Human Vaccines & Immunotherapeutics最新文献

{"title":"Willingness to pay for vaccines in China: A systematic review and single-arm Bayesian meta-analysis.","authors":"Yi Li, Ziwei Liu, Liangru Zhou, Ruifeng Li","doi":"10.1080/21645515.2025.2454076","DOIUrl":"10.1080/21645515.2025.2454076","url":null,"abstract":"<p><p>The effective implementation of vaccination heavily depends on the society's willingness to pay (WTP). There is currently a dearth of comprehensive evidence about WTP for vaccines in China. This systematic review aims to review studies on the WTP for vaccines, to summarize factors affect WTP in China. Base-case analysis and Sensitivity analysis of WTP for every vaccine were estimated via single-arm Bayesian meta-analysis. A total of 28 studies were included for systematic review. The point estimates and 95% Credible Interval of pooled WTP for influenza and HPV (9-valent) vaccine were $27.409 (23.230, 31.486), $464.707 (441.355, 489.456). Influencing factors to WTP were age, income, peer influence, health condition and etc. Future research should give focus to improving sample representativeness and survey tool, conducting intervention trials, identifying effective methods to promote WTP.</p>","PeriodicalId":49067,"journal":{"name":"Human Vaccines & Immunotherapeutics","volume":"21 1","pages":"2454076"},"PeriodicalIF":3.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11796539/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143190986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Profile of <i>Chlamydia</i> vaccine research: A bibliometric analysis.","authors":"Xuemei Wang, Qian Wang, Yidan Gao, Lijuan Jiang, Lingli Tang","doi":"10.1080/21645515.2025.2459459","DOIUrl":"10.1080/21645515.2025.2459459","url":null,"abstract":"<p><p>Vaccination is the most effective measure to prevent <i>Chlamydia</i> infection. However, to date, no vaccine has successfully completed the rigorous clinical trial process and gained regulatory approval for use in clinical practice. Scholars have been working on a safe and effective <i>Chlamydia</i> vaccine. In order to better grasp, the global frontiers and development trends in this field, a comprehensive bibliometric analysis was carried out. A total of 234 publications closely regarding <i>Chlamydia</i> vaccines were culled from the Web of Science Core Collection database, and the bibliometric information was then extracted with CiteSpace and VOSviewer software. After measurement analysis, the most influential papers were identified in this area, including highly cited papers, references with strong citation burst, and high co-citated papers. <i>Vaccine</i> has published the most literature on <i>Chlamydia</i> vaccines. Only scholars from 39 countries/regions have been engaged in studying <i>Chlamydia</i> vaccines. The USA is the most prolific country and has the highest collaborative strength. The current research area has focused on protective immunity and immunopathological response. Major outer membrane protein (MOMP) is the most common target vaccine antigen. This study reveals the status of literature and highlights emerging trends in this field, which helps researchers seek insights into this area and serve as a reference guide for further investigations.</p>","PeriodicalId":49067,"journal":{"name":"Human Vaccines & Immunotherapeutics","volume":"21 1","pages":"2459459"},"PeriodicalIF":4.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11801346/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143191066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fundamental knowledge and research regarding the role of immunity in triple-negative breast cancer from 2014-2024: A bibliometric analysis.","authors":"Xudong Li, Chun Lou, He Ren, Lina Cui, Kexin Chen","doi":"10.1080/21645515.2025.2483022","DOIUrl":"10.1080/21645515.2025.2483022","url":null,"abstract":"<p><p>Immunity has vital research value and promising applications in triple-negative breast cancer (TNBC). Nevertheless, few bibliometric analyses have systematically investigated this area. This study aimed to comprehensively review the collaboration and impact of countries, institutions, authors, and journals on the role of immunity in TNBC from a bibliometric perspective, evaluate the keyword co-occurrence of the knowledge structure, and identify hot trends and emerging topics. Articles and reviews related to immunity in TNBC were retrieved from the Web of Science core collection using subject search. A bibliometric study was conducted primarily using CiteSpace and VOSviewer. A total of 3,104 articles and reviews were included from January 1, 2014, through December 31, 2024. The number of articles on immunization in TNBC is rising. These publications are mainly from 415 institutions in 82 countries, led by China and the USA. Among these publications, <i>Lajos Pusztai</i> published the most papers, while <i>Peter Schmid</i> was co-cited the most. The most productive journals focused on molecular biology, biological immunology, and clinical medicine. Furthermore, co-citation analysis revealed that tumor microenvironment, biomarkers, and immune checkpoint inhibitors are current and developing research areas. The keywords <i>\"immunotherapy\"</i> and <i>\"nanoparticles\"</i> are also likely to be new trends and focal points for future research. This study adopted bibliometric and visualization methods to provide a comprehensive review of the research on immunization in TNBC. This article will help researchers better understand the dynamic evolution of the role of immunity in TNBC and identify areas for future research.</p>","PeriodicalId":49067,"journal":{"name":"Human Vaccines & Immunotherapeutics","volume":"21 1","pages":"2483022"},"PeriodicalIF":4.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951696/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143711836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research hotspots and trends in the field of immune checkpoint inhibitors (ICIs) for cervical cancer: A bibliometric study from 2014 to 2024.","authors":"Chaoyan Shen, Juan Zhang, Guanyu Zhang, Hao Luo, Shuangke Zhang, Quan Yuan, Wei Xu, Wei Wang, Lele Miao","doi":"10.1080/21645515.2025.2483031","DOIUrl":"10.1080/21645515.2025.2483031","url":null,"abstract":"<p><p>In recent years, immune checkpoint inhibitors (ICIs) have emerged as a novel immunotherapeutic approach, offering renewed hope for enhancing cervical cancer patient prognosis. This study represents the inaugural bibliometric analysis of ICIs in the context of cervical cancer, covering the period from 2014 to 2024. A total of 422 articles were identified through the Web of Science Core Collection database, amassing 10,977 citations, with a consistent annual increase in the number of publications. The leading contributors in terms of countries, institutions, journals, and authors included China, the University of Texas System, <i>Frontiers in Oncology</i>, and Bradley J. Monk, respectively. The journal with the highest frequency of citation and co-citation was <i>Journal of Clinical Oncology</i>. The researchers with the highest number of citations and co-citations were Sarina A Piha-Paul and Krishnansu S Tewari respectively. The keyword cluster analysis identified four main research directions. Furthermore, literature co-citation analysis and burst citation analysis revealed three research hotspots and four potential emerging topics within this domain, respectively. This study provides valuable reference and enlightenment for researchers in this field. As research progresses, ICIs are anticipated to offer significant hope and breakthroughs in the treatment of cervical cancer.</p>","PeriodicalId":49067,"journal":{"name":"Human Vaccines & Immunotherapeutics","volume":"21 1","pages":"2483031"},"PeriodicalIF":4.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11959921/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interactions between interstitial lung abnormalities and immune checkpoint inhibitor therapy in non-small cell lung cancer: A review of current understanding and future directions.","authors":"Ryota Kikuchi, Shinji Abe","doi":"10.1080/21645515.2025.2504243","DOIUrl":"10.1080/21645515.2025.2504243","url":null,"abstract":"<p><p>Immunotherapy has revolutionized the treatment landscape of non-small cell lung cancer (NSCLC), significantly improving survival outcomes and offering renewed hope to patients. However, the presence of interstitial lung abnormalities (ILAs) in patients with NSCLC presents unique challenges, especially due to the elevated risk of immune checkpoint inhibitor (ICI)-related pneumonitis, which can result in treatment interruptions and adversely affect prognosis. ILAs, often detected incidentally on computed tomography imaging, are associated with an increased risk of progression to interstitial lung disease and have been identified as a potential predictor of poor clinical outcomes in patients with NSCLC receiving immunotherapy. This review offers an overview of the current understanding of the interaction between ILAs and ICI therapy, discussing prevalence, radiological features, risk stratification, and management strategies. Additionally, it highlights the need for prospective, multicenter studies to establish optimal treatment modalities for patients with NSCLC having ILAs, to ensure safer and more effective immunotherapy.</p>","PeriodicalId":49067,"journal":{"name":"Human Vaccines & Immunotherapeutics","volume":"21 1","pages":"2504243"},"PeriodicalIF":4.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12080731/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing the breadth of SARS-CoV-2-neutralizing antibodies in vivo and in silico.","authors":"Daisuke Kuroda, Saya Moriyama, Hiroaki Sasaki, Yoshimasa Takahashi","doi":"10.1080/21645515.2025.2526873","DOIUrl":"10.1080/21645515.2025.2526873","url":null,"abstract":"<p><p>Since the emergence of SARS-CoV-2, the ongoing arms race between mutating viruses and human antibodies has revealed several novel strategies by which antibodies adapt to viral escape. While SARS-CoV-2 viruses exhibit high variability in epitopes targeted by neutralizing antibodies, certain epitopes remain conserved owing to their essential roles on viral fitness. Antibodies can acquire broadly neutralizing activity by targeting these vulnerable sites through affinity-based somatic evolution of immunoglobulin genes. Notably, the specificity encoded in antibody germline genes also plays a fundamental role in acquiring the breadth. In-depth genetic and structural analyses of the antibody repertoires have uncovered multiple strategies for adapting to evolving targets. The integration of large-scale antibody datasets with computational approaches increases the feasibility and efficiency of designing broadly neutralizing antibody therapeutics from ancestral antibody clones with limited initial efficacy. In this review, we discuss strategies to optimize antibody breadth for the development of broadly neutralizing antibody therapeutics and vaccine antigens.</p>","PeriodicalId":49067,"journal":{"name":"Human Vaccines & Immunotherapeutics","volume":"21 1","pages":"2526873"},"PeriodicalIF":4.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12285597/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144683528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Natural carrier systems in cancer vaccines and immunotherapy.","authors":"Iman Owliaee, Mohammad Shoushtari, Zhina Karimi, Ali Shojaeian","doi":"10.1080/21645515.2025.2535787","DOIUrl":"10.1080/21645515.2025.2535787","url":null,"abstract":"<p><p>Cancer, marked by uncontrolled cell growth, is a leading global cause of death. Conventional cancer treatments such as chemotherapy and radiation, for all their use, often come with severe side effects. This has really pushed the development of immunotherapies and cancer vaccines, which try to leverage the body's immune system to fight tumors. Effective delivery of therapeutic agents to immune cells or tumors is critical, and natural carriers such as exosomes, archaeosomes, virosomes, and dendritic cells offer promising solutions. These systems excel in biocompatibility, low toxicity, and immune activation compared to synthetic alternatives. This review examines their role in cancer vaccines and immunotherapy, highlighting challenges like production consistency and tumor heterogeneity. Future directions include personalized vaccines and combination therapies, advancing these natural carriers in the fight against cancer.</p>","PeriodicalId":49067,"journal":{"name":"Human Vaccines & Immunotherapeutics","volume":"21 1","pages":"2535787"},"PeriodicalIF":3.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12309555/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144709645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum-equivalency comparison, detection, and quantification of Group B <i>Streptococcus</i> anti-capsular polysaccharide antibodies from dried blood spots.","authors":"Shanna Bolcen, Bailey Alston, Palak Y Patel, Yikun Li, Panagiotis Maniatis, Donna Giordano Schmidt, Danka Pavliakova, Jessica E Southwell, Lily Tao Jia, Michelle Gaylord, Raphael Simon, Natalie Clare Silmon de Monerri, Julia Rhodes, Stephanie Schrag, Sundaram Ajay Vishwanathan","doi":"10.1080/21645515.2025.2544461","DOIUrl":"10.1080/21645515.2025.2544461","url":null,"abstract":"<p><p>A standardized multiplex immunoassay (MIA) to quantify group B <i>Streptococcus</i> (GBS) anti-capsular polysaccharide (CPS) IgG serum concentrations was adopted by the <u>G</u>roup B Streptococcal <u>A</u>ssay <u>St</u>andardizati<u>on</u> (GASTON) consortium as a standardized serological assay with the most immediate applications for facilitating the licensure of GBS vaccines. However, dried blood spot (DBS) samples offer advantages for immunological studies, including cost-effectiveness, ease of transport, and storage. To determine suitability of DBS as an alternative sample matrix to serum in MIA, a contrived GBS seropositive panel, including matched DBS and serum samples, was prepared using established methods. The calculated geometric mean titers of GBS anti-CPS IgG values by individual serotype were compared using a paired t-test to establish serum equivalency. Geometric mean values for the matched panel were assessed via Deming regression for precision, accuracy, and concordance correlation coefficient (CCC). The initial acceptance criterion was set at 0.95 for CCC. Two additional criteria based on confidence intervals of CCC, slope, and intercept were used to determine the necessity of a serotype-specific conversion factor. The paired t-test <i>p</i>-values were >.05 for serum equivalency. For sample matrix concordance, CCC values were >0.95 and met correlation criteria for all serotypes. Conversion factors were applied to four serotypes (II, III, IV, and V) that did not meet the criteria for slope, intercept, or both. This demonstration of equivalency between DBS and serum supports the hypothesis that DBS is a suitable testing matrix from which to elucidate anti-CPS IgG concentrations in seroepidemiological and vaccine evaluation studies.</p>","PeriodicalId":49067,"journal":{"name":"Human Vaccines & Immunotherapeutics","volume":"21 1","pages":"2544461"},"PeriodicalIF":3.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12355705/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144856878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influencing factors and dynamic changes of COVID-19 vaccine hesitancy in China: From the perspective of machine learning analysis.","authors":"Lei Li, Hui Jing, Yuqi Zhao, Shenghua Wu, Boyu Zhu","doi":"10.1080/21645515.2025.2536898","DOIUrl":"10.1080/21645515.2025.2536898","url":null,"abstract":"<p><p>Exploring the influencing factors of COVID-19 vaccine hesitancy and summarizing countermeasures is of great significance for effectively addressing potential public health crises. Based on survey data from China, we employed a Gradient Boosting Decision Tree (GBDT) model and conducted SHAP interpretability analysis. The results show that in the primary series of COVID-19 vaccines, the important factors include social norms, vaccine knowledge, anticipated regret, age, vaccine safety, social responsibility, education level, religious belief, vaccine effectiveness, and perceived severity. While for booster shots, the important variables include age, vaccination experience, vaccine knowledge, vaccine effectiveness, gender, perceived severity, concerns about the epidemic, social norms, anticipated regret, and sense of social responsibility. The differences in the composition and significance of these core predictive factors suggest that COVID-19 vaccine hesitancy is dynamically evolving. This pattern of evolution is manifested as a shift in the decision - making basis from social norms to subjective experiences, in the focus of vaccines from safety - first to effectiveness - priority, and in the decision - making mechanism from emotion - dominated to cognition - driven. The research findings inspire us that when formulating vaccination strategies, multiple factors need to be comprehensively considered. Moreover, strategies should be adjusted in a timely manner according to changes in the vaccination stages to align with the shift in public concerns and decision - making mechanisms.</p>","PeriodicalId":49067,"journal":{"name":"Human Vaccines & Immunotherapeutics","volume":"21 1","pages":"2536898"},"PeriodicalIF":3.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12320845/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144745648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to COVID-19 vaccination: Psychological stress and intentions of nursing personnel in Taiwan.","authors":"Yu-Ping Wu, Chung-Ying Lin, Hao-Yun Kao, Yen-Chiao Angel Lu, Chi-Chang Chang, Chiu-Hsiang Lee, Musheer A Aljaberi","doi":"10.1080/21645515.2025.2538904","DOIUrl":"10.1080/21645515.2025.2538904","url":null,"abstract":"<p><p>Although the COVID-19 pandemic has been officially declared over, the global community must remain prepared for future outbreaks. In this regard, understanding the factors associated with willingness to get vaccinated among healthcare workers - given their critical role in infection control - remains essential. Therefore, this study aims to investigate the factors associated with nursing personnel's intention to get vaccinated against COVID-19. Using an online questionnaire survey from April to June 2022, 492 nurses (mean age = 34.4 years, SD = 13.4; 96.7% females) from different settings (including inpatient, outpatient, and ambulatory clinics) participated in the present study. With the use of SmartPLS 4.0, the Partial Least Squares Structural Equation Modeling (PLS-SEM) results showed that intention to get vaccinated was negatively associated with fear of COVID-19 (standardized coefficient = -0.149; <i>p</i> < .01) and vaccine hesitancy (standardized coefficient = -0.168; <i>p</i> < .01) but positively associated with informational support (standardized coefficient = 0.416; <i>p</i> < .01). Those with a higher intention to get vaccinated were positively associated with higher levels of no regrets regarding having received the vaccination (standardized coefficient = 0.544; <i>p</i> < .01). Moreover, fear, informational support, and vaccine hesitancy together explained 28.5% of the variance in intention to get vaccinated. In turn, the intention to get vaccinated explained 30.1% of the variance in the feeling of no regrets regarding having received the vaccination. Based on the results, addressing fear of COVID-19 through educational interventions, strengthening support systems, and promoting positive vaccination intentions may collectively improve vaccination rates among healthcare workers.</p>","PeriodicalId":49067,"journal":{"name":"Human Vaccines & Immunotherapeutics","volume":"21 1","pages":"2538904"},"PeriodicalIF":3.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12320867/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144745650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}