Crystal Research and Technology最新文献_第8页

Growth and Optical Properties of Yellow Luminescent [Epy]2[CuBr3] Single Crystals Based on Self Trapping States 基于自捕获态的黄色发光 [Epy]2[CuBr3]单晶的生长和光学特性

IF 1.5 4区材料科学

Crystal Research and Technology Pub Date : 2024-07-10 DOI: 10.1002/crat.202400012

Xinxin Chen, Shujun Zhu, Jiali Han, Tao Zhao, Jianguo Pan, Shangke Pan

引用次数: 0

Masthead: Crystal Research and Technology 7'2024 刊头：水晶研究与技术 7'2024

IF 1.5 4区材料科学

Crystal Research and Technology Pub Date : 2024-07-07 DOI: 10.1002/crat.202470038

引用次数: 0

(Crystal Research and Technology 7/2024) (水晶研究与技术 7/2024）

IF 1.5 4区材料科学

Crystal Research and Technology Pub Date : 2024-07-07 DOI: 10.1002/crat.202470037

引用次数: 0

Oiling-Out in Industrial Crystallization of Organic Small Molecules: Mechanisms, Characterization, Regulation, and Applications 有机小分子工业结晶中的脱油现象：机理、表征、调节和应用

IF 1.5 4区材料科学

Crystal Research and Technology Pub Date : 2024-07-07 DOI: 10.1002/crat.202400092

Shilei Zhou, Zhenkai Cen, Dandan Han, Bowen Zhang, Junbo Gong

{"title":"Oiling-Out in Industrial Crystallization of Organic Small Molecules: Mechanisms, Characterization, Regulation, and Applications","authors":"Shilei Zhou, Zhenkai Cen, Dandan Han, Bowen Zhang, Junbo Gong","doi":"10.1002/crat.202400092","DOIUrl":"10.1002/crat.202400092","url":null,"abstract":"Oiling-out is a common phenomenon in industrial crystallization processes that not only prolongs the total operating time but also leads to undesirable crystal morphology, making it challenging to control crystallization paths. This review provides a comprehensive overview of the oiling-out phenomenon in organic small molecule crystallization. First, the formation mechanisms of oiling-out are summarized from both thermodynamic and dynamic perspectives, providing the theoretical foundation for understanding the phenomenon. Then, the universal characterization methods for studying the oiling-out phenomenon of organic small molecules are introduced in detail, covering both offline and online analytical tools. Moreover, the regulation strategy for oiling-out, including solvents, impurities, seeding, temperature, and mixing methods are discussed. This paper also focuses on the application of oiling-out in co-assembly and crystal shape modulation. Finally, future opportunities and challenges are presented to address the current shortcomings and application bottlenecks in the study of organic small molecule oiling-out phenomena. This review aims to provide valuable insights and guidance for researchers working on the crystallization of organic small molecules, particularly in the pharmaceutical industry, to better understand, control, and utilize the oiling-out phenomenon.","PeriodicalId":48935,"journal":{"name":"Crystal Research and Technology","volume":"59 8","pages":""},"PeriodicalIF":1.5,"publicationDate":"2024-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141569881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Calcium Carbonate Nanocrystal Growth and Formation on Substrate by Thermal Chemical Vapor Deposition at Different Pre-Cursor Concentration 不同前驱体浓度下热化学气相沉积法在基底上生长和形成碳酸钙纳米晶

IF 1.5 4区材料科学

Crystal Research and Technology Pub Date : 2024-07-05 DOI: 10.1002/crat.202400051

Nurul Hidah Sulimai, Salifairus Mohammad Jafar, Zuraida Khusaimi, Mohd. Firdaus Malek, Saifollah Abdullah, Mohamad Rusop Mahmood

{"title":"Calcium Carbonate Nanocrystal Growth and Formation on Substrate by Thermal Chemical Vapor Deposition at Different Pre-Cursor Concentration","authors":"Nurul Hidah Sulimai, Salifairus Mohammad Jafar, Zuraida Khusaimi, Mohd. Firdaus Malek, Saifollah Abdullah, Mohamad Rusop Mahmood","doi":"10.1002/crat.202400051","DOIUrl":"10.1002/crat.202400051","url":null,"abstract":"Recent observations of crystallization by thermal chemical vapor deposition systems indicate that the classical mechanism of nucleation and growth is followed. Information on aragonite nanocrystal growth and formation on substrate have been lacking due to the lack of reports on diffusional growth that can observe calcium carbonate nucleation processes in thin film formation. This report is important due to the additive-free method able to grow stable single-phase nanocrystals without the presence of other phases, amorphous or impurities. This work demonstrates homogeneous nucleation occurred in gas phase reaction in a constant flow of carbon dioxide gas (100 sccm) with optimally 0.5 M calcium chloride precursor in atmospheric pressure at 400 °C resulting in a calculated crystallite size of 27.8 nm. X-ray diffraction and energy dispersive spectrometer confirm the presence of calcium carbonate nanocrystal, whereas its structural changes are observed by its micrograph from field emission scanning electron microscope. The aim is to convey its importance in gaining control of aragonite nanocrystal morphology and structural properties, and thus generate nanocrystals with controlled phase. This work may contribute to development of more sensitive and crucial applications of calcium carbonate nanocrystal thin film such as in biosensors and biomedical.","PeriodicalId":48935,"journal":{"name":"Crystal Research and Technology","volume":"59 8","pages":""},"PeriodicalIF":1.5,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141569802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring New Solid Forms of Antirheumatic Drug Hydroxychloroquine: Novel Salts with Sustained-Release Performance 探索抗风湿药物羟氯喹的新型固体制剂：具有缓释性能的新型盐类

IF 1.5 4区材料科学

Crystal Research and Technology Pub Date : 2024-07-04 DOI: 10.1002/crat.202400056

Wei-Jie Ji, Yue Wu, Minghuang Hong, Bin Zhu, Guo-Bin Ren, Ming-Hui Qi

{"title":"Exploring New Solid Forms of Antirheumatic Drug Hydroxychloroquine: Novel Salts with Sustained-Release Performance","authors":"Wei-Jie Ji, Yue Wu, Minghuang Hong, Bin Zhu, Guo-Bin Ren, Ming-Hui Qi","doi":"10.1002/crat.202400056","DOIUrl":"10.1002/crat.202400056","url":null,"abstract":"Hydroxychloroquine sulfate is a common drug for the treatment of rheumatoid arthritis. However, the disadvantage of this drug is that it needs to be taken continuously for 3–6 months to be effective and compliance of patients is poor. In this work, four new salt forms of hydroxychloroquine are successfully prepared whose crystal structures and properties are confirmed by a series of solid-state characterization methods, including infrared spectroscopy, single crystal X-ray diffraction, powder X-ray diffraction, thermal analysis, and dynamic vapor sorption analysis. The hygroscopicity, stability, equilibrium solubility, and intrinsic dissolution rate of the four new salts are also tested. The moisture absorption, solubility, and intrinsic dissolution rate of newly prepared salts are significantly reduced, and the dissolution rates of 1-hydroxy-2-naphthoate and 1,5-naphthalenedisulfonate salts are only 1/158 and 1/335 of that of the therapeutically used sulfates, respectively. It is expected that they are potentially useful to be developed into a sustained-release formulation, which can greatly improve the dosing compliance for rheumatoid arthritis treatment.","PeriodicalId":48935,"journal":{"name":"Crystal Research and Technology","volume":"59 8","pages":""},"PeriodicalIF":1.5,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141549800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In Situ Monitoring of Crystallinity of FeSe2 Thin Films During Thermal Annealing and the Annealing Effects on the Structural, Optical and Dielectric Properties 热退火过程中对 FeSe2 薄膜结晶度的现场监测以及退火对结构、光学和介电性质的影响

IF 1.5 4区材料科学

Crystal Research and Technology Pub Date : 2024-07-04 DOI: 10.1002/crat.202400097

Laila H. Gaabour, Atef Fayez Qasrawi, Seham R. Alharbi

{"title":"In Situ Monitoring of Crystallinity of FeSe2 Thin Films During Thermal Annealing and the Annealing Effects on the Structural, Optical and Dielectric Properties","authors":"Laila H. Gaabour, Atef Fayez Qasrawi, Seham R. Alharbi","doi":"10.1002/crat.202400097","DOIUrl":"10.1002/crat.202400097","url":null,"abstract":"Herein stacked layers of iron selenide (FeSe2) thin films are deposited by the physical evaporation technique and thermally annealed. An in situ monitoring of the crystallinity during the annealing process has shown that the crystallinity is reached at 100 °C. The crystallinity of the films that preferred the orthorhombic phase is enhanced with increasing annealing temperature. Evidences about the improved crystallinity are presented by the increased crystallite and grain sizes, decreased microstrain values, decreased stacking faults, and decreased defect densities with increasing annealing temperature. Optical investigations have shown impressive effect of the annealing process on the optical reflectance, optical contrast, and light absorbability. Namely, respective improvement percentages exceeding 170%, 64%, and 140% is achieved near E≈2 eV for samples annealed at 200 °C for 20 min. Both direct and indirect optical transitions are dominant in the film. In addition the annealing increased the dielectric constant in the spectral range of 1.17–4.20 eV. Maximum dielectric enhancement by 214% is reached near ≈2.10 eV. Moreover, the annealing process increases the optical conductivity and drift mobility of the FeSe2 films. The improvement in the crystallinity that resulted in enhanced optical properties makes the thermally annealed FeSe2 films promising for optoelectronic technology applications.","PeriodicalId":48935,"journal":{"name":"Crystal Research and Technology","volume":"59 8","pages":""},"PeriodicalIF":1.5,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141549801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nucleation Control and Isolation of Polymorphic Forms of Aspirin through an Efficient Template-Assisted Swift Cooling Process 通过高效模板辅助快速冷却工艺控制成核并分离多晶型阿司匹林

IF 1.5 4区材料科学

Crystal Research and Technology Pub Date : 2024-06-26 DOI: 10.1002/crat.202400046

Ramya Muthusamy, Nandhu varshini Gnanasekar, Srinivasan Karuppannan

{"title":"Nucleation Control and Isolation of Polymorphic Forms of Aspirin through an Efficient Template-Assisted Swift Cooling Process","authors":"Ramya Muthusamy, Nandhu varshini Gnanasekar, Srinivasan Karuppannan","doi":"10.1002/crat.202400046","DOIUrl":"10.1002/crat.202400046","url":null,"abstract":"Aspirin, a commonly used pharmaceutical therapeutic pharmacological substance, exhibits cross-nucleation (intergrowth or overgrowth) of stable polymorphic Form-I over the preferably required metastable polymorphic Form-II, which creates a bottleneck issue in the solution crystallization of aspirin in most organic solvents and their mixtures. Controlling the overgrowth phenomenon is a key factor for designing the pharmaceutical drug material aspirin with desired properties. Hence, our present work chose a novel template-assisted swift cooling crystallization with selected templates like copper-wire and nylon 6/6 polymer, and also N-N-Dimethylformamide (DMF) as a solvent. The pure solution in the absence and the presence of a nylon 6/6 template in all the experimental supersaturation ranges achieves only thermodynamically stable polymorphic Form-I of aspirin with slightly different morphologies. Contrarily, the presence of a copper-wire template induces both stable and metastable polymorphs of aspirin depending on the level of supersaturation in the mother solution. The effect of templates on the nucleation kinetics of aspirin polymorphs is estimated using classical nucleation theory, and the determined values exactly match with experimental results. The polymorphic nature of the grown crystals is ascertained by powder X-ray diffraction (PXRD), single crystal X-ray diffraction (SCXRD), and differential scanning calorimetry (DSC) analyses.","PeriodicalId":48935,"journal":{"name":"Crystal Research and Technology","volume":"59 8","pages":""},"PeriodicalIF":1.5,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141511346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation on the Crystal Structures of Molecules Related to 2-(Benzylsulfinyl)Benzoic Acid, As a Support to the Studies on the Inhibition of Human Carbonic Anhydrases 研究与 2-(苄基亚磺酰基)苯甲酸有关的分子的晶体结构，为研究人类碳酸酐酶提供支持

IF 1.5 4区材料科学

Crystal Research and Technology Pub Date : 2024-06-26 DOI: 10.1002/crat.202400096

Maria Annunziata M. Capozzi, Angel Alvarez-Larena, Joan F. Piniella Febrer, Cosimo Cardellicchio

{"title":"Investigation on the Crystal Structures of Molecules Related to 2-(Benzylsulfinyl)Benzoic Acid, As a Support to the Studies on the Inhibition of Human Carbonic Anhydrases","authors":"Maria Annunziata M. Capozzi, Angel Alvarez-Larena, Joan F. Piniella Febrer, Cosimo Cardellicchio","doi":"10.1002/crat.202400096","DOIUrl":"10.1002/crat.202400096","url":null,"abstract":"A recent interest attaches to the derivatives of the (2-benzylsulfinyl)benzoic acid as inhibitors of human carbonic anhydrases (hCAs), an action that can be applied in innovative therapies. A set of crystal structures of six sulfides and six enantiopure sulfoxides related to this scaffold, taken from the literature, or derived from the work on the asymmetric synthesis of sulfinyl compounds, is investigated. The lattice energies of these structures are estimated by means of the Crystal Explorer 21 program. The weak interactions building up the crystal structures are identified, and their contributions are analyzed in comparison with the calculated lattice energies. The most stable conformations in the solid phase are identified. It is worth observing that the sulfides of the scaffold under investigation behave almost in the same manner; on the other hand, the presence of the sulfinyl group of the sulfoxides adds complexity, that shall be taken into account in future docking calculations of these molecules with the hCAs enzymes.","PeriodicalId":48935,"journal":{"name":"Crystal Research and Technology","volume":"59 8","pages":""},"PeriodicalIF":1.5,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141511345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A New Polymorphic Form of Maltol: Crystallization and Structure Refinement 一种新的麦芽酚多晶型：结晶与结构完善

IF 1.5 4区材料科学

Crystal Research and Technology Pub Date : 2024-06-25 DOI: 10.1002/crat.202300336

Kavipriya Srinivasan, Srinivasan Karuppannan

引用次数: 0