Acta Neuropsychiatrica最新文献_第3页

Cannabis-induced psychotic disorder with onset during withdrawal: a brief report of emerging evidence. 在戒断期间发病的大麻诱发精神障碍：新证据简要报告。

IF 2.6 4区医学

Acta Neuropsychiatrica Pub Date : 2024-10-01 Epub Date: 2024-01-11 DOI: 10.1017/neu.2023.60

Johan Cohen, Hugues Petitjean, M Belen Blasco, Romina Mizrahi

引用次数: 0

Advancing the understanding of cannabinoids in psychiatry. 促进精神病学对大麻素的了解。

IF 2.6 4区医学

Acta Neuropsychiatrica Pub Date : 2024-10-01 Epub Date: 2024-10-25 DOI: 10.1017/neu.2024.47

Gregers Wegener

引用次数: 0

Salidroside exerts antidepressant-like action by promoting adult hippocampal neurogenesis through SIRT1/PGC-1α signalling. 水杨甙通过SIRT1/PGC-1α信号促进成人海马神经发生，从而发挥类似抗抑郁的作用。

IF 2.6 4区医学

Acta Neuropsychiatrica Pub Date : 2024-09-30 DOI: 10.1017/neu.2024.28

Shan Xing, Shuyi Xu, Linjiao Wang, Liyuan Guo, Xin Zhou, Haoxin Wu, Wei Wang, Lanying Liu

{"title":"Salidroside exerts antidepressant-like action by promoting adult hippocampal neurogenesis through SIRT1/PGC-1α signalling.","authors":"Shan Xing, Shuyi Xu, Linjiao Wang, Liyuan Guo, Xin Zhou, Haoxin Wu, Wei Wang, Lanying Liu","doi":"10.1017/neu.2024.28","DOIUrl":"https://doi.org/10.1017/neu.2024.28","url":null,"abstract":"Depression is one of the major mental disorders, which seriously endangers human health, brings a serious burden to patients’ families. In this study, we intended to further explore the antidepressant-like effect and possible molecular mechanisms of Salidroside (SAL). We built corticosterone (CORT)-induced depressive mice model and used behavioural tests to evaluate depression behaviour. To explore the molecular mechanisms of SAL, we employed a variety of methods such as immunofluorescence, western blot, pharmacological interference, etc. The results demonstrated that SAL both at 25 mg/kg and 50 mg/kg can reduce immobility time in the tail suspension test (TST). At the same time, SAL treatment could restore the reduced sugar water intake preference in the sucrose preference test (SPT) in CORT-induced depressive mice and reduce the immobility time in TST and forced swimming experiments (FST). In addition, SAL treatment reversed the reduction in the number of Ki-67, BrdU, and NeuN in the hippocampus due to CORT treatment. SAL treatment also restored the expression of SIRT1, PGC-1α, brain-derived neurotrophic factor (BDNF) and other proteins in the hippocampus. In addition, after blocking SIRT1 signalling with EX527, we found that the treatment with SAL failed to reduce the immobility time in TST and FST, the level of SIRT1 and PGC-1α activity were correspondingly downregulated, and the expression of DCX and Ki-67 in the hippocampus failed to be activated. These findings suggested that SAL exerts antidepressant-like effects by promoting hippocampal neurogenesis through the SIRT1/PGC-1α signalling pathway.","PeriodicalId":48964,"journal":{"name":"Acta Neuropsychiatrica","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142330589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic association of cholesterol metabolism with the risk of depression and schizophrenia. 胆固醇代谢与抑郁症和精神分裂症风险的遗传关联。

IF 2.6 4区医学

Acta Neuropsychiatrica Pub Date : 2024-08-01 DOI: 10.1017/neu.2024.26

Zheng Chen, Guanghong Sui, Caixia Yang, Zongshun Lv, Feng Wang

{"title":"Genetic association of cholesterol metabolism with the risk of depression and schizophrenia.","authors":"Zheng Chen, Guanghong Sui, Caixia Yang, Zongshun Lv, Feng Wang","doi":"10.1017/neu.2024.26","DOIUrl":"10.1017/neu.2024.26","url":null,"abstract":"Objective: Some observational studies have unexpectedly reported the association of cholesterol metabolism with mental and psychological disorders, but a firm conclusion has not been drawn. The aim of this study was to further investigate the effects of peripheral cholesterol traits and cholesterol-lowering therapy on depression and schizophrenia using a Mendelian randomisation approach.Methods: Instrumental variables meeting the correlation, independence and exclusivity assumptions were extracted from one genome-wide association study for predicting total cholesterol, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol and nonHDL cholesterol. Instrumental variables for total cholesterol and LDL cholesterol were also adopted to predict statin use (a type of cholesterol-lowering drug); these instrumental variables should not only satisfy the above assumptions but also be close to 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR, the target gene of statins) on the chromosome. Three methods (including inverse variance weighted) were used to conduct causal inference of the above exposures with depression and schizophrenia. Sensitivity analyses were performed to assess horizontal pleiotropy.Results: Higher levels of peripheral nonHDL cholesterol were nominally associated with a decreased risk of depression (P = 0.039), and higher levels of HMGCR-mediated total cholesterol and LDL cholesterol were nominally related to a decreased risk of depression (P = 0.013 and P = 0.028, respectively). Moreover, these cholesterol traits cannot affect the risk of schizophrenia. Sensitivity analysis did not reveal any horizontal pleiotropy.Conclusion: The study provided some interesting, but less sufficient, evidence that nonHDL cholesterol may have a protective effect on depression, and lowering cholesterol using statins might increase the risk of the disease.","PeriodicalId":48964,"journal":{"name":"Acta Neuropsychiatrica","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142330586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genistein inhibits Nlrp3/caspase-1 signalling to alleviate traumatic brain injury-induced anxiety-like behaviours in rats. 染料木素可抑制 Nlrp3/caspase-1 信号，从而缓解创伤性脑损伤诱发的大鼠焦虑样行为。

IF 2.6 4区医学

Acta Neuropsychiatrica Pub Date : 2024-08-01 DOI: 10.1017/neu.2024.22

Zhiguang Li, Yan Li, Jiankai Zhao, Zhiyin Pang, Fei Guo

{"title":"Genistein inhibits Nlrp3/caspase-1 signalling to alleviate traumatic brain injury-induced anxiety-like behaviours in rats.","authors":"Zhiguang Li, Yan Li, Jiankai Zhao, Zhiyin Pang, Fei Guo","doi":"10.1017/neu.2024.22","DOIUrl":"10.1017/neu.2024.22","url":null,"abstract":"Objective: Traumatic brain injury (TBI)-induced anxiety is a common but under-investigated disorder, for which neuroinflammation is a significant contributor. Here we aim to investigate the protective effects of genistein, a plant-derived anti-inflammatory drug, against TBI-induced anxiety, and the underlying mechanisms.Methods: A rat model of TBI was constructed using the lateral fluid percussion injury method. Genistein at the doses of 5, 10, and 20 mg/kg were used to treat rats at 30 min, 12 h, 24 h, 48 h, and 72 h up to 14 days after TBI. The evaluation of neurological deficit was performed preoperatively, on days 1, 3, 7, and 14 after TBI. The elevated plus maze test was carried out to assess anxiety and explorative behaviours, and the open field test was performed to assess locomotive activities. Brain injury was assessed by measuring brain water content and TdT-mediated dUTP Nick-End Labeling staining. Inflammatory responses were examined using enzyme-linked immunosorbent assay. The mRNA and protein expression were analysed using real-time polymerase chain reaction and Western blot, respectively.Results: In the behavioural level, genistein treatment alleviated TBI-induced anxiety behaviours and neurological deficit in rats. In the meanwhile, brain oedema was also reduced by genistein treatment, showing alleviating effects of genistein at the pathological level. TUNEL staining also showed reduced apoptosis in rats treated with genistein. Genistein also inhibited Nlrp3/caspase-1 signalling, unveiling the effects of genistein in altering molecular pathways in brains with TBI.Conclusion: Genistein alleviates anxiety-like behaviours in TBI rats, which may be mediated via inhibiting Nlrp/caspase-1 signalling pathway.","PeriodicalId":48964,"journal":{"name":"Acta Neuropsychiatrica","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142330587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phytotherapy in psychiatry: why psychiatrists should know about it. 精神病学中的植物疗法：为什么精神病学家应该了解它？

IF 2.6 4区医学

Acta Neuropsychiatrica Pub Date : 2024-08-01 Epub Date: 2024-10-02 DOI: 10.1017/neu.2024.25

Guilherme Frederico Miranda Lacerda, Paulo César Oliviera, Maria Aparecida Barbato Frazão Vital, Helvo Slomp Junior, José Carlos Fernandes Galduróz, Roberto Andreatini

引用次数: 0

Addressing the neurodevelopmental impacts of prenatal substance exposure: insights from a Taiwanese study on methadone maintenance treatment during pregnancy. 应对产前药物接触对神经发育的影响：台湾一项关于孕期美沙酮维持治疗的研究的启示。

IF 2.6 4区医学

Acta Neuropsychiatrica Pub Date : 2024-08-01 DOI: 10.1017/neu.2024.24

Lien-Chung Wei, Hsien-Jane Chiu

引用次数: 0

Interplay of combat deployment harassment, testosterone concentrations and post-deployment suicide risk in male veterans. 作战部署骚扰、睾酮浓度与男性退伍军人部署后自杀风险的相互作用。

IF 3.8 4区医学

Acta Neuropsychiatrica Pub Date : 2024-06-01 Epub Date: 2024-03-26 DOI: 10.1017/neu.2024.12

Leo Sher, Linda M Bierer, Janine Flory, Iouri Makotkine, Rachel Yehuda

{"title":"Interplay of combat deployment harassment, testosterone concentrations and post-deployment suicide risk in male veterans.","authors":"Leo Sher, Linda M Bierer, Janine Flory, Iouri Makotkine, Rachel Yehuda","doi":"10.1017/neu.2024.12","DOIUrl":"10.1017/neu.2024.12","url":null,"abstract":"Objective: Many combat veterans exhibit suicidal ideation and behaviour, but the relationships among experiences occurring during combat deployment and suicidality are still not fully understood. In this study, we tested the hypothesis that harassment during a combat deployment is associated with post-deployment suicidality and testosterone function.Methods: Male combat veterans who made post-deployment suicide attempts and demographically matched veterans without a history of suicide attempts were enrolled in the study. Demographic and clinical parameters of study participants were assessed and recorded. Study participants were interviewed by a trained clinician using the Mini-International Neuropsychiatric Interview (MINI), the Deployment Risk and Resilience Inventory (DRRI) – Relationships within unit scale, the Scale for Suicidal Ideation (SSI), and the Brown–Goodwin Aggression Scale. Free testosterone levels were assessed in morning blood samples.Results: DRRI harassment scores were higher and free testosterone levels were lower among suicide attempters in comparison with non-attempters. In the whole sample, DRRI harassment scores positively correlated with SSI scores and negatively correlated with free testosterone levels. Free testosterone levels negatively correlated with SSI scores. Aggression scale scores positively correlated with DRRI harassment scores among non-attempters but not among attempters.Conclusion: Our observations that harassment scores are associated with suicidality and testosterone levels, and suicidality is associated with testosterone levels may indicate that there is a link between deployment harassment, testosterone function and suicidality.","PeriodicalId":48964,"journal":{"name":"Acta Neuropsychiatrica","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140289368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Moderating effects of diagnosis and gender on the influence of age on electroconvulsive therapy outcome. 诊断和性别对年龄影响电休克疗法结果的调节作用。

IF 2.6 4区医学

Acta Neuropsychiatrica Pub Date : 2024-06-01 Epub Date: 2024-01-31 DOI: 10.1017/neu.2024.4

Eduardo Tedeschi, Mauricio S Hoffmann, Pedro V S Magalhães

引用次数: 0

Bradykinin actions in the central nervous system: historical overview and psychiatric implications. 中枢神经系统中的缓激肽作用：历史概述和对精神病学的影响。

IF 3.8 4区医学

Acta Neuropsychiatrica Pub Date : 2024-06-01 Epub Date: 2024-01-05 DOI: 10.1017/neu.2023.57

Frederico Guilherme Graeff, Sâmia Joca, Helio Zangrossi

引用次数: 0