Human Vaccines & Immunotherapeutics最新文献

{"title":"Durable response of anaplastic thyroid cancer to pembrolizumab combined with chemotherapy: A case report.","authors":"Zipei Chen, Qiongshan Chen, Yihan Zhuang, Wen Lin","doi":"10.1080/21645515.2025.2608408","DOIUrl":"10.1080/21645515.2025.2608408","url":null,"abstract":"<p><p>Anaplastic thyroid cancer is a notoriously aggressive malignancy with a dismal prognosis, typically associated with a median overall survival of less than one year. Therapeutic alternatives are particularly limited for patients without actionable driver mutations. Here, we report a case of BRAF V600E wild-type, PD-L1-positive (tumor proportion score of 80%) anaplastic thyroid cancer with residual/relapsed disease following surgery and subsequent progression on multi-targeted tyrosine kinase inhibitor therapy. The patient was thereafter treated with a combination of pembrolizumab, nab-paclitaxel and carboplatin, resulting in a sustained near-complete response lasting over 30 months, accompanied by a manageable safety profile. The favorable response in this case suggests that further evaluation of this triplet regimen could be considered for anaplastic thyroid cancer, though this remains a speculative premise requiring validation. Further studies are also needed to clarify the underlying mechanisms of this combination and to identify predictive biomarkers for patient selection.</p>","PeriodicalId":49067,"journal":{"name":"Human Vaccines & Immunotherapeutics","volume":"22 1","pages":"2608408"},"PeriodicalIF":4.2,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13089929/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147693095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A qualitative evaluation of a STEAM (Science, technology, engineering, arts, and mathematics) peer education intervention on teenagers' knowledge, confidence, and advocacy for HPV vaccine communication.","authors":"Carol Gray Brunton, Iain Macdonald, Céline Healy, Richard Firth, Alexandra McDermott, Eva Malone","doi":"10.1080/21645515.2026.2745405","DOIUrl":"https://doi.org/10.1080/21645515.2026.2745405","url":null,"abstract":"<p><p>Vaccine hesitancy is a rising global phenomenon. Ireland experienced a crisis in confidence and vaccine decline for the Human Papillomavirus (HPV) vaccine in 2015, with rapid national efforts to address concerns and improve uptake rates. We developed a unique STEAM (Science, Technology, Engineering, Arts and Mathematics) peer education intervention through an interdisciplinary team (immunologist, educationalist, designer, filmmaker, and psychologist) to address vaccine hesitancy and utilize peer education, which is promising but underused in the literature. We aimed to evaluate the effect of our STEAM intervention on Irish teenagers' knowledge and confidence in advocacy for the HPV vaccine to their younger peers facing their HPV vaccine offer. We used qualitative methods consisting of 12 focus group discussions with teens (n = 53), one qualitative in-class evaluation among younger peers (n = 35), and knowledge exit slips (n = 300) to evaluate teenagers' knowledge, confidence, advocacy, and younger peers' knowledge. Data were analyzed inductively using reflexive thematic analysis. Our overall egalitarian theme indicated democratic participation by teenagers with three related themes that were compatible with behavior as a vaccine advocate. Teenagers reported positive changes overall in HPV knowledge, confidence, and advocacy beliefs following the intervention. Younger peers could recall HPV facts and knowledge during in-class evaluations and exit slips. We conclude that scaffolding through our STEAM intervention enabled Irish teenagers to feel empowered to act as vaccine advocates. Peer education within our intervention shows promise in raising HPV awareness and knowledge and could be explored in wider contexts.</p>","PeriodicalId":49067,"journal":{"name":"Human Vaccines & Immunotherapeutics","volume":"22 1","pages":"2745405"},"PeriodicalIF":4.2,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149289558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunogenicity and safety of an inactivated split-virion influenza vaccine in individuals 6 months of age and older in India.","authors":"Pedro M Folegatti, Cynthia Tabar, Celine Petit, Parth Vachhani, Sonali Kar, Virendra N Tripathi, Anand Kawade, Iris De Bruijn","doi":"10.1080/21645515.2026.2650848","DOIUrl":"10.1080/21645515.2026.2650848","url":null,"abstract":"<p><p>Influenza remains a significant public health burden in India, causing seasonal outbreaks and substantial morbidity across all age groups. Despite available effective vaccines, uptake remains low, and comprehensive safety and immunogenicity data for quadrivalent influenza vaccines in Indian populations are limited. This open-label phase III study evaluated the immunogenicity and safety of a quadrivalent inactivated split-virion influenza vaccine (QIV) in participants aged 6 months and older across five Indian sites. Participants received one or two 0.5 mL doses based on age and prior vaccination history. A total of 401 participants were enrolled in the study. Geometric mean titers increased from baseline across all age groups for all four strains. Hemagglutination inhibition (HAI) geometric mean titer ratios (GMTRs) comparing post-vaccination to baseline values showed higher responses to A/H1N1 in adults aged 18 years and older, while A/H3N2 responses were similar across age groups. Younger participants demonstrated higher GMTRs for B/Yamagata and B/Victoria strains. Seroconversion rates at day 29 were generally highest against A/H1N1 across all ages. Solicited injection site reactions were comparable among age groups, though younger participants reported fewer local reactions. No vaccine-related serious adverse events occurred. These findings demonstrate that QIV induced HAI titer increases in pediatric populations comparable to or somewhat higher adult responses against all four vaccine strains. QIV immunization against influenza was generally safe and well tolerated in both adults and children.<b>Clinical Trials Registry - India:</b> CTRI/2021/11/037841.</p>","PeriodicalId":49067,"journal":{"name":"Human Vaccines & Immunotherapeutics","volume":"22 1","pages":"2650848"},"PeriodicalIF":4.2,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147624513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Herpes zoster knowledge, attitudes, and herpes zoster vaccine acceptability among patients in a tertiary hospital and dermatologists in the Philippines: A cross-sectional study.","authors":"Krisha K Lim, Christine Bernadette O Lo, Maria Christina Filomena R Batac","doi":"10.1080/21645515.2026.2633892","DOIUrl":"10.1080/21645515.2026.2633892","url":null,"abstract":"<p><p>As life expectancy increases, age-related diseases become more frequent and severe, making vaccination a key strategy for disease prevention. To assess the knowledge and attitudes toward herpes zoster and to determine associations with acceptability of vaccination among patients and dermatologists, a descriptive and quantitative analytic cross-sectional survey-based study was conducted among patients aged ≥50 y in a tertiary hospital, and dermatologists in the Philippines. Majority of dermatologists had good knowledge (97.5%) and attitudes (99.7%) toward vaccination. Reported barriers were vaccine cost, procurement, and storage. Only 32.8% of patients were aware of herpes zoster, of which 61.7% had good knowledge and 99.2% had positive attitudes toward vaccination. Majority (87.0%) were willing to be vaccinated. Fear of side effects and unwillingness to pay limited acceptance. Knowledge did not impact vaccine acceptance, but favorable attitudes were associated with acceptance in both groups. Recall and social desirability bias cannot be ruled out, and sampling of patients was limited to a single outpatient clinic. Overall, Filipino dermatologists exhibit high levels of knowledge, positive attitudes, and vaccine acceptability. While patient awareness was limited, vaccine acceptability is high, particularly when recommended by a physician, highlighting their critical role in primary care.</p>","PeriodicalId":49067,"journal":{"name":"Human Vaccines & Immunotherapeutics","volume":"22 1","pages":"2633892"},"PeriodicalIF":4.2,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13014564/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147505251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the burden of HPV-associated cancers in Brazil: Hospitalization and mortality trends from 2011 to 2019.","authors":"Cintia Irene Parellada, Ana Luiza Bierrenbach, Adriana Bittencourt Campaner, Rodrigo Gonçalves Queijo, Tulio Tadeu Rocha Sarmento, Juan Carlos Orengo","doi":"10.1080/21645515.2026.2640760","DOIUrl":"10.1080/21645515.2026.2640760","url":null,"abstract":"<p><p>Human papillomavirus (HPV)-associated cancers represent a substantial public health burden. This study analyzed the national burden of hospitalization and mortality from HPV-associated cancers in Brazil between 2011 and 2019. Outcomes included average annual numbers, crude and age-standardized rates per 100,000 population, and trends estimated via joinpoint regression for cervical, vulvar, vaginal, penile, anal, and head and neck cancers (oropharynx, larynx, and oral cavity). Between 2011 and 2019, HPV-attributable cancers accounted for an average of 29,155 hospitalizations (14.3 per 100,000) and 7526 deaths (3.7 per 100,000) annually across both sexes. Among females, there were an average of 24,921 hospitalizations (24.0 per 100,000) and 6430 deaths annually, largely driven by cervical cancer. Among males, there were an estimated 4234 HPV-attributable hospitalizations and 1096 deaths per year (4.1 and 1.1 per 100,000, respectively), with penile, anal, and oropharyngeal cancers being the largest contributors. Cervical cancer accounted for 74.3% of HPV-attributable hospitalizations, followed by anal (10.4%), head and neck (9.2%), and penile cancers (3.4%). Most HPV-associated cancers showed stable hospitalization and mortality trends over time. For cervical cancer, hospitalizations rose by 3.9% annually between 2016 and 2019, while mortality rose by 0.7% annually over the entire period. Anal cancer showed significant increases in both hospitalizations (AAPC = 3.1%) and mortality (AAPC = 10.9%). These findings underscore the need for continued efforts to prevent and reduce the burden of HPV-associated cancers in Brazil, including expanded cohort vaccination, consideration of higher-valency vaccines, and improved access to early detection and timely treatment for both sexes.</p>","PeriodicalId":49067,"journal":{"name":"Human Vaccines & Immunotherapeutics","volume":"22 1","pages":"2640760"},"PeriodicalIF":4.2,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13007411/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147488130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors influencing COVID-19 vaccine hesitancy in socially vulnerable Latinx communities in North Texas.","authors":"Russell Manzano, Sobur Ali, Stacey B Griner, Malinee Neelamegam, Nolan Kline","doi":"10.1080/21645515.2026.2669428","DOIUrl":"10.1080/21645515.2026.2669428","url":null,"abstract":"<p><p>In the United States, COVID-19 vaccines are widely available, but vaccine hesitancy and vaccine disparities remain. Healthcare providers and community organizational leaders who serve as frontline workers and interact with vaccine-hesitant people, can provide important insights on factors that perpetuate vaccine hesitancy. These perspectives may be especially important for vaccine-hesitant people with intersecting social vulnerabilities, including racial and ethnic minorities who are also LGBTQ+ individuals, immigrants, or pregnant people. While predictors of COVID-19 vaccine hesitancy have been examined, there has been comparatively less research on healthcare providers' and organizational leaders' perspectives about factors influencing vaccine hesitancy. Responsive to this gap, the purpose of this study was to identify healthcare providers' and organizational leaders' perspectives about factors influencing COVID-19 vaccine hesitancy among Latinx people in North Texas who identify as (1) LGBTQ+, (2) immigrants, or (3) pregnant or postpartum individuals. We conducted in-depth interviews with 13 participants that serve these groups. Data were collected in 2022, and interviews were thematically analyzed using MaxQDA software. Participants described misinformation, interpersonal context, and pregnancy concerns as main reasons for vaccine hesitancy among their patients. Findings from this study contribute to overall knowledge of vaccine hesitancy among minoritized people, demonstrating how multilevel factors contribute to vaccine hesitancy. Further, the findings suggest potential pathways where misinformation may operate through interpersonal networks to amplify intrapersonal concerns. Due to current changes in COVID-19 vaccine recommendations, research that focuses on vaccines and misinformation is critical in preventing vaccine hesitancy.</p>","PeriodicalId":49067,"journal":{"name":"Human Vaccines & Immunotherapeutics","volume":"22 1","pages":"2669428"},"PeriodicalIF":4.2,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13178169/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147943383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends, disparities, and multilevel interventions: A global review of HPV vaccination among university students.","authors":"Yunjun Yan, Shuang Guan, Wei Chen, Junli Shi, Ruoyu Chao, Jing Fang, Chunhui Zheng, Zhen Yang","doi":"10.1080/21645515.2026.2667395","DOIUrl":"10.1080/21645515.2026.2667395","url":null,"abstract":"<p><p>Human papillomavirus (HPV) vaccination is a critical yet underutilized strategy for preventing HPV-related cancers in young adults. University students represent a key demographic for catch-up vaccination owing to their risk profile and transitional healthcare access. This review synthesized data from January 2015 to February 2026 to examine the trends, disparities, and determinants of HPV vaccine uptake in this population. Vaccination rates remain suboptimal worldwide, with pronounced disparities across sex, race/ethnicity, socioeconomic status, and geographic regions. Key barriers operate at multiple levels: individual (knowledge gaps, low perceived risk, hesitancy), interpersonal (lack of provider recommendations), and structural (cost, healthcare access). Promising evidence-based interventions include proactive campus health services, digital campaigns tailored to Generation Z, healthcare provider recommendations, and supportive policies. An integrated socioecological approach coordinating strategies across these levels is essential. This review highlights the urgent need for equity-focused multichannel interventions and policies to improve HPV vaccination coverage among university students worldwide.</p>","PeriodicalId":49067,"journal":{"name":"Human Vaccines & Immunotherapeutics","volume":"22 1","pages":"2667395"},"PeriodicalIF":4.2,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13155025/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147845009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A cross-sectional survey of general practitioners' influenza vaccination willingness and influencing factors based on the reasoned action approach.","authors":"Yundi Ma, Yangni Li, Mingmin Chen, Jingjing Ren, Linlin Xu","doi":"10.1080/21645515.2026.2685454","DOIUrl":"10.1080/21645515.2026.2685454","url":null,"abstract":"<p><p>General practitioners (GPs) play a dual role in influenza prevention and control as both medical decision-makers and a high-risk population for infection. This study, based on the Reasoned Action Approach (RAA), aimed to explore GPs' influenza vaccination willingness and its influencing factors. Data were collected via an online questionnaire from February 11 to March 20, 2025, using convenience sampling. The questionnaire covered general profiles, influenza vaccination in the last season, vaccination willingness, and a RAA-based scales (including dimensions of attitude, subjective norms, and perceived behavioral control), and information-seeking behavior (active information collection, methods, and trusted sources). Among 341 questionnaires distributed, 330 valid ones were returned. The mean vaccination willingness score was 3.82 out of 5. Multiple regression analysis showed that vaccination willingness was positively associated with subjective norms (β = 0.367), attitudes (β = 0.291), vaccination in the last season (β = 0.124), and type of workplace (β = 0.111) (all p < .05). Given GPs' exemplary role as health promoters, this study proposed multidimensional strategies like strengthening their health education, establishing social norm guidance mechanisms, and optimizing vaccine service accessibility. These aimed to enhance GPs' vaccination willingness and their positive guidance on preventive behaviors in the population.</p>","PeriodicalId":49067,"journal":{"name":"Human Vaccines & Immunotherapeutics","volume":"22 1","pages":"2685454"},"PeriodicalIF":4.2,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13274125/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148220566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Randomized controlled trial evaluating immunogenicity and safety of a porcine circovirus-free rotavirus vaccine in healthy Chinese infants.","authors":"Xiaoqiang Liu, Yulin Jing, Xiuqing Wang, Fei Yang, Ana Cristy Ugarte Guzmán, Dunson Ejedepang, Jieqiong Hu, Keruo Liu, Yassmine Ammiche, Md Ahsan Habib","doi":"10.1080/21645515.2026.2676381","DOIUrl":"10.1080/21645515.2026.2676381","url":null,"abstract":"<p><p>Rotavirus (RV) is a leading cause of diarrhea-related morbidity and mortality among children under 5 y globally, accounting for approximately one-third of childhood diarrhea cases in China. Vaccination is the most effective strategy for RV prevention. Rotarix, a liquid RV vaccine with a 2-dose schedule, has been modified to exclude porcine circovirus (PCV) components. This study evaluated the immunogenicity and safety of Rotarix PCV-free vs Rotarix in healthy Chinese infants. In this Phase III, observer-blinded, randomized, multicenter study, infants aged 6-16 weeks were randomized to receive two oral doses of either vaccine (Rotarix PCV-free or Rotarix) 1-month apart. Primary endpoints were seroconversion rates (SCRs) and geometric mean concentrations (GMCs) of serum anti-RV IgA antibodies 1-month post-Dose 2. Non-inferiority was defined as a 95% CI lower limit (LL) for both SCR ≥ -10% and GMC ratio ≥ 0.67. Safety was assessed by monitoring solicited adverse events (AEs) within 14 d post-vaccination, unsolicited AEs within 31 d, and serious AEs (SAEs) throughout the study. Of 2000 randomized participants, 96.8% (Rotarix PCV-free) and 96.6% (Rotarix) received both doses. SCR: 84.9% (Rotarix PCV‑free) vs 88.7% (Rotarix); difference -3.73% (95% CI - 6.93, -0.55; <i>p</i> = .0317), met non‑inferiority ≥-10%. GMC ratio did not meet non‑inferiority: ratio 0.71 (95% CI 0.60-0.84; <i>p</i> < .0001), 95% CI LL < prespecified 0.67. The most common systemic AE was cough/runny nose (Rotarix PCV-free 30.6% vs Rotarix 25.4%); SAEs occurred in 26.1% and 25.2% of participants, respectively, with none deemed vaccine-related. Rotarix PCV-free demonstrated non-inferior SCRs vs Rotarix. Both vaccines showed comparable safety profiles.<b>ChinaDrugTrials.org registration</b>: CTR2023189.<b>EudraCT</b>: 2020-000972-38.</p>","PeriodicalId":49067,"journal":{"name":"Human Vaccines & Immunotherapeutics","volume":"22 1","pages":"2676381"},"PeriodicalIF":4.2,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13336297/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148370539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HPV vaccine awareness and uptake among women attending cervical screening in health-resource-limited areas of China: A multicenter cross-sectional study.","authors":"Xinhua Jia, Xi'ao Da, Jingyi Shi, Rufei Duan, Yuqian Zhao, Zhifang Li, Ruimei Feng, Chunxia Yang, Tai Zhang, Hongyun Zhang, Junling Wang, Shangyin Hu, Youlin Qiao","doi":"10.1080/21645515.2026.2644020","DOIUrl":"10.1080/21645515.2026.2644020","url":null,"abstract":"<p><p>Evidence shows HPV vaccination reduces infection, precancer and cervical cancer, yet coverage in health-resource-limited of China remains uncertain. We assessed awareness, uptake and correlates among women attending cervical screening, and examined associations with screening outcomes. We conducted a cross-sectional study in eight county sites in 2023-2024 among women aged 35-64 y. A standardized questionnaire captured sociodemographic factors, awareness and vaccination. Cervical samples were tested for hrHPV. Outcomes were awareness, vaccination, hrHPV, HPV16/18 and CIN2+. Associations were estimated using modified Poisson models with site fixed effects and HC3 robust errors. Adjusted prevalence ratios (aPRs) and covariate-standardized marginal estimates were reported. We included 93,027 unique participants. Awareness was 45.15% and vaccination 6.73%. hrHPV prevalence was 11.38% and CIN2+ detection was 0.70%. In 2024 versus 2023, awareness was lower (40.66% vs 51.34%) while vaccination was higher (7.61% vs 5.53%; aPR 1.25, 95% CI 1.18-1.32). Awareness and uptake declined with age; coverage was 23.23% at ages 35-39 and 0.29% at ages 60-64. Urban residence and higher education were associated with uptake (urban aPR 1.19, 95% CI 1.11-1.27; bachelor's or higher aPR 1.73, 95% CI 1.58-1.90). The age-by-year interaction was significant, with standardized gains concentrated at ages 35-49. Vaccination was associated with lower HPV16/18 infection (aPR 0.66, 95% CI 0.52-0.85) but not with overall hrHPV or CIN2+. HPV vaccine awareness and uptake were low among women aged 35-64 y in health-resource-limited areas, with strong age, educational and urban-rural gradients and marked site heterogeneity. Uptake increased in 2024, mainly at ages 35-49, and vaccination was associated with a lower prevalence of HPV16/18 infection.</p>","PeriodicalId":49067,"journal":{"name":"Human Vaccines & Immunotherapeutics","volume":"22 1","pages":"2644020"},"PeriodicalIF":4.2,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12990939/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147460743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}