Journal of Obsessive-Compulsive and Related Disorders最新文献

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Yale-Brown Obsessive-Compulsive Scale Modified for Body Dysmorphic Disorder: Factor structure and construct validity of subfactors 针对身体畸形障碍修改的耶鲁-布朗强迫量表:子因子的因子结构和结构效度
IF 1.8 4区 医学
Journal of Obsessive-Compulsive and Related Disorders Pub Date : 2024-06-07 DOI: 10.1016/j.jocrd.2024.100881
Ivar Snorrason , Adam C. Jaroszewski , Jennifer L. Greenberg , Hilary Weingarden , Berta J. Summers , Angela Fang , Susanne S. Hoeppner , Eric Hollander , Wayne K. Goodman , Katharine A. Phillips , Sabine Wilhelm
{"title":"Yale-Brown Obsessive-Compulsive Scale Modified for Body Dysmorphic Disorder: Factor structure and construct validity of subfactors","authors":"Ivar Snorrason ,&nbsp;Adam C. Jaroszewski ,&nbsp;Jennifer L. Greenberg ,&nbsp;Hilary Weingarden ,&nbsp;Berta J. Summers ,&nbsp;Angela Fang ,&nbsp;Susanne S. Hoeppner ,&nbsp;Eric Hollander ,&nbsp;Wayne K. Goodman ,&nbsp;Katharine A. Phillips ,&nbsp;Sabine Wilhelm","doi":"10.1016/j.jocrd.2024.100881","DOIUrl":"10.1016/j.jocrd.2024.100881","url":null,"abstract":"<div><p>The Yale-Brown Obsessive-Compulsive Scale modified for Body Dysmorphic Disorder (BDD-YBOCS) is a semi-structured interview designed to assess the severity of current BDD. The aim of the study was to examine the factor structure and construct validity of the BDD-YBOCS. The sample included 366 adults with BDD who completed the BDD-YBOCS and other measures of BDD severity/impairment, psychiatric distress (i.e., anxiety and depression) and quality of life. Exploratory factor analysis supported two factors that were weakly correlated with each other (<em>r</em> = 0.21) (1) Severity (i.e., time, distress, interference, and avoidance; 31.6% of the variance): and (2) Resistance/Control (i.e., reduced effort to resist symptoms and lack of control over symptoms; 16.7% of the variance). The Severity factor had good internal consistency (<em>α</em> = 0.82) and good construct validity (<em>rs</em> = 0.69-0.81 with BDD severity/impairment; <em>rs</em> = 0.38-0.56 with depression and anxiety; and <em>rs</em> = 0.48-0.53 with functional impairment and quality of life). The Resistance/Control factor had acceptable internal consistency (<em>α</em> = 0.74) but more limited construct validity (<em>rs</em> = 0.27-0.28 with BDD severity/impairment (<em>rs</em> = 0.04-0.20 with depression and anxiety and <em>rs</em> = 0.05-0.14 with functional impairment and quality of life). Implications for the conceptualization and assessment of BDD severity are discussed.</p></div>","PeriodicalId":48902,"journal":{"name":"Journal of Obsessive-Compulsive and Related Disorders","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141415375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Incompleteness as a clinical characteristic and predictor of treatment outcome in obsessive-compulsive disorder 不完整性是强迫症的临床特征和治疗效果预测因素
IF 1.8 4区 医学
Journal of Obsessive-Compulsive and Related Disorders Pub Date : 2024-05-24 DOI: 10.1016/j.jocrd.2024.100880
Lina Lundström , Ekaterina Ivanova , David Mataix-Cols , Oskar Flygare , Matti Cervin , Christian Rück , Erik Andersson
{"title":"Incompleteness as a clinical characteristic and predictor of treatment outcome in obsessive-compulsive disorder","authors":"Lina Lundström ,&nbsp;Ekaterina Ivanova ,&nbsp;David Mataix-Cols ,&nbsp;Oskar Flygare ,&nbsp;Matti Cervin ,&nbsp;Christian Rück ,&nbsp;Erik Andersson","doi":"10.1016/j.jocrd.2024.100880","DOIUrl":"10.1016/j.jocrd.2024.100880","url":null,"abstract":"<div><p>Incompleteness, that is, a feeling that things are “not just right”, is an understudied symptom of obsessive-compulsive disorder (OCD). We used data from 167 adult individuals with OCD who received internet-delivered cognitive behaviour therapy (ICBT) to examine how incompleteness was associated with clinical characteristics and treatment outcomes. Incompleteness was assessed using the Obsessive-Compulsive Trait Core Dimensions Questionnaire (OCTCDQ). Results showed that the proposed two-factor structure of the OCTCDQ had adequate model/data fit in the present sample. Incompleteness was positively associated with baseline symmetry/ordering symptoms (β = 0.52, [95% CI 0.48 to 0.56], <em>p</em> &lt; 0.001), psychiatric comorbidity (β = 0.23, [95% CI 0.21 to 0.25], <em>p</em> &lt; 0.05) and self-reported symptom severity (Y-BOCS-SR β = 0.35, [95% CI 0.27 to 0.43], <em>p</em> &lt; 0.001; OCI-R β = 0.46, [95% CI 0.34 to 0.59], <em>p</em> &lt; 0.001). Results showed that higher degree of incompleteness predicted a worse treatment outcome on clinician-rated, but not self-rated, measures of symptom severity. Participants with a high (vs. low) degree of incompleteness were less likely to be classified as responders (39% vs. 52%) and remitters (10% vs. 34%) at post-treatment. The results suggest that incompleteness is a clinically relevant feature of OCD, which may require treatment adaptations for some patients but more research is needed to confirm that the findings are not entirely due to measurement error.</p></div>","PeriodicalId":48902,"journal":{"name":"Journal of Obsessive-Compulsive and Related Disorders","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2211364924000241/pdfft?md5=187972b5cf186f4ea51ebf22fe4f05ae&pid=1-s2.0-S2211364924000241-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141134117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metacognitive profiles in children and adolescents with obsessive-compulsive disorder 患有强迫症的儿童和青少年的元认知特征
IF 1.8 4区 医学
Journal of Obsessive-Compulsive and Related Disorders Pub Date : 2024-04-01 DOI: 10.1016/j.jocrd.2024.100874
Cecilie Schultz Isaksen , Per Hove Thomsen , Lara J. Farrell , Davíð R.M.A. Højgaard , Lidewij Wolters , Judith Nissen , Allison M. Waters , Katja A. Hybel
{"title":"Metacognitive profiles in children and adolescents with obsessive-compulsive disorder","authors":"Cecilie Schultz Isaksen ,&nbsp;Per Hove Thomsen ,&nbsp;Lara J. Farrell ,&nbsp;Davíð R.M.A. Højgaard ,&nbsp;Lidewij Wolters ,&nbsp;Judith Nissen ,&nbsp;Allison M. Waters ,&nbsp;Katja A. Hybel","doi":"10.1016/j.jocrd.2024.100874","DOIUrl":"https://doi.org/10.1016/j.jocrd.2024.100874","url":null,"abstract":"<div><p>It has been suggested that maladaptive metacognition (beliefs and strategies) is related to the development and maintenance of obsessive-compulsive disorder (OCD). The aims of the study were to explore whether subgroups of pediatric OCD patients could be identified based on self-reported generic metacognition, and to compare these potential subgroups with a non-clinical control group. Additionally, differences between subgroups were examined across demographic (age and sex) and clinical characteristics (OCD severity and insight, types of OCD symptoms, and co-occurring symptoms). The study included a pooled sample of 157 pediatric OCD patients (age 7–18 years) and 58 non-clinical controls. Latent profile analyses supported a model with three profiles characterized by low, moderate, and high levels of maladaptive metacognition relative to the control group. Children and adolescents with higher age, greater OCD severity, specific OCD symptoms (e.g., aggressive, sexual, somatic, religious, and self-rated obsessing symptoms), and/or co-occurring internalizing symptoms (including anxiety and depressive symptoms) had a higher probability of belonging to a group with higher levels of maladaptive metacognition. The emergent profiles indicate heterogeneity in metacognition and clinical expression among children and adolescents with OCD, suggesting that generic metacognition could be a possible treatment target for some of these patients.</p></div>","PeriodicalId":48902,"journal":{"name":"Journal of Obsessive-Compulsive and Related Disorders","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2211364924000186/pdfft?md5=d6318757723bf86dc7e804d7bbd113bb&pid=1-s2.0-S2211364924000186-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140633231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Understanding stigma in hoarding disorder: A systematic review 了解囤积症的成见:系统回顾
IF 1.8 4区 医学
Journal of Obsessive-Compulsive and Related Disorders Pub Date : 2024-04-01 DOI: 10.1016/j.jocrd.2024.100872
Rachel M. Prosser , James P. Dennis , Paul M. Salkovskis
{"title":"Understanding stigma in hoarding disorder: A systematic review","authors":"Rachel M. Prosser ,&nbsp;James P. Dennis ,&nbsp;Paul M. Salkovskis","doi":"10.1016/j.jocrd.2024.100872","DOIUrl":"https://doi.org/10.1016/j.jocrd.2024.100872","url":null,"abstract":"<div><p>The degree to which hoarding disorder (HD) is stigmatised by the public, and that this is internalised by people with HD, is a relatively neglected research area. This review aimed to synthesise current understanding of stigma of HD and its impact on help-seeking. A systematic search was conducted to identify publications which investigated public or internalised stigma, or related concepts like shame and blame, in relation to HD. The electronic databases PsycINFO, PubMed, Embase, Scopus, Medline, CINAHL, and Web of Science were searched. Fifteen papers met inclusion criteria and were appraised for quality using the QualSyst tool. There is very little literature exploring stigma in HD and quality of research is variable. Nevertheless, the literature suggests that a significant proportion of people who hoard and their families experience stigma, and HD is stigmatised by the public and associated with more rejecting attitudes and frustration amongst professionals. Finally, research exploring the impact of stigma on help-seeking in HD tentatively suggested a negative impact of stigma. Further research is needed to replicate and extend findings and address methodological limitations to provide an understanding of stigma on which approaches to enhance wellbeing and treatment uptake in HD can be developed. Systematic review (PROSPERO) registration number: CRD42022375820.</p></div>","PeriodicalId":48902,"journal":{"name":"Journal of Obsessive-Compulsive and Related Disorders","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2211364924000162/pdfft?md5=90f2c225078f191ea0ee77296516918d&pid=1-s2.0-S2211364924000162-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140620650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Psychometric properties of the Children's Yale-Brown obsessive compulsive scale second edition in autistic youth 儿童雅礼-布朗强迫症量表第二版在自闭症青少年中的心理测量特性
IF 1.8 4区 医学
Journal of Obsessive-Compulsive and Related Disorders Pub Date : 2024-04-01 DOI: 10.1016/j.jocrd.2024.100879
Minjee Kook , Michelle E. Yang , Mbonobong Usua , Jane Clinger , Sophie C. Schneider , Leandra N. Berry , Robin Goin-Kochel , Andrew Wiese , David Riddle , Amanda Palo , Allie Townsend , Wayne K. Goodman , Eric A. Storch , Andrew G. Guzick
{"title":"Psychometric properties of the Children's Yale-Brown obsessive compulsive scale second edition in autistic youth","authors":"Minjee Kook ,&nbsp;Michelle E. Yang ,&nbsp;Mbonobong Usua ,&nbsp;Jane Clinger ,&nbsp;Sophie C. Schneider ,&nbsp;Leandra N. Berry ,&nbsp;Robin Goin-Kochel ,&nbsp;Andrew Wiese ,&nbsp;David Riddle ,&nbsp;Amanda Palo ,&nbsp;Allie Townsend ,&nbsp;Wayne K. Goodman ,&nbsp;Eric A. Storch ,&nbsp;Andrew G. Guzick","doi":"10.1016/j.jocrd.2024.100879","DOIUrl":"https://doi.org/10.1016/j.jocrd.2024.100879","url":null,"abstract":"<div><p>Autism affects as many as one in 36 children, a majority of whom experience comorbid anxiety or obsessive-compulsive disorder. Obsessive-compulsive symptoms share phenotypic similarities with autism characteristics (e.g., repetitive thoughts and behaviors) and some symptoms are difficult to disentangle (e.g., obsessions from specific interests/fixations). Hence, there is a need for OCD assessments that are validated to be used among autistic youth. This study evaluated the psychometric properties of the Children's Yale-Brown Obsessive Compulsive Scale - Second Edition (CY-BOCS-II) in 91 autistic youth seeking treatment for anxiety and/or obsessive-compulsive symptoms. The CY-BOCS-II demonstrated strong convergent and divergent validity, internal consistency, and treatment sensitivity. The CY-BOCS-II is a psychometrically sound measure of obsessive-compulsive symptoms in autistic youth, although it should be evaluated across larger and more diverse samples.</p></div>","PeriodicalId":48902,"journal":{"name":"Journal of Obsessive-Compulsive and Related Disorders","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140843577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The contribution of inferential confusion and fear of self to psychological models of obsessive-compulsive symptoms: A dimensional approach 推理混乱和自我恐惧对强迫症状心理模型的贡献:维度方法
IF 1.8 4区 医学
Journal of Obsessive-Compulsive and Related Disorders Pub Date : 2024-04-01 DOI: 10.1016/j.jocrd.2024.100875
Nicholas S. Myers , Emily K. Juel , Joseph B. Friedman , Heidi J. Ojalehto , Maya E. Tadross , Chase M. DuBois , Amitai Abramovitch , Dean McKay , Jonathan S. Abramowitz
{"title":"The contribution of inferential confusion and fear of self to psychological models of obsessive-compulsive symptoms: A dimensional approach","authors":"Nicholas S. Myers ,&nbsp;Emily K. Juel ,&nbsp;Joseph B. Friedman ,&nbsp;Heidi J. Ojalehto ,&nbsp;Maya E. Tadross ,&nbsp;Chase M. DuBois ,&nbsp;Amitai Abramovitch ,&nbsp;Dean McKay ,&nbsp;Jonathan S. Abramowitz","doi":"10.1016/j.jocrd.2024.100875","DOIUrl":"https://doi.org/10.1016/j.jocrd.2024.100875","url":null,"abstract":"<div><p>Current psychological models of obsessive-compulsive disorder account for a surprisingly small degree of variability in obsessive-compulsive (OC) symptoms in statistical models. The current study examined whether constructs from the inference-based approach to OCD (i.e., inferential confusion and fear of self) explain OC symptom dimensions above and beyond what is explained by the prevailing cognitive appraisal model. Undergraduate participants (<em>N</em> = 339) completed a battery of self-report questionnaires assessing OC symptoms, obsessive beliefs, inferential confusion, and fear of self. Results revealed that both psychological models together accounted for about one quarter of the variance in OC symptoms. The inference-based approach concepts most closely aligned with responsibility, symmetry, and unacceptable thoughts, and added explanatory value to appraisal models of these symptom domains. Limitations and future directions are discussed.</p></div>","PeriodicalId":48902,"journal":{"name":"Journal of Obsessive-Compulsive and Related Disorders","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140558976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
State-dependent effects of repetitive transcranial magnetic stimulation on symptom dimensions of obsessive-compulsive disorder: A case report 重复经颅磁刺激对强迫症症状维度的状态依赖效应:病例报告
IF 1.8 4区 医学
Journal of Obsessive-Compulsive and Related Disorders Pub Date : 2024-04-01 DOI: 10.1016/j.jocrd.2024.100876
Wellington Chang , Ruibei Li , Barbara Van Noppen, Adam C. Frank
{"title":"State-dependent effects of repetitive transcranial magnetic stimulation on symptom dimensions of obsessive-compulsive disorder: A case report","authors":"Wellington Chang ,&nbsp;Ruibei Li ,&nbsp;Barbara Van Noppen,&nbsp;Adam C. Frank","doi":"10.1016/j.jocrd.2024.100876","DOIUrl":"https://doi.org/10.1016/j.jocrd.2024.100876","url":null,"abstract":"<div><p>Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive neuromodulation procedure that is FDA-cleared for treating obsessive-compulsive disorder (OCD). Evidence suggests that controlling brain state during rTMS treatment can influence treatment outcomes. We present the case of a patient with refractory OCD who received symptom provocation immediately preceding rTMS treatment sessions. The patient experienced more subjective and objective improvement in OCD symptoms targeted by provocations than in other symptom domains. These results suggest the importance of brain state during rTMS and could be used to guide and optimize neuromodulation treatment for OCD.</p></div>","PeriodicalId":48902,"journal":{"name":"Journal of Obsessive-Compulsive and Related Disorders","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2211364924000204/pdfft?md5=e06251ecd3331b3e0fab156efbb46943&pid=1-s2.0-S2211364924000204-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140554528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Approach and barriers to the assessment and treatment of individuals with co-occurring OCD and PTSD: Treatment providers’ perspectives 对同时患有强迫症和创伤后应激障碍的患者进行评估和治疗的方法和障碍:治疗提供者的观点
IF 1.8 4区 医学
Journal of Obsessive-Compulsive and Related Disorders Pub Date : 2024-04-01 DOI: 10.1016/j.jocrd.2024.100877
Caitlin M. Pinciotti , Gabriella T. Ponzini , Natalie E. Hundt , Terri L. Fletcher , Stephanie Y. Wells , Lauren P. Wadsworth , Nathaniel Van Kirk , Jonathan S. Abramowitz , Kimberley Quinlan , Wayne K. Goodman , Eric A. Storch
{"title":"Approach and barriers to the assessment and treatment of individuals with co-occurring OCD and PTSD: Treatment providers’ perspectives","authors":"Caitlin M. Pinciotti ,&nbsp;Gabriella T. Ponzini ,&nbsp;Natalie E. Hundt ,&nbsp;Terri L. Fletcher ,&nbsp;Stephanie Y. Wells ,&nbsp;Lauren P. Wadsworth ,&nbsp;Nathaniel Van Kirk ,&nbsp;Jonathan S. Abramowitz ,&nbsp;Kimberley Quinlan ,&nbsp;Wayne K. Goodman ,&nbsp;Eric A. Storch","doi":"10.1016/j.jocrd.2024.100877","DOIUrl":"https://doi.org/10.1016/j.jocrd.2024.100877","url":null,"abstract":"<div><p>Obsessive-compulsive disorder (OCD) and posttraumatic stress disorder (PTSD) frequently co-occur, and phenotypic and functional similarities between the disorders necessitate assessment and treatment considerations by providers. To date, no research has reported on mental health treatment providers’ approach to, and barriers associated with, assessing and treating patients with this complex comorbidity. The present study included 169 mental health providers, the majority of whom were cognitive behaviorally-oriented specialists who had recently treated co-occurring OCD and PTSD. Having a doctorate degree and overall years of experience predicted greater perceived competence to assess and conceptualize co-occurring OCD and PTSD. Recent clinical experience with co-occurring OCD and PTSD predicted perceived competence to conceptualize and treat individuals with both disorders. PTSD specialists perceived themselves as more competent to treat co-occurring OCD and PTSD than non-PTSD specialists. Most providers indicated some barriers to adequate assessment and treatment of individuals with co-occurring OCD and PTSD, including competing priorities and lack of time. Implications of findings are discussed within the context of future training targets to equip providers with the tools needed to conduct comprehensive and accurate diagnostic and functional assessment, as well as provide evidence-based treatment tailored to the unique needs of individuals with co-occurring OCD and PTSD.</p></div>","PeriodicalId":48902,"journal":{"name":"Journal of Obsessive-Compulsive and Related Disorders","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140618798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Psychedelics, OCD and related disorders: A systematic review 迷幻剂、强迫症和相关障碍:系统回顾
IF 1.8 4区 医学
Journal of Obsessive-Compulsive and Related Disorders Pub Date : 2024-04-01 DOI: 10.1016/j.jocrd.2024.100873
Marianna Graziosi , Julia S. Rohde , Praachi Tiwari , Jedidiah Siev , David B. Yaden
{"title":"Psychedelics, OCD and related disorders: A systematic review","authors":"Marianna Graziosi ,&nbsp;Julia S. Rohde ,&nbsp;Praachi Tiwari ,&nbsp;Jedidiah Siev ,&nbsp;David B. Yaden","doi":"10.1016/j.jocrd.2024.100873","DOIUrl":"https://doi.org/10.1016/j.jocrd.2024.100873","url":null,"abstract":"<div><p>This systematic review analyzes the current literature on the potential therapeutic use of classic psychedelics (i.e., psilocybin, lysergic acid diethylamide [LSD], N,N-dimethyltryptamine [DMT], 5-methoxy-N,N-dimethyltryptamine [5-MeO-DMT], mescaline, and other classic psychedelic analogs utilized in preclinical models) in obsessive-compulsive disorder (OCD) and related disorders. Our search identified 23 articles meeting our predetermined eligibility criteria, comprising 2 non-systematic reviews, 11 preclinical studies investigating the use of classic psychedelics or analogs in preclinical models of OCD, 8 case studies or case reports, and 2 clinical trials. This review provides an up-to-date synthesis of psychedelic OCD research, bridging preclinical findings, historical case reports, and initial clinical trial outcomes. Psilocybin appears to be the most widely used classic psychedelic and is well-tolerated in both OCD and body dysmorphic disorder (BDD) populations, with some participants experiencing significant symptom reduction. This review contributes to our understanding of the potential of classic psychedelics (in particular LSD and psilocybin) as novel therapeutic interventions for OCD and related disorders, offering insights into future research directions and clinical applications in this emerging field.</p></div>","PeriodicalId":48902,"journal":{"name":"Journal of Obsessive-Compulsive and Related Disorders","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140547109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
“Should I keep washing my groceries?“: Predictors of differential patterns of contamination-related obsessive-compulsive symptoms since the onset of COVID-19 pandemic "我是否应该继续清洗我的杂货?COVID-19大流行以来与污染相关的强迫症状差异模式的预测因素
IF 1.8 4区 医学
Journal of Obsessive-Compulsive and Related Disorders Pub Date : 2024-04-01 DOI: 10.1016/j.jocrd.2024.100878
Sara Wilkerson, Dean McKay
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