前额叶皮层背内侧和腹内侧病变对社会影响和时间折扣的影响不同。

IF 9.8 1区 生物学 Q1 Agricultural and Biological Sciences
PLoS Biology Pub Date : 2025-04-28 eCollection Date: 2025-04-01 DOI:10.1371/journal.pbio.3003079
Zhilin Su, Mona M Garvert, Lei Zhang, Todd A Vogel, Jo Cutler, Masud Husain, Sanjay G Manohar, Patricia L Lockwood
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引用次数: 0

摘要

内侧前额叶皮层(mPFC)长期以来在神经影像学研究中与经济和社会决策有关。一些争论质疑不同的腹侧和背侧mPFC区域是否具有特定的功能,或者是否存在支持社会和非社会认知的梯度。在这里,我们测试了一个异常大的样本,包括mPFC局灶性损伤的罕见参与者(N = 33),其他部位有病变的个体(N = 17)和健康对照组(N = 71)(总N = 121)。在了解另外两个人的偏好之前,参与者完成了一项时间折扣任务,以估计他们的基准折扣偏好,其中一个人更冲动,另一个人更耐心。在了解他人的经济偏好后,我们使用贝叶斯计算模型来估计基线折扣和对社会影响的敏感性。与健康对照组相比,mPFC损伤增加了对冲动性社会影响的易感性,与其他地方有损伤的人相比,mPFC损伤增加了对社会影响的总体易感性。重要的是,基于体素的计算参数的病变症状映射(VLSM)表明,这种对社会影响的高易感性特别归因于dmPFC的损伤(区域9;基于置换的无阈值聚类增强(TFCE) p < 0.025)。相比之下,vmPFC(13区和25区)和腹侧纹状体的病变与寻求更直接奖励的偏好有关(基于置换的TFCE p < 0.05)。我们发现,dmPFC与对社会影响的易感性有因果关系,mPFC的腹侧部分与时间折扣有关。这些发现为支撑基本社会和认知过程的mPFC子区域提供了因果证据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Dorsomedial and ventromedial prefrontal cortex lesions differentially impact social influence and temporal discounting.

The medial prefrontal cortex (mPFC) has long been associated with economic and social decision-making in neuroimaging studies. Several debates question whether different ventral mPFC (vmPFC) and dorsal mPFC (dmPFC) regions have specific functions or whether there is a gradient supporting social and nonsocial cognition. Here, we tested an unusually large sample of rare participants with focal damage to the mPFC (N = 33), individuals with lesions elsewhere (N = 17), and healthy controls (N = 71) (total N = 121). Participants completed a temporal discounting task to estimate their baseline discounting preferences before learning the preferences of two other people, one who was more temporally impulsive and one more patient. We used Bayesian computational models to estimate baseline discounting and susceptibility to social influence after learning others' economic preferences. mPFC damage increased susceptibility to impulsive social influence compared to healthy controls and increased overall susceptibility to social influence compared to those with lesions elsewhere. Importantly, voxel-based lesion-symptom mapping (VLSM) of computational parameters showed that this heightened susceptibility to social influence was attributed specifically to damage to the dmPFC (area 9; permutation-based threshold-free cluster enhancement (TFCE) p < 0.025). In contrast, lesions in the vmPFC (areas 13 and 25) and ventral striatum were associated with a preference for seeking more immediate rewards (permutation-based TFCE p < 0.05). We show that the dmPFC is causally implicated in susceptibility to social influence, with distinct ventral portions of mPFC involved in temporal discounting. These findings provide causal evidence for sub-regions of the mPFC underpinning fundamental social and cognitive processes.

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来源期刊
PLoS Biology
PLoS Biology BIOCHEMISTRY & MOLECULAR BIOLOGY-BIOLOGY
CiteScore
15.40
自引率
2.00%
发文量
359
审稿时长
3-8 weeks
期刊介绍: PLOS Biology is the flagship journal of the Public Library of Science (PLOS) and focuses on publishing groundbreaking and relevant research in all areas of biological science. The journal features works at various scales, ranging from molecules to ecosystems, and also encourages interdisciplinary studies. PLOS Biology publishes articles that demonstrate exceptional significance, originality, and relevance, with a high standard of scientific rigor in methodology, reporting, and conclusions. The journal aims to advance science and serve the research community by transforming research communication to align with the research process. It offers evolving article types and policies that empower authors to share the complete story behind their scientific findings with a diverse global audience of researchers, educators, policymakers, patient advocacy groups, and the general public. PLOS Biology, along with other PLOS journals, is widely indexed by major services such as Crossref, Dimensions, DOAJ, Google Scholar, PubMed, PubMed Central, Scopus, and Web of Science. Additionally, PLOS Biology is indexed by various other services including AGRICOLA, Biological Abstracts, BIOSYS Previews, CABI CAB Abstracts, CABI Global Health, CAPES, CAS, CNKI, Embase, Journal Guide, MEDLINE, and Zoological Record, ensuring that the research content is easily accessible and discoverable by a wide range of audiences.
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