用缓慢蒸发法从混合溶剂中结晶对氨基苯甲酸的 α 和 β 多晶体

IF 1.5 4区 材料科学 Q3 Chemistry
Ansu Mathew, Madhumitha Madhesh, Srinivasan Karuppannan
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引用次数: 0

摘要

对氨基苯甲酸(p-ABA)是一种众所周知的具有挑战性的多晶性的药物材料,本文选择对其进行研究。该材料有四种报道的多晶态,包含两种溶液形式(α和β),一种蒸汽形式和高压形式。在298、303和308 K的温度下,用九种不同混合成分的水和异丙醇混合溶剂,实验培养了α和β。用重量法计算了市售p-ABA的溶解度,并采用慢溶剂蒸发法在不同温度下,在所有混合比下生长多晶晶体。一个三元图构建的溶解度的p-ABA在混合溶剂给出了洞察成核性质的两个多晶型。为了了解两种形式的p-ABA的成核和生长的性质,进行了原位显微镜研究,并用粉末x射线衍射分析和差示扫描量热法对生长的晶体进行了表征。这也证实了生长的晶体是两种溶液生长的对氨基苯甲酸多晶型,都属于P21/n空间群的单斜体系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Crystallization of α and β Polymorphs of Para Aminobenzoic Acid from Mixed Solvents by Slow Evaporation Method

Para aminobenzoic acid (p-ABA), a well-known pharmaceutical material with a challenging polymorphic nature, is chosen for study in this paper. The material has four reported polymorphs, containing two solution forms (α and β), a vapor form, and a high-pressure form. The solution-grown forms α and β are experimentally grown using mixed solvents of water and isopropyl alcohol with nine different mixing compositions at temperatures of 298, 303, and 308 K. The solubility of the commercially available p-ABA is calculated gravimetrically, and the polymorphic crystals are grown using the slow solvent evaporation method for all the mixing ratios at different temperatures. A ternary diagram constructed on the solubility of p-ABA in mixed solvents gives an insight into the nucleation nature of two polymorphs. To understand the nature of nucleation and growth of two forms of p-ABA, an in situ microscopic study is carried out, and the grown crystals are characterized using powder X-ray diffraction analysis and differential scanning calorimetry. This also confirmed that the grown crystals are two solutions grown polymorphs of para aminobenzoic acid, both belonging to monoclinic systems with P21/n space group.

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来源期刊
CiteScore
2.50
自引率
6.70%
发文量
121
审稿时长
1.9 months
期刊介绍: The journal Crystal Research and Technology is a pure online Journal (since 2012). Crystal Research and Technology is an international journal examining all aspects of research within experimental, industrial, and theoretical crystallography. The journal covers the relevant aspects of -crystal growth techniques and phenomena (including bulk growth, thin films) -modern crystalline materials (e.g. smart materials, nanocrystals, quasicrystals, liquid crystals) -industrial crystallisation -application of crystals in materials science, electronics, data storage, and optics -experimental, simulation and theoretical studies of the structural properties of crystals -crystallographic computing
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