Human Vaccines & Immunotherapeutics最新文献_第9页

Verification of tetanus vaccination status of children admitted for animal bites in a pediatric emergency department. 在儿科急诊科因动物咬伤入院的儿童破伤风疫苗接种状况的验证。

IF 3.5 4区医学

Human Vaccines & Immunotherapeutics Pub Date : 2025-12-01 Epub Date: 2025-09-15 DOI: 10.1080/21645515.2025.2559509

Mathilde Nibbio, Claire de Jorna, Marion Lagrée, Diariatou Diallo, Constance Leruste, Melany Liber, François Dubos

{"title":"Verification of tetanus vaccination status of children admitted for animal bites in a pediatric emergency department.","authors":"Mathilde Nibbio, Claire de Jorna, Marion Lagrée, Diariatou Diallo, Constance Leruste, Melany Liber, François Dubos","doi":"10.1080/21645515.2025.2559509","DOIUrl":"10.1080/21645515.2025.2559509","url":null,"abstract":"Animal bites are high-risk wounds for tetanus. Our objective was to verify that children admitted to the pediatric emergency department (PED) for bites had reliable management of the risk of tetanus. This retrospective descriptive study was conducted at Lille University Hospital between 2015 and 2020. Patients under the age of 16 years admitted to the PED for bite wounds were included. The rate of appropriate management was calculated using a strict or pragmatic definition, based on the presentation or not of the health booklet. Among 336 patients included (median age 5 years, 47% boys, 69% wounds on the face; 90% of bites by dogs), 86% had their vaccination status mentioned in the medical observation, more often during daytime hours (p = .02) and by the medical team (as compared to the surgical team; p < 10-3). 90% of these were declared up-to-date for their tetanus vaccination. Management was deemed appropriate in 16% according to the strict definition and in 80% using the pragmatic definition. 28 patients were not up to date (10%). Eight of these 28 (29%) had an appropriate management. The management of a bite wound must be systematized with verification of tetanus vaccination status to avoid preventable disasters.","PeriodicalId":49067,"journal":{"name":"Human Vaccines & Immunotherapeutics","volume":"21 1","pages":"2559509"},"PeriodicalIF":3.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12439565/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145066122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structural and temporal dynamics analysis of PD-1/PD-L1 immunotherapy in hepatocellular carcinoma: History, research hotspots, and emerging trends. PD-1/PD-L1免疫治疗肝细胞癌的结构和时间动力学分析：历史、研究热点和新趋势

IF 3.5 4区医学

Human Vaccines & Immunotherapeutics Pub Date : 2025-12-01 Epub Date: 2025-08-17 DOI: 10.1080/21645515.2025.2540143

Talaiti Tuergan, Aimitaji Abulaiti, Yingmei Shao, Tuerganaili Aji

{"title":"Structural and temporal dynamics analysis of PD-1/PD-L1 immunotherapy in hepatocellular carcinoma: History, research hotspots, and emerging trends.","authors":"Talaiti Tuergan, Aimitaji Abulaiti, Yingmei Shao, Tuerganaili Aji","doi":"10.1080/21645515.2025.2540143","DOIUrl":"10.1080/21645515.2025.2540143","url":null,"abstract":"This research aims to explore the historical evolution, key research areas, and new trends in PD-1/PD-L1 immunotherapy for hepatocellular carcinoma (HCC) over the last twenty years, focusing on structural and temporal dynamics. The Web of Science Core Collection (WoSCC) database was used to gather studies on PD-1/PD-L1 immunotherapy for HCC.CiteSpace and HistCite were utilized for a bibliometric analysis to investigate the historical progression, research evolution, and emerging trends in this area. In the last two decades, 2804 papers on PD-1/PD-L1 immunotherapy in HCC have been published, comprising 541 reviews and contributions from 13,796 authors across 2,659 institutions. Since 2014, the number of annual publications has significantly increased, with extensive international collaboration. Several active research topics have emerged, covering 72 disciplines, generating 561 keywords, and 1,199 articles that experienced citation bursts. Cluster analysis of keywords revealed five emerging subfields: lenvatinib, immune escape, immne checkpoint inhibitors, prognostic models, and tumor microenvironment. According to the \"Timeline visualization of references,\" classic topics include CMTM6, regulatory T cells, liver transplantation, and bioinformatics analysis, while emerging topics include prognosis, lenvatinib, transarterial chemoembolization, hepatic arterial infusion chemotherapy, and single-cell RNA sequencing. This study sheds light on the current status and developing trends in PD-1/PD-L1 immunotherapy research for HCC, offering researchers valuable insights to identify crucial areas and explore new research directions.","PeriodicalId":49067,"journal":{"name":"Human Vaccines & Immunotherapeutics","volume":"21 1","pages":"2540143"},"PeriodicalIF":3.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12363510/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144876325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictive model of public health impact of herpes zoster vaccination and related costs for adults aged ≥50 years in Republic of Korea. 韩国50岁以上成人带状疱疹疫苗接种和相关费用对公共卫生影响的预测模型

IF 3.5 4区医学

Human Vaccines & Immunotherapeutics Pub Date : 2025-12-01 Epub Date: 2025-09-25 DOI: 10.1080/21645515.2025.2554488

Serim Min, Sun-Hong Kwon, Jun-Ho Seo, Jin Hyun Nam, Jeong-Hyeon Park, Taeyeon Kwon, Hye-Rim Kang, Cheryl Ng, Eui-Kyung Lee

{"title":"Predictive model of public health impact of herpes zoster vaccination and related costs for adults aged ≥50 years in Republic of Korea.","authors":"Serim Min, Sun-Hong Kwon, Jun-Ho Seo, Jin Hyun Nam, Jeong-Hyeon Park, Taeyeon Kwon, Hye-Rim Kang, Cheryl Ng, Eui-Kyung Lee","doi":"10.1080/21645515.2025.2554488","DOIUrl":"10.1080/21645515.2025.2554488","url":null,"abstract":"Given the rapidly aging population in South Korea, the growing incidence and burden of herpes zoster (HZ) increase the need for HZ prevention. However, the public health impact of HZ vaccination has not been assessed in South Korea. This predictive modeling study estimated the public health and economic impact of available HZ vaccination strategies, using the ZOster ecoNomic Analysis (ZONA) model adapted with South Korea-specific inputs. Base case analysis involved adults ≥50 y of age (YOA), exploring three vaccination strategies (no vaccination/recombinant zoster vaccine [RZV]/zoster vaccine live [ZVL]) under mass vaccination (70% coverage) settings. Scenario and sensitivity analyses were performed. In the base case population of 23,329,743 people, without vaccination, 6,978,500 HZ and 733,278 postherpetic neuralgia (PHN) cases were estimated over their remaining lifetime. Compared with no vaccination, RZV vaccination avoided 3,675,898 HZ and 372,714 PHN cases, while ZVL vaccination avoided 1,013,654 HZ and 107,590 PHN cases. RZV and ZVL avoided 430,190 and 81,975 hospitalizations, respectively. Without considering the costs of vaccination, HZ-related medical costs averted with RZV were 1,399 billion KRW (1,026 million USD), and productivity loss averted was 503 billion KRW (368 million USD); ZVL averted 419 billion KRW (307 million USD) in HZ-related medical costs and 241 billion KRW (177 million USD) in productivity loss. Results were robust under scenario and sensitivity analyses. Mass RZV vaccination among adults ≥50 YOA in South Korea would considerably reduce HZ-related burden. Results may support value assessment and decision-making regarding vaccination strategies for HZ prevention in South Korea.","PeriodicalId":49067,"journal":{"name":"Human Vaccines & Immunotherapeutics","volume":"21 1","pages":"2554488"},"PeriodicalIF":3.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12477880/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145151452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Using immunization registry data to explore initiation of HPV vaccination at ages 9 and 10. 利用免疫登记数据探讨9岁和10岁开始接种HPV疫苗的情况。

IF 3.5 4区医学

Human Vaccines & Immunotherapeutics Pub Date : 2025-12-01 Epub Date: 2025-08-17 DOI: 10.1080/21645515.2025.2547432

Grace W Ryan, Amanda Kahl, Emily Janio, Bethany Kintigh, Don Callaghan, Natoshia M Askelson

{"title":"Using immunization registry data to explore initiation of HPV vaccination at ages 9 and 10.","authors":"Grace W Ryan, Amanda Kahl, Emily Janio, Bethany Kintigh, Don Callaghan, Natoshia M Askelson","doi":"10.1080/21645515.2025.2547432","DOIUrl":"10.1080/21645515.2025.2547432","url":null,"abstract":"Despite evidence highlighting benefits of age 9/10 initiation of human papillomavirus (HPV) vaccination, little is known about who is initiating the series earlier. We describe the population of children who initiate earlier and assess the relationship of earlier initiation with series completion. We used individual-level immunization registry data from Iowa which contained data on male (49.9%) and female (50.1%) children born between 2004-2013 ages 9 and 17. We compared sociodemographic characteristics using chi-square statistics and used logistic regression to assess odds of initiation. Of children with a record of HPV vaccination, only 3.2% initiated early. In comparison to children who initiated at later, the early initiator group had a higher percentage of females (p < .0001), greater representation of nonwhite children (p < .0001), higher percentage living in urban areas (p < .0001) and higher private insurance (p < .0001). In logistic regression models, earlier initiation was significantly associated with higher rates of on-time completion (OR: 10.8 (8.6, 13.5)). These results can support prioritization of efforts to promote earlier initiation. For example, rural areas may need targeted outreach. Future work could integrate geospatial analyses so that local organizations could be able to target specific counties or even zip codes with the lowest rates of initiation.","PeriodicalId":49067,"journal":{"name":"Human Vaccines & Immunotherapeutics","volume":"21 1","pages":"2547432"},"PeriodicalIF":3.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12363527/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144876327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Improving vaccine communication to the often-overlooked young adult population: A qualitative study of 20-29 year olds in British Columbia, Canada. 改善对经常被忽视的年轻人的疫苗传播：加拿大不列颠哥伦比亚省20-29岁人群的定性研究。

IF 3.5 4区医学

Human Vaccines & Immunotherapeutics Pub Date : 2025-12-01 Epub Date: 2025-09-07 DOI: 10.1080/21645515.2025.2552565

Gurvir S Dhutt, Julie A Bettinger, Devon Greyson

{"title":"Improving vaccine communication to the often-overlooked young adult population: A qualitative study of 20-29 year olds in British Columbia, Canada.","authors":"Gurvir S Dhutt, Julie A Bettinger, Devon Greyson","doi":"10.1080/21645515.2025.2552565","DOIUrl":"10.1080/21645515.2025.2552565","url":null,"abstract":"Young adults in their 20s have shown slower uptake of COVID-19 vaccines relative to older adults, potentially endangering themselves and their communities. Despite this, little vaccine communication has specifically targeted this age group. This study explored why \"20-somethings\" in British Columbia (BC), Canada delayed COVID-19 vaccination, and how to better encourage their vaccine uptake. From August 2022 to March 2023, we conducted semi-structured interviews with 25 young adults aged 20-29 years living in southwest BC. Interviews were recorded, transcribed, and analyzed using reflexive thematic analysis. Young adults attributed slower vaccine uptake among their demographic to the perceived lower risks to young and healthy individuals not justifying the effort involved in obtaining vaccination and to lack of trust in the vaccines' safety and effectiveness. To address these factors, participants recommended that vaccine communications attract and maintain young adults' attention, take advantage of the affordances of social media platforms, be clear about both individual advantages and social responsibility to vaccinate, and provide a way to take immediate action. Salient messengers were those deemed credible based on education/credentials or familiarity/similarity to the audience. Marginalized sub-communities may be best reached by health messengers who are already trusted community members. Tailoring vaccine communication to a young adult demographic and using trusted and relatable messengers to deliver vaccine information may facilitate swifter uptake of vaccination in settings with high access but lagging uptake.","PeriodicalId":49067,"journal":{"name":"Human Vaccines & Immunotherapeutics","volume":"21 1","pages":"2552565"},"PeriodicalIF":3.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12427471/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145016488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Longitudinal study on changes in COVID-19 vaccination intentions in Benin and Senegal: Insights from Generalized Estimating Equations (GEE). 贝宁和塞内加尔COVID-19疫苗接种意向变化的纵向研究：来自广义估计方程（GEE）的见解

IF 3.5 4区医学

Human Vaccines & Immunotherapeutics Pub Date : 2025-12-01 Epub Date: 2025-10-07 DOI: 10.1080/21645515.2025.2565927

Ibrahima Gaye, Adama Faye, Elias Martin Avahoundje, Mouhamadou Faly Ba, Valery Ridde

{"title":"Longitudinal study on changes in COVID-19 vaccination intentions in Benin and Senegal: Insights from Generalized Estimating Equations (GEE).","authors":"Ibrahima Gaye, Adama Faye, Elias Martin Avahoundje, Mouhamadou Faly Ba, Valery Ridde","doi":"10.1080/21645515.2025.2565927","DOIUrl":"10.1080/21645515.2025.2565927","url":null,"abstract":"The COVID-19 pandemic prompted strict measures and rapid vaccine deployment in Benin and Senegal. This longitudinal study uses Generalized Estimating Equations (GEE) to analyze the evolution of vaccination intent and its determinants, focusing on attitudes, risk perceptions, and social influence. This descriptive and analytical longitudinal study included 546 Beninese and 319 Senegalese individuals aged 18 and above, selected using marginal quotas. Data were collected via Random Digit Dialing (RDD) based on a questionnaire informed by the Theory of Planned Behavior (TPB) and the Health Belief Model (HBM). Influential factors were assessed using GEE models. Vaccination intent increased more significantly in Senegal (+12.5 points, p = .000) than in Benin (+5.0 points, p = .089). There was a statistically significant increase in vaccine intent among women (+19.9 points) and individuals under 25 (+15.6 points) in Senegal, whereas in Benin, younger respondents showed a decrease (-11.5 points). In both countries, individuals surveyed in the second phase were significantly more likely to express vaccination intent (Benin: OR = 6.9; Senegal: OR = 5.0). Common positive determinants included perceived benefits, social influence, and favorable attitudes toward vaccination. Differences emerged: perceived efficacy and behavioral control were significant in Benin, while safety concerns were a major barrier in Senegal. This study highlights common and context-specific determinants of vaccination intent in Benin and Senegal. It emphasizes the need for tailored communication strategies and efforts to strengthen public trust to enhance vaccine uptake across West Africa.","PeriodicalId":49067,"journal":{"name":"Human Vaccines & Immunotherapeutics","volume":"21 1","pages":"2565927"},"PeriodicalIF":3.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12505502/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145240194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of enterovirus A71 vaccine effectiveness against pediatric hand, foot, and mouth disease caused by enterovirus A71 virus in Tianjin, China, 2016-2023: A test-negative design case-control study. 2016-2023年天津市儿童A71型肠病毒疫苗防治手足口病效果评价：阴性设计病例对照研究

IF 3.5 4区医学

Human Vaccines & Immunotherapeutics Pub Date : 2025-12-01 Epub Date: 2025-10-10 DOI: 10.1080/21645515.2025.2572181

Lu Gao, Si Cheng, Lin Li

{"title":"Evaluation of enterovirus A71 vaccine effectiveness against pediatric hand, foot, and mouth disease caused by enterovirus A71 virus in Tianjin, China, 2016-2023: A test-negative design case-control study.","authors":"Lu Gao, Si Cheng, Lin Li","doi":"10.1080/21645515.2025.2572181","DOIUrl":"https://doi.org/10.1080/21645515.2025.2572181","url":null,"abstract":"Hand, foot and mouth disease (HFMD) caused by enterovirus A71 (EV-A71) is a common acute viral disease that mainly affects children under 5 years and often occurs in outbreaks or clusters in China. Given the high disease burden of HFMD and the absence of an effective drug for treating HFMD, the first inactivated monovalent EV-A71 vaccine was licensed in China in 2016. However, no study has assessed the long-term effectiveness of the EV-A71 vaccine on a large scale. A test-negative design case-control study was conducted to estimate the long-term vaccine effectiveness in Tianjin from 2016 to 2023. HFMD patients with a positive EV-A71 were assigned to the case group, and those with a negative EV-A71 were assigned to the control group. Logistic regression models were used to estimate the effectiveness of the vaccine. A total of 7,221 HFMD patients aged 6 months to 13 years old were included between 2016 and 2023. There were 510 (7.1%) children who tested positive for EV-A71, while 5,160 (71.5%) tested positive for other EVs, and 1551 (21.5%) tested negative for all EVs. Vaccine effectiveness was estimated to be 91.01% (95% CI: 84.03-95.53) for the study population. As for children aged 6-35 months, the vaccine effectiveness was 83.45% (95% CI: 68.28-92.58); while that was 96.97% (95% CI: 90.56-99.50) for children aged more than 35 months. The inactivated monovalent EV-A71 vaccine was found to be effective in preventing the HFMD caused by EV-A71 infection.","PeriodicalId":49067,"journal":{"name":"Human Vaccines & Immunotherapeutics","volume":"21 1","pages":"2572181"},"PeriodicalIF":3.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145276164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human vaccines and immunotherapeutics: News January 2025. 人类疫苗和免疫疗法：新闻2025年1月。

IF 4.1 4区医学

Human Vaccines & Immunotherapeutics Pub Date : 2025-12-01 Epub Date: 2025-02-10 DOI: 10.1080/21645515.2025.2463800

Ronald Ellis, Adam Weiss

引用次数: 0

"The big topic is COVID": A qualitative study about changes in HPV vaccine conversations between parents and primary care team members throughout the COVID-19 pandemic. “大话题是COVID”：一项关于在COVID-19大流行期间父母和初级保健团队成员之间HPV疫苗对话变化的定性研究。

IF 4.1 4区医学

Human Vaccines & Immunotherapeutics Pub Date : 2025-12-01 Epub Date: 2025-02-06 DOI: 10.1080/21645515.2025.2460844

Josheili Y Llavona-Ortiz, Lauren J Van Scoy, Benjamin Fogel, Casey Pinto, Jamelia Graham, William A Calo

{"title":"\"The big topic is COVID\": A qualitative study about changes in HPV vaccine conversations between parents and primary care team members throughout the COVID-19 pandemic.","authors":"Josheili Y Llavona-Ortiz, Lauren J Van Scoy, Benjamin Fogel, Casey Pinto, Jamelia Graham, William A Calo","doi":"10.1080/21645515.2025.2460844","DOIUrl":"10.1080/21645515.2025.2460844","url":null,"abstract":"Pandemic-related disruptions in primary care delayed important discussions between providers and parents about routine vaccinations. Conversations have become even more challenging since the COVID-19 pandemic due to increased vaccine hesitancy. This qualitative study explored changes in human papillomavirus (HPV) vaccine conversations within the context of the pandemic from the perspective of primary care team members (PCTMs). Twenty-five PCTMs serving children between 9 and 17 y old in Pennsylvania during the pandemic were conveniently sampled. PCTMs rated their confidence and agreement related to HPV vaccine conversations and pandemic impact. Semi-structured interview questions assessed changes in their HPV vaccine conversations throughout the pandemic. Open-ended questions inquired about PCTMs' thoughts on the COVID-19 pandemic and if or how it impacted HPV vaccination uptake in their practice. Data were collected from May to July 2024. Verbatim transcriptions were analyzed using both inductive and deductive approaches to thematic analysis. Participants were 44% pediatricians, 50% had ≥20 y experience, and 68% were White. Six themes emerged: (1) parents show a range of reactions about HPV vaccination; (2) disruptions in healthcare visits and heightened parental concerns impede vaccination; (3) PCTMs notice clear changes in vaccine acceptance rates; (4) reasons for vaccination refusal have not substantially changed as a result of the pandemic; (5) importance of interpersonal relationships with parents; and (6) PCTM burnout impacts conversations. The pandemic added challenges to HPV vaccine conversations with parents. Findings from this study can be used to refine existing communication approaches to improve HPV vaccine conversations in primary care.","PeriodicalId":49067,"journal":{"name":"Human Vaccines & Immunotherapeutics","volume":"21 1","pages":"2460844"},"PeriodicalIF":4.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11810078/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of a multimedia campaign to increase human papillomavirus vaccine acceptance in Dhaka, Bangladesh. 孟加拉国达卡为提高人乳头瘤病毒疫苗接受度而开展的多媒体宣传活动的效果。

IF 4.1 4区医学

Human Vaccines & Immunotherapeutics Pub Date : 2025-12-01 Epub Date: 2025-01-08 DOI: 10.1080/21645515.2024.2447105

Sohail Agha, Sarah Francis, Drew Bernard, Aslam Fareed, Kasrina Azad, Firdausi Qadri

{"title":"Effects of a multimedia campaign to increase human papillomavirus vaccine acceptance in Dhaka, Bangladesh.","authors":"Sohail Agha, Sarah Francis, Drew Bernard, Aslam Fareed, Kasrina Azad, Firdausi Qadri","doi":"10.1080/21645515.2024.2447105","DOIUrl":"10.1080/21645515.2024.2447105","url":null,"abstract":"Increasing the uptake of Human Papillomavirus (HPV) vaccine among adolescent girls is a high priority for the government of Bangladesh. This study examines correlates of HPV vaccine adoption in Dhaka Division, the largest division in Bangladesh. The 18-day vaccination campaign was accompanied by multimedia messages. We use the Fogg Behavior Model (FBM) as the theoretical framework for our analysis. Using a survey instrument based on the FBM, we analyze cross-sectional data collected from 611 caregivers of girls aged 9-17 in Dhaka. Survey data was collected in November and December 2023. Caregivers were recruited via Facebook and Instagram ads and interviewed through the Facebook Messenger App. About one-third of caregivers reported that their child had been vaccinated. We conducted bivariate and multivariate analyses to assess the relationships between the caregivers' motivation, ability, exposure to the campaign and their child's vaccination status. Adjusted odds ratios from logistic regression analyses, suggest that caregivers' motivation, ability, and exposure to the multimedia campaign contributed to vaccine uptake. Caregivers' motivation to get their child vaccinated was high (74%) but their ability was low (20%). Exposure to campaign messages had a dose-response relationship with vaccine adoption. However, 48% of caregivers remained unexposed to the multimedia campaign. We discuss challenges that the government's HPV vaccination program is likely to face and identify program-related research questions that are important to answer for the success of future vaccination efforts.","PeriodicalId":49067,"journal":{"name":"Human Vaccines & Immunotherapeutics","volume":"21 1","pages":"2447105"},"PeriodicalIF":4.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11730613/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142957495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0