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Analysis of Demographic Associations and Survival Outcomes in Patients With Colorectal Cancer at a Tertiary Care Hospital in Pakistan. A Retrospective Cross-Sectional Study. 巴基斯坦三级医院结直肠癌患者的人口统计学关联和生存结果分析一项回顾性横断面研究。
IF 2.5 4区 医学
Cancer Control Pub Date : 2025-01-01 Epub Date: 2025-06-15 DOI: 10.1177/10732748251351423
Muhammad Osama, Hira Moosa, Hussain Sohail Rangwala, Burhanuddin Sohail Rangwala, Ayesha Farrukh, Sakeena Fayaz, Muhammad Nalwala, Muhammad Ashir Shafique, Mazhar Iqbal
{"title":"Analysis of Demographic Associations and Survival Outcomes in Patients With Colorectal Cancer at a Tertiary Care Hospital in Pakistan. A Retrospective Cross-Sectional Study.","authors":"Muhammad Osama, Hira Moosa, Hussain Sohail Rangwala, Burhanuddin Sohail Rangwala, Ayesha Farrukh, Sakeena Fayaz, Muhammad Nalwala, Muhammad Ashir Shafique, Mazhar Iqbal","doi":"10.1177/10732748251351423","DOIUrl":"10.1177/10732748251351423","url":null,"abstract":"<p><p>IntroductionColorectal cancer (CRC) is the third most common cancer worldwide, with higher rates in industrialized countries. By 2030, the number of CRC cases may rise by 60%, reaching 2.2 million new cases and 1.1 million deaths. In 2020, CRC accounted for 1.93 million new cases and 940,000 deaths, with the highest prevalence in New Zealand, Australia, and Europe, while lower rates were observed in Southern Asia and Africa. In Pakistan, CRC is the second most common cancer, accounting for 4.8% of all diagnoses. The risk factors include family history, smoking, genetic syndromes, and diet. Screening is recommended from the age of 45. Advances in immunotherapy, chemoradiotherapy, and targeted therapies have improved survival rates. This five-year study analyzed CRC cases at a Pakistani hospital to identify associations between various clinical and demographic factors and mortality.MethodsThis retrospective study, conducted at the Department of Surgery at Jinnah Post Medical Graduate Centre, Karachi, included 121 confirmed CRC patients from July 2022 to August 2024. Data from electronic medical records included diagnostic procedures and treatment histories. Tumor location and staging were determined according to the TNM staging system. Statistical analysis identified trends in tumour location, disease stage, and demographics.ResultsAmong the 121 patients with CRC, the majority were middle-aged (39.7%) and male (62%). The common symptoms included abdominal pain (65.3%) and constipation (43.8%). Most patients were in Duke stage C (42.1%), with metastasis in 7.2% of cases. Open surgery was performed in 71.9% of patients. Significant associations were found between vomiting, abdominal distention, fever, and mortality, as well as between cancer type and surgical method.ConclusionCRC is increasingly common in middle-aged individuals, and early onset CRC is increasing in Pakistan. Targeted screening and personalized treatment are crucial, and further research is needed to address the increasing incidence, especially in younger populations.</p>","PeriodicalId":49093,"journal":{"name":"Cancer Control","volume":"32 ","pages":"10732748251351423"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12174713/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144303410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tumor Mutation Signature Reveals the Risk Factors of Lung Adenocarcinoma with EGFR or KRAS Mutation. 肿瘤突变特征揭示EGFR或KRAS突变肺腺癌的危险因素。
IF 2.5 4区 医学
Cancer Control Pub Date : 2025-01-01 DOI: 10.1177/10732748241307363
Jialiang Wang, Chang Guo, Jiexiao Wang, Xiaopeng Zhang, Jian Qi, Xiang Huang, Zongtao Hu, Hongzhi Wang, Bo Hong
{"title":"Tumor Mutation Signature Reveals the Risk Factors of Lung Adenocarcinoma with <i>EGFR</i> or <i>KRAS</i> Mutation.","authors":"Jialiang Wang, Chang Guo, Jiexiao Wang, Xiaopeng Zhang, Jian Qi, Xiang Huang, Zongtao Hu, Hongzhi Wang, Bo Hong","doi":"10.1177/10732748241307363","DOIUrl":"https://doi.org/10.1177/10732748241307363","url":null,"abstract":"<p><strong>Introduction: </strong><i>EGFR</i> and <i>KRAS</i> mutations are frequently detected in lung adenocarcinoma (LUAD). Tumor mutational signature (TMS) determination is an approach to identify somatic mutational patterns associated with pathogenic factors. In this study, through the analysis of TMS, the underlying pathogenic factors of LUAD with <i>EGFR</i> and <i>KRAS</i> mutations were traced.</p><p><strong>Methods: </strong>This was a retrospective study. TMS of LUAD with <i>KRAS</i> and <i>EGFR</i> mutations from the TCGA, OncoSG, and MSK datasets was determined by two bioinformatics tools, namely the \"MutationalPatterns\" and \"FitMS\" packages. Elevated microsatellite alterations at selected tetranucleotide repeats (EMAST) of LUAD clinical specimens was analyzed using capillary electrophoresis.</p><p><strong>Results: </strong>In LUAD with <i>KRAS</i> mutations, TMS analysis indicated that the smoking-related SBS4 signature was enriched. For LUAD with <i>EGFR</i> L858R mutation, the smoking-related SBS4 signature was enriched in the Western population from the TCGA database; however, the smoking-related SBS4 signature was not obvious in Asian LUAD patients. LUAD with <i>EGFR</i> exon19 deletion (19Del) exhibited stronger SBS15 signature, which was related to defective DNA mismatch repair. Capillary electrophoresis analysis showed that an EMAST locus was frequently instable in LUAD with <i>EGFR</i> 19Del. Different from the Western population, Asian LUAD patients with <i>EGFR</i> mutations exhibited the enrichment of SBS1, SBS2, and SBS13 signatures, which were associated with the endogenous mutation process of cytidine deamination.</p><p><strong>Conclusions: </strong>TMS analysis reveals that smoking is associated with LUAD with <i>KRAS</i> mutations. Defective DNA mismatch repair and endogenous cytidine deamination are associated with LUAD with <i>EGFR</i> mutations, especially for the <i>EGFR</i> 19Del. The endogenous mutational process is stronger in Asian LUAD patients than Western LUAD patients.</p>","PeriodicalId":49093,"journal":{"name":"Cancer Control","volume":"32 ","pages":"10732748241307363"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142933385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Can the Use of Artificial Intelligence-Generated Content Bridge the Cancer Knowledge Gap? A Longitudinal Study With Health Self-Efficacy as a Mediator and Educational Level as a Moderator. 使用人工智能生成的内容能弥合癌症知识鸿沟吗?以健康自我效能为中介、教育程度为调节因子的纵向研究。
IF 2.5 4区 医学
Cancer Control Pub Date : 2025-01-01 DOI: 10.1177/10732748251319487
Zehang Xie, Ru Chen, Wenjuan Ding
{"title":"Can the Use of Artificial Intelligence-Generated Content Bridge the Cancer Knowledge Gap? A Longitudinal Study With Health Self-Efficacy as a Mediator and Educational Level as a Moderator.","authors":"Zehang Xie, Ru Chen, Wenjuan Ding","doi":"10.1177/10732748251319487","DOIUrl":"10.1177/10732748251319487","url":null,"abstract":"<p><strong>Objectives: </strong>The cancer knowledge gap represents a significant disparity in awareness and understanding of cancer-related information across different demographic groups. Leveraging Artificial Intelligence-Generated Content (AIGC) offers a promising approach to personalize health education and potentially bridge this gap. This study aimed to evaluate the potential of AIGC to bridge the cancer knowledge gap, assessing the roles of health self-efficacy as a mediator and educational level as a moderator in this relationship.</p><p><strong>Methods: </strong>A 6-month longitudinal study was conducted using online surveys distributed to undergraduate students in non-medical disciplines at one university and graduate students in medical specialties at another university in China. The study assessed the frequency of AIGC use, health self-efficacy, and cancer knowledge at two time points.</p><p><strong>Results: </strong>The results indicated that AIGC use significantly enhanced cancer knowledge levels and health self-efficacy over time. Educational level notably moderated the effects of AIGC use, with non-medical undergraduate students showing greater gains in knowledge and self-efficacy. Additionally, health self-efficacy mediated the relationship between AIGC use and cancer knowledge, underscoring the importance of health self-efficacy. The study confirms the efficacy of AIGC in narrowing the cancer knowledge gap and enhancing health self-efficacy, particularly among students with lower initial medical knowledge.</p><p><strong>Conclusion: </strong>These findings highlight the potential of integrating AIGC tools in cancer education and public health interventions, particularly for individuals at different educational levels. By tailoring digital health resources to varying educational needs, these interventions could enhance cancer knowledge acquisition, improve health self-efficacy, and contribute to better cancer prevention and control outcomes.</p>","PeriodicalId":49093,"journal":{"name":"Cancer Control","volume":"32 ","pages":"10732748251319487"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11811976/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143392226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In reply to: From Diagnosis to Survivorship: How the Tumor Boards Facilitation Forum (TEFF) Shapes the Breast Cancer Journey in Pakistan. 回复从诊断到生存:肿瘤委员会促进论坛(TEFF)如何塑造巴基斯坦的乳腺癌之旅。
IF 2.5 4区 医学
Cancer Control Pub Date : 2025-01-01 Epub Date: 2025-04-04 DOI: 10.1177/10732748251331745
Muhammad Abdul Rehman
{"title":"In reply to: From Diagnosis to Survivorship: How the Tumor Boards Facilitation Forum (TEFF) Shapes the Breast Cancer Journey in Pakistan.","authors":"Muhammad Abdul Rehman","doi":"10.1177/10732748251331745","DOIUrl":"10.1177/10732748251331745","url":null,"abstract":"","PeriodicalId":49093,"journal":{"name":"Cancer Control","volume":"32 ","pages":"10732748251331745"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12032452/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143781831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Whole-Brain Radiotherapy Simultaneous Integrated Boost Intensity-Modulated Radiotherapy Combined With Anlotinib in the Treatment of Brain Metastases. 全脑放疗同步综合增强调强放疗联合安洛替尼治疗脑转移瘤。
IF 2.5 4区 医学
Cancer Control Pub Date : 2025-01-01 DOI: 10.1177/10732748251319489
Wei Tao, Chunyu Jiang, Jiaqi Xie, Wei Liu, Shuan Wang, Jianyu Zhang, Xue Qiao, Jingyi Yu, Ting Jia, Yuandong Cao
{"title":"Whole-Brain Radiotherapy Simultaneous Integrated Boost Intensity-Modulated Radiotherapy Combined With Anlotinib in the Treatment of Brain Metastases.","authors":"Wei Tao, Chunyu Jiang, Jiaqi Xie, Wei Liu, Shuan Wang, Jianyu Zhang, Xue Qiao, Jingyi Yu, Ting Jia, Yuandong Cao","doi":"10.1177/10732748251319489","DOIUrl":"10.1177/10732748251319489","url":null,"abstract":"<p><strong>Introduction: </strong>Whole-brain radiotherapy simultaneous integrated boost intensity-modulated radiotherapy (WBRT + SIB-IMRT) is a potential treatment approach for brain metastasis (BM) that may result in improved overall survival (OS). However, the safety and efficacy of WBRT + SIB-IMRT combined with anlotinib for BM treatment remain uncertain.</p><p><strong>Methods: </strong>We retrospectively compared the safety and efficacy of anlotinib + WBRT + SIB-IMRT with those of WBRT + SIB-IMRT in patients with BM from 2019 to 2022. The adverse reaction type and grade, intracranial objective response rate (iORR), intracranial disease control rate (iDCR), OS, and intracranial progression-free survival (iPFS) of anlotinib + WBRT + SIB-IMRT were compared with those of WBRT + SIB-IMRT alone.</p><p><strong>Results: </strong>In total, 63 patients received either anlotinib + WBRT + SIB-IMRT or WBRT + SIB-IMRT alone (n = 31 and 32, respectively). No significant clinical differences were found between the two groups. The iORR and iDCR were higher in the anlotinib + WBRT + SIB-IMRT group than in the WBRT + SIB-IMRT group. The median iPFS and median OS of the 31 patients who received anlotinib + WBRT + SIB-IMRT were 14.5 and 18.9 months, respectively, whereas the median iPFS and median OS for the 32 patients who received WBRT + SIB-IMRT alone were 11.4 and 14.9 months, respectively. Thus, anlotinib combined with WBRT + SIB-IMRT increased the duration of iPFS, but not OS. iPFS was influenced by the Karnofsky Performance Status (KPS) score, age, extracranial distant metastasis, and addition of anlotinib to treatment, whereas OS correlated with age, extracranial distant metastasis, and KPS score. No treatment-related adverse events of grade 3 or higher occurred in either group.</p><p><strong>Conclusions: </strong>Anlotinib combined with WBRT + SIB-IMRT is effective for BM and is well tolerated by patients.</p>","PeriodicalId":49093,"journal":{"name":"Cancer Control","volume":"32 ","pages":"10732748251319489"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11829290/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143416751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Persistent Health Inequalities in the Burden of Gastrointestinal Cancers Among the Elderly From 1990 to 2021: A Population-Based Study. 1990 至 2021 年老年人胃肠道癌症负担中持续存在的健康不平等:一项基于人口的研究。
IF 2.5 4区 医学
Cancer Control Pub Date : 2025-01-01 Epub Date: 2025-04-04 DOI: 10.1177/10732748251330693
Zijian Qiu, Shengjian Yu, Ying Lou, Xiaofeng Ma, Feng Xuan
{"title":"Persistent Health Inequalities in the Burden of Gastrointestinal Cancers Among the Elderly From 1990 to 2021: A Population-Based Study.","authors":"Zijian Qiu, Shengjian Yu, Ying Lou, Xiaofeng Ma, Feng Xuan","doi":"10.1177/10732748251330693","DOIUrl":"10.1177/10732748251330693","url":null,"abstract":"<p><p>IntroductionGlobally, aging populations highlight gastrointestinal cancers as a major public health concern. Our study aimed to quantify the trends and inequalities in the burden of gastrointestinal cancers among the elderly from 1990 to 2021.MethodsUtilizing the 2021 Global Burden of Diseases (GBD) database, our secondary analysis targeted disability-adjusted life-years (DALYs) for gastrointestinal cancers among the elderly (60+). DALYs are a composite indicator of health loss, calculated as the sum of years of life lost due to premature mortality and years lived with disability. The age-standardized DALYs rate (ASDR) was calculated using the direct standardization method. Trends were quantified by estimated annual percentage change in ASDR. The Slope index of inequality (SII) and concentration index were employed to quantify absolute and relative health inequalities.ResultsIn 2021, colon and rectum cancer (CRC) had the highest global ASDR among the elderly, followed by stomach cancer (SC), esophageal cancer (EC), pancreatic cancer (PC), liver cancer (LC), and gallbladder and biliary tract cancer (GBTC). Between 1990 and 2021, ASDR for gastrointestinal cancers decreased globally, except for PC. Health inequalities exhibited varied patterns: EC showed a worsening inequality among lower SDI countries in SII, while SC experienced a shift to higher burden among lower SDI countries in SII. LC displayed an improving inequality among lower SDI countries in SII. The concentration index for EC, SC, and LC demonstrated a transition towards higher SDI countries. CRC, GBTC, and PC maintained a higher burden in higher SDI countries, while the SII and concentration index reflected improvements in inequality.ConclusionFrom 1990 to 2021, a substantial decline was observed in the burden of gastrointestinal cancers, except for PC. Persistent and evolving health inequalities highlight the need for comprehensive, multi-level interventions to reduce disparities and achieve equitable health outcomes for all.</p>","PeriodicalId":49093,"journal":{"name":"Cancer Control","volume":"32 ","pages":"10732748251330693"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11970069/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143781833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evolving Dynamics of Colorectal Cancer in High Socio-Demographic Regions. 结直肠癌在高社会人口统计学地区的演变动态。
IF 2.5 4区 医学
Cancer Control Pub Date : 2025-01-01 DOI: 10.1177/10732748251321672
Laalithya Konduru, Simranjeet Singh Dahia, Claudia Szabo, Savio G Barreto
{"title":"Evolving Dynamics of Colorectal Cancer in High Socio-Demographic Regions.","authors":"Laalithya Konduru, Simranjeet Singh Dahia, Claudia Szabo, Savio G Barreto","doi":"10.1177/10732748251321672","DOIUrl":"10.1177/10732748251321672","url":null,"abstract":"<p><strong>Background: </strong>Colorectal cancer (CRC) poses a significant global health challenge, with evolving demographic trends emphasizing the need for accurate forecasting models. Existing forecasting models lack comprehensive coverage. By integrating machine learning algorithms, this study aims to provide more accurate and precise predictions, filling critical gaps in understanding CRC incidence, death, and disability-adjusted life year (DALY) rate trends, especially in high socio-demographic index (SDI) regions. Specific emphasis is placed on exploring age-, sex-, and country-specific variations in CRC trends.</p><p><strong>Materials and methods: </strong>An ensemble forecasting algorithm integrating Simple Linear Regression, Exponential Smoothing, and Autoregressive Integrated Moving Average, capable of handling a short time series was developed and validated, utilizing a dataset encompassing age-, sex-, and country-specific CRC incidence, mortality, and DALY rates.</p><p><strong>Results: </strong>Our forecasting models reveal rising trends in CRC burden in the 15-49 years age group (young-onset) and decreasing trends in CRC burden in the 50-74 years age group (late-onset) in high SDI regions with sex-specific variations in incidence, mortality, and DALY rates. Some inflection points for demographic shifts in CRC disease burden, particularly death rates, were identified as early as within the next 5 years. We predict a shift in CRC burden towards females, particularly in older adults.</p><p><strong>Conclusion: </strong>A novel multifactor model was developed for comparing the incidence, mortality, and DALY rates of young- and late-onset CRC in high SDI regions. The rising incidence of young-onset CRC in high SDI regions underscores the need for proactive health strategies. By refining predictive models, adjusting screening guidelines to target younger, high-risk populations, and investing in public awareness and research, we can facilitate early detection and improve outcomes. This study addresses a significant gap in CRC forecasting and provides a robust framework for anticipating demographic shifts in CRC burden, making it an indispensable tool for healthcare planning.</p>","PeriodicalId":49093,"journal":{"name":"Cancer Control","volume":"32 ","pages":"10732748251321672"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11833813/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143442514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Do Nutritional and Inflammatory Indices Predict Response in Geriatric Gastric Cancer Patients Treated with Neoadjuvant FLOT Regimen? 营养和炎症指标能否预测新辅助FLOT方案治疗的老年胃癌患者的反应?
IF 2.5 4区 医学
Cancer Control Pub Date : 2025-01-01 Epub Date: 2025-04-18 DOI: 10.1177/10732748251335367
Yonca Yılmaz Ürün, Muslih Ürün
{"title":"Do Nutritional and Inflammatory Indices Predict Response in Geriatric Gastric Cancer Patients Treated with Neoadjuvant FLOT Regimen?","authors":"Yonca Yılmaz Ürün, Muslih Ürün","doi":"10.1177/10732748251335367","DOIUrl":"https://doi.org/10.1177/10732748251335367","url":null,"abstract":"<p><p><b>Introduction:</b> Docetaxel-based chemotherapy is a standardized neoadjuvant treatment for gastric cancer. There are still no reliable indicators to predict tumor response and prognosis of geriatric patients prior to chemotherapy. The aim of our study was to investigate the value of pretreatment prognostic nutritional index (PNI), serum albumin, total lymphocyte, neutrophil-lymphocyte ratio (NLR), and platelet-lymphocyte ratio (PLR) in predicting the response to treatment in geriatric gastric cancer patients treated with FLOT (5-Fluorouracil, leucovorin, oxaliplatin, and docetaxel) regimen as neoadjuvant chemotherapy.<b>Methods:</b> A total of 91 geriatric gastric cancer patients (≥65-year-old) who received a neoadjuvant FLOT regimen were retrospectively analyzed. Pretreatment data, including demographic characteristics, complete blood count, serum albumin level (g/dL), serum tumor markers (CEA and CA19-9), PNI values and other clinicopathological parameters, were collected. Independent sample t-tests and Mann-Whitney U tests were used to analyze quantitative independent data. In the analysis of independent qualitative data, the chi-squared test and Fischer's exact test were used when the chi-squared test conditions were not met.<b>Results:</b> The mean age was 69.9 ± 4. There were 22 patients in the treatment-responsive group and 69 in the treatment-nonresponsive group. Serum albumin levels were significantly higher in the treatment-responsive group. The lymphocyte counts were significantly lower in the treatment-responsive group. Additionally, both disease-free survival and overall survival were significantly extended in patients who responded to treatment.<b>Conclusion:</b> We demonstrated that serum albumin and total lymphocyte counts, which are easily accessible blood parameters routinely examined before treatment, may predict the response in geriatric gastric cancer patients receiving neoadjuvant FLOT treatment. However, larger prospective, multicenter studies are required to confirm this relationship.</p>","PeriodicalId":49093,"journal":{"name":"Cancer Control","volume":"32 ","pages":"10732748251335367"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12035122/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144044894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Perceptions, Attitudes, and Concerns on Artificial Intelligence Applications in Patients with Cancer. 人工智能在癌症患者中的应用的认知、态度和关注。
IF 2.5 4区 医学
Cancer Control Pub Date : 2025-01-01 Epub Date: 2025-05-23 DOI: 10.1177/10732748251343245
Enes Erul, Yusuf Aktekin, Furkan Berk Danışman, Şükrü Armanç Gümüştaş, Büşra Saraç Aktekin, Emre Yekedüz, Yüksel Ürün
{"title":"Perceptions, Attitudes, and Concerns on Artificial Intelligence Applications in Patients with Cancer.","authors":"Enes Erul, Yusuf Aktekin, Furkan Berk Danışman, Şükrü Armanç Gümüştaş, Büşra Saraç Aktekin, Emre Yekedüz, Yüksel Ürün","doi":"10.1177/10732748251343245","DOIUrl":"10.1177/10732748251343245","url":null,"abstract":"<p><p>IntroductionThe use of artificial intelligence (AI) in oncology has increased rapidly, transforming various healthcare areas such as pathology, radiology, diagnostics, prognosis, genomics, treatment planning, and clinical trials. However, perspectives, comfort levels, and concerns about AI in cancer care remain largely unexplored.Materials and MethodsThis prospective, descriptive cross-sectional survey study was conducted between May 20, 2024 and October 22, 2024, among 363 patients with cancer from two different hospitals affiliated with Ankara University, a tertiary care center in Türkiye. The survey included three distinct sections: (1) Perceptions: Patients' general views on AI's impact in oncology; (2) Attitudes: Comfort level with AI performing medical tasks; (3) Concerns: Specific fears related to AI implementation (eg, diagnostic errors, data privacy, healthcare costs). Survey responses were summarized descriptively, and differences by age, gender, and education were analyzed using chi-square tests.ResultsA majority (50.7%) believed AI would somewhat (32%) or significantly (18.7%) improve healthcare. However, one-third of patients (33.1%) were very uncomfortable with AI diagnosing cancer, with higher discomfort among less-educated participants (<i>P</i> < .005). Top patient concerns included AI making incorrect diagnoses (31.1%), increasing healthcare costs (27.5%), and not keeping data private (19.6%). Patients with higher education levels expressed less discomfort and fewer concerns.ConclusionsPatients' perceptions and attitudes on AI varied significantly based on education, highlighting the need for targeted educational initiatives. While AI holds potential to revolutionize cancer care, addressing concerns about accuracy, security, and transparency is critical to enhance its acceptance and effectiveness in clinical practice.</p>","PeriodicalId":49093,"journal":{"name":"Cancer Control","volume":"32 ","pages":"10732748251343245"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12102565/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144129313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Be Well Baytown: Whole-Community Cancer Prevention Initiative Based on Multi-Sector Capacity and Partnership Building. 善待贝敦:基于多部门能力和伙伴关系建设的全社区癌症预防倡议。
IF 2.5 4区 医学
Cancer Control Pub Date : 2025-01-01 Epub Date: 2025-06-02 DOI: 10.1177/10732748251347584
Margaret Raber, Katherine Oestman, Lori Rumfield, Rosemary Coffman, Nikki Rincon, Mayra Aquino, Brad Love, Michael T Walsh, Ruth Rechis
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