PLoS Biology最新文献_第9页

How does the cerebellum contribute to cognitive functions? 小脑是如何影响认知功能的？

IF 7.2 1区生物学

PLoS Biology Pub Date : 2026-03-23 eCollection Date: 2026-03-01 DOI: 10.1371/journal.pbio.3003688

Jörn Diedrichsen, Samuel D McDougle

引用次数: 0

Why do we have so many different transcripts? 为什么我们有这么多不同的抄本？

IF 7.2 1区生物学

PLoS Biology Pub Date : 2026-03-20 eCollection Date: 2026-03-01 DOI: 10.1371/journal.pbio.3003686

Laurence D Hurst

引用次数: 0

Curvature of the Drosophila corneal lens depends on localized chitin secretion. 果蝇角膜晶状体的曲率取决于局部几丁质分泌。

IF 7.2 1区生物学

PLoS Biology Pub Date : 2026-03-20 eCollection Date: 2026-03-01 DOI: 10.1371/journal.pbio.3003725

Neha Ghosh, Eva Rojo-Iost, Jessica E Treisman

引用次数: 0

Host jumps need not be common just because spillover is. 宿主跳跃不必仅仅因为溢出是普遍的。

IF 7.2 1区生物学

PLoS Biology Pub Date : 2026-03-20 eCollection Date: 2026-03-01 DOI: 10.1371/journal.pbio.3003682

Mete Yuksel, Nicole Mideo

引用次数: 0

Transcript diversity reflects deleterious RNA processing errors shaped by population size in metazoans. 转录物多样性反映了由后生动物群体大小形成的有害RNA加工错误。

IF 7.2 1区生物学

PLoS Biology Pub Date : 2026-03-19 eCollection Date: 2026-03-01 DOI: 10.1371/journal.pbio.3003671

Kai Mi, Lili Guan, Bandhan Sarker, Siliang Song, Tianjiao Zhou, Hongliang Yi, Jianzhi Zhang, Chuan Xu

引用次数: 0

Pathogen host jump risk is not predicted by spillover rate, but rather by novelty. 病原宿主跳跃风险不是由溢出率预测的，而是由新颖性预测的。

IF 7.2 1区生物学

PLoS Biology Pub Date : 2026-03-19 eCollection Date: 2026-03-01 DOI: 10.1371/journal.pbio.3003640

Brandon J Simony, David A Kennedy

{"title":"Pathogen host jump risk is not predicted by spillover rate, but rather by novelty.","authors":"Brandon J Simony, David A Kennedy","doi":"10.1371/journal.pbio.3003640","DOIUrl":"10.1371/journal.pbio.3003640","url":null,"abstract":"Host jumps-defined as the process by which a pathogen establishes sustained transmission in novel hosts-are threats to human and animal welfare, but anticipating which pathogen will be the next to successfully host jump remains elusive. A spillover event must precede a host jump, and so spillover rate is thought to be related to risk. However, nonendemic pathogens that spill over frequently have demonstrated a poor ability to host jump from any given spillover. So which is riskier, pathogens that spill over rarely or commonly? Applying a Bayesian framework to a general model of host jump risk, we show that 1) the riskiest pathogens can be those that spill over at low, intermediate, or high rates, and 2) as the rate of spillover gets large, the information gained from past spillovers is exactly counterbalanced by the increased number of future spillovers. Taken together, this means that spillover rate has little to no value in explaining host jump risk. Rather, we show that novel pathogens (i.e., pathogens with a relatively short history of spilling over in their current form) are substantially more likely to result in host jumps than pathogens that have had long-associated opportunities for spillover into the novel host. Notably, a pathogen might be thought of as novel if spillover only recently became possible, or if it recently underwent substantial evolutionary change. We therefore propose that the length of historical association, but not spillover rate, will be an important predictor of host jump risk.","PeriodicalId":49001,"journal":{"name":"PLoS Biology","volume":"24 3","pages":"e3003640"},"PeriodicalIF":7.2,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13001934/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147488125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Distinct Cdc42 protein levels differentially regulate polarized growth and cell fusion in Schizosaccharomyces pombe. 不同的Cdc42蛋白水平对裂糖菌的极化生长和细胞融合有不同的调节作用。

IF 7.2 1区生物学

PLoS Biology Pub Date : 2026-03-19 eCollection Date: 2026-03-01 DOI: 10.1371/journal.pbio.3003712

Sajjita Saha, Aiswarya Sajeevan, Laura Merlini, Vincent Vincenzetti, Sophie G Martin

{"title":"Distinct Cdc42 protein levels differentially regulate polarized growth and cell fusion in Schizosaccharomyces pombe.","authors":"Sajjita Saha, Aiswarya Sajeevan, Laura Merlini, Vincent Vincenzetti, Sophie G Martin","doi":"10.1371/journal.pbio.3003712","DOIUrl":"10.1371/journal.pbio.3003712","url":null,"abstract":"The conserved Cdc42 GTPase is a key driver of symmetry breaking and polarized growth, forming zones of activity that locally recruit effectors to organize the cytoskeleton and polarize secretion. Here, we show that Cdc42 also functions in cell-cell fusion during Schizosaccharomyces pombe sexual reproduction, but concentrates at the fusion site through mechanisms distinct from those proposed in Saccharomyces cerevisiae. Notably, the cdc42-mCherrySW allele, which is functional for cell polarization and has been used across organisms for dynamic studies, exhibits a strong fusion defect. These cells block fusion before cell wall digestion but after actin fusion focus formation, indicating that Cdc42 is required to translate the vesicle cluster into polarized cargo delivery. We trace the defect to instability of Cdc42-mCherrySW and demonstrate that mating and cell fusion require higher Cdc42 protein levels than mitotic polarized growth. Remarkably, by constructing an allelic series driving Cdc42 expression over a 5-fold range, we discover that mitotic polarized growth responds linearly to Cdc42 protein levels, whereas mating exhibits a sharp switch-like response. We further trace this all-or-none response to pheromone-induced polarized growth. Thus, polarized growth in response to intrinsic or extrinsic cues exhibits distinct requirements to Cdc42 protein levels.","PeriodicalId":49001,"journal":{"name":"PLoS Biology","volume":"24 3","pages":"e3003712"},"PeriodicalIF":7.2,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13016475/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147488188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pharmacological and non-pharmacological methods of inducing wakefulness activate distinct neural populations in the mouse brain. 诱导清醒的药理学和非药理学方法激活小鼠大脑中不同的神经群。

IF 7.2 1区生物学

PLoS Biology Pub Date : 2026-03-19 eCollection Date: 2026-03-01 DOI: 10.1371/journal.pbio.3003622

Renato Maciel, Justin Malcey, Kylian Gautier, Amarine Chancel, Blandine Duval, Théo Brunel, Patrice Fort, Claudio Marcos Queiroz, Pierre-Hervé Luppi

{"title":"Pharmacological and non-pharmacological methods of inducing wakefulness activate distinct neural populations in the mouse brain.","authors":"Renato Maciel, Justin Malcey, Kylian Gautier, Amarine Chancel, Blandine Duval, Théo Brunel, Patrice Fort, Claudio Marcos Queiroz, Pierre-Hervé Luppi","doi":"10.1371/journal.pbio.3003622","DOIUrl":"10.1371/journal.pbio.3003622","url":null,"abstract":"A large body of data indicate that the aminergic, cholinergic and hypocretin/orexin neurons are responsible for inducing wakefulness. However, recent data showed that other systems might also play a key role. Further, wakefulness induced by different drugs versus non-pharmacological means could be generated by different populations of neurons. To address these questions, we evaluated at the whole brain level in the same mice using TRAP2 model whether the same neurons were activated by the wake-inducing drugs modafinil and solriamfetol versus non-pharmacological wake. Our results show that nine subcortical structures namely the oval part of the bed nucleus of the stria terminalis, lateral part of the central amygdalar nucleus, paraventricular hypothalamic and thalamic and supraoptic nuclei, external part of the lateral parabrachial nucleus, caudal part of the nucleus of the solitary tract and the area postrema are significantly more activated by solriamfetol than modafinil and non-pharmacological wakefulness. In contrast, a second category of structures including the orexin neurons, the parasubthalamic and laterodorsal tegmental nucleus are strongly activated in all types of induced wake. Further, some classical wake systems like the dopaminergic neurons of the ventral tegmental area or the dorsal raphe nucleus and the noradrenergic neurons of the locus coeruleus are either very poorly or not strongly activated. These results reveal that many structures not previously involved in wakefulness might play a key role in regulating the state and that some structures might be more recruited by solriamfetol than modafinil or non-pharmacological wakefulness. Our results are particularly relevant for pathologies such as hypersomnia. They open a new era in the study of the mechanisms responsible for inducing wakefulness.","PeriodicalId":49001,"journal":{"name":"PLoS Biology","volume":"24 3","pages":"e3003622"},"PeriodicalIF":7.2,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13038112/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147488137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Measures to strengthen international biosafety and biosecurity practices. 加强国际生物安全和生物安保实践的措施。

IF 7.2 1区生物学

PLoS Biology Pub Date : 2026-03-18 eCollection Date: 2026-03-01 DOI: 10.1371/journal.pbio.3003691

Etienne Decroly, Patrick Berche, Ali Asy, Maggie L Bartlett, Åsa Szekely Björndal, Christian Brechot, Patrick G Casey, Patrick Couvreur, Maria J Espona, Claudia Filippone, Diah Iskandriati, Wilmot James, Rafael Elias Marques, Zabta Khan Shinwari, Bernadett Pályi, Dana Perkins, Kathrin Summermatter, Olivier Vandenberg, Kurt Zatloukal, Jonathan Ewbank

引用次数: 0

Thaliacean tunicates, vertebrate sisters regained lifelong mobility. 海樽纲被囊动物，脊椎动物姐妹恢复了终生的活动能力。

IF 7.2 1区生物学

PLoS Biology Pub Date : 2026-03-18 eCollection Date: 2026-03-01 DOI: 10.1371/journal.pbio.3003674

Yasunori Sasakura

引用次数: 0