatment strategy. Invasive restaging after induction therapy was strongly supported in selected scenarios. Across all recommendations, the panel emphasized the importance of multidisciplinary evaluation and individualized decision-making.ConclusionsThis consensus provides practical, context-specific recommendations on the resectability of stage III NSCLC in settings with limited diagnostic and therapeutic resources. By integrating available evidence with expert judgment, these recommendations aim to support multidisciplinary teams in selecting appropriate candidates for surgical management as part of multimodality therapy.</p>","PeriodicalId":49093,"journal":{"name":"Cancer Control","volume":"33 ","pages":"10732748261457714"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13242608/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148176998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health Literacy, Socioeconomic Status, and Health Behavior Adherence Among Young Adult Survivors With Cancer: A Cross-Sectional Study.","authors":"Sandra Soca Lozano, Ana Paula S Rodrigues, Robert F Dedrick, Kathy Bradley-Klug, Marilyn Stern","doi":"10.1177/10732748261452792","DOIUrl":"10.1177/10732748261452792","url":null,"abstract":"<p><p>IntroductionYoung adults (YAs) with cancer are at elevated risk for chronic conditions and late effects, making adherence to healthy eating and physical activity guidelines a key survivorship priority. Health literacy is theorized to support guideline-concordant behaviors, yet its role in YA oncology remains unclear, particularly in the context of socioeconomic and environmental influences. This study aimed to characterize health literacy among YA cancer survivors and examine its association with adherence to healthy eating and physical activity guidelines, after accounting for sociodemographic/clinical factors.Methods273 YAs (18-39 years) receiving care at an NCI-designated cancer center completed an anonymous online survey. Measures included the BRIEF Health Literacy Tool, the Rapid Eating Assessment for Participants-Short Version, the Rapid Assessment of Physical Activity, the Social Support and Eating Habits and Exercise Surveys, and self-reported sociodemographic and clinical variables. Analyses included descriptive statistics, bivariate correlations, and multiple regression models controlling for variables of interest.ResultsMost participants demonstrated adequate health literacy, and health literacy was positively associated with education and household income. However, health literacy was not significantly associated with adherence to healthy eating or physical activity guidelines. Higher BMI was associated with lower adherence to healthy eating, whereas having a college degree or higher and family participation in exercise were associated with adherence to healthy eating. For physical activity, friends' discouragement of healthy eating and family participation in exercise were associated with better adherence.ConclusionsIn this relatively well-educated, higher-income YA oncology sample, health literacy was generally adequate and did not independently predict adherence to healthy eating or physical activity guidelines. These findings suggest that, in higher socioeconomic status settings, structural and social determinants may outweigh the influence of health literacy on lifestyle behaviors. Survivorship interventions should combine health literacy-sensitive communication with multilevel strategies targeting weight management, food/activity environments, and family/peer support.</p>","PeriodicalId":49093,"journal":{"name":"Cancer Control","volume":"33 ","pages":"10732748261452792"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13180213/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147950131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond the Hospital: Understanding Psychosocial Support Uptake for Adolescents and Young Adults With Cancer in Community-Based and Nonprofit Programs.","authors":"Christabel K Cheung, Nishtha Gupta, Haelim Lee, Susan K Parsons, Wendy Griffith, Gail Betz, Maria Gianelle, Adishree Nayak, Sophie C Lu, Bria N Thomas, Kimberly A Miller, David R Freyer, Melissa Beauchemin, Anao Zhang, Alexandra Psihogios, Michael E Roth","doi":"10.1177/10732748261450729","DOIUrl":"10.1177/10732748261450729","url":null,"abstract":"<p><p>IntroductionAdolescents and young adults (AYAs) with cancer experience substantial psychosocial distress, yet participation in supportive oncology services remains low. Community-based and nonprofit programs outside hospital systems provide essential developmentally appropriate supportive care, particularly during transitions to surveillance and longer-term follow-up, yet determinants of uptake in these settings are understudied. We examined program leaders' perspectives on participation gaps and strategies to strengthen equitable engagement beyond the hospital.MethodsWe conducted a qualitative interview study using semi-structured interviews with leaders of community-based and nonprofit AYA psychosocial support programs in the United States and Canada (N = 21). A structured environmental scan and expert verification yielded a 132-program sampling frame; 33 organizations expressed interest. Interviews were analyzed using the Framework Method, organized deductively with the Social Ecological Model and the Theoretical Domains Framework and refined inductively. Transcripts were double-coded, and themes were developed through team consensus.ResultsLeaders described multilevel determinants of uptake, including fragmented referral pathways, limited organizational capacity and program visibility, stigma and safety concerns, and misalignment between program structures and early adulthood realities. Timing was a cross-cutting determinant: engagement was described as least feasible during intensive treatment and especially vulnerable at transitions such as treatment completion and early survivorship, when routines shift and clinical contact decreases. A central finding was wide variability in sociodemographic data collection. Many programs did not routinely collect participant sociodemographic information, limiting their ability to identify representation gaps and tailor outreach. Leaders prioritized strategies including ethical sociodemographic data collection, trust-based community partnerships, clinician-facing referral workflow supports, and shared infrastructure for repeated needs assessment and resource matching.ConclusionLow participation was shaped by implementation conditions, not individual disinterest. Improving equitable uptake may require investments in referral and re-referral workflows across care transitions, equity-monitoring infrastructure, and community-embedded approaches that build trust and improve discoverability beyond the hospital.</p>","PeriodicalId":49093,"journal":{"name":"Cancer Control","volume":"33 ","pages":"10732748261450729"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13172688/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147870198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parks and Recreation in Cancer Prevention: Bringing Cancer Center Outreach and Engagement Initiatives to Public Spaces Through Partnership With Local Governments.","authors":"Katherine Oestman, Margaret Raber, Karen Basen-Engquist, Brad Love, Trina Rodriguez, Clifford Hatch, Louis Moore, Howard Frumkin, Ruth Rechis","doi":"10.1177/10732748261425732","DOIUrl":"10.1177/10732748261425732","url":null,"abstract":"<p><p>IntroductionPublic parks are an integral part of the built environment, with a considerable role to promote public health by advancing physical health, mental wellness and overall quality of life. The potential exists for parks and greenspace to contribute to cancer control and prevention, and local park and recreation departments (PARDs) are natural partners for Comprehensive Cancer Centers as they pursue Community Outreach and Engagement activities. However there is a lack of research on best practices for structuring these relationships to ensure success.MethodsA collaboration framework for Comprehensive Cancer Centers and PARDs was informed by the Exploration, Preparation, Implementation, Sustainment (EPIS) model of implementation science. The model was applied by a large cancer center to 3 implementation sites in the greater Houston area. A set of shared measures were developed and tracked across all sites.ResultsThree PARDs implemented 5 unique active living and sun safety evidence-based interventions (EBIs) of 2 main types, educational focused interventions (to increase knowledge and change behavior) and infrastructure interventions (to modify the physical environment). Three-quarters (75%, 9/12) of all educational EBIs across communities were sustained by the PARDs one or more years after the funding ended; all (13/13) infrastructure projects were completed during the active implementation period and sustained by the PARDs. A range of 10-39 partners supported the work of the PARDs.ConclusionThe 3 collaboration sites each offer a case study on the impact and effectiveness of health promotion across sectors to impact modifiable risk factors for cancer, leveraging the replicable EPIS model. Partnership is critical to both sectors to advance community health and impact.</p>","PeriodicalId":49093,"journal":{"name":"Cancer Control","volume":"33 ","pages":"10732748261425732"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12949261/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147291792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Voluntary Wheel Running Modulates Tumour-Associated Macrophage Polarization in Breast Cancer Lung Metastases of Old BALB/C Mice, in a Dose-dependent Manner.","authors":"Patrick Henry Sebastian Sitjar, Li Yen Chong, Warren Ladiges, Joe Poh Sheng Yeong, Jorming Goh","doi":"10.1177/10732748261448644","DOIUrl":"10.1177/10732748261448644","url":null,"abstract":"<p><p>IntroductionTumour-associated macrophages (TAMs) are highly plastic immune cells that polarize into tumour killing M1-like or tumour promoting M2-like macrophages depending on signals in the tumour microenvironment (TME). Exercise training may induce TAMs towards M1-like phenotypes to slow cancer progression and metastasis. In this study, we explored the effects of wheel running in tumour-challenged mice by analysing immune cell expression in metastatic tissues.MethodsArchival breast cancer lung metastases tissues of old BALB/c mice were subjected to multiplex immunofluorescence (mIHC) to quantify immune cell subsets. The immune cell expressions were then analysed against the primary mammary tumour mass, metastatic lung tissue area, as well as distance ran before and after tumour implant for the exercise mice.ResultsBased on the mIHC results from control (n=9) and exercise (n=10) mice tissues, wheel running did not significantly alter immune cell expressions relative to lung metastases or mammary tumour. Correlations between immune cell expression and the metastatic foci area revealed significant trends. Of note, F4/80⁺ CD163⁺ or M2-like macrophage expression is positively correlated for both control (r=0.835, <i>p</i>=0.005) and exercise (r=0.669, <i>p</i>=0.034). The F4/80⁺ cells or overall macrophage expression was only positively correlated in the control (r=0.764, <i>p</i>=0.017) group. Likewise, the mammary tumour mass was positively correlated in the control group (r=0.834, <i>p</i>=0.010) but not in the exercise group. Interestingly, F4/80⁺ CD86⁺ or M1-like macrophage cells (r=0.758, <i>p</i>=0.011) and M1/M2 ratio (r=0.642, <i>p</i>=0.045) were only significantly correlated with mean distances ran after tumour implant.ConclusionVoluntary wheel running may shift the expression of metastatic TAMs towards anti-tumour M1-like macrophages in a dose-dependent manner after tumour challenge. This study demonstrates the importance and potential of implementing exercise training in combination with immunotherapy to treat metastatic breast cancer.</p>","PeriodicalId":49093,"journal":{"name":"Cancer Control","volume":"33 ","pages":"10732748261448644"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13550861/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148888849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Online Learning to Support Culturally Safe Communication with First Nations Australians in Radiation Therapy: A Pre-Post Intervention Study.","authors":"L Stoll, K Carter, S Jahan, H M Dhillon, J Cunningham, S Sabesan, G K B Halkett, S Baxi, G Kar, J Shaw, S Smith, M Penniment, A Stoneley, L McGhee, G Garvey","doi":"10.1177/10732748261423252","DOIUrl":"10.1177/10732748261423252","url":null,"abstract":"<p><p>IntroductionCulturally safe communication is essential for supporting First Nations Australians undergoing radiation therapy. First Nations Australian patients, however, often face barriers in accessing culturally safe communication and cancer care. This study evaluates changes in healthcare professionals' (HCPs) confidence, skills, and knowledge in culturally safe communication with First Nations cancer patients after completing an online learning program.MethodsThis single group pre-post intervention study recruited HCPs from three regional Australian cancer centres. Pre- and post-training surveys, administered via Qualtrics, assessed self-reported confidence, knowledge, and communication skills for engaging with First Nations radiation therapy patients. Participants completed an online learning program consisting of three self-directed modules focused on cultural competency, health literacy and communication, and application of an Indigenous radiation therapy talking book resource. The post-training survey also included module evaluation items. Pre- and post-training data were analysed using paired-sample t-tests (α = 0.05). Descriptive statistics and content analysis were applied to evaluate participant feedback.ResultsOf the 49 participants recruited, 38 participated in this study, most were non-Indigenous (94.7%), 52.6% were radiation therapists, and 65.8% reported seeing between 11-50 First Nations Australian patients annually. The participants' mean confidence in communicating with First Nations Australian patients increased from 3.50 to 4.03 (<i>p</i> = 0.006), and preparedness to support patient needs rose from 3.55 to 3.95 (<i>p</i> = 0.04). The online modules were highly rated as good or excellent by 95% of participants.ConclusionThe findings demonstrate that tailored online learning modules can significantly enhance HCP's self-reported confidence, skills, and knowledge in communicating with First Nations cancer patients receiving radiation therapy. Integrating training into routine practice may promote more culturally responsive cancer care, strengthening engagement and support for First Nations Australian radiation therapy patients.</p>","PeriodicalId":49093,"journal":{"name":"Cancer Control","volume":"33 ","pages":"10732748261423252"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12966548/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147370518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Prediction of Distant Metastasis in Renal Cell Carcinoma Using Machine Learning Algorithms: A Multicenter Cohort Study\".","authors":"","doi":"10.1177/10732748261493214","DOIUrl":"https://doi.org/10.1177/10732748261493214","url":null,"abstract":"","PeriodicalId":49093,"journal":{"name":"Cancer Control","volume":"33 ","pages":"10732748261493214"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149041692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microplastic Pollution and Risk of Cancer: A Prospective Study Based on UK Biobank.","authors":"Simeng You, Zhiyi Wang, Chuandong Liu, Liting Zhong, Lei Yang, Zhenqiu Xia, Jian Wang, Yuan Fang, Jingyuan Sun, Chuanhui Cao, Jianghua Deng, Yan Lin, Qingxiang Lai","doi":"10.1177/10732748261493417","DOIUrl":"https://doi.org/10.1177/10732748261493417","url":null,"abstract":"<p><p>IntroductionVarious industrial pollutants have been implicated in tumorigenesis. However, the cancer risk associated with microplastics, a pervasive environmental pollutant, remains poorly understood. This study aimed to evaluate the association between basin-level environmental microplastic contamination and cancer incidence.MethodsIn this secondary analysis of a prospective UK Biobank cohort, 378,985 participants were linked to basin-level river microplastic measurements using residential coordinates. The 2019 measurements were treated as an ecological proxy for regional environmental microplastic contamination. Participants were categorized into low, moderate, or high exposure groups, and Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs).ResultsDuring a mean follow-up of 12.39 years, 37,322 participants developed at least one of the 24 cancer outcomes. Compared with participants in low-exposure basins, participants in high-exposure basins had increased risks of liver cancer (HR, 1.252; 95% CI, 1.031-1.520), colon cancer (HR, 1.167; 95% CI, 1.088-1.252), and lung cancer (HR, 1.198; 95% CI, 1.095-1.309). These estimates represent modest relative increases and should be interpreted alongside absolute event counts and confidence intervals.ConclusionsHigher basin-level river microplastic contamination was associated with modestly higher incidence of selected digestive and respiratory cancers.Patient or Public ContributionThis study was a secondary analysis of de-identified data from the prospective UK Biobank cohort. Patients, service users, and members of the public were not directly involved in the design, analysis, interpretation, or preparation of this study.</p>","PeriodicalId":49093,"journal":{"name":"Cancer Control","volume":"33 ","pages":"10732748261493417"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149076407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Awareness, Accessibility, Authenticity, and Appropriateness: Multilevel Determinants of Research Engagement Among Underrepresented AYA Cancer Survivors.","authors":"Lauren V Ghazal, Jacob Dogtir, J Lea Brown, Rachel Brandon, Meiyan Chen, Nina Francis-Levin, Robin Voisine, Christabel K Cheung, Addison Rappaport, Brad Zebrack, Anao Zhang","doi":"10.1177/10732748261494049","DOIUrl":"10.1177/10732748261494049","url":null,"abstract":"<p><p>IntroductionAdolescent and young adult (AYA) cancer survivors (ages 15-39 at diagnosis) who identify as sexual and gender minorities [SGM] and/or Black, Indigenous, and Persons of Color [BIPOC]) experience survivorship challenges compounded by discrimination, mistrust, and culturally incongruent care. These factors contribute to inequities in health outcomes and research participation. This qualitative study explored the experiences of underrepresented AYA cancer survivors and key stakeholders in research engagement.MethodsParticipants were recruited through five US-based academic cancer centers and five community-based organizations. Interviews were conducted via two-way video conferencing, and transcripts were analyzed using inductive thematic analysis. A Community Advisory Panel (CAP) consisting of 10 underrepresented AYAs co-developed semi-structured interview guides and contributed to study interpretation.ResultsTwenty-eight participants completed interviews (n=22 survivors, n=5 healthcare professionals, n=1 caregiver). Participants identified as BIPOC (64.3%), SGM (46.4%), and both (23.1%). Four themes shaped research engagement: (1) Awareness (visibility and pathways to research opportunities); (2) Accessibility (emotional, logistical, and institutional feasibility); (3) Authenticity (trust and perceived legitimacy); and (4) Appropriateness (alignment with identity and lived context).ConclusionResearch engagement among underrepresented AYA cancer survivors is shaped by interconnected multilevel factors. Advancing equity requires moving beyond recruitment to redesign research approaches that enhance visibility, reduce structural barriers, build trust, and align participation with AYAs' identities and lived experiences.</p>","PeriodicalId":49093,"journal":{"name":"Cancer Control","volume":"33 ","pages":"10732748261494049"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149076448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incident Delirium in Hospitalized Cancer Patients: Clinical Factors Associated With Mortality and Prolonged Hospitalization.","authors":"Brandon Dyer, Joel Kallarackal, Robert Baldwin, Aasha Hoogland, Kenneth Snell, Heather Jim, Jeffrey Huang","doi":"10.1177/10732748251411005","DOIUrl":"10.1177/10732748251411005","url":null,"abstract":"<p><p>IntroductionDelirium is a common neuropsychiatric syndrome in hospitalized cancer patients that is associated with poor outcomes such as increased mortality and prolonged hospital stays. However, clinical predictors of delirium-related outcomes in acutely hospitalized, non-surgical cancer patients remain underexplored.MethodsThis was a retrospective cohort study of hospitalized cancer patients at a tertiary-care oncology center between May 2024 and August 2024 who developed delirium. Delirium was defined by a positive Confusion Assessment Method (CAM) screen. Patients who were admitted for surgical reasons or had an altered mental status (AMS) present on admission were excluded. Patient demographics and clinical factors associated with their hospital course were abstracted from electronic medical records. Primary outcomes analyzed were in-hospital mortality, delirium duration, and length of stay (LOS).ResultsA total of 126 patients met the inclusion criteria from a screening pool of 219 patients. The median age was 65.5 years (IQR: 58,73) and 65 patients (51.6%) were male. Nearly half (43.7%) had hematologic malignancies. Twenty patients (15.9%) died during hospitalization. Non-survivors had significantly lower albumin (3.0 vs 3.5 g/dL, <i>P</i> < 0.01), platelets (86 vs 190 × 10³/µL, <i>P</i> = 0.031), BMI (23.3 vs 27.1 kg/m², <i>P</i> = 0.046), and higher LDH (515 vs 273 U/L, <i>P</i> = 0.044). They also experienced delirium for longer (median 3 vs 1 days, <i>P</i> = 0.011), had a higher incidence of sepsis (27% vs 14%, <i>P</i> = 0.015), and received more benzodiazepines before delirium onset (0.152 vs 0.045 mg/day, <i>P</i> = 0.040). Prolonged delirium (>1 day) was associated with similar factors. LOS positively correlated with delirium duration and sedative exposure, and inversely with hemoglobin and platelet counts.ConclusionsDelirium in hospitalized cancer patients may reflect underlying physiological frailty that increases susceptibility to mortality from metabolic derangements, malnutrition, sepsis, and sedative exposure. Early identification of these high-risk clinical factors in cancer inpatients with delirium may help mitigate risks posed by these abnormalities.</p>","PeriodicalId":49093,"journal":{"name":"Cancer Control","volume":"33 ","pages":"10732748251411005"},"PeriodicalIF":2.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12775293/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145907176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}